Search Results - "DOCHERTY, A. J. P"

Matrix metalloproteinase degradation of elastin, type IV collagen and proteoglycan : a quantitative comparison of the activities of 95 kDa and 72 kDa gelatinases, stromelysins-1 and -2 and punctuated metalloproteinase (PUMP) by MURPHY, G, COCKETT, M. I, WARD, R. V, DOCHERTY, A. J. P

“…The abilities of the matrix metalloproteinases 95 kDa and 72 kDa gelatinases (type IV collagenases), stromelysins-1 and -2 and punctuated metalloproteinase…”
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Functional heterogeneity of osteoclasts: matrix metalloproteinases participate in osteoclastic resorption of calvarial bone but not in resorption of long bone by Everts, V., Korper, W., Jansen, D. C., Steinfort, J., Lammerse, I., Heera, S., Docherty, A. J. P., Beertsen, W.

“…ABSTRACTData in the literature suggest that site‐specific differences exist in the skeleton with respect to digestion of bone by osteoclasts. Therefore, we…”
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Binding of gelatinases A and B to type-I collagen and other matrix components by Allan, J A, Docherty, A J, Barker, P J, Huskisson, N S, Reynolds, J J, Murphy, G

“…Matrix sequestration of matrix metalloproteinases may be important for the facilitation of remodelling events and the migration of cells through the…”
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Inhibition of bone resorption in vitro by selective inhibitors of gelatinase and collagenase by Hill, P A, Docherty, A J, Bottomley, K M, O'Connell, J P, Morphy, J R, Reynolds, J J, Meikle, M C

“…Two low-molecular-mass inhibitors of matrix metalloproteinases (MMPs), CT1166, a concentration-dependent selective inhibitor of gelatinases A and B, and Ro…”
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Comparison of human stromelysin and collagenase by cloning and sequence analysis by Whitham, S E, Murphy, G, Angel, P, Rahmsdorf, H J, Smith, B J, Lyons, A, Harris, T J, Reynolds, J J, Herrlich, P, Docherty, A J

“…A comparison of the cDNA-derived amino acid sequences of human stromelysin and collagenase with the N-terminal sequences of purified enzymes reveals that these…”
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The matrix metalloproteinases and their inhibitors by Murphy, G, Docherty, A J

“…A number of metalloproteinases that degrade the extracellular matrix of connective tissues and two specific tissue inhibitors of metalloproteinases (TIMPs)…”
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Assignment of the TIMP gene to the murine X-chromosome using an inter-species cross by JACKSON, I. J, LECRAS, T. D, DOCHERTY, A. J. P

“…Images…”
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Chromosomal assignment of the gene encoding the human tissue inhibitor of metalloproteinases to Xp11.1-p11.4 by Spurr, N K, Goodfellow, P N, Docherty, A J

“…The tissue inhibitor of metalloproteinases (TIMP) is thought to play a regulatory role in connective tissues by forming inactive complexes with those…”
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The tissue metalloproteinase family and the inhibitor TIMP : a study using cDNAs and recombinant proteins by DOCHERTY, A. J. P, MURPHY, G

“…Loss of connective tissue integrity occurs in many disease processes, including rheumatoid arthritis and osteoarthritis. Although there is a high incidence of…”
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The C-terminal domain of 72 kDa gelatinase A is not required for catalysis, but is essential for membrane activation and modulates interactions with tissue inhibitors of metalloproteinases by Murphy, G, Willenbrock, F, Ward, R V, Cockett, M I, Eaton, D, Docherty, A J

“…Recombinant 72 kDa gelatinase A and a truncated form lacking the C-terminal domain were shown to be activated by organomercurials and to possess similar…”
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The matrix metalloproteinases and their natural inhibitors: prospects for treating degenerative tissue diseases by Docherty, A J, O'Connell, J, Crabbe, T, Angal, S, Murphy, G

“…Uncontrolled matrix metalloproteinase activity is thought to be a cause of the tissue damage observed in many disease processes. None of the drugs currently in…”
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The role of the C-terminal domain in collagenase and stromelysin specificity by MURPHY, G, ALLAN, J. A, WILLENBROCK, F, COCKETT, M. I, O'CONNEL, J. P, DOCHERTY, A. J. P

“…Recombinant human interstitial collagenase, an N-terminal truncated form, delta 243-450 collagenase, recombinant human stromelysin-1, and an N-terminal…”
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Assessment of the role of the fibronectin-like domain of gelatinase A by analysis of a deletion mutant by MURPHY, G, QUANG NGUYEN, COCKETT, M. I, ATKINSON, S. J, ALLAN, J. A, KNIGHT, C. G, WILLENBROCK, F, DOCHERTY, A. J. P

“…The properties of a deletion mutant delta V191-Q364 of gelatinase A, which represents the removal of the fibronectin-like type II repeats defined by exons 5-7,…”
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The activity of the tissue inhibitors of metalloproteinases is regulated by C-terminal domain interactions: A kinetic analysis of the inhibition of gelatinase A by Willenbrock, Frances, Crabbe, Thomas, Slocombe, Patrick M, Sutton, Chris W, Docherty, Andrew J. P, Cockett, Mark I, O'Shea, Mark, Brocklehurst, Keith, Phillips, Ian R, Murphy, Gillian

“…The cloning and expression of the full-length tissue inhibitor of metalloproteinase 2 (TIMP-2), delta 187-194TIMP-2, and delta 128-194TIMP-2 and the…”
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The N-terminal domain of tissue inhibitor of metalloproteinases retains metalloproteinase inhibitory activity by Murphy, Gillian, Houbrechts, Annick, Cockett, Mark I, Williamson, Richard A, O'Shea, Mark, Docherty, Andrew J. P

“…Recombinant tissue inhibitor of metalloproteinases (TIMP-1) and a truncated version containing only the three N-terminal loops, delta 127-184TIMP, have been…”
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Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor by Edwards, D. R., Murphy, G., Reynolds, J. J., Whitham, S. E., Docherty, A. J., Angel, P., Heath, J. K.

“…Exposure of quiescent MRC‐5 human fibroblasts to growth factors such as epidermal growth factor, basic fibroblast growth factor or embryonal carcinoma‐derived…”
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Analysis of the role of the COOH-terminal domain in the activation, proteolytic activity, and tissue inhibitor of metalloproteinase interactions of gelatinase B by O'CONNELL, J. P, WILLENBROCK, F, DOCHERTY, A. J. P, EATON, D, MURPHY, G

“…Recombinant human progelatinase B and a COOH terminally truncated version, pro-delta426-688 gelatinase B have been prepared from a myeloma cell expression…”
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Stromelysin is an activator of procollagenase. A study with natural and recombinant enzymes by Murphy, G, Cockett, M I, Stephens, P E, Smith, B J, Docherty, A J

“…The latent forms of stromelysin and collagenase from human gingival fibroblasts were purified to homogeneity. These latent proenzymes underwent serial small…”
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Kupffer cell-derived 95-kd type IV collagenase/gelatinase B: characterization and expression in cultured cells by Winwood, P J, Schuppan, D, Iredale, J P, Kawser, C A, Docherty, A J, Arthur, M J

“…Release of 92-kd type IV collagenase/gelatinase, also known as gelatinase B, by inflammatory and tumor cells is increasingly recognized and is believed to…”
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Increased serum stromelysin-1 levels in systemic lupus erythematosus: lack of correlation with disease activity by Zucker, S, Mian, N, Drews, M, Conner, C, Davidson, A, Miller, F, Birembaut, P, Nawrocki, B, Docherty, A J, Greenwald, R A, Grimson, R, Barland, P

“…In view of evidence that stromelysin-1 and collagenase-1 are involved in tissue injury in inflammatory joint diseases, we sought to determine whether matrix…”
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