Search Results - "DOHERTY, K"

Autophagic lysosome reformation dysfunction in glucocerebrosidase deficient cells: relevance to Parkinson disease by Magalhaes, Joana, Gegg, Matthew E, Migdalska-Richards, Anna, Doherty, Mary K, Whitfield, Phillip D, Schapira, Anthony H V

“…Glucocerebrosidase (GBA1) gene mutations increase the risk of Parkinson disease (PD). While the cellular mechanisms associating GBA1 mutations and PD are…”
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How does Oyster work? The simple interpretation of Oyster mathematics by Renzi, E., Doherty, K., Henry, A., Dias, F.

“…Oyster®  is a surface-piercing flap-type device designed to harvest wave energy in the nearshore environment. Established mathematical theories of wave energy…”
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Mitochondrial DNA Is a Pro-Inflammatory Damage-Associated Molecular Pattern Released During Active IBD by Boyapati, Ray K, Dorward, David A, Tamborska, Arina, Kalla, Rahul, Ventham, Nicholas T, Doherty, Mary K, Whitfield, Philip D, Gray, Mohini, Loane, Joseph, Rossi, Adriano G, Satsangi, Jack, Ho, Gwo-tzer

“…Abstract Background Due to common evolutionary origins, mitochondrial DNA (mtDNA) shares many similarities with immunogenic bacterial DNA. MtDNA is recognized…”
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Fecal Microbiota Signatures Are Associated with Response to Ustekinumab Therapy among Crohn's Disease Patients by Doherty, Matthew K, Ding, Tao, Koumpouras, Charlie, Telesco, Shannon E, Monast, Calixte, Das, Anuk, Brodmerkel, Carrie, Schloss, Patrick D

“…The fecal microbiota is a rich source of biomarkers that have previously been shown to be predictive of numerous disease states. Less well studied is the…”
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High strain-rate compressive deformation behavior of the Al0.1CrFeCoNi high entropy alloy by Kumar, N., Ying, Q., Nie, X., Mishra, R.S., Tang, Z., Liaw, P.K., Brennan, R.E., Doherty, K.J., Cho, K.C.

“…High entropy alloy is a new class of structural metallic materials. No work, so far, has been carried-out to understand high strain-rate plastic deformation…”
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A framework for shear driven dissolution of thermally stable particles during friction stir welding and processing by Palanivel, S., Arora, A., Doherty, K.J., Mishra, R.S.

“…A framework is proposed to explain the dissolution and fragmentation of particles during friction stir welding and processing. Two major mechanisms dissolve…”
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Microstructural comparison of friction-stir-welded aluminum alloy 7449 starting from different tempers by Martinez, N., Kumar, N., Mishra, R. S., Doherty, K. J.

“…Since friction stir welding (FSW) does not create defects that are normally associated with fusion welds, it has become the preferred method for joining…”
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Direct recycling of machine chips through a novel solid-state additive manufacturing process by Jordon, J.B., Allison, P.G., Phillips, B.J., Avery, D.Z., Kinser, R.P., Brewer, L.N., Cox, Chase, Doherty, K.

“…Recycling of metal waste for feedstock material in additive manufacturing (AM) is typically carried out through energy extensive melting and solidification…”
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Multiplexed absolute quantification in proteomics using artificial QCAT proteins of concatenated signature peptides by Beynon, Robert J, Doherty, Mary K, Pratt, Julie M, Gaskell, Simon J

“…Absolute quantification in proteomics usually involves simultaneous determination of representative proteolytic peptides and stable isotope-labeled analogs…”
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Are tomorrow’s doctors prepared to prevent dementia? A cross-sectional study of Tasmanian medical students’ knowledge of dementia risk factors by Morgan, J., Bindoff, A., Doherty, K., Vickers, J., Alty, J.

“…•Prevention is the key strategy to reduce rising dementia incidence globally.•40% dementia cases are attributable to modifiable risk factors and doctors have…”
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Fenretinide inhibits obesity and fatty liver disease but induces Smpd3 to increase serum ceramides and worsen atherosclerosis in LDLR−/− mice by Thompson, Dawn, Mahmood, Shehroz, Morrice, Nicola, Kamli-Salino, Sarah, Dekeryte, Ruta, Hoffmann, Philip A., Doherty, Mary K., Whitfield, Philip D., Delibegović, Mirela, Mody, Nimesh

“…Fenretinide is a synthetic retinoid that can prevent obesity and improve insulin sensitivity in mice by directly altering retinol/retinoic acid homeostasis and…”
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Neuronal human BACE1 knockin induces systemic diabetes in mice by Plucińska, Kaja, Dekeryte, Ruta, Koss, David, Shearer, Kirsty, Mody, Nimesh, Whitfield, Phillip D., Doherty, Mary K., Mingarelli, Marco, Welch, Andy, Riedel, Gernot, Delibegovic, Mirela, Platt, Bettina

“…Aims β-Secretase 1 (BACE1) is a key enzyme in Alzheimer’s disease pathogenesis that catalyses the amyloidogenic cleavage of amyloid precursor protein (APP)…”
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Turnover of the Human Proteome: Determination of Protein Intracellular Stability by Dynamic SILAC by Doherty, Mary K, Hammond, Dean E, Clague, Michael J, Gaskell, Simon J, Beynon, Robert J

“…The proteome of any system is a dynamic entity, such that the intracellular concentration of a protein is dictated by the relative rates of synthesis and…”
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Lipidomics analysis of juveniles' blue mussels (Mytilus edulis L. 1758), a key economic and ecological species by Laudicella, Vincenzo Alessandro, Beveridge, Christine, Carboni, Stefano, Franco, Sofia C, Doherty, Mary K, Long, Nina, Mitchell, Elaine, Stanley, Michele S, Whitfield, Phillip D, Hughes, Adam D

“…Blue mussels (Mytilus edulis L. 1758) are important components of coastal ecosystems and in the economy of rural and coastal areas. The understanding of their…”
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Analysis of the brain palmitoyl-proteome using both acyl-biotin exchange and acyl-resin-assisted capture methods by Edmonds, Matthew J., Geary, Bethany, Doherty, Mary K., Morgan, Alan

“…Palmitoylation is a reversible post-translational protein modification in which palmitic acid is added to cysteine residues, allowing association with…”
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Altered ceramide metabolism is a feature in the extracellular vesicle-mediated spread of alpha-synuclein in Lewy body disorders by Kurzawa-Akanbi, Marzena, Tammireddy, Seshu, Fabrik, Ivo, Gliaudelytė, Lina, Doherty, Mary K., Heap, Rachel, Matečko-Burmann, Irena, Burmann, Björn M., Trost, Matthias, Lucocq, John M., Gherman, Anda V., Fairfoul, Graham, Singh, Preeti, Burté, Florence, Green, Alison, McKeith, Ian G., Härtlova, Anetta, Whitfield, Phillip D., Morris, Christopher M.

“…Mutations in glucocerebrosidase ( GBA ) are the most prevalent genetic risk factor for Lewy body disorders (LBD)—collectively Parkinson’s disease, Parkinson’s…”
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Microstructure Prediction from Smooth Particle Hydrodynamics Process Simulations of Additive Friction Stir Deposition by Palya, N. I., Fraser, K., Zhu, N., Hoarston, J. B., Doherty, K., Allison, P. G., Jordon, J. B.

“…Additive friction stir deposition (AFSD) is a solid-state additive manufacturing method that exploits frictional heat generation and severe plastic deformation…”
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Endoplasmic reticulum stress as a key mechanism in stunted growth of seawater rainbow trout (Oncorhynchus mykiss) by Morro, Bernat, Broughton, Richard, Balseiro, Pablo, Handeland, Sigurd O, Mackenzie, Simon, Doherty, Mary K, Whitfield, Phillip D, Shimizu, Munetaka, Gorissen, Marnix, Sveier, Harald, Albalat, Amaya

“…Abstract Background Rainbow trout ( Oncorhynchus mykiss ) is a salmonid species with a complex life-history. Wild populations are naturally divided into…”
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Plasma proteome profiling of freshwater and seawater life stages of rainbow trout (Oncorhynchus mykiss) by Morro, Bernat, Doherty, Mary K, Balseiro, Pablo, Handeland, Sigurd O, MacKenzie, Simon, Sveier, Harald, Albalat, Amaya

“…The sea-run phenotype of rainbow trout (Oncorhynchus mykiss), like other anadromous salmonids, present a juvenile stage fully adapted to life in freshwater…”
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Emotional awareness and expression training improves irritable bowel syndrome: A randomized controlled trial by Thakur, E. R., Holmes, H. J., Lockhart, N. A., Carty, J. N., Ziadni, M. S., Doherty, H. K., Lackner, J. M., Schubiner, H., Lumley, M. A.

“…Background Current clinical guidelines identify several psychological treatments for irritable bowel syndrome (IBS). IBS patients, however, have elevated…”
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