Search Results - "DOMAGALA, M"

What Do We Know So Far About Ventricular Arrhythmias and Sudden Cardiac Death Prediction in the Mitral Valve Prolapse Population? Could Biomarkers Help Us Predict Their Occurrence? by Dziadosz, D., Daniłowicz-Szymanowicz, L., Wejner-Mik, P., Budnik, M., Brzezińska, B., Duchnowski, P., Golińska-Grzybała, K., Jaworski, K., Jedliński, I., Kamela, M., Kasprzak, J., Kowalczyk-Domagała, M., Kurnicka, K., Kustrzycka-Kratochwil, D., Mickiewicz, K., Możeńska, O., Oko-Sarnowska, Z., Plewka, M., Polewczyk, A., Uziębło-Życzkowska, B., Wierzbowska-Drabik, K., Wachnicka-Truty, R., Wołoszyn-Horák, E., Szymański, P., Gackowski, A., Mizia-Stec, K.

“…Purpose of the Review To summarize currently available data on the topic of mitral valve prolapse (MVP) and its correlation to the occurrence of atrial and…”
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Structure-activity and structure-side-effect relationships for the quinolone antibacterials by Domagala, J M

“…The fluoroquinolones represent a major class of antibacterials with great therapeutic potential. Over the years, several structure-activity and side-effect…”
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Synthesis and structural–activity relationships of 3-hydroxyquinazoline-2,4-dione antibacterial agents by Tran, Tuan P., Ellsworth, Edmund L., Stier, Michael A., Domagala, John M., Hollis Showalter, H.D., Gracheck, Stephen J., Shapiro, Martin A., Joannides, Themis E., Singh, Rajeshwar

“…The synthesis and SAR of the 3-hydroxyquinazoline diones, a novel class of bacterial topoisomerase inhibitors, is reported. A series of…”
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Widespread hyperexcitability of nociceptor somata outlasts enhanced avoidance behavior after incision injury by Bavencoffe, Alexis, Lopez, Elia R, Johnson, Kayla N, Tian, Jinbin, Gorgun, Falih M, Shen, Breanna Q, Domagala, Drue M, Zhu, Michael X, Dessauer, Carmen W, Walters, Edgar T

“…Nociceptors with somata in dorsal root ganglia (DRGs) readily switch from an electrically silent state to a hyperactive state of tonic, nonaccommodating,…”
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A maxillary laser-welded component removable partial denture: A clinical report by Domagala, Daniel M., DDS, Waliszewski, Michael P., DDS, MsD

“…Component removable partial dentures (RPDs) are fabricated in pieces and assembled on the definitive cast. The treatment modality described is believed by the…”
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Respect for illiterate or unconscious patient's autonomy as a requirement for the legality of medical procedures in the polish healthcare system: a case report and review of the literature by Kocańda, K, Głuszek, S, Szerla, M K, Domagała, M

“…According to the Polish law, each patient has the right to refuse to consent to a medical procedure, even if the refusal concerns a life-saving procedure. It…”
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NPP-669, a Novel Broad-Spectrum Antiviral Therapeutic with Excellent Cellular Uptake, Antiviral Potency, Oral Bioavailability, Preclinical Efficacy, and a Promising Safety Margin by Lipka, Elke, Chadderdon, Aaron M., Harteg, Cheryl C., Doherty, Matthew K., Simon, Eric S., Domagala, John M., Reyna, Dawn M., Hutchings, Kim M., Gan, Xinmin, White, Andrew D., Hartline, Caroll B., Harden, Emma A., Keith, Kathy A., Prichard, Mark N., James, Scott H., Cardin, Rhonda D., Bernstein, David I., Spencer, Jacqueline F., Tollefson, Ann E., Wold, William S. M., Toth, Karoly

“…DNA viruses are responsible for many diseases in humans. Current treatments are often limited by toxicity, as in the case of cidofovir (CDV, Vistide), a…”
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Structure−Activity Relationships of the Quinolone Antibacterials against Mycobacteria:  Effect of Structural Changes at N-1 and C-7 by Renau, Thomas E, Sanchez, Joseph P, Gage, Jeffrey W, Dever, Julie A, Shapiro, Martin A, Gracheck, Stephen J, Domagala, John M

“…The re-emergence of tuberculosis infections which are resistant to conventional drug therapy has demonstrated the need for alternative chemotherapy against…”
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5,6-Dihydropyran-2-ones Possessing Various Sulfonyl Functionalities:  Potent Nonpeptidic Inhibitors of HIV Protease by Boyer, Frederick E, Vara Prasad, J. V. N, Domagala, John M, Ellsworth, Edmund L, Gajda, Christopher, Hagen, Susan E, Markoski, Larry J, Tait, Bradley D, Lunney, Elizabeth A, Palovsky, Alexander, Ferguson, Donna, Graham, Neil, Holler, Tod, Hupe, Donald, Nouhan, Carolyn, Tummino, Peter J, Urumov, A, Zeikus, Eric, Zeikus, Greg, Gracheck, Stephen J, Sanders, James M, VanderRoest, Steven, Brodfuehrer, Joanne, Iyer, Krishna, Sinz, Michael, Gulnik, Sergei V, Erickson, John W

“…On the basis of previous SAR findings and molecular modeling studies, a series of compounds were synthesized which possessed various sulfonyl moieties…”
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Fluoroquinolones: relationships between structural variations, mammalian cell cytotoxicity and antimicrobial activity by Suto, Mark J, Domagala, John M, Roland, Gregory E, Mailloux, Gail B, Cohen, Michael A

“…Fluoroquinolones are potent inhibitors of bacterial topoisomerase II (DNA gyrase). They can also inhibit eukaryotic topoisomerases, which could possibly lead…”
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A Novel Nonpeptide HIV-1 Protease Inhibitor: Elucidation of the Binding Mode and Its Application in the Design of Related Analogs by Lunney, Elizabeth A, Hagen, Susan E, Domagala, John M, Humblet, Christine, Kosinski, Janet, Tait, Bradley D, Warmus, Joseph S, Wilson, Michael, Ferguson, Donna

“…HIV-1 protease has been identified as a significant target enzyme in AIDS research. While numerous peptide-derived inhibitors have been described, the…”
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The Synthesis, Structure-Activity, and Structure-Side Effect Relationships of a Series of 8-Alkoxy- and 5-Amino-8-alkoxyquinolone Antibacterial Agents by Sanchez, Joseph P, Gogliotti, Rocco D, Domagala, John M, Gracheck, Stephen J, Huband, Michael D, Sesnie, Josephine A, Cohen, Michael A, Shapiro, Martin A

“…A series of 1-cyclopropyl-6-fluoro-8-alkoxy (8-methyoxy and 8-ethoxy)-quionoline-3-carboxylic acids and…”
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Structure-activity relationships of quinolone agents against mycobacteria: effect of structural modifications at the 8 position by RENAU, T. E, GAGE, J. W, REYNOLDS, R. C, DEVER, J. A, ROLAND, G. E, JOANNIDES, E. T, SHAPIRO, M. A, SANCHEZ, J. P, GRACHECK, S. J, DOMAGALA, J. M, JACOBS, M. R

“…Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon…”
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Synthesis of 5,6-Dihydro-4-hydroxy-2- pyrones as HIV-1 Protease Inhibitors:  The Profound Effect of Polarity on Antiviral Activity by Hagen, Susan E, Vara Prasad, J. V. N, Boyer, Frederick E, Domagala, John M, Ellsworth, Edmund L, Gajda, Christopher, Hamilton, Harriet W, Markoski, Larry J, Steinbaugh, Bruce A, Tait, Bradley D, Lunney, Elizabeth A, Tummino, Peter J, Ferguson, Donna, Hupe, Donald, Nouhan, Carolyn, Gracheck, Stephen J, Saunders, James M, VanderRoest, Steven

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Effect of Lipophilicity at N-1 on Activity of Fluoroquinolones against Mycobacteria by Renau, Thomas E, Sanchez, Joseph P, Shapiro, Martin A, Dever, Julie A, Gracheck, Stephen J, Domagala, John M

“…The dramatic increase in drug resistant Mycobacterium tuberculosis has caused a resurgence in research targeted toward these organisms. As part of a systematic…”
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New structure-activity relationships of the quinolone antibacterials using the target enzyme. The development and application of a DNA gyrase assay by Domagala, John M, Hanna, Lori Doyle, Heifetz, Carl L, Hutt, Marland P, Mich, Thomas F, Sanchez, Joseph P, Solomon, Marjorie

“…A series of 60 newly synthesized and known quinolone antibacterials, including quinoline- and 1,8-naphthyridine-3-carboxylic acids,…”
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Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids by Sanchez, Joseph P, Domagala, John M, Hagen, Susan E, Heifetz, Carl L, Hutt, Marland P, Nichols, Jeffry B, Trehan, Ashok K

“…A series of 7,8-disubstituted 1-cyclopropyl-6-fluoroquinoline-3-carboxylic acids, 7-substituted 1-cyclopropyl-6-fluoro-1,8-naphthyridine-3-carboxylic acids,…”
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1-Substituted 7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids. New quantitative structure activity relationships at N1 for the quinolone antibacterials by Domagala, John M, Heifetz, Carl L, Hutt, Marland P, Mich, Thomas F, Nichols, Jeffry B, Solomon, Marjorie, Worth, Donald F

“…A series of 18 1-substituted 7-[3-[(ethylamino)methyl]-1- pyrrolidinyl]-6,8-difluoro-1,4-dihydro-4-oxo-3-quinoline- carboxylic acids (N1 analogues of CI-934)…”
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3-Aminoquinazolinediones as a New Class of Antibacterial Agents Demonstrating Excellent Antibacterial Activity Against Wild-Type and Multidrug Resistant Organisms by Ellsworth, Edmund L, Tran, Tuan P, Hollis Showalter, H. D, Sanchez, Joseph P, Watson, Brian M, Stier, Michael A, Domagala, John M, Gracheck, Stephen J, Joannides, E. Themis, Shapiro, Martin A, Dunham, Steve A, Hanna, Debra L, Huband, Michael D, Gage, Jeffrey W, Bronstein, Joel C, Liu, Jia Yeu, Nguyen, Dai Q, Singh, Rajeshwar

“…The 3-aminoquinzolinediones represent a new series of antibacterial agents structurally related to the fluoroquinolones. They are inhibitors of bacterial…”
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Possible drug interactions among quinolones by Domagala, Beata M, Leung, Simon, Regal, Randolph E

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