Search Results - "DOBRINSKA, Michael R"

Concomitant use of cytochrome P450 3A4 inhibitors and simvastatin by Gruer, Peter J.K, Vega, Jose M, Mercuri, Michele F, Dobrinska, Michael R, Tobert, Jonathan A

“…The long-term safety profile of simvastatin, established over 10 years of clinical use, is excellent. The principal adverse effect of all inhibitors of…”
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The Efficacy and Six-Week Tolerability of Simvastatin 80 and 160 mg/Day by Davidson, Michael H., Stein, Evan A., Dujovne, Carlos A., Hunninghake, Donald B., Weiss, Stuart R., Knopp, Robert H., Illingworth, D.Roger, Mitchel, Yale B., Melino, Michael R., Zupkis, Robert V., Dobrinska, Michael R., Amin, Raju D., Tobert, Jonathan A.

“…The hydroxymethylglutaryl coenzyme A reductase inhibitor simvastatin is the most effective of the currently approved hypolipidemic drugs and has been shown to…”
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Use of In Vitro Drug Metabolism Data to Evaluate Metabolic Drug-Drug Interactions in Man: The Need for Quantitative Databases by Rodrigues, A. David, Winchell, Gregory A., Dobrinska, Michael R.

“…It has become widely accepted that metabolic drug‐drug interactions can be forecast using in vitro cytochrome P450 (CYP) data. For any CYP form‐inhibitor pair,…”
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In-vivo phenotyping for CYP3A by a single-point determination of midazolam plasma concentration by LIN, Yvonne S, LOCKWOOD, Graham F, THUMMEL, Kenneth E, GRAHAM, Martin A, BRIAN, William R, LOI, Cho-Ming, DOBRINSKA, Michael R, SHEN, Danny D, WATKINS, Paul B, WILKINSON, Grant R, KHARASCH, Evan D

“…We investigated whether a single plasma midazolam concentration could serve as an accurate predictor of total midazolam clearance, an established in-vivo probe…”
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Determination of simvastatin-derived HMG-CoA reductase inhibitors in biomatrices using an automated enzyme inhibition assay with radioactivity detection by Liu, Lida, Zhang, Rena, Zhao, Jamie J., Rogers, John D., Hsieh, John Y.-K., Fang, Wei, Matuszewski, Bogdan K., Dobrinska, Michael R.

“…A robust, automated enzyme inhibition assay method was developed and validated for the determination of HMG-CoA reductase inhibitory activities in plasma and…”
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Robotic inhibition assay for determination of HMG-CoA reductase inhibitors in human plasma by Fang, Wei, Liu, Lida, Hsieh, John Y.-K., Zhao, Jamie, Matuszewski, Bogdan K., Rogers, John D., Dobrinska, Michael R.

“…The cholesterol‐lowering drug simvastatin (SIMV, Zocor®) reduced heart attacks by 42% in patients who had high cholesterol levels and suffered from heart…”
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3-Hydroxy-.alpha.-methyltyrosine progenitors, synthesis and evaluation of some (2-oxo-1,3-dioxol-4-yl)methyl esters by Saari, Walfred S, Halczenko, Wasyl, Cochran, David W, Dobrinska, Michael R, Vincek, William C, Titus, David C, Gaul, S. Lee, Sweet, Charles S

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Use of In Vitro Drug Metabolism Data to Evaluate Metabolic Drug-Drug Interactions in Man: The Need for Quantitative Databases by Rodrigues, David A, Winchell, Gregory A, Dobrinska, Michael R

“…It has become widely accepted that metabolic drug-drug interactions can be forecast using in vitro cytochrome P450 (CYP) data. For any CYP form-inhibitor pair,…”
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Reply by Gruer, Peter J.K, Vega, Jose, Mercuri, Michele F, Dobrinska, Michael R, Tobert, Jonathan A

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Influence of age and gender on the plasma profiles of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitory activity following multiple doses of lovastatin and simvastatin by HAIYUNG CHENG, ROGERS, J. D, SWEANY, A. E, DOBRINSKA, M. R, STEIN, E. A, TATE, A. C, AMIN, R. D, HUI QUAN

“…The effects of age and of gender on the plasma profiles of HMG-CoA reductase inhibitors following separate once-a-day dosage regimens (17 days) of lovastatin…”
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An automated sample preparation and high performance liquid chromatographic method for the determination of MK-591, a novel leukotriene biosynthesis inhibitor, in human plasma by Lin, Charles, Hsieh, John Y.-K., Matuszewski, Bogdan K., Dobrinska, Michael R.

“…A high performance liquid chromatography assay utilizing an automated sample preparation procedure for the determination of a novel leukotriene biosynthesis…”
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Picogram determination of an avermectin analog in dog plasma by high-performance liquid chromatography with fluorescence detection. [Erratum: 1997, v. 20 (6), p. 971.] by Lin, C.C, Hsieh, J.Y.K, Matuszewski, B.K, Zagrobelny, J, Dobrinska, M.R

“…A sensitive and automated method for the determination of a new avermectin analog (MK-324) in dog plasma has been developed and validated. The drug and…”
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THE PHARMACOKINETICS OF METHSUXIMIDE AND A MAJOR METABOLITE IN THE DOG AND MAN by DOBRINSKA, MICHAEL R

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Pharmacokinetics of methsuximide and a major metabolite in dogs by Dobrinska, M R, Welling, P G

“…The pharmacokinetics of methsuximide and its major metabolite 2-methyl-2-phenylsuccinimide were studied in dogs after single intravenous doses. Plasma…”
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Pharmacokinetics of 125I-iothalamate and 131I-o-iodohippurate in man by Welling, P G, Mosegaard, A, Dobrinska, M R, Madsen, P O

“…The pharmacokinetics of 125I-iothalamate (IOT125I) and 131I-o-iodohippurate (OIH131I) have been studied in patients with varying degrees of renal…”
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