Search Results - "DORSA, Daniel M"

Social Interaction Deficits Caused by Chronic Phencyclidine Administration are Reversed by Oxytocin by LEE, Paul R, BRADY, Dana L, SHAPIRO, Robert A, DORSA, Daniel M, KOENIG, James I

“…Chronic administration of phencyclidine (PCP) has been advanced as a valid animal model of the social deficit symptoms of schizophrenia. In these studies, the…”
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Ovarian hormone loss impairs excitatory synaptic transmission at hippocampal CA3-CA1 synapses by Wu, Wendy W, Bryant, Damani N, Dorsa, Daniel M, Adelman, John P, Maylie, James

“…Premature and long-term ovarian hormone loss following ovariectomy (OVX) is associated with cognitive impairment. This condition is prevented by estradiol (E2)…”
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CNS Region-Specific Oxytocin Receptor Expression: Importance in Regulation of Anxiety and Sex Behavior by Bale, Tracy L, Davis, Aline M, Auger, Anthony P, Dorsa, Daniel M, McCarthy, Margaret M

“…The oxytocin receptor (OTR) is differentially expressed in the CNS. Because there are multiple mechanisms by which the OTR can be transcriptionally induced, we…”
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The Mitogen-Activated Protein Kinase Pathway Mediates Estrogen Neuroprotection after Glutamate Toxicity in Primary Cortical Neurons by Singer, Cherie A, Figueroa-Masot, Xavier A, Batchelor, Robert H, Dorsa, Daniel M

“…Pharmacological and biochemical approaches were used to elucidate the involvement of growth factor signaling pathways mediating estrogen neuroprotection in…”
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Estrogen Receptor-Mediated Neuroprotection from Oxidative Stress Requires Activation of the Mitogen-Activated Protein Kinase Pathway by Mize, Amy L, Shapiro, Robert A, Dorsa, Daniel M

“…It is well documented that estrogen mediates responses by both genomic and nongenomic mechanisms, both of which are important for cell survival. Because direct…”
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Cloning, Novel Promoter Sequence, and Estrogen Regulation of a Rat Oxytocin Receptor Gene by Bale, Tracy L., Dorsa, Daniel M.

“…Abstract Expression of the oxytocin receptor (OR) gene in vivo is known to be regulated by estradiol (E2). We have cloned and sequenced 4 kilobases (kb) of…”
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Induction of Stereotypy in Dopamine-Deficient Mice Requires Striatal D1 Receptor Activation by Chartoff, Elena H., Marck, Brett T., Matsumoto, Alvin M., Dorsa, Daniel M., Palmiter, Richard D.

“…Motor stereotypies are abnormally repetitive behaviors that can develop with excessive dopaminergic stimulation and are features of some neurologic disorders…”
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Prenatal stress generates deficits in rat social behavior: Reversal by oxytocin by Lee, Paul R, Brady, Dana L, Shapiro, Robert A, Dorsa, Daniel M, Koenig, James I

“…Abstract Neurodevelopmental changes induced by environmental stress exposure play a significant but poorly defined role in the etiology of schizophrenia…”
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Estrogen Activation of Cyclic Adenosine 5′-Monophosphate Response Element-Mediated Transcription Requires the Extracellularly Regulated Kinase/Mitogen-Activated Protein Kinase Pathway by Wade, Christian B, Dorsa, Daniel M

“…The ability of estrogen to rapidly initiate a variety of signal transduction cascades is increasingly recognized as playing an important role in a number of…”
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Estrogen Receptor (ER)α and ERβ Exhibit Unique Pharmacologic Properties When Coupled to Activation of the Mitogen-Activated Protein Kinase Pathway by Wade, Christian B., Robinson, Siobhan, Shapiro, Robert A., Dorsa, Daniel M.

“…Abstract The rapid, nongenomic effects of estrogen are increasingly recognized as playing an important role in several aspects of estrogen action. Rapid…”
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Rapid Membrane Effects of Steroids in Neuroblastoma Cells: Effects of Estrogen on Mitogen Activated Protein Kinase Signalling Cascade and c-fos Immediate Early Gene Transcription by Watters, Jyoti J, Campbell, Jean S, Cunningham, Matthew J, Krebs, Edwin G, Dorsa, Daniel M

“…Rapid effects of steroid hormones have been observed in neuronal cells for many years. We show here, that in the human neuroblastoma cell line SK-N-SH, the…”
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Multiple pathways transmit neuroprotective effects of gonadal steroids by Bryant, Damani N, Sheldahl, Laird C, Marriott, Lisa K, Shapiro, Robert A, Dorsa, Daniel M

“…Numerous preclinical studies suggest that gonadal steroids, particularly estrogen, may be neuroprotective against insult or disease progression. This paper…”
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Estrogen‐mediated neuroprotection against β‐amyloid toxicity requires expression of estrogen receptor α or β and activation of the MAPK pathway by Fitzpatrick, Jennifer L., Mize, Amy L., Wade, Christian B., Harris, Julie A., Shapiro, Robert A., Dorsa, Daniel M.

“…It is well documented that estrogen can activate rapid signaling pathways in a variety of cell types. These non‐classical effects of estrogen have been…”
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Transcriptional Effects of Estrogen on Neuronal Neurotensin Gene Expression Involve cAMP/Protein Kinase A-Dependent Signaling Mechanisms by Watters, Jyoti J, Dorsa, Daniel M

“…Steroid hormones exert dramatic effects on neuronal expression of genes that encode neuropeptides. Expression of the neurotensin/neuromedin (NT/N) gene in…”
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Hypothalamic Expression of Eap1 Is Not Directly Controlled by Ovarian Steroids by Matagne, Valerie, Mastronardi, Claudio, Shapiro, Robert A, Dorsa, Daniel M, Ojeda, Sergio R

“…A gene termed EAP1 (enhanced at puberty 1) was recently identified as a transcriptional regulator of female neuroendocrine reproductive function. We have now…”
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Neuronal apoptosis resulting from high doses of the isoflavone genistein: role for calcium and p42/44 mitogen-activated protein kinase by Linford, N J, Yang, Y, Cook, D G, Dorsa, D M

“…Genistein is a potent plant-derived isoflavone displaying estrogenic activity at low (nanomolar) concentrations and antiproliferative and antiangiogenic…”
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Modulation of Bcl-2 expression: a potential component of estrogen protection in NT2 neurons by Singer, Cherie A, Rogers, Keith L, Dorsa, Daniel M

“…EUROPROTECTIVE effects of estrogen have been demonstrated against a variety of cytotoxic insults. We present data here addressing a possible mechanism of…”
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17β-Estradiol and the phytoestrogen genistein attenuate neuronal apoptosis induced by the endoplasmic reticulum calcium-ATPase inhibitor thapsigargin by Linford, Nancy J, Dorsa, Daniel M

“…Estrogenic compounds have been shown to protect neurons from a variety of toxic stimuli in vitro and in vivo and depletion of estrogen at menopause has been…”
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Estradiol Reduces Nonclassical Transcription at Cyclic Adenosine 3′,5′-Monophosphate Response Elements in Glioma Cells Expressing Estrogen Receptor Alpha by Mhyre, Andrew J, Shapiro, Robert A, Dorsa, Daniel M

“…Estradiol can protect the brain from a variety of insults by activating membrane-initiated signaling pathways, and thereby modulate gene expression and lead to…”
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Specific downregulation of presenilin 2 gene expression is prominent during early stages of sporadic late-onset Alzheimer’s disease by McMillan, Pamela J, Leverenz, James B, Dorsa, Daniel M

“…Mutations in the presenilin genes PS1 and PS2 cause familial Alzheimer’s disease (AD). In a previous study, we reported that PS2 mRNA levels are decreased in…”
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