Search Results - "DORSCHEID, Delbert R"

ACE-2 expression in the small airway epithelia of smokers and COPD patients: implications for COVID-19 by Leung, Janice M, Yang, Chen X, Tam, Anthony, Shaipanich, Tawimas, Hackett, Tillie-Louise, Singhera, Gurpreet K, Dorscheid, Delbert R, Sin, Don D

“…The World Health Organization (WHO) has declared coronavirus disease 2019 (COVID-19) a pandemic [1]. COVID-19 is caused by severe acute respiratory syndrome…”
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Various factors affect lipopolysaccharide sensitization in cell cultures by Yang, Nan, Sin, Don D, Dorscheid, Delbert R

“…Commercially available lipopolysaccharide (LPS) is commonly used in research. Although protocols for its use are well established, we experienced a loss of LPS…”
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Intrinsic phenotypic differences of asthmatic epithelium and its inflammatory responses to respiratory syncytial virus and air pollution by Hackett, Tillie-Louise, Singhera, Gurpreet K, Shaheen, Furquan, Hayden, Patrick, Jackson, George R, Hegele, Richard G, Van Eeden, Stephan, Bai, Tony R, Dorscheid, Delbert R, Knight, Darryl A

“…A substantial proportion of healthcare cost associated with asthma is attributable to exacerbations of the disease. Within the airway, the epithelium forms the…”
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Toll-Like Receptor 4-Mediated Activation of p38 Mitogen-Activated Protein Kinase Is a Determinant of Respiratory Virus Entry and Tropism by MARCHANT, David, SINGHERA, Gurpreet K, UTOKAPARCH, Soraya, HACKETT, Tillie L, BOYD, John H, ZONGSHU LUO, XIAONING SI, DORSCHEID, Delbert R, MCMANUS, Bruce M, HEGELE, Richard G

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Guidance for Administering Biologics for Severe Asthma and Allergic Conditions by Dorscheid, Delbert R., Lee, Jason K., Ramesh, Warren, Greenwald, Mark, Del Carpio, Jaime

“…Asthma is a common respiratory disorder in Canada for which biologics may be prescribed for poorly controlled illness. Treatment with biologics, however, is…”
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Transcriptomic and proteomic host response to Aspergillus fumigatus conidia in an air-liquid interface model of human bronchial epithelium by Toor, Amreen, Culibrk, Luka, Singhera, Gurpreet K, Moon, Kyung-Mee, Prudova, Anna, Foster, Leonard J, Moore, Margo M, Dorscheid, Delbert R, Tebbutt, Scott J

“…Aspergillus fumigatus (A. fumigatus) is a wide-spread fungus that is a potent allergen in hypersensitive individuals but also an opportunistic pathogen in…”
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Airway Epithelial-Derived Immune Mediators in COVID-19 by Guo, Tony J. F, Singhera, Gurpreet K, Leung, Janice M, Dorscheid, Delbert R

“…The airway epithelium, which lines the conducting airways, is central to the defense of the lungs against inhaled particulate matter and pathogens such as…”
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Olodaterol exerts anti-inflammatory effects on COPD airway epithelial cells by Yang, Nan, Singhera, Gurpreet K, Yan, Yi Xuan, Pieper, Michael P, Leung, Janice M, Sin, Don D, Dorscheid, Delbert R

“…Airway inflammation is a key feature of chronic obstructive pulmonary disease (COPD) and inhaled corticosteroids (ICS) remain the main treatment for airway…”
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Secretion of IL-13 by Airway Epithelial Cells Enhances Epithelial Repair via HB-EGF by Allahverdian, Sima, Harada, Norihiro, Singhera, Gurpreet K, Knight, Darryl A, Dorscheid, Delbert R

“…Inappropriate repair after injury to the epithelium generates persistent activation, which may contribute to airway remodeling. In the present study we…”
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IL-4Rα blockade reduces influenza-associated morbidity in a murine model of allergic asthma by Shahangian, Kimia, Ngan, David A, Chen, H H Rachel, Oh, Yeni, Tam, Anthony, Wen, Jing, Cheung, Chung, Knight, Darryl A, Dorscheid, Delbert R, Hackett, Tillie L, Hughes, Michael R, McNagny, Kelly M, Hirota, Jeremy A, Niikura, Masahiro, Man, S F Paul, Sin, Don D

“…Asthma was identified as the most common comorbidity in hospitalized patients during the 2009 H1N1 influenza pandemic. We determined using a murine model of…”
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Omalizumab in patients with severe asthma and persistent sputum eosinophilia by Mukherjee, Manali, Kjarsgaard, Melanie, Radford, Katherine, Huang, Chynna, Leigh, Richard, Dorscheid, Delbert R, Lemiere, Catherine, Boulet, Louis-Philippe, Waserman, Susan, Martin, James, Nair, Parameswaran

“…Omalizumab, a recombinant humanized monoclonal antibody targeting the IgE molecule, is the first biologic approved for moderate-to-severe allergic asthmatics,…”
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Gene expression analysis in asthma using a targeted multiplex array by Pascoe, Christopher D, Obeidat, Ma'en, Arsenault, Bryna A, Nie, Yunlong, Warner, Stephanie, Stefanowicz, Dorota, Wadsworth, Samuel J, Hirota, Jeremy A, Jasemine Yang, S, Dorscheid, Delbert R, Carlsten, Chris, Hackett, Tillie L, Seow, Chun Y, Paré, Peter D

“…Gene expression changes in the structural cells of the airways are thought to play a role in the development of asthma and airway hyperresponsiveness. This…”
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Epithelial expression of TLR4 is modulated in COPD and by steroids, salmeterol and cigarette smoke by MacRedmond, Ruth E, Greene, Catherine M, Dorscheid, Delbert R, McElvaney, Noel G, O'Neill, Shane J

“…The toll-like receptors (TLRs) are a key component of host defense in the respiratory epithelium. Cigarette smoking is associated with increased susceptibility…”
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Phagocytosis of Aspergillus fumigatus by Human Bronchial Epithelial Cells Is Mediated by the Arp2/3 Complex and WIPF2 by Culibrk, Luka, Croft, Carys A, Toor, Amreen, Yang, S Jasemine, Singhera, Gurpreet K, Dorscheid, Delbert R, Moore, Margo M, Tebbutt, Scott J

“…is an opportunistic fungal pathogen capable of causing severe infection in humans. One of the limitations in our understanding of how causes infection concerns…”
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Formation of a Stable Mimic of Ambient Particulate Matter Containing Viable Infectious Respiratory Syncytial Virus and Its Dry-Deposition Directly onto Cell Cultures by Cruz-Sanchez, Teresita M, Haddrell, Allen E, Hackett, Tillie L, Singhera, Gurpreet K, Marchant, David, Lekivetz, Ryan, Meredith, Anna, Horne, Derrick, Knight, Darryl A, van Eeden, Stephen F, Bai, Tony R, Hegele, Richard G, Dorscheid, Delbert R, Agnes, George R

“…Epidemiological associations of worse respiratory outcomes from combined exposure to ambient particulate matter (PM) and respiratory viral infection suggest…”
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Hedgehog Signaling as a Therapeutic Target for Airway Remodeling and Inflammation in Allergic Asthma by Tam, Anthony, Osei, Emmanuel Twumasi, Cheung, Chung Y, Hughes, Michael, Yang, Chen X, McNagny, Kelly M, Dorscheid, Delbert R, Singhera, Gurpreet K, Hallstrand, Teal S, Warner, Stephanie, Hogg, James C, Hackett, Tillie L, Lim, Chinten J, Sin, Don D

“…Genome-wide association studies (GWAS) have shown that variants of patched homolog 1 (PTCH1) are associated with lung function abnormalities in the general…”
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IL-13 and TH2 cytokine exposure triggers matrix metalloproteinase 7-mediated Fas ligand cleavage from bronchial epithelial cells by Wadsworth, Samuel J, Atsuta, Ryo, McIntyre, J Oliver, Hackett, Tillie-Louise, Singhera, Gurpreet K, Dorscheid, Delbert R

“…Bronchial epithelial damage and activation likely contribute to the inflammatory and airway-remodeling events characteristic of severe asthma. Interaction of…”
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Apoptosis of Airway Epithelial Cells Induced by Corticosteroids by DORSCHEID, DELBERT R, WOJCIK, KIMBERLY R, SUN, STEVEN, MARROQUIN, BERTHA, WHITE, STEVEN R

“…Damage to the airway epithelium is one prominent feature of chronic asthma. Corticosteroids induce apoptosis in inflammatory cells, which in part explains…”
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IL‐13 signaling through IL‐13 receptor α2 mediates airway epithelial wound repair by Yang, S. Jasemine, Allahverdian, Sima, Saunders, Angela D. R., Liu, Emily, Dorscheid, Delbert R.

“…ABSTRACT Asthma is an airway inflammatory disease characterized by epithelial barrier dysfunction and airway remodeling. Interleukin‐13 (IL‐13) is a…”
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Corticosteroid-induced apoptosis of airway epithelium: a potential mechanism for chronic airway epithelial damage in asthma by White, Steven R, Dorscheid, Delbert R

“…Damage to the airway epithelium is one prominent feature of chronic asthma. Mucosal damage includes gap openings, partial denudation, and loss of ciliated…”
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