Search Results - "DOOSEOP KIM"

Discovery of a peripheral 5HT2A antagonist as a clinical candidate for metabolic dysfunction-associated steatohepatitis by Pagire, Haushabhau S., Pagire, Suvarna H., Jeong, Byung-kwan, Choi, Won-Il, Oh, Chang Joo, Lim, Chae Won, Kim, Minhee, Yoon, Jihyeon, Kim, Seong Soon, Bae, Myung Ae, Jeon, Jae-Han, Song, Sungmin, Lee, Hee Jong, Lee, Eun Young, Goughnour, Peter C., Kim, Dooseop, Lee, In-Kyu, Loomba, Rohit, Kim, Hail, Ahn, Jin Hee

“…Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is currently the leading cause of chronic liver disease worldwide. Metabolic…”
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Potent, orally absorbed glucagon receptor antagonists by de Laszlo, Stephen E., Hacker, Candice, Li, Bing, Kim, Dooseop, MacCoss, Malcolm, Mantlo, Nathan, Pivnichny, James V., Colwell, Larry, Koch, Gregory E., Cascieri, Margaret A., Hagmann, William K.

“…The SAR of 2-pyridyl-3,5-diaryl pyrroles, ligands of the human glucagon receptor and inhibitors of p38 kinase, were investigated. This effort resulted in the…”
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Characterization of Two Cyclic Metabolites of Sitagliptin by LIU, David Q, ARISON, Byron H, STEARNS, Ralph A, KIM, Dooseop, VINCENT, Stella H

“…Two novel metabolites of the dipeptidyl peptidase inhibitor sitagliptin (MK-0431, (2 R )-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3- a…”
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Translocation of radical sites by intramolecular 1,5-hydrogen atom transfer by Curran, Dennis P, Kim, Dooseop, Liu, Hong Tao, Shen, Wang

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Dipeptidyl Peptidase IV Inhibition for the Treatment of Type 2 Diabetes by Lankas, George R., Leiting, Barbara, Roy, Ranabir Sinha, Eiermann, George J., Beconi, Maria G., Biftu, Tesfaye, Chan, Chi-Chung, Edmondson, Scott, Feeney, William P., He, Huaibing, Ippolito, Dawn E., Kim, Dooseop, Lyons, Kathryn A., Ok, Hyun O., Patel, Reshma A., Petrov, Aleksandr N., Pryor, Kelly Ann, Qian, Xiaoxia, Reigle, Leah, Woods, Andrea, Wu, Joseph K., Zaller, Dennis, Zhang, Xiaoping, Zhu, Lan, Weber, Ann E., Thornberry, Nancy A.

“…Dipeptidyl Peptidase IV Inhibition for the Treatment of Type 2 Diabetes Potential Importance of Selectivity Over Dipeptidyl Peptidases 8 and 9 George R. Lankas…”
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Atom transfer cyclization reactions of hex-5-ynyl iodides: synthetic and mechanistic studies by Curran, Dennis P, Chen, Meng Hsin, Kim, Dooseop

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Design, Synthesis, and Biological Evaluation of New Peripheral 5HT2A Antagonists for Nonalcoholic Fatty Liver Disease by Kim, Minhee, Hwang, Inseon, Pagire, Haushabhau S, Pagire, Suvarna H, Choi, Wonsuk, Choi, Won Gun, Yoon, Jihyeon, Lee, Won Mi, Song, Jin Sook, Yoo, Eun Kyung, Lee, Seung Mi, Kim, Mi-jin, Bae, Myung Ae, Kim, Dooseop, Lee, Heejong, Lee, Eun-Young, Jeon, Jae-Han, Lee, In-Kyu, Kim, Hail, Ahn, Jin Hee

“…Nonalcoholic fatty liver disease (NAFLD) is increasingly prevalent worldwide, causing serious liver complications, including nonalcoholic steatohepatitis…”
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Atom-transfer cyclization. A novel isomerization of hex-5-ynyl iodides to (iodomethylene)cyclopentanes by CURRAN, D. P, MENG-HSIN CHEN, DOOSEOP KIM

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Design, Synthesis, and Biological Evaluation of New Peripheral 5HT 2A Antagonists for Nonalcoholic Fatty Liver Disease by Kim, Minhee, Hwang, Inseon, Pagire, Haushabhau S, Pagire, Suvarna H, Choi, Wonsuk, Choi, Won Gun, Yoon, Jihyeon, Lee, Won Mi, Song, Jin Sook, Yoo, Eun Kyung, Lee, Seung Mi, Kim, Mi-Jin, Bae, Myung Ae, Kim, Dooseop, Lee, Heejong, Lee, Eun-Young, Jeon, Jae-Han, Lee, In-Kyu, Kim, Hail, Ahn, Jin Hee

“…Nonalcoholic fatty liver disease (NAFLD) is increasingly prevalent worldwide, causing serious liver complications, including nonalcoholic steatohepatitis…”
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NMR uncovers direct interaction between human NEDD4-1 and p34SEI−1 by Shrestha, Pravesh, Yun, Ji-Hye, Ko, Yoon-Joo, Yeon, Kyu Jeong, Kim, Dooseop, Lee, Heejong, Jin, Dong-Hoon, Nam, Ki-Yup, Yoo, Hye Dong, Lee, Weontae

“…PTEN, an important tumor suppressor and a key regulator of the PI3K/AKT signaling pathway, is often deleted/mutated in different types of cancer. The E3…”
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Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes : Potential importance of selectivity over dipeptidyl peptidases 8 and 9 by LANKAS, George R, LEITING, Barbara, IPPOLITO, Dawn E, KIM, Dooseop, LYONS, Kathryn A, OK, Hyun O, PATEL, Reshma A, PETROV, Aleksandr N, PRYOR, Kelly Ann, XIAOXIA QIAN, REIGLE, Leah, WOODS, Andrea, ROY, Ranabir Sinha, WU, Joseph K, ZALLER, Dennis, XIAOPING ZHANG, LAN ZHU, WEBER, Ann E, THORNBERRY, Nancy A, EIERMANN, George J, BECONI, Maria G, BIFTU, Tesfaye, CHAN, Chi-Chung, EDMONDSON, Scott, FEENEY, William P, HUAIBING HE

“…Dipeptidyl peptidase (DPP)-IV inhibitors are a new approach to the treatment of type 2 diabetes. DPP-IV is a member of a family of serine peptidases that…”
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Discovery of a peripheral 5HT 2A antagonist as a clinical candidate for metabolic dysfunction-associated steatohepatitis by Pagire, Haushabhau S, Pagire, Suvarna H, Jeong, Byung-Kwan, Choi, Won-Il, Oh, Chang Joo, Lim, Chae Won, Kim, Minhee, Yoon, Jihyeon, Kim, Seong Soon, Bae, Myung Ae, Jeon, Jae-Han, Song, Sungmin, Lee, Hee Jong, Lee, Eun Young, Goughnour, Peter C, Kim, Dooseop, Lee, In-Kyu, Loomba, Rohit, Kim, Hail, Ahn, Jin Hee

“…Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is currently the leading cause of chronic liver disease worldwide. Metabolic…”
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Discovery and optimization of adamantane carboxylic acid derivatives as potent diacylglycerol acyltransferase 1 inhibitors for the potential treatment of obesity and diabetes by Pagire, Suvarna H., Pagire, Haushabhau S., Lee, Gwi Bin, Han, Seo-Jung, Kwak, Hyun Jung, Kim, Ji Young, Kim, Ki Young, Rhee, Sang Dal, Ryu, Jeong Im, Song, Jin Sook, Bae, Myung Ae, Park, Mi-jin, Kim, Dooseop, Lee, Duck Hyung, Ahn, Jin Hee

“…We have developed a series of adamantane carboxylic acid derivatives exhibiting potent diacylglycerol acyltransferase 1 (DGAT1) inhibitory activities…”
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Discovery of Potent and Selective Dipeptidyl Peptidase IV Inhibitors Derived from β-Aminoamides Bearing Subsituted Triazolopiperazines by Kim, Dooseop, Kowalchick, Jennifer E, Brockunier, Linda L, Parmee, Emma R, Eiermann, George J, Fisher, Michael H, He, Huaibing, Leiting, Barbara, Lyons, Kathryn, Scapin, Giovanna, Patel, Sangita B, Petrov, Aleksandr, Pryor, KellyAnn D, Roy, Ranabir Sinha, Wu, Joseph K, Zhang, Xiaoping, Wyvratt, Matthew J, Zhang, Bei B, Zhu, Lan, Thornberry, Nancy A, Weber, Ann E

“…A series of β-aminoamides bearing triazolopiperazines have been discovered as potent, selective, and orally active dipeptidyl peptidase IV (DPP-4) inhibitors…”
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Potent 1,3,4-trisubstituted pyrrolidine CCR5 receptor antagonists: effects of fused heterocycles on antiviral activity and pharmacokinetic properties by Kim, Dooseop, Wang, Liping, Hale, Jeffrey J., Lynch, Christopher L., Budhu, Richard J., MacCoss, Malcolm, Mills, Sander G., Malkowitz, Lorraine, Gould, Sandra L., DeMartino, Julie A., Springer, Martin S., Hazuda, Daria, Miller, Michael, Kessler, Joseph, Hrin, Renee C., Carver, Gwen, Carella, Anthony, Henry, Karen, Lineberger, Janet, Schleif, William A., Emini, Emilio A.

“…[Display omitted] A series of 1,3,4-trisubstituted pyrrolidine CCR5 receptor antagonists containing a variety of fused heterocycles at the 4-position of the…”
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(2R)-4-Oxo-4-[3-(Trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin- 7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine:  A Potent, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes by Kim, Dooseop, Wang, Liping, Beconi, Maria, Eiermann, George J, Fisher, Michael H, He, Huaibing, Hickey, Gerard J, Kowalchick, Jennifer E, Leiting, Barbara, Lyons, Kathryn, Marsilio, Frank, McCann, Margaret E, Patel, Reshma A, Petrov, Aleksandr, Scapin, Giovanna, Patel, Sangita B, Roy, Ranabir Sinha, Wu, Joseph K, Wyvratt, Matthew J, Zhang, Bei B, Zhu, Lan, Thornberry, Nancy A, Weber, Ann E

“…A novel series of β-amino amides incorporating fused heterocycles, i.e., triazolopiperazines, were synthesized and evaluated as inhibitors of dipeptidyl…”
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NMR uncovers direct interaction between human NEDD4-1 and p34 SEI-1 by Shrestha, Pravesh, Yun, Ji-Hye, Ko, Yoon-Joo, Yeon, Kyu Jeong, Kim, Dooseop, Lee, Heejong, Jin, Dong-Hoon, Nam, Ki-Yup, Yoo, Hye Dong, Lee, Weontae

“…PTEN, an important tumor suppressor and a key regulator of the PI3K/AKT signaling pathway, is often deleted/mutated in different types of cancer. The E3…”
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2-Arylbenzoxazoles as CETP inhibitors: Raising HDL-C in cynoCETP transgenic mice by Kallashi, Florida, Kim, Dooseop, Kowalchick, Jennifer, Park, You Jung, Hunt, Julianne A., Ali, Amjad, Smith, Cameron J., Hammond, Milton L., Pivnichny, James V., Tong, Xinchun, Xu, Suoyu S., Anderson, Matt S., Chen, Ying, Eveland, Suzanne S., Guo, Qiu, Hyland, Sheryl A., Milot, Denise P., Cumiskey, Anne-Marie, Latham, Melanie, Peterson, Laurence B., Rosa, Raymond, Sparrow, Carl P., Wright, Samuel D., Sinclair, Peter J.

“…Compound 4 was found to be a potent inhibitor of CETP (CE IC50=16nM, TG IC50=18nM) with good pharmacokinetic properties and in vivo efficacy (ΔHDL-C=24mg/dL)…”
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Triazolopiperazine-amides as dipeptidyl peptidase IV inhibitors: Close analogs of JANUVIA™ (sitagliptin phosphate) by Kim, Dooseop, Kowalchick, Jennifer E., Edmondson, Scott D., Mastracchio, Anthony, Xu, Jinyou, Eiermann, George J., Leiting, Barbara, Wu, Joseph K., Pryor, KellyAnn D., Patel, Reshma A., He, Huaibing, Lyons, Kathryn A., Thornberry, Nancy A., Weber, Ann E.

“…A series of β-aminoamides bearing triazolopiperazines has been prepared and evaluated as potent, selective, orally active dipeptidyl peptidase IV (DPP-4)…”
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AT1/AT2-BALANCED ANGIOTENSIN II ANTAGONISTS by Ashton, Wallace T., Chang, Linda L., Flanagan, Kelly L., Mantlo, Nathan B., Ondeyka, Debra L., Kim, Dooseop, de Laszlo, Stephen E., Glinka, Tomasz W., Rivero, Ralph A., Kevin, Nancy J., Chang, Raymond S.L., Siegl, Peter K.S., Kivlighn, Salah D., Greenlee, William J.

“…Three heterocyclic series of nonpeptide angiotensin II receptor antagonists (quinazolinones, imidazo[4,5-b]pyridines, and triazolinones) have been transformed…”
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