Search Results - "DOENHOFF, Michael J"

Praziquantel: mechanisms of action, resistance and new derivatives for schistosomiasis by Doenhoff, Michael J, Cioli, Donato, Utzinger, Jürg

“…PURPOSE OF REVIEWPraziquantel (PZQ) is the only drug being used to treat human schistosomiasis on a large scale. This review focuses on current knowledge about…”
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Omega-1, a glycoprotein secreted by Schistosoma mansoni eggs, drives Th2 responses by Everts, Bart, Perona-Wright, Georgia, Smits, Hermelijn H, Hokke, Cornelis H, van der Ham, Alwin J, Fitzsimmons, Colin M, Doenhoff, Michael J, van der Bosch, Jürgen, Mohrs, Katja, Haas, Helmut, Mohrs, Markus, Yazdanbakhsh, Maria, Schramm, Gabriele

“…Soluble egg antigens of the parasitic helminth Schistosoma mansoni (S. mansoni egg antigen [SEA]) induce strong Th2 responses both in vitro and in vivo…”
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Schistosoma mansoni Egg-Released IPSE/alpha-1 Dampens Inflammatory Cytokine Responses via Basophil Interleukin (IL)-4 and IL-13 by Knuhr, Katrin, Langhans, Kristina, Nyenhuis, Sandra, Viertmann, Kerstin, Kildemoes, Anna M Overgaard, Doenhoff, Michael J, Haas, Helmut, Schramm, Gabriele

“…Schistosomes control inflammation in their hosts highly effective mechanisms such as induction of Tregs, Bregs, and alternatively activated macrophages (AAMs)…”
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Cross-Reactivity between Schistosoma mansoni Antigens and the Latex Allergen Hev b 7: Putative Implication of Cross-Reactive Carbohydrate Determinants (CCDs) by Doenhoff, Michael J, El-Faham, Marwa, Liddell, Susan, Fuller, Heidi R, Stanley, Ronald G, Schramm, Gabriele, Igetei, Joseph E

“…IgG antibodies produced by rabbits immunized against S. mansoni antigens cross-reacted with aqueous soluble constituents of a variety of allergens. The…”
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Treatment of Schistosoma mansoni with miltefosine in vitro enhances serological recognition of defined worm surface antigens by El-Faham, Marwa H, Eissa, Maha M, Igetei, Joseph E, Amer, Eglal I, Liddell, Susan, El-Azzouni, Mervat Z, Doenhoff, Michael J

“…Miltefosine, an anti-cancer drug that has been successfully repositioned for treatment of Leishmania infections, has recently also shown promising effects…”
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Effects of Schistosoma mansoni worms and eggs on circulating cholesterol and liver lipids in mice by Stanley, Ronald G, Jackson, Christopher L, Griffiths, Keith, Doenhoff, Michael J

“…Abstract It has previously been shown that experimental infections of the parasitic trematode Schistosoma mansoni , the adult worms of which reside in the…”
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new rapid diagnostic test for detection of anti-Schistosoma mansoni and anti-Schistosoma haematobium antibodies by Coulibaly, Jean T, N’Goran, Eliézer K, Utzinger, Jürg, Doenhoff, Michael J, Dawson, Emily M

“…BACKGROUND: Parasitological methods are widely used for the diagnosis of schistosomiasis. However, they are insensitive, particularly in areas of low…”
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Intestinal schistosomiasis in pre school-aged children of Lake Albert, Uganda: diagnostic accuracy of a rapid test for detection of anti-schistosome antibodies by DAWSON, Emily M, SOUSA-FIGUEIREDO, José C, KABATEREINE, Narcis B, DOENHOFF, Michael J, RUSSELL STOTHARD, J

“…A sensitive and reliable rapid diagnostic test (RDT) which should have comparable diagnostic performance against reference host serological methods is urgently…”
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Distinct Schistosoma mansoni -Specific Immunoglobulin Subclasses Are Induced by Different Schistosoma mansoni Stages-A Tool to Decipher Schistosoma mansoni Infection Stages by Arndts, Kathrin, Elfaki, Tayseer E M, Doenhoff, Michael J, Katawa, Gnatoulma, Goreish, Ibtisam A, Atti El Mekki, Misk El Yemen A, Hoerauf, Achim, Ritter, Manuel, Layland, Laura E

“…Despite the existence of an effective medication against schistosomiasis, the disease remains a major health problem in affected areas, especially for those…”
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Use of humanised rat basophilic leukaemia cell line RS-ATL8 for the assessment of allergenicity of Schistosoma mansoni proteins by Wan, Daniel, Ludolf, Fernanda, Alanine, Daniel G W, Stretton, Owen, Ali Ali, Eman, Al-Barwary, Nafal, Wang, Xiaowei, Doenhoff, Michael J, Mari, Adriano, Fitzsimmons, Colin M, Dunne, David W, Nakamura, Ryosuke, Oliveira, Guilherme C, Alcocer, Marcos J C, Falcone, Franco H

“…Parasite-specific IgE is thought to correlate with protection against Schistosoma mansoni infection or re-infection. Only a few molecular targets of the IgE…”
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Schistosoma mansoni infection reduces the incidence of murine cerebral malaria by Waknine-Grinberg, Judith H, Gold, Daniel, Ohayon, Ariel, Flescher, Eliezer, Heyfets, Alina, Doenhoff, Michael J, Schramm, Gabriele, Haas, Helmut, Golenser, Jacob

“…Plasmodium and Schistosoma are two of the most common parasites in tropical areas. Deregulation of the immune response to Plasmodium falciparum, characterized…”
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Molecular Characterization of an Interleukin-4-inducing Factor from Schistosoma mansoni Eggs by Schramm, Gabriele, Falcone, Franco H, Gronow, Achim, Haisch, Karin, Mamat, Uwe, Doenhoff, Michael J, Oliveira, Guilherme, Galle, Jürgen, Dahinden, Clemens A, Haas, Helmut

“…The eggs of the parasitic trematode Schistosoma mansoni are powerful inducers of a T helper type 2 (Th2) immune response and immunoglobulin E (IgE) production…”
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Serodiagnosis of Imported Schistosomiasis by a Combination of a Commercial Indirect Hemagglutination Test with Schistosoma mansoni Adult Worm Antigens and an Enzyme-Linked Immunosorbent Assay with S. mansoni Egg Antigens by VAN GOOL, Tom, VETTER, Hans, VERVOORT, Tony, DOENHOFF, Michael J, WETSTEYN, Jose, OVERBOSCH, David

“…Article Usage Stats Services JCM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Failure of in vitro-cultured schistosomes to produce eggs: how does the parasite meet its needs for host-derived cytokines such as TGF-β? by Doenhoff, Michael J., Modha, Jay, Walker, Anthony J.

“…[Display omitted] •Adult schistosome worms do not produce many viable eggs after being placed in culture.•Female worms do not produce eggs in the absence of…”
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Molecular characterization of omega-1: A hepatotoxic ribonuclease from Schistosoma mansoni eggs by Fitzsimmons, Colin M., Schramm, Gabriele, Jones, Frances M., Chalmers, Iain W., Hoffmann, Karl F., Grevelding, Christoph G., Wuhrer, Manfred, Hokke, Cornelis H., Haas, Helmut, Doenhoff, Michael J., Dunne, David W.

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Antigenic cross-reactivity between Schistosoma mansoni and pollen allergens from the birch tree (Betula verrucosa) and Timothy grass (Phleum pratense): involvement of shared glycan epitopes and implications for the hygiene hypothesis by Igetei, Joseph E., El-Faham, Marwa, Liddell, Susan, Schramm, Gabriele, Doenhoff, Michael J.

“…[Display omitted] •Anti-Schistosoma mansoni IgG were cross-reactive with some molecules in Timothy grass (TGP) and birch tree pollens (BTP)•Three…”
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Drug-resistant schistosomiasis: resistance to praziquantel and oxamniquine induced in Schistosoma mansoni in mice is drug specific by Fallon, P G, Doenhoff, M J

“…Schistosoma mansoni infections in mice were treated with subcurative multiple doses of either praziquantel (PZQ) or oxamniquine (OX). With an early exception,…”
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Praziquantel for the treatment of schistosomiasis: its use for control in areas with endemic disease and prospects for drug resistance by Doenhoff, Michael J, Pica-Mattoccia, Livia

“…Praziquantel became available for the treatment of schistosomiasis and other trematode-inflicted diseases in the 1970s. It was revolutionary because it could…”
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Cutting Edge: IPSE/alpha-1, a Glycoprotein from Schistosoma mansoni Eggs, Induces IgE-Dependent, Antigen-Independent IL-4 Production by Murine Basophils In Vivo by Schramm, Gabriele, Mohrs, Katja, Wodrich, Maren, Doenhoff, Michael J, Pearce, Edward J, Haas, Helmut, Mohrs, Markus

“…During infection with the helminth parasite Schistosoma mansoni, the deposition of eggs coincides with the onset of IL-4 production and Th2 development…”
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Antigenic cross-reactivity between Schistosoma mansoni and allergenic invertebrates putatively due to shared glycanic epitopes by El-Faham, Marwa H., Gai, Fatou, Igetei, Joseph E., Richter, Sarah, Falcone, Franco H., Schramm, Gabi, Doenhoff, Michael J.

“…Previous studies have shown that rabbit IgG antibodies against Schistosoma mansoni egg antigens (SmSEA) cross-react with allergens in natural rubber latex,…”
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