Search Results - "DOERGE, D. R"

Effects of acrylamide exposure on serum hormones, gene expression, cell proliferation, and histopathology in male reproductive tissues of Fischer 344 rats by Camacho, L., Latendresse, J.R., Muskhelishvili, L., Patton, R., Bowyer, J.F., Thomas, M., Doerge, D.R.

“…► At doses above 10mg/kg, acrylamide treatment of male F344 rats reduced serum testosterone levels. ► At doses above 10mg/kg, acrylamide treatment activated…”
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Evaluation of serum and liver toxicokinetics for furan and liver DNA adduct formation in male Fischer 344 rats by Churchwell, M.I., Scheri, R.C., Von Tungeln, L.S., Gamboa da Costa, G., Beland, F.A., Doerge, D.R.

“…Furan is a food processing contaminant found in many common cooked foods that induces liver toxicity and liver cancer in animal models treated with sufficient…”
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The effects of subchronic acrylamide exposure on gene expression, neurochemistry, hormones, and histopathology in the hypothalamus–pituitary–thyroid axis of male Fischer 344 rats by Bowyer, J.F., Latendresse, J.R., Delongchamp, R.R., Muskhelishvili, L., Warbritton, A.R., Thomas, M., Tareke, E., McDaniel, L.P., Doerge, D.R.

“…Acrylamide (AA) is an important industrial chemical that is neurotoxic in rodents and humans and carcinogenic in rodents. The observation of cancer in…”
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Physiological concentrations of dietary genistein dose-dependently stimulate growth of estrogen-dependent human breast cancer (MCF-7) tumors implanted in athymic nude mice by Ju, Y H, Allred, C D, Allred, K F, Karko, K L, Doerge, D R, Helferich, W G

“…Previously our laboratory has shown that the soy isoflavone, genistein, stimulates growth of human breast cancer (MCF-7) cells in vivo and in vitro. In this…”
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Mass spectrometric determination of Genistein tissue distribution in diet-exposed Sprague-Dawley rats by Chang, H C, Churchwell, M I, Delclos, K B, Newbold, R R, Doerge, D R

“…Genistein, the principal soy isoflavone, was administered in the diet to male and female Sprague-Dawley rats as part of a multigeneration study of potential…”
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Analysis of Soy Isoflavone Conjugation In Vitro and in Human Blood Using Liquid Chromatography-Mass Spectrometry by DOERGE, D. R, CHANG, H. C, CHURCHWELL, M. I, HOLDER, C. L

“…Soybean products containing isoflavones are widely consumed in Western and Asian diets for putative health benefits, but adverse effects are also possible. The…”
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Anti-Thyroid Isoflavones from Soybean: Isolation, Characterization, and Mechanisms of Action by Divi, Rao L., Chang, Hebron C., Doerge, Daniel R.

“…The soybean has been implicated in diet-induced goiter by many studies. The extensive consumption of soy products in infant formulas and in vegetarian diets…”
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Dietary Genistein Inactivates Rat Thyroid Peroxidase in Vivo without an Apparent Hypothyroid Effect by Chang, Hebron C., Doerge, Daniel R.

“…Biological effects of genistein are currently under investigation by the National Toxicology Program because of widespread and increasing soy consumption by…”
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The effects of chronic methylphenidate administration on operant test battery performance in juvenile rhesus monkeys by Rodriguez, J.S, Morris, S.M, Hotchkiss, C.E, Doerge, D.R, Allen, R.R, Mattison, D.R, Paule, M.G

“…Abstract Methylphenidate (MPH) is an amphetamine derivative widely prescribed for the treatment of attention deficit–hyperactivity disorder. Recent concern…”
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A two-year toxicology study of bisphenol A (BPA) in Sprague-Dawley rats: CLARITY-BPA core study results by Camacho, L., Lewis, S.M., Vanlandingham, M.M., Olson, G.R., Davis, K.J., Patton, R.E., Twaddle, N.C., Doerge, D.R., Churchwell, M.I., Bryant, M.S., McLellen, F.M., Woodling, K.A., Felton, R.P., Maisha, M.P., Juliar, B.E., Gamboa da Costa, G., Delclos, K.B.

“…We report the data from the guideline-compliant two-year toxicology study conducted as part of the Consortium Linking Academic and Regulatory Insights on…”
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Quantification of Soy Isoflavones, Genistein and Daidzein, and Conjugates in Rat Blood Using LC/ES-MS by Holder, C. Lee, Churchwell, Mona I, Doerge, Daniel R

“…Genistein is the principal soy isoflavone to which the putative beneficial effects of soy consumption have been attributed; however, the possibility of adverse…”
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Ketamine-Induced Neuronal Cell Death in the Perinatal Rhesus Monkey by Slikker, William, Zou, Xiaoju, Hotchkiss, Charlotte E., Divine, Rebecca L., Sadovova, Natalya, Twaddle, Nathan C., Doerge, Daniel R., Scallet, Andrew C., Patterson, Tucker A., Hanig, Joseph P., Paule, Merle G., Wang, Cheng

“…Ketamine is widely used as a pediatric anesthetic. Studies in developing rodents have indicated that ketamine-induced anesthesia results in brain cell death…”
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Dietary genistein negates the inhibitory effect of letrozole on the growth of aromatase-expressing estrogen-dependent human breast cancer cells (MCF-7Ca) in vivo by Ju, Young H., Doerge, Daniel R., Woodling, Kellie A., Hartman, James A., Kwak, Jieun, Helferich, William G.

“…Genistein (GEN), a soy isoflavone, stimulates growth of estrogen-dependent human tumor cells (MCF-7) in a preclinical mouse model for postmenopausal breast…”
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A Simple Colorimetric Assay for Phenotyping the Major Human Thermostable Phenol Sulfotransferase (SULT1A1) Using Platelet Cytosols by FRAME, L. T, OZAWA, S, NOWELL, S. A, CHOU, H.-C, DELONGCHAMP, R. R, DOERGE, D. R, LANG, N. P, KADLUBAR, F. F

“…A thermostable phenol sulfotransferase, SULT1A1, has been implicated in numerous detoxification and bioactivation pathways; however, little is known regarding…”
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Effect of dietary genistein on cell replication indices in C57BL6 mice by Morris, S.M, Akerman, G.S, Warbritton, A.R, Patton, R.E, Doerge, D.R, Ding, Xuhong, Chen, J.J

“…The phytoestrogen and isoflavone, genistein, inhibited the activity of the DNA synthesis-related enzyme, topoisomerase-II (topo-II), altered cell-cycle…”
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Degradation of biphenyl by Mycobacterium sp. strain PYR-1 by Moody, J.D, Doerge, D.R, Freeman, J.P, Cerniglia, C.E

“…The metabolism of biphenyl by Mycobacterium sp. PYR-1 was investigated. The Mycobacterium sp. degraded >98% of the biphenyl added within 72 h. Analysis of…”
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Quantitative analysis of 4-aminobiphenyl-C8-deoxyguanosyl DNA adducts produced in vitro and in vivo using HPLC–ES-MS by Doerge, Daniel R., Churchwell, Mona I., Marques, M. Matilde, Beland, Frederick A.

“…Electrospray mass spectrometry (ES-MS) is a powerful tool for analysis of carcinogen-adducted DNA. In this study, we developed a quantitative isotope dilution…”
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Gender-Based Differences in Rats after Chronic Dietary Exposure to Genistein by Slikker, W., Scallet, A. C., Doerge, D. R., Ferguson, S. A.

“…Gender-based differences can be observed from pharmacokinetic, behavioral, or anatomical assessments. No single assessment tool will provide a complete answer,…”
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Quantitative Analysis of Etheno-2‘-Deoxycytidine DNA Adducts Using On-Line Immunoaffinity Chromatography Coupled With LC/ES-MS/MS Detection by Roberts, Dean W, Churchwell, Mona I, Beland, Frederick A, Fang, Jia-Long, Doerge, Daniel R

“…Etheno DNA adducts, including 3,N 4-etheno-2‘-deoxycytidine (etheno-dC), are promutagenic lesions present in normal animal and human tissues. These DNA adducts…”
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Quantitative analysis of interindividual variation of glutathione S-transferase expression in human pancreas and the ambiguity of correlating genotype with phenotype by COLES, B. F, ANDERSON, K. E, DOERGE, D. R, CHURCHWELL, M. I, LANG, N. P, KADLUBAR, F. F

“…Analysis of glutathione S-transferases (GSTs) of the alpha, mu, and pi classes by reverse-phase high-performance liquid chromatography and…”
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