Search Results - "DODD, Kayleigh M"

Leucine and mTORC1: a complex relationship by Dodd, Kayleigh M, Tee, Andrew R

“…Amino acid availability is a rate-limiting factor in the regulation of protein synthesis. When amino acid supplies become restricted, mammalian cells employ…”
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Mammalian target of rapamycin complex 1-mediated phosphorylation of eukaryotic initiation factor 4E-binding protein 1 requires multiple protein–protein interactions for substrate recognition by Dunlop, Elaine A., Dodd, Kayleigh M., Seymour, Lyndsey A., Tee, Andrew R.

“…The mammalian target of rapamycin (mTOR) pathway is implicated in a number of human diseases, but the pathway details are not fully understood. Here we…”
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A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS by Zhang, Jiangwei, Kim, Jinhee, Alexander, Angela, Cai, Shengli, Tripathi, Durga Nand, Dere, Ruhee, Tee, Andrew R., Tait-Mulder, Jacqueline, Di Nardo, Alessia, Han, Juliette M., Kwiatkowski, Erica, Dunlop, Elaine A., Dodd, Kayleigh M., Folkerth, Rebecca D., Faust, Phyllis L., Kastan, Michael B., Sahin, Mustafa, Walker, Cheryl Lyn

“…Subcellular localization is emerging as an important mechanism for mTORC1 regulation. We report that the tuberous sclerosis complex (TSC) signalling node,…”
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Tuberous sclerosis—A model for tumour growth by Dodd, Kayleigh M., Dunlop, Elaine A.

“…Tuberous sclerosis complex (TSC) is a rare genetic disorder where patients develop benign tumours in several organ systems. Central to TSC pathology is…”
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Drug Inhibition of Redox Factor-1 Restores Hypoxia-Driven Changes in Tuberous Sclerosis Complex 2 Deficient Cells by Champion, Jesse D, Dodd, Kayleigh M, Lam, Hilaire C, Alzahrani, Mohammad A M, Seifan, Sara, Rad, Ellie, Scourfield, David Oliver, Fishel, Melissa L, Calver, Brian L, Ager, Ann, Henske, Elizabeth P, Davies, David Mark, Kelley, Mark R, Tee, Andrew R

“…Therapies with the mechanistic target of rapamycin complex 1 (mTORC1) inhibitors are not fully curative for tuberous sclerosis complex (TSC) patients. Here, we…”
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STAT3 and mTOR: co-operating to drive HIF and angiogenesis by Dodd, Kayleigh M, Tee, Andrew R

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Evaluation of copy number variation and gene expression in neurofibromatosis type-1-associated malignant peripheral nerve sheath tumours by Thomas, Laura E, Winston, Jincy, Rad, Ellie, Mort, Matthew, Dodd, Kayleigh M, Tee, Andrew R, McDyer, Fionnuala, Moore, Stephen, Cooper, David N, Upadhyaya, Meena

“…Neurofibromatosis type-1 (NF1) is a complex neurogenetic disorder characterised by the development of benign and malignant tumours of the peripheral nerve…”
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Determining the pathogenicity of patient-derived TSC2 mutations by functional characterization and clinical evidence by DUNLOP, Elaine A, DODD, Kayleigh M, DUARTE MEDEIRA, Ana Maria, KINGSTON, Helen, SAMPSON, Julian R, DAVIES, David Mark, TEE, Andrew R, LAND, Stephen C, DAVIES, Peter A, MARTINS, Nicole, STUART, Helen, MCKEE, Shane, KINGSWOOD, Chris, SAGGAR, Anand, CORDERIO, Isabel

“…Tuberous sclerosis complex (TSC) is a genetic condition characterized by the growth of benign tumours in multiple organs, including the brain and kidneys,…”
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mTORC1 drives HIF-1α and VEGF-A signalling via multiple mechanisms involving 4E-BP1, S6K1 and STAT3 by Dodd, K M, Yang, J, Shen, M H, Sampson, J R, Tee, A R

“…Recent clinical trials using rapalogues in tuberous sclerosis complex show regression in volume of typically vascularised tumours including angiomyolipomas and…”
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A TSC signaling node at the peroxisome regulates mTORC1 and autophagy in response to ROS by Zhang, Jiangwei, Kim, Jinhee, Alexander, Angela, Cai, Shengli, Tripathi, Durga Nand, Dere, Ruhee, Tee, Andrew R., Tait-Mulder, Jacqueline, Di Nardo, Alessia, Han, Juliette M., Kwiatkowski, Erica, Dunlop, Elaine A., Dodd, Kayleigh M., Folkerth, Rebecca D., Faust, Phyllis L., Kastan, Michael B., Sahin, Mustafa, Walker, Cheryl Lyn

“…Subcellular localization is emerging as an important mechanism for mTORC1 regulation. We report that the tuberous sclerosis complex (TSC) signaling node, TSC1,…”
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Determining the pathogenicity of patient-derived mutations by functional characterization and clinical evidence by Tee, Andrew Robert, Dunlop, Elaine A, Dodd, Kayleigh M, Land, Stephen C, Davies, Peter A, Martins, Nicole, Stuart, Helen, Mckee, Shane, Kingswood, Chris, Saggar, Anand, Cordeiro, Isabel, Medeira, Ana, Kingston, Helen, Sampson, Julian R., Davies, D Mark

“…Tuberous Sclerosis Complex is a genetic condition characterised by the growth of benign tumours in multiple organs, including the brain and kidneys, alongside…”
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