Search Results - "DONIS, Ruben"

A Covid-19 Milestone Attained — A Correlate of Protection for Vaccines by Gilbert, Peter B., Donis, Ruben O., Koup, Richard A., Fong, Youyi, Plotkin, Stanley A., Follmann, Dean

“…The rapid identification of a correlate of protection for Covid-19 vaccines — on the basis of several harmonized randomized phase 3 trials using common…”
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Antiviral activity and increased host defense against influenza infection elicited by the human cathelicidin LL-37 by Barlow, Peter G, Svoboda, Pavel, Mackellar, Annie, Nash, Anthony A, York, Ian A, Pohl, Jan, Davidson, Donald J, Donis, Ruben O

“…The extensive world-wide morbidity and mortality caused by influenza A viruses highlights the need for new insights into the host immune response and novel…”
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Immune correlates analysis of the mRNA-1273 COVID-19 vaccine efficacy clinical trial by Gilbert, Peter B, Montefiori, David C, McDermott, Adrian B, Fong, Youyi, Benkeser, David, Deng, Weiping, Zhou, Honghong, Houchens, Christopher R, Martins, Karen, Jayashankar, Lakshmi, Castellino, Flora, Flach, Britta, Lin, Bob C, O'Connell, Sarah, McDanal, Charlene, Eaton, Amanda, Sarzotti-Kelsoe, Marcella, Lu, Yiwen, Yu, Chenchen, Borate, Bhavesh, van der Laan, Lars W P, Hejazi, Nima S, Huynh, Chuong, Miller, Jacqueline, El Sahly, Hana M, Baden, Lindsey R, Baron, Mira, De La Cruz, Luis, Gay, Cynthia, Kalams, Spyros, Kelley, Colleen F, Andrasik, Michele P, Kublin, James G, Corey, Lawrence, Neuzil, Kathleen M, Carpp, Lindsay N, Pajon, Rolando, Follmann, Dean, Donis, Ruben O, Koup, Richard A

“…In the coronavirus efficacy (COVE) phase 3 clinical trial, vaccine recipients were assessed for neutralizing and binding antibodies as correlates of risk for…”
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New world bats harbor diverse influenza A viruses by Tong, Suxiang, Zhu, Xueyong, Li, Yan, Shi, Mang, Zhang, Jing, Bourgeois, Melissa, Yang, Hua, Chen, Xianfeng, Recuenco, Sergio, Gomez, Jorge, Chen, Li-Mei, Johnson, Adam, Tao, Ying, Dreyfus, Cyrille, Yu, Wenli, McBride, Ryan, Carney, Paul J, Gilbert, Amy T, Chang, Jessie, Guo, Zhu, Davis, Charles T, Paulson, James C, Stevens, James, Rupprecht, Charles E, Holmes, Edward C, Wilson, Ian A, Donis, Ruben O

“…Aquatic birds harbor diverse influenza A viruses and are a major viral reservoir in nature. The recent discovery of influenza viruses of a new H17N10 subtype…”
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Nomenclature updates resulting from the evolution of avian influenza A(H5) virus clades 2.1.3.2a, 2.2.1, and 2.3.4 during 2013–2014 by Smith, Gavin J. D., Donis, Ruben O.

“…Aim The A/goose/Guangdong/1/96‐like hemagglutinin (HA) genes of highly pathogenic avian influenza (HPAI) A(H5) viruses have continued to rapidly evolve since…”
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Improving the selection and development of influenza vaccine viruses – Report of a WHO informal consultation on improving influenza vaccine virus selection, Hong Kong SAR, China, 18–20 November 2015 by Alan, Hampson, Ian, Barr, Nancy, Cox, Ruben O., Donis, Siddhivinayak, Hirve, Daniel, Jernigan, Jacqueline, Katz, John, McCauley, Fernando, Motta, Takato, Odagiri, Tam, John S, Anthony, Waddell, Richard, Webby, Thedi, Ziegler, Wenqing, Zhang

“…Abstract Since 2010 the WHO has held a series of informal consultations to explore ways of improving the currently highly complex and time-pressured influenza…”
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IFITM3 inhibits influenza A virus infection by preventing cytosolic entry by Feeley, Eric M, Sims, Jennifer S, John, Sinu P, Chin, Christopher R, Pertel, Thomas, Chen, Li-Mei, Gaiha, Gaurav D, Ryan, Bethany J, Donis, Ruben O, Elledge, Stephen J, Brass, Abraham L

“…To replicate, viruses must gain access to the host cell's resources. Interferon (IFN) regulates the actions of a large complement of interferon effector genes…”
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A potent broad-spectrum protective human monoclonal antibody crosslinking two haemagglutinin monomers of influenza A virus by Wu, Ying, Cho, MyungSam, Shore, David, Song, Manki, Choi, JungAh, Jiang, Tao, Deng, Yong-Qiang, Bourgeois, Melissa, Almli, Lynn, Yang, Hua, Chen, Li-Mei, Shi, Yi, Qi, Jianxu, Li, An, Yi, Kye Sook, Chang, MinSeok, Bae, Jin Soo, Lee, HyunJoo, Shin, JiYoung, Stevens, James, Hong, SeoungSuh, Qin, Cheng-Feng, Gao, George F., Chang, Shin Jae, Donis, Ruben O.

“…Effective annual influenza vaccination requires frequent changes in vaccine composition due to both antigenic shift for different subtype hemagglutinins (HAs)…”
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distinct lineage of influenza A virus from bats by Tong, Suxiang, Li, Yan, Rivailler, Pierre, Conrardy, Christina, Castillo, Danilo A. Alvarez, Chen, Li-Mei, Recuenco, Sergio, Ellison, James A, Davis, Charles T, York, Ian A, Turmelle, Amy S, Moran, David, Rogers, Shannon, Shi, Mang, Tao, Ying, Weil, Michael R, Tang, Kevin, Rowe, Lori A, Sammons, Scott, Xu, Xiyan, Frace, Michael, Lindblade, Kim A, Cox, Nancy J, Anderson, Larry J, Rupprecht, Charles E, Donis, Ruben O

“…Influenza A virus reservoirs in animals have provided novel genetic elements leading to the emergence of global pandemics in humans. Most influenza A viruses…”
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Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses by Perez, Sandra, Cox, Nancy J, Hwang, William C, Chen, Li-mei, Santelli, Eugenio, Wan, Hongquan, Cadwell, Greg, Aird, Daniel, Donis, Ruben O, Han, Thomas, Wei, Ge, Ali, Maryam, Murakami, Akikazu, Marasco, Wayne A, Sui, Jianhua, Liddington, Robert C, Bankston, Laurie A, Stec, Boguslaw, Yammanuru, Anuradha

“…A group of neutralizing monoclonal antibodies (mAbs) targeting the influenza A hemagglutinin has been selected and characterized. Remarkably, these mAbs were…”
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Replication and transmission of H9N2 influenza viruses in ferrets: evaluation of pandemic potential by Wan, Hongquan, Sorrell, Erin M, Song, Haichen, Hossain, Md Jaber, Ramirez-Nieto, Gloria, Monne, Isabella, Stevens, James, Cattoli, Giovanni, Capua, Ilaria, Chen, Li-Mei, Donis, Ruben O, Busch, Julia, Paulson, James C, Brockwell, Christy, Webby, Richard, Blanco, Jorge, Al-Natour, Mohammad Q, Perez, Daniel R

“…H9N2 avian influenza A viruses are endemic in poultry of many Eurasian countries and have caused repeated human infections in Asia since 1998. To evaluate the…”
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Emergence and dissemination of clade 2.3.4.4 H5Nx influenza viruses—how is the Asian HPAI H5 lineage maintained by Claes, Filip, Morzaria, Subhash P, Donis, Ruben O

“…•A new avian influenza A(H5N1) virus clade (2.3.4.4) is spreading globally in birds.•This virus revealed surprising propensity to reassort with NA subtypes…”
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Immune correlates analysis of the PREVENT-19 COVID-19 vaccine efficacy clinical trial by Fong, Youyi, Huang, Yunda, Benkeser, David, Carpp, Lindsay N., Áñez, Germán, Woo, Wayne, McGarry, Alice, Dunkle, Lisa M., Cho, Iksung, Houchens, Christopher R., Martins, Karen, Jayashankar, Lakshmi, Castellino, Flora, Petropoulos, Christos J., Leith, Andrew, Haugaard, Deanne, Webb, Bill, Lu, Yiwen, Yu, Chenchen, Borate, Bhavesh, van der Laan, Lars W. P., Hejazi, Nima S., Randhawa, April K., Andrasik, Michele P., Kublin, James G., Hutter, Julia, Keshtkar-Jahromi, Maryam, Beresnev, Tatiana H., Corey, Lawrence, Neuzil, Kathleen M., Follmann, Dean, Ake, Julie A., Gay, Cynthia L., Kotloff, Karen L., Koup, Richard A., Donis, Ruben O., Gilbert, Peter B.

“…In the PREVENT-19 phase 3 trial of the NVX-CoV2373 vaccine (NCT04611802), anti-spike binding IgG concentration (spike IgG), anti-RBD binding IgG concentration…”
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Structures of receptor complexes of a North American H7N2 influenza hemagglutinin with a loop deletion in the receptor binding site by Yang, Hua, Chen, Li-Mei, Carney, Paul J, Donis, Ruben O, Stevens, James

“…Human infections with subtype H7 avian influenza viruses have been reported as early as 1979. In 1996, a genetically stable 24-nucleotide deletion emerged in…”
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Hemagglutinin homologue from H17N10 bat influenza virus exhibits divergent receptor-binding and pH-dependent fusion activities by Zhu, Xueyong, Yu, Wenli, McBride, Ryan, Li, Yan, Chen, Li-Mei, Donis, Ruben O., Tong, Suxiang, Paulson, James C., Wilson, Ian A.

“…Bat influenza virus H17N10 represents a distinct lineage of influenza A viruses with gene segments coding for proteins that are homologs of the surface…”
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A government-led effort to identify correlates of protection for COVID-19 vaccines by Koup, Richard A., Donis, Ruben O., Gilbert, Peter B., Li, Andrew W., Shah, Najaf A., Houchens, Christopher R.

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Genetic compatibility and virulence of reassortants derived from contemporary avian H5N1 and human H3N2 influenza A viruses by Chen, Li-Mei, Davis, C Todd, Zhou, Hong, Cox, Nancy J, Donis, Ruben O

“…The segmented structure of the influenza virus genome plays a pivotal role in its adaptation to new hosts and the emergence of pandemics. Despite concerns…”
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A broadly neutralizing anti-influenza antibody reveals ongoing capacity of haemagglutinin-specific memory B cells to evolve by Fu, Ying, Zhang, Zhen, Sheehan, Jared, Avnir, Yuval, Ridenour, Callie, Sachnik, Thomas, Sun, Jiusong, Hossain, M. Jaber, Chen, Li-Mei, Zhu, Quan, Donis, Ruben O., Marasco, Wayne A.

“…Understanding the natural evolution and structural changes involved in broadly neutralizing antibody (bnAb) development holds great promise for improving the…”
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Genetically Diverse Low Pathogenicity Avian Influenza A Virus Subtypes Co-Circulate among Poultry in Bangladesh by Gerloff, Nancy A, Khan, Salah Uddin, Zanders, Natosha, Balish, Amanda, Haider, Najmul, Islam, Ausraful, Chowdhury, Sukanta, Rahman, Mahmudur Ziaur, Haque, Ainul, Hosseini, Parviez, Gurley, Emily S, Luby, Stephen P, Wentworth, David E, Donis, Ruben O, Sturm-Ramirez, Katharine, Davis, C Todd

“…Influenza virus surveillance, poultry outbreak investigations and genomic sequencing were assessed to understand the ecology and evolution of low pathogenicity…”
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In vitro evolution of H5N1 avian influenza virus toward human-type receptor specificity by Chen, Li-Mei, Blixt, Ola, Stevens, James, Lipatov, Aleksandr S, Davis, Charles T, Collins, Brian E, Cox, Nancy J, Paulson, James C, Donis, Ruben O

“…Abstract Acquisition of α2-6 sialoside receptor specificity by α2-3 specific highly-pathogenic avian influenza viruses (H5N1) is thought to be a prerequisite…”
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