Search Results - "DONNELLY, L"

Advantages of Single-Nucleus over Single-Cell RNA Sequencing of Adult Kidney: Rare Cell Types and Novel Cell States Revealed in Fibrosis by Wu, Haojia, Kirita, Yuhei, Donnelly, Erinn L, Humphreys, Benjamin D

“…A challenge for single-cell genomic studies in kidney and other solid tissues is generating a high-quality single-cell suspension that contains rare or…”
Get full text

Single-Cell Transcriptomics of a Human Kidney Allograft Biopsy Specimen Defines a Diverse Inflammatory Response by Wu, Haojia, Malone, Andrew F, Donnelly, Erinn L, Kirita, Yuhei, Uchimura, Kohei, Ramakrishnan, Sai M, Gaut, Joseph P, Humphreys, Benjamin D

“…Single-cell genomics techniques are revolutionizing our ability to characterize complex tissues. By contrast, the techniques used to analyze renal biopsy…”
Get full text

Defective monocyte-derived macrophage phagocytosis is associated with exacerbation frequency in COPD by Singh, R, Belchamber, K B R, Fenwick, P S, Chana, K, Donaldson, G, Wedzicha, J A, Barnes, P J, Donnelly, L E

“…Lower airway bacterial colonisation (LABC) in COPD patients is associated with increased exacerbation frequency and faster lung function decline. Defective…”
Get full text

Frequency and predictors of hypoglycaemia in Type 1 and insulin-treated Type 2 diabetes: a population-based study by Donnelly, L. A., Morris, A. D., Frier, B. M., Ellis, J. D., Donnan, P. T., Durrant, R., Band, M. M., Reekie, G., Leese, G. P.

“…Aims  To ascertain the frequency and identify predictors of self‐reported hypoglycaemia in Type 1 and insulin‐treated Type 2 diabetes. Methods  A random sample…”
Get full text

Defective macrophage phagocytosis of bacteria in COPD by Taylor, A E, Finney-Hayward, T K, Quint, J K, Thomas, C M R, Tudhope, S J, Wedzicha, J A, Barnes, P J, Donnelly, L E

“…Exacerbations of chronic obstructive pulmonary disease (COPD) are an increasing cause of hospitalisations and are associated with accelerated progression of…”
Get full text

The use of geoscience methods for terrestrial forensic searches by Pringle, J.K., Ruffell, A., Jervis, J.R., Donnelly, L., McKinley, J., Hansen, J., Morgan, R., Pirrie, D., Harrison, M.

“…Geoscience methods are increasingly being utilised in criminal, environmental and humanitarian forensic investigations, and the use of such methods is…”
Get full text

Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors by Donnelly‐Roberts, Diana L, Namovic, Marian T, Han, Ping, Jarvis, Michael F

“…Background and purpose:  Acute activation of P2X7 receptors rapidly opens a non‐selective cation channel. Sustained P2X7 receptor activation leads to the…”
Get full text

Uptake of tamoxifen in consecutive premenopausal women under surveillance in a high-risk breast cancer clinic by Donnelly, L S, Evans, D G, Wiseman, J, Fox, J, Greenhalgh, R, Affen, J, Juraskova, I, Stavrinos, P, Dawe, S, Cuzick, J, Howell, A

“…Background: Randomised trials of tamoxifen versus placebo indicate that tamoxifen reduces breast cancer risk by approximately 33%, yet uptake is low…”
Get full text

Monoaminergic orchestration of motor programs in a complex C. elegans behavior by Donnelly, Jamie L, Clark, Christopher M, Leifer, Andrew M, Pirri, Jennifer K, Haburcak, Marian, Francis, Michael M, Samuel, Aravinthan D T, Alkema, Mark J

“…Monoamines provide chemical codes of behavioral states. However, the neural mechanisms of monoaminergic orchestration of behavior are poorly understood. Touch…”
Get full text

The HIV and SARS-CoV-2 Parallel in Dentistry from the Perspectives of the Oral Health Care Team by Brondani, M., Donnelly, L.

“…Objectives: The aim of this study was to unravel the professional and social consequences of COVID-19 as compared with the AIDS pandemic according to oral…”
Get full text

eIF2B activator prevents neurological defects caused by a chronic integrated stress response by Wong, Yao Liang, LeBon, Lauren, Basso, Ana M, Kohlhaas, Kathy L, Nikkel, Arthur L, Robb, Holly M, Donnelly-Roberts, Diana L, Prakash, Janani, Swensen, Andrew M, Rubinstein, Nimrod D, Krishnan, Swathi, McAllister, Fiona E, Haste, Nicole V, O'Brien, Jonathon J, Roy, Margaret, Ireland, Andrea, Frost, Jennifer M, Shi, Lei, Riedmaier, Stephan, Martin, Kathleen, Dart, Michael J, Sidrauski, Carmela

“…The integrated stress response (ISR) attenuates the rate of protein synthesis while inducing expression of stress proteins in cells. Various insults activate…”
Get full text

Characteristics of people with high visit‐to‐visit glycaemic variability in Type 2 diabetes by Noyes, J. D., Soto‐Pedre, E., Donnelly, L. A., Pearson, E. R.

“…Aims Increased visit‐to‐visit glycaemic variability is independently associated with adverse outcomes in Type 2 diabetes. Our aim was to identify the patient…”
Get full text

Adherence to insulin and its association with glycaemic control in patients with type 2 diabetes by Donnelly, L.A., Morris, A.D., Evans, J.M.M.

“…Background: Good glycaemic control improves outcomes in patients with type 2 diabetes, but the extent to which this depends on adherence to insulin treatment…”
Get full text

Pregnant women's perspectives on integrating preventive oral health in prenatal care by Adeniyi, A, Donnelly, L, Janssen, P, Jevitt, C, Kardeh, B, von Bergmann, H, Brondani, M

“…Oral diseases are considered a silent epidemic including among pregnant women. Given the prevalence of oral conditions among pregnant women and the reported…”
Get full text

Common Nonsynonymous Substitutions in SLCO1B1 Predispose to Statin Intolerance in Routinely Treated Individuals With Type 2 Diabetes: A Go‐DARTS Study by Donnelly, LA, Doney, ASF, Tavendale, R, Lang, CC, Pearson, ER, Colhoun, HM, McCarthy, MI, Hattersley, AT, Morris, AD, Palmer, CNA

“…SLCO1B1 gene variants are associated with severe statin‐induced myopathy. We examined whether these variants are also associated with general statin…”
Get full text

Exploring the Relationship between BODIPY Structure and Spectroscopic Properties to Design Fluorophores for Bioimaging by Donnelly, Joanna L., Offenbartl‐Stiegert, Daniel, Marín‐Beloqui, José M., Rizzello, Loris, Battaglia, Guiseppe, Clarke, Tracey M., Howorka, Stefan, Wilden, Jonathan D.

“…Designing chromophores for biological applications requires a fundamental understanding of how the chemical structure of a chromophore influences its…”
Get full text

Increased levels of the chemokines GROα and MCP-1 in sputum samples from patients with COPD by Traves, S L, Culpitt, S V, Russell, R E K, Barnes, P J, Donnelly, L E

“…Background: Patients with chronic obstructive pulmonary disease (COPD) have increased numbers of neutrophils and macrophages in their lungs. Growth related…”
Get full text

Rapid detection of drug-resistant Escherichia coli by Vitek 2 compact system by Tshabuse, F, Buthelezi, Makhosi N., Folami, Olakunle Michael, Donnelly, L, Swalaha, FM

“…Sewage treatment facilities aim to reduce biological contaminants such as pathogenic bacteria, fungi, protozoa, and viruses in wastewaters before discharging…”
Get full text

Perspectives of socially disadvantaged women on oral healthcare during pregnancy by Adeniyi, A A, Laronde, D M, Brondani, M, Donnelly, L

“…Oral health is considered important during pregnancy, however many pregnant women, especially socially disadvantaged women such as immigrants, working poor and…”
Get more information

Inhibition by red wine extract, resveratrol, of cytokine release by alveolar macrophages in COPD by Culpitt, S V, Rogers, D F, Fenwick, P S, Shah, P, De Matos, C, Russell, R E K, Barnes, P J, Donnelly, L E

“…Background: The pathophysiology of chronic obstructive pulmonary disease (COPD) features pulmonary inflammation with a predominant alveolar macrophage…”
Get full text