Search Results - "DONIA, Marco"

Tertiary lymphoid structures improve immunotherapy and survival in melanoma by Cabrita, Rita, Lauss, Martin, Sanna, Adriana, Donia, Marco, Skaarup Larsen, Mathilde, Mitra, Shamik, Johansson, Iva, Phung, Bengt, Harbst, Katja, Vallon-Christersson, Johan, van Schoiack, Alison, Lövgren, Kristina, Warren, Sarah, Jirström, Karin, Olsson, Håkan, Pietras, Kristian, Ingvar, Christian, Isaksson, Karolin, Schadendorf, Dirk, Schmidt, Henrik, Bastholt, Lars, Carneiro, Ana, Wargo, Jennifer A., Svane, Inge Marie, Jönsson, Göran

“…Checkpoint blockade therapies that reactivate tumour-associated T cells can induce durable tumour control and result in the long-term survival of patients with…”
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Mutational and putative neoantigen load predict clinical benefit of adoptive T cell therapy in melanoma by Lauss, Martin, Donia, Marco, Harbst, Katja, Andersen, Rikke, Mitra, Shamik, Rosengren, Frida, Salim, Maryem, Vallon-Christersson, Johan, Törngren, Therese, Kvist, Anders, Ringnér, Markus, Svane, Inge Marie, Jönsson, Göran

“…Adoptive T-cell therapy (ACT) is a highly intensive immunotherapy regime that has yielded remarkable response rates and many durable responses in clinical…”
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Clinical responses to adoptive T-cell transfer can be modeled in an autologous immune-humanized mouse model by Jespersen, Henrik, Lindberg, Mattias F., Donia, Marco, Söderberg, Elin M. V., Andersen, Rikke, Keller, Ulrich, Ny, Lars, Svane, Inge Marie, Nilsson, Lisa M., Nilsson, Jonas A.

“…Immune checkpoint inhibitors and adoptive cell transfer (ACT) of autologous tumor-infiltrating T cells have shown durable responses in patients with melanoma…”
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Neoantigen-reactive CD8+ T cells affect clinical outcome of adoptive cell therapy with tumor-infiltrating lymphocytes in melanoma by Kristensen, Nikolaj Pagh, Heeke, Christina, Tvingsholm, Siri A, Borch, Annie, Draghi, Arianna, Crowther, Michael D, Carri, Ibel, Munk, Kamilla K, Holm, Jeppe Sejerø, Bjerregaard, Anne-Mette, Bentzen, Amalie Kai, Marquard, Andrea M, Szallasi, Zoltan, McGranahan, Nicholas, Andersen, Rikke, Nielsen, Morten, Jönsson, Göran B, Donia, Marco, Svane, Inge Marie, Hadrup, Sine Reker

“…BACKGROUNDNeoantigen-driven recognition and T cell-mediated killing contribute to tumor clearance following adoptive cell therapy (ACT) with tumor-infiltrating…”
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CTLA-4 blockade boosts the expansion of tumor-reactive CD8+ tumor-infiltrating lymphocytes in ovarian cancer by Friese, Christina, Harbst, Katja, Borch, Troels Holz, Westergaard, Marie Christine Wulff, Pedersen, Magnus, Kverneland, Anders, Jönsson, Göran, Donia, Marco, Svane, Inge Marie, Met, Özcan

“…Adoptive cell therapy (ACT) with autologous tumor-infiltrating lymphocytes (TILs) can induce durable complete tumor regression in patients with advanced…”
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Collagen density regulates the activity of tumor-infiltrating T cells by Kuczek, Dorota E, Larsen, Anne Mette H, Thorseth, Marie-Louise, Carretta, Marco, Kalvisa, Adrija, Siersbæk, Majken S, Simões, Ana Micaela C, Roslind, Anne, Engelholm, Lars H, Noessner, Elfriede, Donia, Marco, Svane, Inge Marie, Straten, Per Thor, Grøntved, Lars, Madsen, Daniel H

“…Tumor progression is accompanied by dramatic remodeling of the surrounding extracellular matrix leading to the formation of a tumor-specific ECM, which is…”
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Genetic Biomarkers in Melanoma of the Ocular Region: What the Medical Oncologist Should Know by Bol, Kalijn Fredrike, Donia, Marco, Heegaard, Steffen, Kiilgaard, Jens Folke, Svane, Inge Marie

“…Melanoma of the ocular region (ocular melanoma) comprises about 5% of all patients with melanoma and covers posterior uveal melanoma, iris melanoma, and…”
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Molecular patterns of resistance to immune checkpoint blockade in melanoma by Lauss, Martin, Phung, Bengt, Borch, Troels Holz, Harbst, Katja, Kaminska, Kamila, Ebbesson, Anna, Hedenfalk, Ingrid, Yuan, Joan, Nielsen, Kari, Ingvar, Christian, Carneiro, Ana, Isaksson, Karolin, Pietras, Kristian, Svane, Inge Marie, Donia, Marco, Jönsson, Göran

“…Immune checkpoint blockade (ICB) has improved outcome for patients with metastatic melanoma but not all benefit from treatment. Several immune- and tumor…”
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Loss of Ambra1 promotes melanoma growth and invasion by Di Leo, Luca, Bodemeyer, Valérie, Bosisio, Francesca M., Claps, Giuseppina, Carretta, Marco, Rizza, Salvatore, Faienza, Fiorella, Frias, Alex, Khan, Shawez, Bordi, Matteo, Pacheco, Maria P., Di Martino, Julie, Bravo-Cordero, Jose J., Daniel, Colin J., Sears, Rosalie C., Donia, Marco, Madsen, Daniel H., Guldberg, Per, Filomeni, Giuseppe, Sauter, Thomas, Robert, Caroline, De Zio, Daniela, Cecconi, Francesco

“…Melanoma is the deadliest skin cancer. Despite improvements in the understanding of the molecular mechanisms underlying melanoma biology and in defining new…”
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Adoptive cell therapy with tumor-infiltrating lymphocytes in patients with metastatic ovarian cancer: a pilot study by Pedersen, Magnus, Westergaard, Marie Christine Wulff, Milne, Katy, Nielsen, Morten, Borch, Troels Holz, Poulsen, Lars Grønlund, Hendel, Helle Westergren, Kennedy, Mia, Briggs, Gillian, Ledoux, Stacey, Nøttrup, Trine Jakobi, Andersen, Pernille, Hasselager, Thomas, Met, Özcan, Nelson, Brad H., Donia, Marco, Svane, Inge Marie

“…Objective:Ovarian cancer (OC) is often diagnosed at an advanced stage with two thirds of patients experiencing recurrent disease with a poor prognosis…”
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Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging by Steelman, Linda S, Chappell, William H, Abrams, Stephen L, Kempf, Ruth C, Long, Jacquelyn, Laidler, Piotr, Mijatovic, Sanja, Maksimovic-Ivanic, Danijela, Stivala, Franca, Mazzarino, Maria C, Donia, Marco, Fagone, Paolo, Malaponte, Graziella, Nicoletti, Ferdinando, Libra, Massimo, Milella, Michele, Tafuri, Agostino, Bonati, Antonio, Bäsecke, Jörg, Cocco, Lucio, Evangelisti, Camilla, Martelli, Alberto M, Montalto, Giuseppe, Cervello, Melchiorre, McCubrey, James A

“…Dysregulated signaling through the Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways is often the result of genetic alterations in critical components in these…”
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Development of anti-drug antibodies is associated with shortened survival in patients with metastatic melanoma treated with ipilimumab by Kverneland, Anders H., Enevold, Christian, Donia, Marco, Bastholt, Lars, Svane, Inge Marie, Nielsen, Claus H.

“…Introduction: Checkpoint inhibitors, including the CTLA-4 blocking antibody ipilimumab, have become the new standard therapy for many metastatic cancers…”
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Future role for adoptive T-cell therapy in checkpoint inhibitor-resistant metastatic melanoma by Borch, Troels Holz, Andersen, Rikke, Ellebaek, Eva, Met, Özcan, Donia, Marco, Marie Svane, Inge

“…Personalized cell therapy targeting tumor antigens with expanded tumor-infiltrating lymphocytes (TILs) has shown great promise in metastatic melanoma (MM)…”
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Highly efficient PD-1-targeted CRISPR-Cas9 for tumor-infiltrating lymphocyte-based adoptive T cell therapy by Chamberlain, Christopher Aled, Bennett, Eric Paul, Kverneland, Anders Handrup, Svane, Inge Marie, Donia, Marco, Met, Özcan

“…Adoptive T cell therapy (ACT) with expanded tumor-infiltrating lymphocytes (TIL) can induce durable responses in cancer patients from multiple histologies,…”
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Corrigendum: Ex vivo modulation of intact tumor fragments with anti-PD-1 and anti-CTLA-4 influences the expansion and specificity of tumor-infiltrating lymphocytes by Hulen, Thomas Morgan, Friese, Christina, Kristensen, Nikolaj Pagh, Granhøj, Joachim Stoltenborg, Borch, Troels Holz, Peeters, Marlies J W, Donia, Marco, Andersen, Mads Hald, Hadrup, Sine Reker, Svane, Inge Marie, Met, Özcan

“…[This corrects the article DOI: 10.3389/fimmu.2023.1180997.]…”
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Tumor-Infiltrating T Cells From Clear Cell Renal Cell Carcinoma Patients Recognize Neoepitopes Derived From Point and Frameshift Mutations by Hansen, Ulla Kring, Ramskov, Sofie, Bjerregaard, Anne-Mette, Borch, Annie, Andersen, Rikke, Draghi, Arianna, Donia, Marco, Bentzen, Amalie Kai, Marquard, Andrea Marion, Szallasi, Zoltan, Eklund, Aron Charles, Svane, Inge Marie, Hadrup, Sine Reker

“…Mutation-derived neoantigens are important targets for T cell-mediated reactivity toward tumors and, due to their unique tumor expression, an attractive target…”
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Personalized therapy with peptide-based neoantigen vaccine (EVX-01) including a novel adjuvant, CAF®09b, in patients with metastatic melanoma by Mørk, Sofie Kirial, Kadivar, Mohammad, Bol, Kalijn Fredrike, Draghi, Arianna, Westergaard, Marie Christine Wulff, Skadborg, Signe Koggersbøl, Overgaard, Nana, Sørensen, Anders Bundgård, Rasmussen, Ida Svahn, Andreasen, Lars Vibe, Yde, Christina Westmose, Trolle, Thomas, Garde, Christian, Friis-Nielsen, Jens, Nørgaard, Nis, Christensen, Dennis, Kringelum, Jens Vindahl, Donia, Marco, Hadrup, Sine Reker, Svane, Inge Marie

“…The majority of neoantigens arise from unique mutations that are not shared between individual patients, making neoantigen-directed immunotherapy a fully…”
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Reorienting the immune system in the treatment of cancer by using anti-PD-1 and anti-PD-L1 antibodies by Borch, Troels H., Donia, Marco, Andersen, Mads H., Svane, Inge M.

“…•We review PD-1 pathway blockade in the context of immunotherapy of cancer.•PD-1 and its ligands are excellent targets in anti-cancer therapy.•Anti-PD-1 and…”
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Long-Term Vemurafenib Exposure Induced Alterations of Cell Phenotypes in Melanoma: Increased Cell Migration and Its Association with EGFR Expression by Molnár, Eszter, Garay, Tamás, Donia, Marco, Baranyi, Marcell, Rittler, Dominika, Berger, Walter, Tímár, József, Grusch, Michael, Hegedűs, Balázs

“…Acquired resistance during BRAF inhibitor therapy remains a major challenge for melanoma treatment. Accordingly, we evaluated the phenotypical and molecular…”
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Adoptive cell therapy with autologous tumor infiltrating lymphocytes and low-dose Interleukin-2 in metastatic melanoma patients by Ellebaek, Eva, Iversen, Trine Zeeberg, Junker, Niels, Donia, Marco, Engell-Noerregaard, Lotte, Met, Özcan, Hölmich, Lisbet Rosenkrantz, Andersen, Rikke Sick, Hadrup, Sine Reker, Andersen, Mads Hald, thor Straten, Per, Svane, Inge Marie

“…Adoptive cell therapy may be based on isolation of tumor-specific T cells, e.g. autologous tumor infiltrating lymphocytes (TIL), in vitro activation and…”
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