Search Results - "DONE, Susan"

Glutathione and Thioredoxin Antioxidant Pathways Synergize to Drive Cancer Initiation and Progression by Harris, Isaac S., Treloar, Aislinn E., Inoue, Satoshi, Sasaki, Masato, Gorrini, Chiara, Lee, Kim Chung, Yung, Ka Yi, Brenner, Dirk, Knobbe-Thomsen, Christiane B., Cox, Maureen A., Elia, Andrew, Berger, Thorsten, Cescon, David W., Adeoye, Adewunmi, Brüstle, Anne, Molyneux, Sam D., Mason, Jacqueline M., Li, Wanda Y., Yamamoto, Kazuo, Wakeham, Andrew, Berman, Hal K., Khokha, Rama, Done, Susan J., Kavanagh, Terrance J., Lam, Ching-Wan, Mak, Tak W.

“…Controversy over the role of antioxidants in cancer has persisted for decades. Here, we demonstrate that synthesis of the antioxidant glutathione (GSH), driven…”
Get full text

GLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer by Wu, Qin, ba-alawi, Wail, Deblois, Genevieve, Cruickshank, Jennifer, Duan, Shili, Lima-Fernandes, Evelyne, Haight, Jillian, Tonekaboni, Seyed Ali Madani, Fortier, Anne-Marie, Kuasne, Hellen, McKee, Trevor D., Mahmoud, Hassan, Kushida, Michelle, Cameron, Sarina, Dogan-Artun, Nergiz, Chen, WenJun, Nie, Yan, Zhang, Lan Xin, Vellanki, Ravi N., Zhou, Stanley, Prinos, Panagiotis, Wouters, Bradly G., Dirks, Peter B., Done, Susan J., Park, Morag, Cescon, David W., Haibe-Kains, Benjamin, Lupien, Mathieu, Arrowsmith, Cheryl H.

“…Triple negative breast cancer (TNBC) is a deadly form of breast cancer due to the development of resistance to chemotherapy affecting over 30% of patients. New…”
Get full text

MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis by Kalkat, Manpreet, Resetca, Diana, Lourenco, Corey, Chan, Pak-Kei, Wei, Yong, Shiah, Yu-Jia, Vitkin, Natasha, Tong, Yufeng, Sunnerhagen, Maria, Done, Susan J., Boutros, Paul C., Raught, Brian, Penn, Linda Z.

“…Transforming members of the MYC family (MYC, MYCL1, and MYCN) encode transcription factors containing six highly conserved regions, termed MYC homology boxes…”
Get full text

Therapeutic inhibition of USP9x-mediated Notch signaling in triple-negative breast cancer by Jaiswal, Arushi, Murakami, Kiichi, Elia, Andrew, Shibahara, Yukiko, Done, Susan J., Wood, Stephen A., Donato, Nicholas J., Ohashi, Pamela S., Reedijk, Michael

“…Triple-negative breast cancer (TNBC) is a breast cancer subtype that lacks targeted treatment options. The activation of the Notch developmental signaling…”
Get full text

Performance Measures of Magnetic Resonance Imaging Plus Mammography in the High Risk Ontario Breast Screening Program by Chiarelli, Anna M, Blackmore, Kristina M, Muradali, Derek, Done, Susan J, Majpruz, Vicky, Weerasinghe, Ashini, Mirea, Lucia, Eisen, Andrea, Rabeneck, Linda, Warner, Ellen

“…Abstract Background The Ontario Breast Screening Program expanded in July 2011 to screen high-risk women age 30–69 years with annual magnetic resonance imaging…”
Get full text

Resident Depression and Burnout During the COVID-19 Pandemic: A Survey of Canadian Laboratory Medicine Trainees by Han, Rachel, Hahn, Elan, Done, Susan J, Pun, Cherry, Shivji, Sameer, Lu, Fang-I

“…Resident physicians face a higher rate of burnout and depression than the general population. Few studies have examined burnout and depression in Canadian…”
Get full text

Machine learning-enabled cancer diagnostics with widefield polarimetric second-harmonic generation microscopy by Mirsanaye, Kamdin, Uribe Castaño, Leonardo, Kamaliddin, Yasmeen, Golaraei, Ahmad, Augulis, Renaldas, Kontenis, Lukas, Done, Susan J., Žurauskas, Edvardas, Stambolic, Vuk, Wilson, Brian C., Barzda, Virginijus

“…The extracellular matrix (ECM) collagen undergoes major remodeling during tumorigenesis. However, alterations to the ECM are not widely considered in cancer…”
Get full text

Identification of genomic signatures in circulating tumor cells from breast cancer by Kanwar, Nisha, Hu, Pingzhao, Bedard, Philippe, Clemons, Mark, McCready, David, Done, Susan J.

“…Levels of circulating tumor cells (CTCs) in blood have prognostic value in early and metastatic breast cancer. CTCs also show varying degrees of concordance…”
Get full text

A Four-Chemokine Signature Is Associated with a T-cell-Inflamed Phenotype in Primary and Metastatic Pancreatic Cancer by Romero, Joan M, Grünwald, Barbara, Jang, Gun-Ho, Bavi, Prashant P, Jhaveri, Aaditeya, Masoomian, Mehdi, Fischer, Sandra E, Zhang, Amy, Denroche, Robert E, Lungu, Ilinca M, De Luca, Angela, Bartlett, John M S, Xu, Jing, Li, Niandong, Dhaliwal, Sharon, Liang, Sheng-Ben, Chadwick, Dianne, Vyas, Foram, Bronsert, Peter, Khokha, Rama, McGaha, Tracy L, Notta, Faiyaz, Ohashi, Pamela S, Done, Susan J, O'Kane, Grainne M, Wilson, Julie M, Knox, Jennifer J, Connor, Ashton, Wang, Yifan, Zogopoulos, George, Gallinger, Steven

“…The molecular drivers of antitumor immunity in pancreatic ductal adenocarcinoma (PDAC) are poorly understood, posing a major obstacle for the identification of…”
Get full text

Metformin in early breast cancer: a prospective window of opportunity neoadjuvant study by Niraula, Saroj, Dowling, Ryan J. O., Ennis, Marguerite, Chang, Martin C., Done, Susan J., Hood, Nicky, Escallon, Jaime, Leong, Wey Liang, McCready, David R., Reedijk, Michael, Stambolic, Vuk, Goodwin, Pamela J.

“…Metformin may exert anti-cancer effects through indirect (insulin-mediated) or direct (insulin-independent) mechanisms. We report results of a neoadjuvant…”
Get full text

Changes of collagen ultrastructure in breast cancer tissue determined by second-harmonic generation double Stokes-Mueller polarimetric microscopy by Golaraei, Ahmad, Kontenis, Lukas, Cisek, Richard, Tokarz, Danielle, Done, Susan J, Wilson, Brian C, Barzda, Virginijus

“…Second-harmonic generation (SHG) double Stokes-Mueller polarimetric microscopy is applied to study the alteration of collagen ultrastructure in a tissue…”
Get full text

Breast specimen handling and reporting in the post-neoadjuvant setting: challenges and advances by Mrkonjic, Miralem, Berman, Hal K, Done, Susan J, Youngson, Bruce, Mulligan, Anna Marie

“…Neoadjuvant systemic therapy is becoming more commonly used in patients with earlier stages of breast cancer. To assess tumour response to neoadjuvant…”
Get more information

Identification of a Low-Risk Luminal A Breast Cancer Cohort That May Not Benefit From Breast Radiotherapy by Liu, Fei-Fei, Shi, Wei, Done, Susan J, Miller, Naomi, Pintilie, Melania, Voduc, David, Nielsen, Torsten O, Nofech-Mozes, Sharon, Chang, Martin C, Whelan, Timothy J, Weir, Lorna M, Olivotto, Ivo A, McCready, David R, Fyles, Anthony W

“…To determine the prognostic and predictive value of intrinsic subtyping by using immunohistochemical (IHC) biomarkers for ipsilateral breast relapse (IBR) in…”
Get full text

Annual vs Biennial Screening: Diagnostic Accuracy Among Concurrent Cohorts Within the Ontario Breast Screening Program by Chiarelli, Anna M, Blackmore, Kristina M, Mirea, Lucia, Done, Susan J, Majpruz, Vicky, Weerasinghe, Ashini, Rabeneck, Linda, Muradali, Derek

“…Abstract Background The Ontario Breast Screening Program recommends annual mammography to women age 50–74 years at increased risk because of family history of…”
Get full text

The tumor cell‐derived matrix of lobular breast cancer: a new vulnerability by Kozma, Katelyn J, Done, Susan J, Egan, Sean E

“…Invasive lobular carcinoma (ILC) of the breast is a very common disease. Despite its prevalence, these tumors are relatively understudied. One reason for this…”
Get full text

Primary MALT lymphoma of the breast: pathological and radiological characteristics by Shibahara, Yukiko, Delabie, Jan M. A., Kulkarni, Supriya, Grant, Allison, Prica, Anca, McCready, David R., Done, Susan J.

“…Purpose Primary Mucosa-associated lymphoid tissue (MALT) lymphoma is a rare diagnosis in the breast, and clinical diagnosis based on radiological features is…”
Get full text

Negative Enrichment and Isolation of Circulating Tumor Cells for Whole Genome Amplification by Kanwar, Nisha, Done, Susan J

“…Circulating tumor cells (CTCs) are a rare population of cells found in the peripheral blood of patients with many types of cancer such as breast, prostate,…”
Get more information

Changes in insulin receptor signaling underlie neoadjuvant metformin administration in breast cancer: a prospective window of opportunity neoadjuvant study by Dowling, Ryan J O, Niraula, Saroj, Chang, Martin C, Done, Susan J, Ennis, Marguerite, McCready, David R, Leong, Wey L, Escallon, Jaime M, Reedijk, Michael, Goodwin, Pamela J, Stambolic, Vuk

“…The antidiabetic drug metformin exhibits potential anticancer properties that are believed to involve both direct (insulin-independent) and indirect…”
Get full text

Healthcare and Cancer Treatment Costs of Breast Screening Outcomes among Higher than Average Risk Women by Mittmann, Nicole, Blackmore, Kristina M, Seung, Soo Jin, Diong, Christina, Done, Susan J, Chiarelli, Anna M

“…Concurrent cohorts of 644,932 women aged 50–74 screened annually due to family history, dense breasts or biennially in the Ontario Breast Screening Program…”
Get full text

Proteomic analyses reveal high expression of decorin and endoplasmin (HSP90B1) are associated with breast cancer metastasis and decreased survival by Cawthorn, Thomas R, Moreno, Juan C, Dharsee, Moyez, Tran-Thanh, Danh, Ackloo, Suzanne, Zhu, Pei Hong, Sardana, Girish, Chen, Jian, Kupchak, Peter, Jacks, Lindsay M, Miller, Naomi A, Youngson, Bruce J, Iakovlev, Vladimir, Guidos, Cynthia J, Vallis, Katherine A, Evans, Kenneth R, McCready, David, Leong, Wey L, Done, Susan J

“…Breast cancer is the most common malignancy among women worldwide in terms of incidence and mortality. About 10% of North American women will be diagnosed with…”
Get full text