Search Results - "DONAT, K."

Microglial Activation in Traumatic Brain Injury by Donat, Cornelius K, Scott, Gregory, Gentleman, Steve M, Sastre, Magdalena

“…Microglia have a variety of functions in the brain, including synaptic pruning, CNS repair and mediating the immune response against peripheral infection…”
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Multiscale modelling of cerebrovascular injury reveals the role of vascular anatomy and parenchymal shear stresses by Farajzadeh Khosroshahi, Siamak, Yin, Xianzhen, K. Donat, Cornelius, McGarry, Aisling, Yanez Lopez, Maria, Baxan, Nicoleta, J. Sharp, David, Sastre, Magdalena, Ghajari, Mazdak

“…Neurovascular injury is often observed in traumatic brain injury (TBI). However, the relationship between mechanical forces and vascular injury is still…”
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In vivo Imaging of Glial Activation in Alzheimer's Disease by Edison, Paul, Donat, Cornelius K, Sastre, Magdalena

“…Alzheimer's disease (AD) is characterized by memory loss and decline of cognitive function, associated with progressive neurodegeneration. While…”
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Exploring Hydrophilic PD-L1 Radiotracers Utilizing Phosphonic Acids: Insights into Unforeseen Pharmacokinetics by Krutzek, Fabian, Donat, Cornelius K, Stadlbauer, Sven

“…Immune checkpoint inhibitor therapy targeting the PD-1/PD-L1 axis in cancer patients, is a promising oncological treatment. However, the number of…”
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A quantitative neuropathological assessment of translocator protein expression in multiple sclerosis by Nutma, Erik, Stephenson, Jodie A, Gorter, Rianne P, de Bruin, Joy, Boucherie, Deirdre M, Donat, Cornelius K, Breur, Marjolein, van der Valk, Paul, Matthews, Paul M, Owen, David R, Amor, Sandra

“…The 18 kDa translocator protein (TSPO) is increasingly used to study brain and spinal cord inflammation in degenerative diseases of the CNS such as multiple…”
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Plumage damage and back skin lesions in laying hens with untrimmed beak depend on rearing of pullets and genetics by Gernand, E., Ahlers, C., Huchler, M., Donat, K.

“…1. Within a triennial project, 34 layer flocks with untrimmed beaks were examined regularly throughout the laying period to broaden knowledge on the occurrence…”
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Axonal marker neurofilament light predicts long-term outcomes and progressive neurodegeneration after traumatic brain injury by Graham, Neil S N, Zimmerman, Karl A, Moro, Federico, Heslegrave, Amanda, Maillard, Samia Abed, Bernini, Adriano, Miroz, John-Paul, Donat, Cornelius K, Lopez, Maria Yanez, Bourke, Niall, Jolly, Amy E, Mallas, Emma-Jane, Soreq, Eyal, Wilson, Mark H, Fatania, Gavin, Roi, Dylan, Patel, Maneesh C, Garbero, Elena, Nattino, Giovanni, Baciu, Camelia, Fainardi, Enrico, Chieregato, Arturo, Gradisek, Primoz, Magnoni, Sandra, Oddo, Mauro, Zetterberg, Henrik, Bertolini, Guido, Sharp, David J

“…Axonal injury is a key determinant of long-term outcomes after traumatic brain injury (TBI) but has been difficult to measure clinically. Fluid biomarker…”
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Factors associated with keel bone damage - a longitudinal study of commercial layer flocks during the laying period by Marggraff, J., Gernand, E., Ahlers, C., Huchler, M., Rautenschlein, S., Donat, K.

“…1. Keel bone damage, such as deformations and fractures, is a severe problem regarding animal welfare in layers. To identify risk factors under commercial…”
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Chelator impact: investigating the pharmacokinetic behavior of copper-64 labeled PD-L1 radioligands by Krutzek, Fabian, Donat, Cornelius K., Stadlbauer, Sven

“…Background Programmed cell death ligand 1 (PD-L1) plays a critical role in the tumor microenvironment and overexpression in several solid cancers has been…”
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Predicting sensitivity of repeated environmental sampling for Mycobacterium avium subsp. paratuberculosis in dairy herds using a Bayesian latent class model by Zoche-Golob, V., Donat, K., Barkema, H.W., De Buck, J., Kastelic, J., Wolf, R.

“…•M. avium ssp paratuberculosis detection by TREK culture on dairy farms was studied.•Two vs. four environmental samples were compared over multiple collection…”
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Preparation of 18F-Labeled Tracers Targeting Fibroblast Activation Protein via Sulfur [18F]Fluoride Exchange Reaction by Craig, Austin, Kogler, Jürgen, Laube, Markus, Ullrich, Martin, Donat, Cornelius K., Wodtke, Robert, Kopka, Klaus, Stadlbauer, Sven

“…Early detection and treatment of cancers can significantly increase patient prognosis and enhance the quality of life of affected patients. The emerging…”
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Design and Biological Evaluation of Small-Molecule PET-Tracers for Imaging of Programmed Death Ligand 1 by Krutzek, Fabian, Donat, Cornelius K, Ullrich, Martin, Zarschler, Kristof, Ludik, Marie-Charlotte, Feldmann, Anja, Loureiro, Liliana R, Kopka, Klaus, Stadlbauer, Sven

“…Noninvasive molecular imaging of the PD-1/PD-L1 immune checkpoint is of high clinical relevance for patient stratification and therapy monitoring in cancer…”
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CRISPR/Cas9 Mediated Knockout of Cyclooxygenase-2 Gene Inhibits Invasiveness in A2058 Melanoma Cells by Haase-Kohn, Cathleen, Laube, Markus, Donat, Cornelius K, Belter, Birgit, Pietzsch, Jens

“…The inducible isoenzyme cyclooxygenase-2 (COX-2) is an important hub in cellular signaling, which contributes to tumor progression by modulating and enhancing…”
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Within-herd prevalence thresholds for herd-level detection of mastitis pathogens using multiplex real-time PCR in bulk tank milk samples by Soltau, J B, Einax, E, Klengel, K, Katholm, J, Failing, K, Wehrend, A, Donat, K

“…The objective of the study was to assess the value of quantitative multiplex real-time PCR examination of bulk tank milk samples for bovine mastitis pathogens…”
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Traumatic Brain Injury Leads to Alterations in Contusional Cortical miRNAs Involved in Dementia by Naseer, Shahmir, Abelleira-Hervas, Laura, Savani, Dhwani, de Burgh, Ross, Aleksynas, Robertas, Donat, Cornelius K, Syed, Nelofer, Sastre, Magdalena

“…There is compelling evidence that head injury is a significant environmental risk factor for Alzheimer’s disease (AD) and that a history of traumatic brain…”
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Heritability estimates for Mycobacterium avium subspecies paratuberculosis status of German Holstein cows tested by fecal culture by Küpper, J, Brandt, H, Donat, K, Erhardt, G

“…The objective of this study was to estimate genetic manifestation of Mycobacterium avium ssp. paratuberculosis (MAP) infection in German Holstein cows…”
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Evaluation of the Enantiomer Specific Biokinetics and Radiation Doses of [(18)F]Fluspidine-A New Tracer in Clinical Translation for Imaging of σ₁ Receptors by Kranz, Mathias, Sattler, Bernhard, Wüst, Nathanael, Deuther-Conrad, Winnie, Patt, Marianne, Meyer, Philipp M, Fischer, Steffen, Donat, Cornelius K, Wünsch, Bernhard, Hesse, Swen, Steinbach, Jörg, Brust, Peter, Sabri, Osama

“…The enantiomers of [(18)F]fluspidine, recently developed for imaging of σ₁ receptors, possess distinct pharmacokinetics facilitating their use in different…”
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In Vitro and In Vivo Characterization of Dibenzothiophene Derivatives [ 125 I]Iodo-ASEM and [ 18 F]ASEM as Radiotracers of Homo- and Heteromeric α7 Nicotinic Acetylcholine Receptors by Donat, Cornelius K, Hansen, Henrik H, Hansen, Hanne D, Mease, Ronnie C, Horti, Andrew G, Pomper, Martin G, L'Estrade, Elina T, Herth, Matthias M, Peters, Dan, Knudsen, Gitte M, Mikkelsen, Jens D

“…The α7 nicotinic acetylcholine receptor (α7 nAChR) is involved in several cognitive and physiologic processes; its expression levels and patterns change in…”
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Within-herd prevalence thresholds for the detection of Mycobacterium avium subspecies paratuberculosis-positive dairy herds using boot swabs and liquid manure samples by DONAT, K., HAHN, N., EISENBERG, T., SCHLEZ, K., KÖHLER, H., WOLTER, W., ROHDE, M., PÜTZSCHEL, R., RÖSLER, U., FAILING, K., ZSCHÖCK, P. M.

“…The control of Johne's disease requires the identification of Mycobacterium avium ssp. paratuberculosis (MAP)-positive herds. Boot swabs and liquid manure…”
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Detection of Mycobacterium avium subspecies paratuberculosis in environmental samples by faecal culture and real-time PCR in relation to apparent within-herd prevalence as determined by individual faecal culture by DONAT, K., KUBE, J., DRESSEL, J., EINAX, E., PFEFFER, M., FAILING, K.

“…Environmental samples are a cost-saving and easy-to-use approach to diagnose paratuberculosis at the herd level. Detailed knowledge concerning its…”
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