Search Results - "DONAHUE, D."

Concepts of nanoparticle cellular uptake, intracellular trafficking, and kinetics in nanomedicine by Donahue, Nathan D., Acar, Handan, Wilhelm, Stefan

“…Nanoparticle-based therapeutics and diagnostics are commonly referred to as nanomedicine and may significantly impact the future of healthcare. However, the…”
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Closed-loop insulin delivery in suboptimally controlled type 1 diabetes: a multicentre, 12-week randomised trial by Tauschmann, Martin, Thabit, Hood, Bally, Lia, Allen, Janet M, Hartnell, Sara, Wilinska, Malgorzata E, Ruan, Yue, Sibayan, Judy, Kollman, Craig, Cheng, Peiyao, Beck, Roy W, Acerini, Carlo L, Evans, Mark L, Dunger, David B, Elleri, Daniela, Campbell, Fiona, Bergenstal, Richard M, Criego, Amy, Shah, Viral N, Leelarathna, Lalantha, Hovorka, Roman, Alvarado, B, Ashanti, C, Baggott, J, Balakrishnan, K, Barber, N, Bath, L, Beasley, S, Beatson, C, Borgman, S, Bradshaw, S, Bugielski, B, Carlson, AB, Collett, E, Curtis, J, Demmitt, J, Donahue, D, Exall, J, Forshaw, R, Hayes, J, Heath, S, Hellmann, A, Huegel, V, Hyatt, J, James, L, Joseph, H, Joshee, P, Konerza, W, Lum, J, Madden, M, Martens, T, McCarthy, C, McDonald, M, Mikityuk, V, Miles, H, Miller, D, Mubita, W, Murphy, C, Olson, B, Pad, R, Patibandla, N, Riding, K, Shaju, A, Thomas, LA, Thomson, J, White, D, Yau, S, Yong, J

“…The achievement of glycaemic control remains challenging for patients with type 1 diabetes. We assessed the effectiveness of day-and-night hybrid closed-loop…”
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Implementing multiplexed genotyping of non-small-cell lung cancers into routine clinical practice by Sequist, L.V., Heist, R.S., Shaw, A.T., Fidias, P., Rosovsky, R., Temel, J.S., Lennes, I.T., Digumarthy, S., Waltman, B.A., Bast, E., Tammireddy, S., Morrissey, L., Muzikansky, A., Goldberg, S.B., Gainor, J., Channick, C.L., Wain, J.C., Gaissert, H., Donahue, D.M., Muniappan, A., Wright, C., Willers, H., Mathisen, D.J., Choi, N.C., Baselga, J., Lynch, T.J., Ellisen, L.W., Mino-Kenudson, M., Lanuti, M., Borger, D.R., Iafrate, A.J., Engelman, J.A., Dias-Santagata, D.

“…Personalizing non-small-cell lung cancer (NSCLC) therapy toward oncogene addicted pathway inhibition is effective. Hence, the ability to determine a more…”
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Micro‐CT scouting for transmission electron microscopy of human tissue specimens by MORALES, A.G., STEMPINSKI, E.S., XIAO, X., PATEL, A., PANNA, A., OLIVIER, K.N., MCSHANE, P.J., ROBINSON, C., GEORGE, A.J., DONAHUE, D.R., CHEN, P., WEN, H.

“…Summary Transmission electron microscopy (TEM) provides sub‐nanometre‐scale details in volumetric samples. Samples such as pathology tissue specimens are often…”
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Exploring Maleimide-Based Nanoparticle Surface Engineering to Control Cellular Interactions by Lee, Joanne C, Donahue, Nathan D, Mao, Angelina S, Karim, Amber, Komarneni, Mallikharjuna, Thomas, Emily E, Francek, Emmy R, Yang, Wen, Wilhelm, Stefan

“…Nanoparticle cellular interactions are governed by nanoparticle surface chemistry and the surface display of functional (bio)­molecules. To conjugate and…”
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Global Health - The Lessons of Ebola: Two Universities Join to Teach an International Audience Via an Inter-professional Massive Open Online Course (MOOC) by Olsen, J., Marconi, K., Donahue, D.

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Modeling the Gas Nitriding Process of Low Alloy Steels by Yang, M., Zimmerman, C., Donahue, D., Sisson, R. D.

“…The effort to simulate the nitriding process has been ongoing for the last 20 years. Most of the work has been done to simulate the nitriding process of pure…”
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Implementation outcomes of military provider training in cognitive processing therapy and prolonged exposure therapy for post-traumatic stress disorder by Borah, Elisa V, Wright, Edward C, Donahue, D Allen, Cedillos, Elizabeth M, Riggs, David S, Isler, William C, Peterson, Alan L

“…Between 2006 and 2012, the Department of Defense trained thousands of military mental health providers in the use of evidence-based treatments for…”
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Development and climate change adaptation funding: coordination and integration by Smith, Joel B., Dickinson, Thea, Donahue, Joseph D.B., Burton, Ian, Haites, Erik, Klein, Richard J.T., Patwardhan, Anand

“…Within a few decades, tens of billions, and possibly over a hundred billion, dollars will be needed for climate change adaptation in developing countries. In…”
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The vitronectin‐binding domain of plasminogen activator inhibitor‐1 plays an important functional role in lipopolysaccharide‐induced lethality in mice by NARASAKI, R., XU, Z., LIANG, Z., FUNG, L. C. W., DONAHUE, D., CASTELLINO, F. J., PLOPLIS, V. A.

“…Narasaki R, Xu Z, Liang Z, Fung LCW, Donahue D, Castellino FJ, Ploplis VA. The vitronectin‐binding domain of plasminogen activator inhibitor‐1 plays an…”
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Synthesis, Characterization, and Acute Cytotoxicity Evaluation of Chloroquine Encapsulating Liposomes by Donahue, Nathan D., Vance, Ellen A., Sheth, Vinit, Francek, Emmy R., Wilhelm, Stefan

“…Liposomes encapsulating chloroquine were synthesized and characterized. Cryogenic transmission electron microscopy and dynamic light scattering confirmed a…”
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Severe deficiency of coagulation Factor VII results in spontaneous cardiac fibrosis in mice by Xu, H, Noria, F, Sandoval-Cooper, MJ, Menchen, H, Donahue, DL, Ploplis, VA, Castellino, FJ

“…Mice genetically modified to produce low levels (~1% of wild-type) of coagulation FVII presented with echocardiographic evidence of heart abnormalities…”
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Quantifying Chemical Composition and Reaction Kinetics of Individual Colloidally Dispersed Nanoparticles by Donahue, Nathan D, Kanapilly, Sandy, Stephan, Chady, Marlin, M. Caleb, Francek, Emmy R, Haddad, Majood, Guthridge, Joel, Wilhelm, Stefan

“…To control a nanoparticle’s chemical composition and thus function, researchers require readily accessible and economical characterization methods that provide…”
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Negligible penetration of incidental amounts of alpha-hydroxy acid from rinse-off personal care products in human skin using an in vitro static diffusion cell model by Okuda, M., Donahue, D.A., Kaufman, L.E., Avalos, J., Simion, F.A., Story, D.C., Sakaguchi, H., Fautz, R., Fuchs, A.

“…► 10% glycolic acid lotions reportedly increase skin damage after UV light exposure. ► Penetration of AHAs into human skin is pH-, concentration-, and…”
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Absolute Quantification of Nanoparticle Interactions with Individual Human B Cells by Single Cell Mass Spectrometry by Donahue, Nathan D., Sheth, Vinit, Frickenstein, Alex N., Holden, Alyssa, Kanapilly, Sandy, Stephan, Chady, Wilhelm, Stefan

“…We report on the absolute quantification of nanoparticle interactions with individual human B cells using quadrupole-based inductively coupled plasma mass…”
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Cell-to-cell transmission of HIV-1 between CD4+T-cells involves clathrin-mediated endocytosis by Sloan, Richard D, Kuhl, Björn D, Münch, Jan, Donahue, D Aaron, Wainberg, Mark A

“…[...] inhibition of clathrin-mediated endocytosis and dynamin-mediated endosome scission both prevented transfer and transmission of virus, whilst inhibition…”
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Survey of ocular irritation predictive capacity using Chorioallantoic Membrane Vascular Assay (CAMVA) and Bovine Corneal Opacity and Permeability (BCOP) test historical data for 319 personal care products over fourteen years by Donahue, D.A., Kaufman, L.E., Avalos, J., Simion, F.A., Cerven, D.R.

“…The Chorioallantoic Membrane Vascular Assay (CAMVA) and Bovine Corneal Opacity and Permeability (BCOP) test are widely used to predict ocular irritation…”
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Nanoparticle Surface Engineering with Heparosan Polysaccharide Reduces Serum Protein Adsorption and Enhances Cellular Uptake by Yang, Wen, Wang, Lin, Fang, Mulin, Sheth, Vinit, Zhang, Yushan, Holden, Alyssa M, Donahue, Nathan D, Green, Dixy E, Frickenstein, Alex N, Mettenbrink, Evan M, Schwemley, Tyler A, Francek, Emmy R, Haddad, Majood, Hossen, Md Nazir, Mukherjee, Shirsha, Wu, Si, DeAngelis, Paul L, Wilhelm, Stefan

“…Nanoparticle modification with poly­(ethylene glycol) (PEG) is a widely used surface engineering strategy in nanomedicine. However, since the artificial PEG…”
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Confirmation of in vitro and clinical safety assessment of behentrimonium chloride-containing leave-on body lotions using post-marketing adverse event data by Cameron, D.M., Donahue, D.A., Costin, G.-E., Kaufman, L.E., Avalos, J., Downey, M.E., Billhimer, W.L., Gilpin, S., Wilt, N., Simion, F.A.

“…•Safety of whole-body leave-on skin care products with 1–5% BTC assessed.•In vitro EpiDerm® skin irritation and BCOP/CAMVA tests predicted non-irritancy.•No…”
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Assessing nanoparticle colloidal stability with single-particle inductively coupled plasma mass spectrometry (SP-ICP-MS) by Donahue, Nathan D., Francek, Emmy R., Kiyotake, Emi, Thomas, Emily E., Yang, Wen, Wang, Lin, Detamore, Michael S., Wilhelm, Stefan

“…Biological interactions, toxicity, and environmental fate of engineered nanoparticles are affected by colloidal stability and aggregation. To assess…”
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