Search Results - "DONGCHENG DAI"

A Novel Inhibitor of Dengue Virus Replication That Targets the Capsid Protein by Byrd, Chelsea M, Dai, Dongcheng, Grosenbach, Douglas W, Berhanu, Aklile, Jones, Kevin F, Cardwell, Kara B, Schneider, Christine, Wineinger, Kristin A, Page, Jessica M, Harver, Chris, Stavale, Eric, Tyavanagimatt, Shanthakumar, Stone, Melialani A, Bartenschlager, Ralf, Scaturro, Pietro, Hruby, Dennis E, Jordan, Robert

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A potent Lassa virus antiviral targets an arenavirus virulence determinant by Madu, Ikenna G, Files, Megan, Gharaibeh, Dima N, Moore, Amy L, Jung, Kie-Hoon, Gowen, Brian B, Dai, Dongcheng, Jones, Kevin F, Tyavanagimatt, Shanthakumar R, Burgeson, James R, Korth, Marcus J, Bedard, Kristin M, Iadonato, Shawn P, Amberg, Sean M

“…Arenaviruses are a significant cause of hemorrhagic fever, an often-fatal disease for which there is no approved antiviral therapy. Lassa fever in particular…”
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pH-Induced Activation of Arenavirus Membrane Fusion Is Antagonized by Small-Molecule Inhibitors by YORK, Joanne, DONGCHENG DAI, AMBERG, Sean M, NUNBERG, Jack H

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Novel Benzoxazole Inhibitor of Dengue Virus Replication That Targets the NS3 Helicase by BYRD, Chelsea M, GROSENBACH, Douglas W, WINEINGER, Kristin A, PAGE, Jessica, STAVALE, Eric, STONE, Melialani A, FULLER, Kathleen P, LOVEJOY, Candace, LEEDS, Janet M, HRUBY, Dennis E, JORDAN, Robert, BERHANU, Aklile, DONGCHENG DAI, JONES, Kevin F, CARDWELL, Kara B, SCHNEIDER, Christine, GUANG YANG, TYAVANAGIMATT, Shanthakumar, HARVER, Chris

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Identification of a Broad-Spectrum Arenavirus Entry Inhibitor by Larson, Ryan A, Dai, Dongcheng, Hosack, Virginia T, Tan, Ying, Bolken, Tove' C, Hruby, Dennis E, Amberg, Sean M

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Evaluation of Lassa antiviral compound ST-193 in a guinea pig model by Cashman, Kathleen A., Smith, Mark A., Twenhafel, Nancy A., Larson, Ryan A., Jones, Kevin F., Allen, Robert D., Dai, Dongcheng, Chinsangaram, Jarasvech, Bolken, Tove’ C., Hruby, Dennis E., Amberg, Sean M., Hensley, Lisa E., Guttieri, Mary C.

“…Lassa virus (LASV), a member of the Arenaviridae family, causes a viral hemorrhagic fever endemic to West Africa, where as many as 300,000 infections occur per…”
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Ruthenium-Promoted C–H Activation Reactions between DNA-Conjugated Acrylamide and Aromatic Acids by Wang, Xuan, Sun, Hui, Liu, Jiaxiang, Dai, Dongcheng, Zhang, Mingqiang, Zhou, Hu, Zhong, Wenge, Lu, Xiaojie

“…The first example of DNA-compatible C–H activation reaction between DNA-conjugated acrylamides and aromatic acids has been developed. This new transformation…”
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Construction of Thiazole-Fused Dihydropyrans via Formal [4 + 2] Cycloaddition Reaction on DNA by Wu, Wenting, Sun, Zhen, Wang, Xuan, Lu, Xiaojie, Dai, Dongcheng

“…An efficient and facile formal [4 + 2] cycloaddition reaction was developed to synthesize diverse thiazole-fused dihydropyrans (TFDP) on DNA. Mild reaction…”
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Palladium-Promoted DNA-Compatible Heck Reaction by Wang, Xuan, Sun, Hui, Liu, Jiaxiang, Zhong, Wenge, Zhang, Mingqiang, Zhou, Hu, Dai, Dongcheng, Lu, Xiaojie

“…Optimal conditions for palladium-promoted Heck reaction on DNA were developed with good to excellent conversions. Versatility with either DNA-conjugated…”
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Inverse-Electron-Demand Diels–Alder Reactions for the Synthesis of Pyridazines on DNA by Li, Hailong, Sun, Zhen, Wu, Wenting, Wang, Xuan, Zhang, Mingqiang, Lu, Xiaojie, Zhong, Wenge, Dai, Dongcheng

“…The synthesis of pyridazines on DNA has been developed on the basis of inverse-electron-demand Diels–Alder (IEDDA) reactions of 1,2,4,5-tetrazines. The broad…”
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Diversified strategy for the synthesis of DNA-encoded oxindole libraries by Wang, Xuan, Liu, Jiaxiang, Yan, Ziqin, Liu, Xiaohong, Liu, Sixiu, Suo, Yanrui, Lu, Weiwei, Yue, Jinfeng, Chen, Kaixian, Jiang, Hualiang, Zhao, Yujun, Zheng, Mingyue, Dai, Dongcheng, Lu, Xiaojie

“…DNA-encoded library technology (DELT) employs DNA as a barcode to track the sequence of chemical reactions and enables the design and synthesis of libraries…”
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Fragment-Based Computational Method for Designing GPCR Ligands by Li, Yan, Sun, Yaping, Song, Yunpeng, Dai, Dongcheng, Zhao, Zhixiong, Zhang, Qing, Zhong, Wenge, Hu, Liaoyuan A, Ma, Yingli, Li, Xun, Wang, Renxiao

“…G protein-coupled receptors (GPCRs) are the largest family of cell surface receptors, which is arguably the most important family of drug target. With the…”
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A Specific Interaction of Small Molecule Entry Inhibitors with the Envelope Glycoprotein Complex of the Junín Hemorrhagic Fever Arenavirus by Thomas, Celestine J., Casquilho-Gray, Hedi E., York, Joanne, DeCamp, Dianne L., Dai, Dongcheng, Petrilli, Erin B., Boger, Dale L., Slayden, Richard A., Amberg, Sean M., Sprang, Stephen R., Nunberg, Jack H.

“…Arenaviruses are responsible for acute hemorrhagic fevers worldwide and are recognized to pose significant threats to public health and biodefense. Small…”
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SAR analysis of a series of acylthiourea derivatives possessing broad-spectrum antiviral activity by Burgeson, James R., Moore, Amy L., Boutilier, Jordan K., Cerruti, Natasha R., Gharaibeh, Dima N., Lovejoy, Candace E., Amberg, Sean M., Hruby, Dennis E., Tyavanagimatt, Shanthakumar R., Allen, Robert D., Dai, Dongcheng

“…The SAR study of an acylthiourea scaffold capable of broad-spectrum antiviral activity is reported. A series of acylthiourea derivatives were designed,…”
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Discovery and optimization of potent broad-spectrum arenavirus inhibitors derived from benzimidazole by Dai, Dongcheng, Burgeson, James R., Gharaibeh, Dima N., Moore, Amy L., Larson, Ryan A., Cerruti, Natasha R., Amberg, Sean M., Bolken, Tove’ C., Hruby, Dennis E.

“…A chemically diverse library of about 400,000 small molecules was screened for antiviral activity against lentiviral pseudotypes with the Lassa virus envelope…”
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Lead optimization of an acylhydrazone scaffold possessing antiviral activity against Lassa virus by Burgeson, James R., Gharaibeh, Dima N., Moore, Amy L., Larson, Ryan A., Amberg, Sean M., Bolken, Tove’ C., Hruby, Dennis E., Dai, Dongcheng

“…SAR analysis and optimization of an acylhydrazone-linked scaffold for potential treatment of arenavirus derived hemorrhagic fever. Previously we reported the…”
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Discovery and optimization of potent broad-spectrum arenavirus inhibitors derived from benzimidazole and related heterocycles by Burgeson, James R., Moore, Amy L., Gharaibeh, Dima N., Larson, Ryan A., Cerruti, Natasha R., Amberg, Sean M., Hruby, Dennis E., Dai, Dongcheng

“…Modifications to the core scaffold of broad-spectrum arenavirus inhibitors. A series of potent arenavirus inhibitors sharing a benzimidazole core were…”
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N-(3,3a,4,4a,5,5a,6,6a-Octahydro-1,3-dioxo-4,6- ethenocycloprop[f]isoindol-2-(1H)-yl)carboxamides:  Identification of Novel Orthopoxvirus Egress Inhibitors by Bailey, Thomas R, Rippin, Susan R, Opsitnick, Elizabeth, Burns, Christopher J, Pevear, Daniel C, Collett, Marc S, Rhodes, Gerry, Tohan, Sanjeev, Huggins, John W, Baker, Robert O, Kern, Earl R, Keith, Kathy A, Dai, Dongcheng, Yang, Guang, Hruby, Dennis, Jordan, Robert

“…A series of novel, potent orthopoxvirus egress inhibitors was identified during high-throughput screening of the ViroPharma small molecule collection. Using…”
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Discovery of small molecule inhibitors of ubiquitin-like poxvirus proteinase I7L using homology modeling and covalent docking approaches by Katritch, Vsevolod, Byrd, Chelsea M, Tseitin, Vladimir, Dai, Dongcheng, Raush, Eugene, Totrov, Maxim, Abagyan, Ruben, Jordan, Robert, Hruby, Dennis E

“…Essential for viral replication and highly conserved among poxviridae, the vaccinia virus I7L ubiquitin-like proteinase (ULP) is an attractive target for…”
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Small Molecule Inhibitors of Dengue Virus Replication are Active In Vivo by Byrd, Chelsea, Harver, Chris, Cardwell, Kara, Grosenbach, Doug, Berhanu, Aklile, Dai, Dongcheng, Hruby, Dennis, Jordan, Robert

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