Search Results - "DORA, Kim"

EDHF: spreading the influence of the endothelium by Garland, Christopher J, Hiley, C Robin, Dora, Kim A

“…Our view of the endothelium was transformed around 30 years ago, from one of an inert barrier to that of a key endocrine organ central to cardiovascular…”
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Low intravascular pressure activates endothelial cell TRPV4 channels, local Ca²⁺ events, and IKCₐ channels, reducing arteriolar tone by Bagher, Pooneh, Beleznai, Timea, Kansui, Yasuo, Mitchell, Ray, Garland, Christopher J, Dora, Kim A

“…Endothelial cell (EC) Ca ²⁺-activated K channels (SK Cₐ and IK Cₐ channels) generate hyperpolarization that passes to the adjacent smooth muscle cells causing…”
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Endothelial-smooth muscle cell interactions in the regulation of vascular tone in skeletal muscle by Dora, Kim A.

“…The SMCs of skeletal muscle arterioles are intricately sensitive to changes in membrane potential. Upon increasing luminal pressure, the SMCs depolarize,…”
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Endothelin-1 in Health and Disease by Banecki, Katherine M R M, Dora, Kim A

“…Discovered almost 40 years ago, the potent vasoconstrictor peptide endothelin-1 (ET-1) has a wide range of roles both physiologically and pathologically. In…”
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The three faces of pericytes by Borysova, Lyudmyla, Dora, Kim A.

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Gβγ subunit signalling underlies neuropeptide Y-stimulated vasoconstriction in rat mesenteric and coronary arteries by Lin, JinHeng, Scullion, Lauren, Garland, Christopher J, Dora, Kim

“…Raised serum concentrations of the sympathetic co-transmitter neuropeptide Y (NPY) are linked to cardiovascular diseases. However, the signalling mechanism for…”
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Endothelium-Dependent Hyperpolarization: The Evolution of Myoendothelial Microdomains by Garland, Christopher J., Dora, Kim A.

“…Endothelium-derived hyperpolarizing factor (EDHF) was envisaged as a chemical entity causing vasodilation by hyperpolarizing vascular smooth muscle (VSM) cells…”
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Coordination of Vasomotor Responses by the Endothelium by Dora, Kim A.

“…Increases in the diameter of small resistance arteries and arterioles occur secondary to processes that can be dependent or independent of changes in membrane…”
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Smooth muscle gap-junctions allow propagation of intercellular Ca2+ waves and vasoconstriction due to Ca2+ based action potentials in rat mesenteric resistance arteries by Borysova, Lyudmyla, Dora, Kim A., Garland, Christopher J., Burdyga, Theodor

“…[Display omitted] •In rat mesenteric resistance arteries (MA), smooth muscle (SMC) gap junctions enable intercellular Ca2+ waves and…”
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The kindlin‐2 double act by Ye, Xi, Dora, Kim A.

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Modulation of Endothelial Cell KCa3.1 Channels During Endothelium-Derived Hyperpolarizing Factor Signaling in Mesenteric Resistance Arteries by Dora, Kim A, Gallagher, Nicola T, McNeish, Alister, Garland, Christopher J

“…Arterial hyperpolarization to acetylcholine (ACh) reflects coactivation of KCa3.1 (IKCa) channels and KCa2.3 (SKCa) channels in the endothelium that transfers…”
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Endothelial Nitric Oxide Suppresses Action-Potential-Like Transient Spikes and Vasospasm in Small Resistance Arteries by Smith, Josh F., Lemmey, Hamish A.L., Borysova, Lyudmyla, Hiley, C. Robin, Dora, Kim A., Garland, Christopher J.

“…Endothelial dysfunction in small arteries is a ubiquitous, early feature of cardiovascular disease, including hypertension. Dysfunction reflects reduced…”
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Asymmetric Dimethylarginine Enables Depolarizing Spikes and Vasospasm in Mesenteric and Coronary Resistance Arteries by Ng, Yu Y Hanson, Dora, Kim A, Lemmey, Hamish A L, Lin, JinHeng, Alden, James, Wallis, Lillian, Donovan, Lucy, Shorthose, Oliver, Leiper, Fiona C, Leiper, James, Garland, Christopher J

“…Increased vasoreactivity due to reduced endothelial NO bioavailability is an underlying feature of cardiovascular disease, including hypertension. In small…”
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High spatial and temporal resolution Ca2+ imaging of myocardial strips from human, pig and rat by Borysova, Lyudmyla, Ng, Y. Y. Hanson, Wragg, Edward S., Wallis, Lillian E., Fay, Emily, Ascione, Raimondo, Dora, Kim A.

“…Ca 2+ handling within cardiac myocytes underpins coordinated contractile function within the beating heart. This protocol enables high spatial and temporal Ca…”
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VEGF‐A inhibits agonist‐mediated Ca2+ responses and activation of IKCa channels in mouse resistance artery endothelial cells by Ye, Xi, Beckett, Taylor, Bagher, Pooneh, Garland, Christopher J., Dora, Kim A.

“…Key points Prolonged exposure to vascular endothelial growth factor A (VEGF‐A) inhibits agonist‐mediated endothelial cell Ca2+ release and subsequent…”
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Human coronary microvascular contractile dysfunction associates with viable synthetic smooth muscle cells by Dora, Kim A, Borysova, Lyudmyla, Ye, Xi, Powell, Chloe, Beleznai, Timea Z, Stanley, Christopher P, Bruno, Vito D, Starborg, Tobias, Johnson, Errin, Pielach, Anna, Taggart, Michael, Smart, Nicola, Ascione, Raimondo

“…Abstract Aims Coronary microvascular smooth muscle cells (SMCs) respond to luminal pressure by developing myogenic tone (MT), a process integral to the…”
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Hyperpolarization and the endothelium by Garland, Christopher J, Dora, Kim A

“…The ability of vascular endothelial cells to generate and conduct membrane hyperpolarization is a critical integrative mechanism controlling local blood flow…”
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Phospholemman Phosphorylation Regulates Vascular Tone, Blood Pressure, and Hypertension in Mice and Humans by Boguslavskyi, Andrii, Tokar, Sergiy, Prysyazhna, Oleksandra, Rudyk, Olena, Sanchez-Tatay, David, Lemmey, Hamish A.L., Dora, Kim A., Garland, Christopher J., Warren, Helen R., Doney, Alexander, Palmer, Colin N.A., Caulfield, Mark J., Vlachaki Walker, Julia, Howie, Jacqueline, Fuller, William, Shattock, Michael J.

“…Although it has long been recognized that smooth muscle Na/K ATPase modulates vascular tone and blood pressure (BP), the role of its accessory protein…”
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Tracking endothelium-dependent NO release in pressurized arteries by Wallis, Lillian, Donovan, Lucy, Johnston, Aaron, Phillips, Lauren C, Lin, Jinheng, Garland, Christopher J, Dora, Kim A

“…Endothelial cell (EC) dysfunction is an early hallmark of cardiovascular disease associated with the reduced bioavailability of nitric oxide (NO) resulting in…”
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VEGF-A inhibits agonist-mediated Ca 2+ responses and activation of IK Ca channels in mouse resistance artery endothelial cells by Ye, Xi, Beckett, Taylor, Bagher, Pooneh, Garland, Christopher J, Dora, Kim A

“…Prolonged exposure to vascular endothelial growth factor A (VEGF-A) inhibits agonist-mediated endothelial cell Ca release and subsequent activation of…”
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