Search Results - "DONALD CAPRA, J"

Rapid generation of fully human monoclonal antibodies specific to a vaccinating antigen by Wilson, Patrick C, Smith, Kenneth, Garman, Lori, Wrammert, Jens, Zheng, Nai-Ying, Capra, J Donald, Ahmed, Rafi

“…We describe herein a protocol for the production of antigen-specific human monoclonal antibodies (hmAbs). Antibody-secreting cells (ASCs) are isolated from…”
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Rapid cloning of high-affinity human monoclonal antibodies against influenza virus by Wilson, Patrick C, Wrammert, Jens, Smith, Kenneth, Miller, Joe, Langley, William A, Kokko, Kenneth, Larsen, Christian, Zheng, Nai-Ying, Mays, Israel, Garman, Lori, Helms, Christina, James, Judith, Air, Gillian M, Capra, J. Donald, Ahmed, Rafi

“…Pre-existing neutralizing antibody provides the first line of defence against pathogens in general. For influenza virus, annual vaccinations are given to…”
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Mature B cells class switched to IgD are autoreactive in healthy individuals by Koelsch, Kristi, Zheng, Nai-Ying, Zhang, Qingzhao, Duty, Andrew, Helms, Christina, Mathias, Melissa D, Jared, Mathew, Smith, Kenneth, Capra, J Donald, Wilson, Patrick C

“…Determination of the origin and fate of autoreactive B cells is critical to understanding and treating autoimmune diseases. We report that, despite being…”
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A novel human B cell subpopulation representing the initial germinal center population to express AID by Kolar, Grant R., Mehta, Darshna, Pelayo, Rosana, Capra, J. Donald

“…We have identified a novel mature human B-cell subpopulation in the human tonsil that has characteristics of both naive B cells and germinal center B cells…”
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Key developmental transitions in human germinal center B cells are revealed by differential CD45RB expression by Jackson, Stephen M., Harp, Natessa, Patel, Darshna, Wulf, Jordan, Spaeth, Erich D., Dike, Uzoamaka K., James, Judith A., Capra, J. Donald

“…We previously reported that RO+ expression correlated with increased mutation, activation, and selection among human germinal center (GC) B cells. Here, we…”
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Human Monoclonal Antibodies as a New Class of Antiinfective Compounds by Burioni, Roberto, Capra, J. Donald, Lang, Alois B.

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Targeting mucosal sites by polymeric immunoglobulin receptor-directed peptides by White, Kendra D, Capra, J Donald

“…Polymeric immunoglobulins provide first line humoral defense at mucosal surfaces to which they are specifically transported by the polymeric immunoglobulin…”
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Human B cell subsets by Jackson, Stephen M, Wilson, Patrick C, James, Judith A, Capra, J Donald

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Human CD14 mediates recognition and phagocytosis of apoptotic cells by Gregory, Christopher D, Devitt, Andrew, Moffatt, Odette D, Raykundalia, Chandra, Capra, J. Donald, Simmons, David L

“…Cells undergoing programmed cell death (apoptosis) are cleared rapidly in vivo by phagocytes without inducing inflammation. Here we show that the…”
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Human immunoglobulin selection associated with class switch and possible tolerogenic origins for C delta class-switched B cells by Zheng, Nai-Ying, Wilson, Kenneth, Wang, Xiaojian, Boston, Angela, Kolar, Grant, Jackson, Stephen M, Liu, Yong-Jun, Pascual, Virginia, Capra, J Donald, Wilson, Patrick C

“…Current paradigms of peripheral B cell selection suggest that autoreactive B cells are controlled by clonal deletion, anergy, and developmental arrest. We…”
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Use of D Gene Segments with Irregular Spacers in Terminal Deoxynucleotidyltransferase (TdT)+/+and TdT-/-Mice Carrying a Human Ig Heavy Chain Transgenic Minilocus by Tuaillon, Nadine, Capra, J. Donald

“…D gene segments with irregular spacers (DIR) are D gene segments that are specific to higher primates. Their use is controversial because of their G+C-rich…”
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CD45RO enriches for activated, highly mutated human germinal center B cells by Jackson, Stephen M., Harp, Natessa, Patel, Darshna, Zhang, Jeffrey, Willson, Savannah, Kim, Yoon J., Clanton, Christian, Capra, J. Donald

“…To date, there is no consensus regarding the influence of different CD45 isoforms during peripheral B-cell development. Examining correlations between surface…”
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Funding agencies and disease organizations: Resources and recommendations to facilitate ALS clinical research by Chad, David A., Bidichandani, Sanjay, Bruijn, Lucie, Capra, J. Donald, Dickie, Brian, Ferguson, John, Figlewicz, Denise, Forsythe, Melissa, Kaufmann, Petra, Kirshner, Annette, Monti, William

“…Abstract Ten groups presented their perspectives on facilitating clinical research in ALS including four federal agencies, four disease organizations, one…”
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Molecular Characterization of Five Human Anti-Human Immunodeficiency Virus Type 1 Antibody Heavy Chains Reveals Extensive Somatic Mutation Typical of an Antigen-Driven Immune Response by ANDRIS, J. S, JOHNSON, S, ZOLLA-PAZNER, S, DONALD CAPRA, J

“…We report the heavy chain variable region sequences from the cDNAs of five previously described monoclonal cell lines producing human antibodies specific for…”
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Multiple genes, one polypeptide chain by Capra, J Donald

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Ig V region restrictions in human chronic lymphocytic leukemia suggest some cases have a common origin by Kolar, Grant R, Capra, J Donald

“…The factors that contribute to the development of B cell chronic lymphocytic leukemia (B-CLL) are unknown, and the groups of individuals at the greatest risk…”
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DNA Cleavage of a Cryptic Recombination Signal Sequence by RAG1 and RAG2: IMPLICATIONS FOR PARTIAL V[subscript H] GENE REPLACEMENT by Rahman, Negar S, Godderz, LeAnn J, Stray, Stephen J, Capra, J. Donald, Rodgers, Karla K

“…Antibody and T cell receptor genes are assembled from gene segments by V(D)J recombination to produce an almost infinitely diverse repertoire of antigen…”
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IgH V-Region Sequence Does Not Predict the Survival Fate of Human Germinal Center B Cells by Jackson, Stephen M, Capra, J. Donald

“…Germinal center (GC) B cell survival fate is governed in part by the outcome of successful/failed BCR-mediated interactions with accessory cells. However, the…”
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Human fetal, cord blood, and adult lymphocyte progenitors have similar potential for generating B cells with a diverse immunoglobulin repertoire by Kolar, Grant R., Yokota, Takafumi, Rossi, Maria Isabel D., Nath, Swapan K., Capra, J. Donald

“…Several characteristics of the immunoglobulin (Ig) repertoire in fetuses and adults set them apart from each other. Functionally, this translates into…”
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Transient Association of Ku with Nuclear Substrates Characterized Using Fluorescence Photobleaching by Rodgers, William, Jordan, Stephen J, Capra, J. Donald

“…The autoantigen Ku, composed of subunits Ku70 and Ku86, is necessary for repair of DNA double-strand breaks by nonhomologous end joining. Similarly, Ku…”
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