Search Results - "DORAN, Robert"
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Transfer of Electrophilic NH Using Convenient Sources of Ammonia: Direct Synthesis of NH Sulfoximines from Sulfoxides
Published in Angewandte Chemie International Edition (13-06-2016)“…A new system for NH transfer is developed for the preparation of sulfoximines, which are emerging as valuable motifs for drug discovery. The protocol employs…”
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2
c-kit⁺ precursors support postinfarction myogenesis in the neonatal, but not adult, heart
Published in Proceedings of the National Academy of Sciences - PNAS (14-08-2012)“…We examined the myogenic response to infarction in neonatal and adult mice to determine the role of c-kit ⁺ cardiovascular precursor cells (CPC) that are known…”
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Synthesis of Sulfoximine Carbamates by Rhodium-Catalyzed Nitrene Transfer of Carbamates to Sulfoxides
Published in Journal of organic chemistry (19-06-2015)“…Sulfoximines are of considerable interest for incorporation into medicinal compounds. A convenient synthesis of N-protected sulfoximines is achieved, under…”
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4
c-kit expression identifies cardiovascular precursors in the neonatal heart
Published in Proceedings of the National Academy of Sciences - PNAS (10-02-2009)“…Directed differentiation of embryonic stem cells indicates that mesodermal lineages in the mammalian heart (cardiac, endothelial, and smooth muscle cells)…”
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Investigation of the Anti-Methicillin-Resistant Staphylococcus aureus Activity of (+)-Tanikolide- and (+)-Malyngolide-Based Analogues Prepared by Asymmetric Synthesis
Published in International journal of molecular sciences (15-06-2021)“…Herein, we report antibacterial and antifungal evaluation of a series of previously prepared (+)-tanikolide analogues. One analogue,…”
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Engraftment of connexin 43-expressing cells prevents post-infarct arrhythmia
Published in Nature (06-12-2007)“…Ventricular tachyarrhythmias are the main cause of sudden death in patients after myocardial infarction. Here we show that transplantation of embryonic…”
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Genomic variation in captive deer mouse (Peromyscus maniculatus) populations
Published in BMC genomics (14-09-2021)“…Deer mice (genus Peromyscus) are the most common rodents in North America. Despite the availability of reference genomes for some species, a comprehensive…”
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Overexpression of Cx43 in cells of the myocardial scar: Correction of post-infarct arrhythmias through heterotypic cell-cell coupling
Published in Scientific reports (08-05-2018)“…Ventricular tachycardia (VT) is the most common and potentially lethal complication following myocardial infarction (MI). Biological correction of the…”
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Imaging cellular signals in the heart in vivo: Cardiac expression of the high-signal Ca2+ indicator GCaMP2
Published in Proceedings of the National Academy of Sciences - PNAS (21-03-2006)“…Genetically encoded sensor proteins provide unique opportunities to advance the understanding of complex cellular interactions in physiologically relevant…”
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10
A Stereoselective Switch: Enantiodivergent Approach to the Synthesis of Isoflavanones
Published in Chemistry : a European journal (17-11-2014)“…A modular six‐step asymmetric synthesis of two naturally occurring and three non‐natural isoflavanones containing tertiary α‐aryl carbonyls is reported. This…”
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A New Project in Systematic Theology
Published in Theological studies (Baltimore) (01-06-2015)“…The article explores the possibility of a new collaborative venture in systematic theology based in the work of Bernard Lonergan and Robert Doran. A prospectus…”
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Direct bone marrow injection of human bone marrow-derived stromal cells into mouse femurs results in greater prostate cancer PC-3 cell proliferation, but not specifically proliferation within the injected femurs
Published in BMC cancer (17-05-2022)“…While prostate cancer (PCa) cells most often metastasize to bone in men, species-specific differences between human and mouse bone marrow mean that this…”
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Nox2 and Nox4 influence neonatal c-kit(+) cardiac precursor cell status and differentiation
Published in American journal of physiology. Heart and circulatory physiology (15-09-2013)“…Redox status has emerged as critical in modulating stemness and lineage commitment in several precursor cell types. However, a role for redox genes,…”
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14
BAC transgenic mice express enhanced green fluorescent protein in central and peripheral cholinergic neurons
Published in Physiological genomics (27-11-2006)“…1 Biomedical Science Department, College of Veterinary Medicine, Ithaca, New York 2 School of Applied and Engineering Physics, Cornell University, Ithaca, New…”
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Using high throughput microtissue culture to study the difference in prostate cancer cell behavior and drug response in 2D and 3D co-cultures
Published in BMC cancer (24-05-2018)“…There is increasing appreciation that non-cancer cells within the tumour microenvironment influence cancer progression and anti-cancer drug efficacy. For…”
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Human bone marrow-derived stromal cell behavior when injected directly into the bone marrow of NOD-scid-gamma mice pre-conditioned with sub-lethal irradiation
Published in Stem cell research & therapy (12-04-2021)“…Direct bone marrow injection of cells into murine marrow cavities is used in a range of cell characterization assays and to develop disease models. While human…”
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The Nonviolent Cross: Lonergan and Girard on Redemption
Published in Theological studies (Baltimore) (01-03-2010)“…Bernard Lonergan and René Girard provide succinct statements of the meaning of redemption. The article, having raised the question as to how the statements…”
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The rapid manufacture of uniform composite multicellular-biomaterial micropellets, their assembly into macroscopic organized tissues, and potential applications in cartilage tissue engineering
Published in PloS one (28-05-2015)“…We and others have published on the rapid manufacture of micropellet tissues, typically formed from 100-500 cells each. The micropellet geometry enhances…”
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Collagenase treatment appears to improve cartilage tissue integration but damage to collagen networks is likely permanent
Published in Journal of tissue engineering (01-01-2022)“…When repairing cartilage defects a major challenge is achieving high-quality integration between the repair tissue and adjacent native cartilage. Matrix-rich…”
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John Womersley: Applied Mathematician and Pioneer of Modern Computing
Published in IEEE annals of the history of computing (01-04-2014)“…John R. Womersley's career epitomized how numerical and statistical methods came into widespread use from the 1930s, in Britain as in other Western countries…”
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