Search Results - "DORN, Conrad P"

Orally active .beta.-lactam inhibitors of human leukocyte elastase-1. Activity of 3,3-diethyl-2-azetidinones by Shah, Shrenik K, Dorn, Conrad P, Finke, Paul E, Hale, Jeffrey J, Hagmann, William K, Brause, Karen A, Chandler, Gilbert O, Kissinger, Amy L, Ashe, Bonnie M

“…A thorough analysis of the mechanism of inhibition of human leukocyte elastase (HLE) by a monocyclic beta-lactam and the mechanism of beta-lactam hydrolysis…”
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Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 1: Discovery and initial structure-activity relationships for 1-amino-2-phenyl-4-(piperidin-1-yl)butanes by DORN, Conrad P, FINKE, Paul E, DEMARTINO, Julie A, SICILIANO, Salvatore J, CARELLA, Anthony, CARVER, Gwen, HOLMES, Karen, DANZEISEN, Renee, HAZUDA, Daria, KESSLER, Joseph, LINEBERGER, Janet, MILLER, Michael, OATES, Bryan, SCHLEIF, William A, EMINI, Emilio A, BUDHU, Richard J, MILLS, Sander G, MACCOSS, Malcolm, MALKOWITZ, Lorraine, SPRINGER, Martin S, DAUGHERTY, Bruce L, GOULD, Sandra L

“…Screening of the Merck sample collection for compounds with CCR5 receptor binding afforded…”
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Phosphorylated Morpholine Acetal Human Neurokinin-1 Receptor Antagonists as Water-Soluble Prodrugs by Hale, Jeffrey J, Mills, Sander G, MacCoss, Malcolm, Dorn, Conrad P, Finke, Paul E, Budhu, Richard J, Reamer, Robert A, Huskey, Su-Er W, Luffer-Atlas, Debra, Dean, Brian J, McGowan, Erin M, Feeney, William P, Chiu, Shuet-Hing Lee, Cascieri, Margaret A, Chicchi, Gary G, Kurtz, Marc M, Sadowski, Sharon, Ber, Elzbieta, Tattersall, F. David, Rupniak, Nadia M. J, Williams, Angela R, Rycroft, Wayne, Hargreaves, Richard, Metzger, Joseph M, MacIntyre, D. Euan

“…The regioselective dibenzylphosphorylation of 2 followed by catalytic reduction in the presence of N-methyl-d-glucamine afforded…”
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Orally active .beta.-lactam inhibitors of human leukocyte elastase. 2. Effect of C-4 substitution by Hagmann, William K, Kissinger, Amy L, Shah, Shrenik K, Finke, Paul E, Dorn, Conrad P, Brause, Karen A, Ashe, Bonnie M, Weston, Hazel, Maycock, Alan L

“…The effect of changing the C-4 substituent of 3,3-diethyl-1-[(benzylamino)carbonyl]-2-azetidinone on inhibition of HLE and in a model of HLE-induced lung…”
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Expression and characterization of the chemokine receptor CCR2B from rhesus monkey by Jin, Hong, Vicario, Pasquale P., Zweerink, Hans, Goyal, Shefali, Hanlon, William A., Dorn, Conrad P., Mills, Sander G., DeMartino, Julie A., Cascieri, Margaret A., Struthers, Mary

“…Species selectivity of chemokine receptor antagonists is a potential deterrent to making preclinical assessments in vivo. To determine if rhesus monkey disease…”
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Cephalosporin antibiotics can be modified to inhibit human leukocyte elastase by Doherty, James B, Ashe, Bonnie M, Argenbright, Lawrence W, Barker, Peter L, Bonney, Robert J, Chandler, Gilbert O, Dahlgren, Mary Ellen, Dorn, Conrad P, Finke, Paul E, Firestone, Raymond A, Fletcher, Daniel, Hagmann, William K, Mumford, Richard, O'Grady, Laura, Maycock, Alan L, Pisano, Judith M, Shah, Shrenik K, Thompson, Kevan R, Zimmerman, Morris

“…Several laboratories, including our own have reported the synthesis and activity of certain low relative molecular mass inhibitors of mammalian serine…”
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Inhibition of human leukocyte elastase. 1. Inhibition by C-7-substituted cephalosporin tert-butyl esters by Doherty, James B, Ashe, Bonnie M, Barker, Peter L, Blacklock, Thomas J, Butcher, John W, Chandler, Gilbert O, Dahlgren, M. Ellen, Davies, Philip, Dorn, Conrad P

“…Time-dependent inhibitors of the enzyme human leukocyte elastase have been developed based on the cephem nucleus. A series of cephalosporin tert-butyl esters…”
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Synthesis and immunoadjuvant activities of 2-acetamido-5-O-acetyl-6-O-acyl-2-deoxy-3-O-[(R)-2-propionyl-L-alanyl-D-isoglutamine]-D-glucofuranoses as potential prodrug forms of 6-O-acyl derivatives of N-acetylmuramyl dipeptide by Durette, Philippe L, Dorn, Conrad P, Friedman, Arthur, Schlabach, Abner

“…2-Acetamido-5-O-acetyl-6-O-acyl-2-deoxy-3-O-[(R)-2-propionyl-L-alanyl-D- isoglutamine]-D-glucofuranoses, designed as prodrug forms of the corresponding…”
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Synthesis and antiinflammatory/analgesic activities of 11H-dibenzo[b,e]dioxepinacetic acids by Hagmann, William K, Dorn, Conrad P, Frankshun, Robert A, O'Grady, Laura A, Bailey, Philip J, Rackham, Anita, Dougherty, Harry W

“…A new class of tricyclic arylacetic acids was synthesized and evaluated as antiinflammatory/analgesic agents as well as inhibitors of prostaglandin synthetase…”
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Proteinase inhibitors. 1. Inhibitors of elastase by Dorn, Conrad P, Zimmerman, Morris, Yang, Shu Shu, Yurewicz, Edward C, Ashe, Bonnie M, Frankshun, Robert, Jones, Howard

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Steroids. IX. Synthesis of some thiazolosteroids by DOORENBOS, N J, DORN, Jr, C P

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Chemical, Biochemical, Pharmacokinetic, and Biological Properties of L-680, 833: A Potent, Orally Active Monocyclic β-Lactam Inhibitor of Human Polymorphonuclear Leukocyte Elastase by Doherty, James B., Shah, Shrenik K., Finke, Paul E., Dorn, Conrad P., Hagmann, William K., Hale, Jeffrey J., Kissinger, Amy L., Thompson, Kevan R., Brause, karen, Chandler, Gilbert O., Knight, Wilson B., Maycock, Alan L., Ashe, Bonnie M., Weston, Hazel, Gale, Paul, Mumford, Richard A., Andersen, O. Frederick, Williams, Hollis R., Nolan, Thomas E., Frankenfield, Dale L., Underwood, Dennis, Vyas, Kamlesh P., Kari, Prasad H., Dahlgren, Mary E., Mao, Jennifer, Fletcher, Daniel S., Pa. S. Dellea, Hand, Karen M., Osinga, Donald G., Peterson, Laurence B., Williams, Dorsey T., Metzger, Joseph M., Bonney, Robert J., Humes, John L., Pacholok, Steven P., Hanlon, William A., Opas, Evan, Stolk, Jan, Davies, Philip

“…A series of potent and highly selective time-dependent monocyclic β-lactam inhibitors of human polymorphonuclear leukocyte elastase (PMNE, EC 3.4.21.37) is…”
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Inhibition of human leukocyte elastase. 4. Selection of a substituted cephalosporin (L-658,758) as a topical aerosol by Finke, Paul E, Shah, Shrenik K, Ashe, Bonnie M, Ball, Richard G, Blacklock, Thomas J, Bonney, Robert J, Brause, Karen A, Chandler, Gilbert O, Cotton, Meredith

“…Human leukocyte elastase (HLE) is a serine protease which has been implicated as a causative agent in several pulmonary diseases. The continued modification of…”
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Synthesis and acylation of 2‐nitro‐11 H ‐dibenzo[ b,e ][1,4]dioxepin by Hagmann, William K., O'Grady, Laura A., Dorn, Conrad P., Springer, James P.

“…A one‐pot synthesis of the 11 H ‐dibenzo[ b,e ]1,4]dioxepin ring system from catechol and an o ‐chlorobenzyl chloride is described. Friedel‐Crafts acylation…”
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Structure of Human Neutrophil Elastase in Complex with a Peptide Chloromethyl Ketone Inhibitor at 1.84- angstrom Resolution by Navia, Manuel A., McKeever, Brian M., Springer, James P., Lin, Tsau-Yen, Williams, Hollis R., Fluder, Eugene M., Dorn, Conrad P., Hoogsteen, Karst

“…Human neutrophil elastase (HNE) has been implicated as a major contributor to tissue destruction in various disease states, including emphysema. The structure…”
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Synthesis and acylation of 2-nitro-11H-dibenzo[b,e][1,4]dioxepin by Hagmann, William K., O'Grady, Laura A., Dorn, Conrad P., Springer, James P.

“…A one‐pot synthesis of the 11H‐dibenzo[b,e]1,4]dioxepin ring system from catechol and an o‐chlorobenzyl chloride is described. Friedel‐Crafts acylation occurs…”
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Synthesis of 24-dehydrocholecalciferol by Yang, S S, Dorn, C P, Jones, H

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Steroids. VI. Thiazoloandrostanes by DOORENBOS, N J, DORN, Jr, C P

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