Ornithine decarboxylase and tyrosine kinase activity in juvenile polyps of childhood

Ornithine decarboxylase and tyrosine kinase activity in juvenile polyps of childhood

Juvenile polyps (JP) are the most common colonic tumor in children. Although considered benign, malignant transformation has been reported in JP. Ornithine decarboxylase (ODC) and tyrosine kinase (TyK) enzymes are markers for a rapid cell proliferation index. DNA aneuploidy score and p53 gene expres...

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Bibliographic Details
Published in:Pediatric research Vol. 38; no. 4; pp. 574 - 578
Main Authors: ELITSUR, Y, KOH, S. J. G, MOSHIER, J. A, DODESCU, J, TUREAUD, J, MAJUMDAR, A. P. N
Format: Conference Proceeding Journal Article
Language:English
Published: Hagerstown, MD Lippincott Williams & Wilkins 01-10-1995
Subjects:
Adolescent
Aneuploidy
Biological and medical sciences
Child
Child, Preschool
Colon - enzymology
Colonic Polyps - enzymology
Colonic Polyps - genetics
DNA, Neoplasm - genetics
Gastroenterology. Liver. Pancreas. Abdomen
Gene Expression
Genes, p53
Humans
Infant
Intestinal Mucosa - enzymology
Medical sciences
Ornithine Decarboxylase - metabolism
Protein-Tyrosine Kinases - metabolism
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumors
Human
Enzyme
Transferases
Biological marker
Lyases
Ornithine decarboxylase
Malignant tumor
Colonic disease
Carbon-carbon lyases
Enzymatic activity
Carboxy-lyases
Risk factor
Digestive diseases
Intestinal disease
Tumor
Colon
Child
Protein-tyrosine kinase
Polyp
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Summary:Juvenile polyps (JP) are the most common colonic tumor in children. Although considered benign, malignant transformation has been reported in JP. Ornithine decarboxylase (ODC) and tyrosine kinase (TyK) enzymes are markers for a rapid cell proliferation index. DNA aneuploidy score and p53 gene expression are late malignant changes seen in patients with colon cancer. In this study, we investigated ODC and TyK activities as well as DNA aneuploidy score and p53 expression in juvenile polyps compared with the adjacent normal colonic mucosa. Results showed that ODC was significantly increased in JP compared with the adjacent normal colonic mucosa. TyK activity was increased in 3/5 polyps and decreased in 2/5 polyps compared with the mucosa. Mean TyK activity was higher in JP compared with normal mucosa but did not reach significance (707 and 632 pmol/mg pmol, respectively). Moreover, changes in phosphorylization of TyK proteins was also observed in JP but not in normal mucosa. JP had a normal DNA aneuploidy score and showed no expression of p53 gene. We conclude that JP do not express p53 gene and aneuploidy but had higher activity of ODC and TyK enzymes, suggesting a higher stage of cell proliferation.
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ISSN:0031-3998
1530-0447
DOI:10.1203/00006450-199510000-00017