Search Results - "DOHLSTEN, M."

Characterization of two distinct MHC class II binding sites in the superantigen staphylococcal enterotoxin A by Abrahmsén, L., Dohlsten, M., Segrén, S., Björk, P., Jonsson, E., Kalland, T.

“…Bacterial superantigens (SAgs) are potent activators of T lymphocytes and play a pathophysiological role in Gram‐positive septic shock and food poisoning. To…”
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Crystal structure of the superantigen staphylococcal enterotoxin type A by Schad, E.M., Zaitseva, I., Zaitsev, V.N., Dohlsten, M., Kalland, T., Schlievert, P.M., Ohlendorf, D.H., Svensson, L.A.

“…Staphylococcal enterotoxins are prototype superantigens characterized by their ability to bind to major histocompatibility complex (MHC) class II molecules and…”
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Therapy of human non-small-cell lung carcinoma using antibody targeting of a modified superantigen by FORSBERG, G, OHLSSON, L, BRODIN, T, BJÖRK, P, LANDO, P. A, SHAW, D, STERN, P. L, DOHLSTEN, M

“…Superantigens activate T-cells by linking the T-cell receptor to MHC class II on antigen-presenting cells, and novel reactivity can be introduced by fusing the…”
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The crystal structure of staphylococcal enterotoxin type D reveals Zn2+‐mediated homodimerization by Sundström, M., Abrahmsén, L., Antonsson, P., Mehindate, K., Mourad, W., Dohlsten, M.

“…Bacterial superantigens, including the staphylococcal enterotoxins, are the most potent activators of T cells known and have been suggested as a causative…”
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In vivo Anergized CD4+ T Cells Express Perturbed AP-1 and NF-κ B Transcription Factors by Sundstedt, Anette, Sigvardsson, Mikael, Leanderson, Tomas, Hedlund, Gunnar, Kalland, Terje, Dohlsten, Mikael

“…Anergy is a major mechanism to ensure antigen-specific tolerance in T lymphocytes in the adult. In vivo, anergy has mainly been studied at the cellular level…”
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Monoclonal Antibody-Superantigen Fusion Proteins: Tumor-Specific Agents for T-Cell-Based Tumor Therapy by Dohlsten, Mikael, Abrahmsen, Lars, Bjork, Per, Lando, Peter A., Hedlund, Gunnar, Forsberg, Goran, Brodin, Thomas, Nick R. J. Gascoigne, Forberg, Cecilia, Lind, Peter, Kalland, Terje

“…The bacterial superantigen staphylococcal enterotoxin A (SEA) is an extremely potent activator of T lymphocytes when presented on major histocompatibility…”
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Superantigen-based immunotherapy: a phase I trial of PNU-214565, a monoclonal antibody-staphylococcal enterotoxin A recombinant fusion protein, in advanced pancreatic and colorectal cancer by Giantonio, B J, Alpaugh, R K, Schultz, J, McAleer, C, Newton, D W, Shannon, B, Guedez, Y, Kotb, M, Vitek, L, Persson, R, Gunnarsson, P O, Kalland, T, Dohlsten, M, Persson, B, Weiner, L M

“…To establish the maximum-tolerated dose (MTD) and define the toxicities of a single-dose infusion of PNU-214565, a recombinant Escherichia coli-derived fusion…”
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Antibody-Targeted Superantigens are Potent Inducers of Tumor-Infiltrating T Lymphocytes in vivo by Dohlsten, Mikael, Hansson, Johan, Ohlsson, Lennart, Litton, Mark, Kalland, Terje

“…Recruitment of antigen-specific tumorinfiltrating lymphocytes (TILs) is a major goal for immunotherapy of malignant tumors. We now describe that…”
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Identification of a CD28 Response Element in the CD40 Ligand Promoter by Parra, Eduardo, Mustelin, Tomas, Dohlsten, Mikael, Mercola, Dan

“…Ligation of the T cell coreceptor CD28 or CD2 by its cognate ligands B7-1 or LFA-3, respectively, greatly aids the Ag-induced up-regulation of several genes,…”
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Monoclonal Antibody-Targeted Superantigens: A Different Class of Anti-Tumor Agents by Dohlsten, Mikael, Hedlund, Gunnar, Akerblom, Eva, Lando, Peter A., Kalland, Terje

“…The bacterial superantigen staphylococcal enterotoxin (SE) A (SEA) directs cytotoxic T lymphocytes (CTLs) expressing particular sequences of the T-cell…”
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The distinct role of CD4 and CD8 T-cells during the anti-tumour effects of targeted superantigens by LITTON, M. J, DOHLSTEN, M, ROSENDAHL, A, OHLSSON, L, SØGAARD, M, ANDERSSON, J, ANDERSSON, U

“…To target T-cells to the tumour area we created a recombinant protein of the bacterial superantigen (SAg) Staphylococcal enterotoxin A (SEA) and the…”
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Binding of staphylococcal enterotoxin A to HLA-DR on B cell lines by Fischer, H, Dohlsten, M, Lindvall, M, Sjogren, HO, Carlsson, R

“…Staphylococcal enterotoxin A (SEA) is a potent polyclonal T cell activator. Its activating effect is entirely dependent upon its binding to accessory cells…”
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T cell activation pathways: B7, LFA-3, and ICAM-1 shape unique T cell profiles by Wingren, A G, Parra, E, Varga, M, Kalland, T, Sjögren, H O, Hedlund, G, Dohlsten, M

“…Two signals are required for induction of cell proliferation and cytokine production in resting T cells. Occupancy of the T cell receptor by antigen/MHC…”
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T-cell cytotoxicity assays for studying the functional interaction between the superantigen staphylococcal enterotoxin A and T-cell receptors by Rosendahl, A, Kristensson, K, Riesbeck, K, Dohlsten, M

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ICAM‐1 costimulation induces IL‐2 but inhibits IL‐10 production in superantigen‐activated human CD4+ T cells by Labuda, T, Wendt, J, Hedlund, G, Dohlsten, M

“…We have previously reported that costimulatory pathways including B7–CD28 and lymphocyte function‐associated antigen‐3 (LFA‐3)–CD2 shape distinct activation…”
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Costimulation by B7-1 and LFA-3 targets distinct nuclear factors that bind to the interleukin-2 promoter: B7-1 negatively regulates LFA-3-induced NF-AT DNA binding by Parra, Eduardo, Varga, Mikael, Hedlund, Gunnar, Kalland, Terje, Dohlsten, Mikael

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Production of TNF-alpha and TNF-beta by staphylococcal enterotoxin A activated human T cells by Fischer, H, Dohlsten, M, Andersson, U, Hedlund, G, Ericsson, P, Hansson, J, Sjogren, HO

“…Staphylococcal enterotoxin at concentrations of less than 1 pg/ml induces significant TNF activity in human peripheral blood T cells and monocytes. Maximal TNF…”
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T cell‐ and perforin‐dependent depletion of B cells in vivo by staphylococcal enterotoxin A by Sundstedt, A, Grundström, S, Dohlsten, M

“…Bacterial superantigens bind to major histocompatibility complex (MHC) class II and subsequently activate both CD4+ and CD8+ T lymphocytes expressing certain…”
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Superantigen-based tumor therapy : in vivo activation of cytotoxic T cells by HEDLUND, G, DOHLSTEN, M, PETERSSON, C, KALLAND, T

“…We have recently demonstrated that the superantigen staphylococcal enterotoxin A (SEA) targets in vitro activated cytotoxic T lymphocytes against tumor cells…”
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Tumor‐growth inhibition with bispecific antibody fragments in a syngeneic mouse melanoma model: The role of targeted T‐cell co‐stimulation via CD28 by Grosse‐Hovest, Ludger, Brandl, Martina, Dohlsten, Mikael, Kalland, Terje, Wilmanns, Wolfgang, Jung, Gundram

“…The ability of bispecific antibodies with anti‐tumor × anti‐CD3 specificity to mediate the killing of tumor cells by activated T cells has been demonstrated in…”
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