Search Results - "DOBBIE, Lorraine"

Expression of Butyrophilin (Btn1a1) in Lactating Mammary Gland Is Essential for the Regulated Secretion of Milk-Lipid Droplets by Ogg, Sherry L., Weldon, Anne K., Dobbie, Lorraine, Andrew J. H. Smith, Mather, Ian H., Baldwin, Ransom L.

“…Butyrophilin 1a1 (Btn1a1), which is a member of the Ig superfamily, is highly expressed in the lactating mammary gland and is secreted into milk in association…”
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Loss of Atrx affects trophoblast development and the pattern of X-inactivation in extraembryonic tissues by Garrick, David, Sharpe, Jackie A, Arkell, Ruth, Dobbie, Lorraine, Smith, Andrew J H, Wood, William G, Higgs, Douglas R, Gibbons, Richard J

“…ATRX is an X-encoded member of the SNF2 family of ATPase/helicase proteins thought to regulate gene expression by modifying chromatin at target loci. Mutations…”
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Disruption of the Striated Muscle Glycogen Targeting Subunit PPP1R3A of Protein Phosphatase 1 Leads to Increased Weight Gain, Fat Deposition, and Development of Insulin Resistance by DELIBEGOVIC, Mirela, ARMSTRONG, Christopher G, DOBBIE, Lorraine, WATT, Peter W, SMITH, Andrew J. H, COHEN, Patricia T. W

“…Disruption of the Striated Muscle Glycogen Targeting Subunit PPP1R3A of Protein Phosphatase 1 Leads to Increased Weight Gain, Fat Deposition, and Development…”
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A conserved truncated isoform of the ATR-X syndrome protein lacking the SWI/SNF-homology domain by Garrick, David, Samara, Vassiliki, McDowell, Tarra L., Smith, Andrew J.H., Dobbie, Lorraine, Higgs, Douglas R., Gibbons, Richard J.

“…Mutations in the ATRX gene cause a severe X-linked mental retardation syndrome that is frequently associated with α thalassemia (ATR-X syndrome). The…”
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Neurosteroid Hydroxylase CYP7B by Rose, Ken, Allan, Adrian, Gauldie, Stephan, Stapleton, Genevieve, Dobbie, Lorraine, Dott, Karin, Martin, Cécile, Wang, Ling, Hedlund, Eva, Seckl, Jonathan R., Gustafsson, Jan-Åke, Lathe, Richard

“…The major adrenal steroid dehydroepiandrosterone (DHEA) enhances memory and immune function but has no known dedicated receptor; local metabolism may govern…”
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Altered Immune Responses and Susceptibility to Leishmania major and Staphylococcus aureus Infection in IL-18-Deficient Mice by Wei, Xiao-qing, Leung, Bernard P, Niedbala, Wanda, Piedrafita, David, Feng, Gui-jie, Sweet, Matt, Dobbie, Lorraine, Smith, Andrew J. H, Liew, Foo Yew

“…IL-18, formerly designated IFN-inducing factor, is a novel cytokine produced by activated macrophages. It synergizes with IL-12 in the induction of the…”
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Neurosteroid hydroxylase CYP7B: vivid reporter activity in dentate gyrus of gene-targeted mice and abolition of a widespread pathway of steroid and oxysterol hydroxylation by Rose, K, Allan, A, Gauldie, S, Stapleton, G, Dobbie, L, Dott, K, Martin, C, Wang, L, Hedlund, E, Seckl, J R, Gustafsson, J A, Lathe, R

“…The major adrenal steroid dehydroepiandrosterone (DHEA) enhances memory and immune function but has no known dedicated receptor; local metabolism may govern…”
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Tumour incidence, spectrum and ploidy in mice with a large deletion in the p53 gene by Purdie, C A, Harrison, D J, Peter, A, Dobbie, L, White, S, Howie, S E, Salter, D M, Bird, C C, Wyllie, A H, Hooper, M L

“…In human tumourigenesis the tumour suppressor gene most commonly affected by mutation, inactivation or allele loss is p53. Loss of p53 function is associated…”
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Disruption of the striated muscle glycogen targeting subunit PPP1R3A of protein phosphatase 1 leads to increased weight gain, fat deposition, and development of insulin by Delibegovic, Mirela, Armstrong, Christopher G, Dobbie, Lorraine, Watt, Peter W

“…Disruption of the PPP1R3A gene encoding the glycogen targeting subunit (G(M)/R(GL)) of protein phosphatase 1 (PP1) causes substantial lowering of the glycogen…”
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Loss of Atrx affects trophoblast development and the pattern of X-inactivation in extraembryonic tissues by David Garrick, Jackie A Sharpe, Ruth Arkell, Lorraine Dobbie, Andrew J H Smith, William G Wood, Douglas R Higgs, Richard J Gibbons

“…ATRX is an X-encoded member of the SNF2 family of ATPase/helicase proteins thought to regulate gene expression by modifying chromatin at target loci. Mutations…”
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Genomic organization and comparative analysis of the mouse tuberous sclerosis 1 (Tsc1) locus by Cheadle, J P, Dobbie, L, Idziaszczyk, S, Hodges, A K, Smith, A J, Sampson, J R, Young, J

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Combining methods for direct cDNA selection by Dobbie, Lorraine, Maule, John C., Brookes, Anthony J.

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Successful targeting of the mouse cystic fibrosis transmembrane conductance regulator gene in embryonal stem cells by Dorin, J R, Dickinson, P, Emslie, E, Clarke, A R, Dobbie, L, Hooper, M L, Halford, S, Wainwright, B J, Porteous, D J

“…We wish to construct a mouse model for the human inherited disease cystic fibrosis. We describe here the successful targeting in embryonal stem cells of the…”
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