Search Results - "DOERFFLER, Edward"

Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1‑f][triazin-4-amino] Adenine C‑Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses by Siegel, Dustin, Hui, Hon C, Doerffler, Edward, Clarke, Michael O, Chun, Kwon, Zhang, Lijun, Neville, Sean, Carra, Ernest, Lew, Willard, Ross, Bruce, Wang, Queenie, Wolfe, Lydia, Jordan, Robert, Soloveva, Veronica, Knox, John, Perry, Jason, Perron, Michel, Stray, Kirsten M, Barauskas, Ona, Feng, Joy Y, Xu, Yili, Lee, Gary, Rheingold, Arnold L, Ray, Adrian S, Bannister, Roy, Strickley, Robert, Swaminathan, Swami, Lee, William A, Bavari, Sina, Cihlar, Tomas, Lo, Michael K, Warren, Travis K, Mackman, Richard L

“…The recent Ebola virus (EBOV) outbreak in West Africa was the largest recorded in history with over 28,000 cases, resulting in >11,000 deaths including >500…”
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Early Development and Kilogram Scale-Up of a Non-steroidal FXR Agonist for the Treatment of Non-alcoholic Steatohepatitis (NASH) by Cizio, Greg T, Dao, Kathy, Doerffler, Edward M, Griggs, Nolan D, Ischay, Michael A, Kang, Baldip S, Logan, Matthew M, MacLeod, Patricia D, Weinstein, Adam B, Yu, Lok Him L

“…Non-alcoholic steatohepatitis (NASH) is a serious chronic liver disease characterized by progressive fibrosis that can lead to cirrhosis, liver failure, and…”
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Preclinical Characterization of GS-9669, a Thumb Site II Inhibitor of the Hepatitis C Virus NS5B Polymerase by FENAUX, Martijn, ENG, Stacey, LAZERWITH, Scott E, LEW, Willard, QI LIU, MERTZMAN, Michael, MORGANELLI, Philip, LIANHONG XU, HONG YE, JENNIFER ZHANG, MATLES, Mike, MURRAY, Bernard P, LEAVITT, Stephanie A, MWANGI, Judy, JINGYU ZHANG, HASHASH, Ahmad, KRAWCZYK, Steve H, BIDGOOD, Alison M, APPLEBY, Todd C, WATKINS, William J, LEE, Yu-Jen, MABERY, Eric M, YANG TIAN, BYUN, Daniel, CANALES, Eda, CLARKE, Michael O, DOERFFLER, Edward

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Poly(4-(aminomethyl)styrene)-b-polystyrene:  Synthesis and Unilamellar Vesicle Formation by Gravano, Stefanie M, Borden, Mark, von Werne, Timothy, Doerffler, Edward M, Salazar, Georgina, Chen, Aaron, Kisak, Edward, Zasadzinski, Joseph A, Patten, Timothy E, Longo, Marjorie L

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Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys by Warren, Travis K., Jordan, Robert, Lo, Michael K., Ray, Adrian S., Mackman, Richard L., Soloveva, Veronica, Siegel, Dustin, Perron, Michel, Bannister, Roy, Hui, Hon C., Larson, Nate, Strickley, Robert, Wells, Jay, Stuthman, Kelly S., Van Tongeren, Sean A., Garza, Nicole L., Donnelly, Ginger, Shurtleff, Amy C., Retterer, Cary J., Gharaibeh, Dima, Zamani, Rouzbeh, Kenny, Tara, Eaton, Brett P., Grimes, Elizabeth, Welch, Lisa S., Gomba, Laura, Wilhelmsen, Catherine L., Nichols, Donald K., Nuss, Jonathan E., Nagle, Elyse R., Kugelman, Jeffrey R., Palacios, Gustavo, Doerffler, Edward, Neville, Sean, Carra, Ernest, Clarke, Michael O., Zhang, Lijun, Lew, Willard, Ross, Bruce, Wang, Queenie, Chun, Kwon, Wolfe, Lydia, Babusis, Darius, Park, Yeojin, Stray, Kirsten M., Trancheva, Iva, Feng, Joy Y., Barauskas, Ona, Xu, Yili, Wong, Pamela, Braun, Molly R., Flint, Mike, McMullan, Laura K., Chen, Shan-Shan, Fearns, Rachel, Swaminathan, Swami, Mayers, Douglas L., Spiropoulou, Christina F., Lee, William A., Nichol, Stuart T., Cihlar, Tomas, Bavari, Sina

“…The discovery is reported of a small molecule drug, GS-5734, which has antiviral activity against Ebola virus and other filoviruses, and is capable of…”
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The synthesis of 2-ketopiperazine acetic acid esters and amides from ethylenediamines with maleates and maleimides by Abelman, Matthew M, Fisher, Karl J, Doerffler, Edward M, Edwards, Paul J

“…The reaction of substituted ethylenediamines with various fumarates, maleates, and maleimides to form substituted ketopiperazine acetic acid esters and amides…”
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Benzyl Acetate and Benzyl Ether Groups as Latent Initiator Sites for Atom Transfer Radical Polymerization by Doerffler, Edward M, Patten, Timothy E

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Discovery of the First C‑Nucleoside HCV Polymerase Inhibitor (GS-6620) with Demonstrated Antiviral Response in HCV Infected Patients by Cho, Aesop, Zhang, Lijun, Xu, Jie, Lee, Rick, Butler, Thomas, Metobo, Sammy, Aktoudianakis, Vangelis, Lew, Willard, Ye, Hong, Clarke, Michael, Doerffler, Edward, Byun, Daniel, Wang, Ting, Babusis, Darius, Carey, Anne C., German, Polina, Sauer, Dorothea, Zhong, Weidong, Rossi, Stephen, Fenaux, Martijn, McHutchison, John G., Perry, Jason, Feng, Joy, Ray, Adrian S., Kim, Choung U.

“…Hepatitis C virus (HCV) infection presents an unmet medical need requiring more effective treatment options. Nucleoside inhibitors (NI) of HCV polymerase…”
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Discovery of GS-7682, a Novel 4′-Cyano-Modified C‑Nucleoside Prodrug with Broad Activity against Pneumo- and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys by Siegel, Dustin S., Hui, Hon C., Pitts, Jared, Vermillion, Meghan S., Ishida, Kazuya, Rautiola, Davin, Keeney, Michael, Irshad, Hammad, Zhang, Lijun, Chun, Kwon, Chin, Gregory, Goyal, Bindu, Doerffler, Edward, Yang, Hai, Clarke, Michael O., Palmiotti, Chris, Vijjapurapu, Arya, Riola, Nicholas C., Stray, Kirsten, Murakami, Eisuke, Ma, Bin, Wang, Ting, Zhao, Xiaofeng, Xu, Yili, Lee, Gary, Marchand, Bruno, Seung, Minji, Nayak, Arabinda, Tomkinson, Adrian, Kadrichu, Nani, Ellis, Scott, Barauskas, Ona, Feng, Joy Y., Perry, Jason K., Perron, Michel, Bilello, John P., Kuehl, Philip J., Subramanian, Raju, Cihlar, Tomas, Mackman, Richard L.

“…Acute respiratory viral infections, such as pneumovirus and respiratory picornavirus infections, exacerbate disease in COPD and asthma patients. A research…”
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Discovery of β-d-2′-deoxy-2′-α-fluoro-4′-α-cyano-5-aza-7,9-dideaza adenosine as a potent nucleoside inhibitor of respiratory syncytial virus with excellent selectivity over mitochondrial RNA and DNA polymerases by Clarke, Michael O., Mackman, Richard, Byun, Daniel, Hui, Hon, Barauskas, Ona, Birkus, Gabriel, Chun, Byoung-Kwon, Doerffler, Edward, Feng, Joy, Karki, Kapil, Lee, Gary, Perron, Michel, Siegel, Dustin, Swaminathan, Swami, Lee, William

“…[Display omitted] Novel 4′-substituted β-d-2′-deoxy-2′-α-fluoro (2′d2′F) nucleoside inhibitors of respiratory syncytial virus (RSV) are reported. The…”
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Discovery of GS-9669, a Thumb Site II Non-Nucleoside Inhibitor of NS5B for the Treatment of Genotype 1 Chronic Hepatitis C Infection by Lazerwith, Scott E., Lew, Willard, Zhang, Jennifer, Morganelli, Philip, Liu, Qi, Canales, Eda, Clarke, Michael O., Doerffler, Edward, Byun, Daniel, Mertzman, Michael, Ye, Hong, Chong, Lee, Xu, Lianhong, Appleby, Todd, Chen, Xiaowu, Fenaux, Martijn, Hashash, Ahmad, Leavitt, Stephanie A., Mabery, Eric, Matles, Mike, Mwangi, Judy W., Tian, Yang, Lee, Yu-Jen, Zhang, Jingyu, Zhu, Christine, Murray, Bernard P., Watkins, William J.

“…Investigation of thiophene-2-carboxylic acid HCV NS5B site II inhibitors, guided by measurement of cell culture medium binding, revealed the structure–activity…”
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Discovery of a 2′-fluoro-2′-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties by Kirschberg, Thorsten A., Metobo, Sammy, Clarke, Michael O., Aktoudianakis, Vangelis, Babusis, Darius, Barauskas, Ona, Birkus, Gabriel, Butler, Thomas, Byun, Daniel, Chin, Gregory, Doerffler, Edward, Edwards, Thomas E., Fenaux, Martijn, Lee, Rick, Lew, Willard, Mish, Michael R., Murakami, Eisuke, Park, Yeojin, Squires, Neil H., Tirunagari, Neeraj, Wang, Ting, Whitcomb, Mark, Xu, Jie, Yang, Huiling, Ye, Hong, Zhang, Lijun, Appleby, Todd C., Feng, Joy Y., Ray, Adrian S., Cho, Aesop, Kim, Choung U.

“…[Display omitted] A series of 2′-fluorinated C-nucleosides were prepared and tested for anti-HCV activity. Among them, the triphosphate of…”
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Discovery of GS-9256: A novel phosphinic acid derived inhibitor of the hepatitis C virus NS3/4A protease with potent clinical activity by Sheng, X. Christopher, Casarez, Anthony, Cai, Ruby, Clarke, Michael O., Chen, Xiaowu, Cho, Aesop, Delaney, William E., Doerffler, Edward, Ji, Mingzhe, Mertzman, Michael, Pakdaman, Rowchanak, Pyun, Hyung-Jung, Rowe, Tanisha, Wu, Qiaoyin, Xu, Jie, Kim, Choung U.

“…A potent and novel class of phosphinic acid derived product-like inhibitors of the HCV NS3/4A protease was discovered previously. Modification of the…”
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Discovery of GS-9451: An acid inhibitor of the hepatitis C virus NS3/4A protease by Christopher Sheng, X., Appleby, Todd, Butler, Thomas, Cai, Ruby, Chen, Xiaowu, Cho, Aesop, Clarke, Michael O., Cottell, Jeromy, Delaney, William E., Doerffler, Edward, Link, John, Ji, Mingzhe, Pakdaman, Rowchanak, Pyun, Hyung-Jung, Wu, Qiaoyin, Xu, Jie, Kim, Choung U.

“…The discovery of GS-9451 is reported. Modification of the P3 cap and P2 quinoline with a series of solubilizing groups led to the identification of potent HCV…”
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Discovery of novel phosphonate derivatives as hepatitis C virus NS3 protease inhibitors by Sheng, X. Christopher, Pyun, Hyung-Jung, Chaudhary, Kleem, Wang, Jianying, Doerffler, Edward, Fleury, Melissa, McMurtrie, Darren, Chen, Xiaowu, Delaney, William E., Kim, Choung U.

“…The design and preparation of highly potent tricyclic HIV integrase inhibitors are reported. The lead compound has shown good oral bioavailability in both rat…”
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Novel, potent, and orally bioavailable phosphinic acid inhibitors of the hepatitis C virus NS3 protease by Clarke, Michael O., Chen, Xiaowu, Cho, Aesop, Delaney, William E., Doerffler, Edward, Fardis, Maria, Ji, Mingzhe, Mertzman, Michael, Pakdaman, Rowchanak, Pyun, Hyun-Jun, Rowe, Tanisha, Yang, Cheng Y., Sheng, X. Christopher, Kim, Choung U.

“…A potent and novel class of product-like inhibitors of the HCV NS3 protease was discovered by employing a phosphinic acid as a carboxylate isostere. The…”
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Novel, potent and orally bioavailable indolizidinone-derived inhibitors of the hepatitis C virus NS3 protease by Clarke, Michael O., Byun, Daniel, Chen, Xiaowu, Doerffler, Edward, Leavitt, Stephanie A., Sheng, X. Christopher, Yang, Cheng Y., Kim, Choung U.

“…A novel, potent, and orally bioavailable class of product-like inhibitors of the HCV NS3 protease was discovered by constraining the P2–P3 amide bond and the…”
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Nucleotide Prodrug GS-5734 Is a Broad-Spectrum Filovirus Inhibitor That Provides Complete Therapeutic Protection Against the Development of Ebola Virus Disease (EVD) in Infected Non-human Primates by Warren, Travis, Jordan, Robert, Lo, Michale, Soloveva, Veronica, Ray, Adrian, Bannister, Roy, Mackman, Richard, Perron, Michel, Stray, Kirsten, Feng, Joy, Xu, Yili, Wells, Jay, Stuthman, Kelly, Welch, Lisa, Doerffler, Edward, Zhang, Lijun, Chun, Kwon, Hui, Hon, Neville, Sean, Lew, Willard, Park, Yeojin, Babusis, Darius, Strickley, Robert, Wong, Pamela, Swaminathan, Swami, Lee, William, Mayers, Douglas, Cihlar, Tomas, Bavari, Sina

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Optimization of Pharmacokinetics through Manipulation of Physicochemical Properties in a Series of HCV Inhibitors by Lazerwith, Scott E, Bahador, Gina, Canales, Eda, Cheng, Guofeng, Chong, Lee, Clarke, Michael O, Doerffler, Edward, Eisenberg, Eugene J, Hayes, Jaclyn, Lu, Bing, Liu, Qi, Matles, Mike, Mertzman, Michael, Mitchell, Michael L, Morganelli, Philip, Murray, Bernard P, Robinson, Margaret, Strickley, Robert G, Tessler, Megan, Tirunagari, Neeraj, Wang, Jianhong, Wang, Yujin, Zhang, Jennifer R, Zheng, Xubin, Zhong, Weidong, Watkins, William J

“…A novel series of HCV replication inhibitors based on a pyrido[3,2-d]pyrimidine core were optimized for pharmacokinetics (PK) in rats. Several associations…”
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LB-2Nucleotide Prodrug GS-5734 Is a Broad-Spectrum Filovirus Inhibitor That Provides Complete Therapeutic Protection Against the Development of Ebola Virus Disease (EVD) in Infected Non-human Primates by Warren, Travis, Jordan, Robert, Lo, Michale, Soloveva, Veronica, Ray, Adrian, Bannister, Roy, Mackman, Richard, Perron, Michel, Stray, Kirsten, Feng, Joy, Xu, Yili, Wells, Jay, Stuthman, Kelly, Welch, Lisa, Doerffler, Edward, Zhang, Lijun, Chun, Kwon, Hui, Hon, Neville, Sean, Lew, Willard, Park, Yeojin, Babusis, Darius, Strickley, Robert, Wong, Pamela, Swaminathan, Swami, Lee, William, Mayers, Douglas, Cihlar, Tomas, Bavari, Sina

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