Search Results - "DORMITZER, Philip R"

Neutralization of SARS-CoV-2 lineage B.1.1.7 pseudovirus by BNT162b2 vaccine-elicited human sera by Muik, Alexander, Wallisch, Ann-Kathrin, Sänger, Bianca, Swanson, Kena A, Mühl, Julia, Chen, Wei, Cai, Hui, Maurus, Daniel, Sarkar, Ritu, Türeci, Özlem, Dormitzer, Philip R, Şahin, Uğur

“…Recently, a new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineage called B.1.1.7 (variant of concern: VOC 202012/01), which is reported to…”
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Neutralization of SARS-CoV-2 spike 69/70 deletion, E484K and N501Y variants by BNT162b2 vaccine-elicited sera by Xie, Xuping, Liu, Yang, Liu, Jianying, Zhang, Xianwen, Zou, Jing, Fontes-Garfias, Camila R., Xia, Hongjie, Swanson, Kena A., Cutler, Mark, Cooper, David, Menachery, Vineet D., Weaver, Scott C., Dormitzer, Philip R., Shi, Pei-Yong

“…We engineered three severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viruses containing key spike mutations from the newly emerged United Kingdom…”
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Neutralizing Activity of BNT162b2-Elicited Serum by Liu, Yang, Liu, Jianying, Xia, Hongjie, Zhang, Xianwen, Fontes-Garfias, Camila R, Swanson, Kena A, Cai, Hui, Sarkar, Ritu, Chen, Wei, Cutler, Mark, Cooper, David, Weaver, Scott C, Muik, Alexander, Sahin, Ugur, Jansen, Kathrin U, Xie, Xuping, Dormitzer, Philip R, Shi, Pei-Yong

“…How well do serum samples obtained from persons injected with the BNT162b2 vaccine neutralize the P.1, B.1.1.7, and B.1.135 lineages of SARS-CoV-2, first…”
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Phase I/II study of COVID-19 RNA vaccine BNT162b1 in adults by Mulligan, Mark J., Lyke, Kirsten E., Kitchin, Nicholas, Absalon, Judith, Gurtman, Alejandra, Lockhart, Stephen, Neuzil, Kathleen, Raabe, Vanessa, Bailey, Ruth, Swanson, Kena A., Li, Ping, Koury, Kenneth, Kalina, Warren, Cooper, David, Fontes-Garfias, Camila, Shi, Pei-Yong, Türeci, Özlem, Tompkins, Kristin R., Walsh, Edward E., Frenck, Robert, Falsey, Ann R., Dormitzer, Philip R., Gruber, William C., Şahin, Uğur, Jansen, Kathrin U.

“…In March 2020, the World Health Organization (WHO) declared coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome…”
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BNT162b2-elicited neutralization of B.1.617 and other SARS-CoV-2 variants by Liu, Jianying, Liu, Yang, Xia, Hongjie, Zou, Jing, Weaver, Scott C., Swanson, Kena A., Cai, Hui, Cutler, Mark, Cooper, David, Muik, Alexander, Jansen, Kathrin U., Sahin, Ugur, Xie, Xuping, Dormitzer, Philip R., Shi, Pei-Yong

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is continuing to evolve around the world, generating new variants that are of concern on the basis…”
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Safety, Immunogenicity, and Efficacy of the BNT162b2 Covid-19 Vaccine in Adolescents by Frenck, Robert W, Klein, Nicola P, Kitchin, Nicholas, Gurtman, Alejandra, Absalon, Judith, Lockhart, Stephen, Perez, John L, Walter, Emmanuel B, Senders, Shelly, Bailey, Ruth, Swanson, Kena A, Ma, Hua, Xu, Xia, Koury, Kenneth, Kalina, Warren V, Cooper, David, Jennings, Timothy, Brandon, Donald M, Thomas, Stephen J, Türeci, Özlem, Tresnan, Dina B, Mather, Susan, Dormitzer, Philip R, Şahin, Uğur, Jansen, Kathrin U, Gruber, William C

“…This randomized trial of the BNT162b2 vaccine involved 2260 adolescents 12 to 15 years of age. Similar levels of antibody to SARS-CoV-2 were elicited in the…”
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A Randomized Phase 1/2 Study of a Respiratory Syncytial Virus Prefusion F Vaccine by Walsh, Edward E, Falsey, Ann R, Scott, Daniel A, Gurtman, Alejandra, Zareba, Agnieszka M, Jansen, Kathrin U, Gruber, William C, Dormitzer, Philip R, Swanson, Kena A, Radley, David, Gomme, Emily, Cooper, David, Schmoele-Thoma, Beate

“…Abstract Background Protection against human respiratory syncytial virus (RSV) remains an unmet need potentially addressable by maternal immunization. This…”
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Atomic model of an infectious rotavirus particle by Settembre, Ethan C, Chen, James Z, Dormitzer, Philip R, Grigorieff, Nikolaus, Harrison, Stephen C

“…Non‐enveloped viruses of different types have evolved distinct mechanisms for penetrating a cellular membrane during infection. Rotavirus penetration appears…”
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Influenza: Options to Improve Pandemic Preparation by Rappuoli, Rino, Dormitzer, Philip R.

“…Science and society have been struggling to find a way to protect humankind from recurring epidemics and pandemics of influenza. Here, we review the options…”
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Nonviral delivery of self-amplifying RNA vaccines by Geall, Andrew J, Verma, Ayush, Otten, Gillis R, Shaw, Christine A, Hekele, Armin, Banerjee, Kaustuv, Cu, Yen, Beard, Clayton W, Brito, Luis A, Krucker, Thomas, O’Hagan, Derek T, Singh, Manmohan, Mason, Peter W, Valiante, Nicholas M, Dormitzer, Philip R, Barnett, Susan W, Rappuoli, Rino, Ulmer, Jeffrey B, Mandl, Christian W

“…Despite more than two decades of research and development on nucleic acid vaccines, there is still no commercial product for human use. Taking advantage of the…”
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A Cationic Nanoemulsion for the Delivery of Next-generation RNA Vaccines by Brito, Luis A, Chan, Michelle, Shaw, Christine A, Hekele, Armin, Carsillo, Thomas, Schaefer, Mary, Archer, Jacob, Seubert, Anja, Otten, Gillis R, Beard, Clayton W, Dey, Antu K, Lilja, Anders, Valiante, Nicholas M, Mason, Peter W, Mandl, Christian W, Barnett, Susan W, Dormitzer, Philip R, Ulmer, Jeffrey B, Singh, Manmohan, O'Hagan, Derek T, Geall, Andrew J

“…Nucleic acid-based vaccines such as viral vectors, plasmid DNA, and mRNA are being developed as a means to address a number of unmet medical needs that current…”
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Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza virus hemagglutinin by Whittle, James R. R, Zhang, Ruijun, Khurana, Surender, King, Lisa R, Manischewitz, Jody, Golding, Hana, Dormitzer, Philip R, Haynes, Barton F, Walter, Emmanuel B, Moody, M. Anthony, Kepler, Thomas B, Liao, Hua-Xin, Harrison, Stephen C

“…Seasonal antigenic drift of circulating influenza virus leads to a requirement for frequent changes in vaccine composition, because exposure or vaccination…”
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Structural basis for immunization with postfusion respiratory syncytial virus fusion F glycoprotein (RSV F) to elicit high neutralizing antibody titers by Swanson, Kurt A, Settembre, Ethan C, Shaw, Christine A, Dey, Antu K, Rappuoli, Rino, Mandl, Christian W, Dormitzer, Philip R, Carfi, Andrea

“…Respiratory syncytial virus (RSV), the main cause of infant bronchiolitis, remains a major unmet vaccine need despite more than 40 years of vaccine research…”
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Near-atomic resolution using electron cryomicroscopy and single-particle reconstruction by Zhang, Xing, Settembre, Ethan, Xu, Chen, Dormitzer, Philip R, Bellamy, Richard, Harrison, Stephen C, Grigorieff, Nikolaus

“…Electron cryomicroscopy (cryo-EM) yields images of macromolecular assemblies and their components, from which 3D structures can be determined, by using an…”
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Influenza vaccine immunology by Dormitzer, Philip R., Galli, Grazia, Castellino, Flora, Golding, Hana, Khurana, Surender, Del Giudice, Giuseppe, Rappuoli, Rino

“…Studying the spread of influenza in human populations and protection by influenza vaccines provides important insights into immunity against influenza. The…”
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Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody by Schmidt, Aaron G., Xu, Huafeng, Khan, Amir R., O'Donnell, Timothy, Khurana, Surender, King, Lisa R., Manischewitz, Jody, Golding, Hana, Suphaphiphat, Pirada, Carfi, Andrea, Settembre, Ethan C., Dormitzer, Philip R., Kepler, Thomas B., Zhang, Ruijun, Moody, M. Anthony, Haynes, Barton F., Liao, Hua-Xin, Shaw, David E., Harrison, Stephen C.

“…Affinity maturation refines a naive B-cell response by selecting mutations in antibody variable domains that enhance antigen binding. We describe a B-cell…”
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A randomized study to evaluate safety and immunogenicity of the BNT162b2 COVID-19 vaccine in healthy Japanese adults by Haranaka, Miwa, Baber, James, Ogama, Yoichiro, Yamaji, Masako, Aizawa, Masakazu, Kogawara, Osamu, Scully, Ingrid, Lagkadinou, Eleni, Türeci, Ӧzlem, Şahin, Uğur, Dormitzer, Philip R., Gruber, William C., Lockhart, Stephen

“…We report interim safety and immunogenicity findings from an ongoing phase 1/2 study of BNT162b2 in healthy Japanese adults. Participants were randomized 3:1…”
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Molecular interactions in rotavirus assembly and uncoating seen by high-resolution cryo-EM by Chen, James Z, Settembre, Ethan C, Aoki, Scott T, Zhang, Xing, Bellamy, A. Richard, Dormitzer, Philip R, Harrison, Stephen C, Grigorieff, Nikolaus

“…Rotaviruses, major causes of childhood gastroenteritis, are nonenveloped, icosahedral particles with double-strand RNA genomes. By the use of electron…”
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The effect of SARS-CoV-2 D614G mutation on BNT162b2 vaccine-elicited neutralization by Zou, Jing, Xie, Xuping, Fontes-Garfias, Camila R., Swanson, Kena A., Kanevsky, Isis, Tompkins, Kristin, Cutler, Mark, Cooper, David, Dormitzer, Philip R., Shi, Pei-Yong

“…Initial COVID-19 vaccine candidates were based on the original sequence of SARS-CoV-2. However, the virus has since accumulated mutations, among which the…”
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SARS Coronavirus, but Not Human Coronavirus NL63, Utilizes Cathepsin L to Infect ACE2-expressing Cells by Huang, I-Chueh, Bosch, Berend Jan, Li, Fang, Li, Wenhui, Lee, Kyoung Hoa, Ghiran, Sorina, Vasilieva, Natalya, Dermody, Terence S., Harrison, Stephen C., Dormitzer, Philip R., Farzan, Michael, Rottier, Peter J.M., Choe, Hyeryun

“…Viruses require specific cellular receptors to infect their target cells. Angiotensin-converting enzyme 2 (ACE2) is a cellular receptor for two divergent…”
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