Search Results - "DNA repair"

Inflammation-induced DNA damage, mutations and cancer by Kay, Jennifer, Thadhani, Elina, Samson, Leona, Engelward, Bevin

“…The relationships between inflammation and cancer are varied and complex. An important connection linking inflammation to cancer development is DNA damage…”
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Multiple functions of p21 in cell cycle, apoptosis and transcriptional regulation after DNA damage by Karimian, Ansar, Ahmadi, Yasin, Yousefi, Bahman

“…An appropriate control over cell cycle progression depends on many factors. Cyclin-dependent kinase (CDK) inhibitor p21 (also known as p21WAF1/Cip1) is one of…”
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Mechanisms of PARP inhibitor sensitivity and resistance by D’Andrea, Alan D.

“…BRCA1 and BRCA2 deficient tumor cells are sensitive to inhibitors of Poly ADP Ribose Polymerase (PARP1) through the mechanism of synthetic lethality. Several…”
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The comings and goings of PARP-1 in response to DNA damage by Pascal, John M.

“…Poly(ADP-ribose) polymerase (PARP) enzymes are broadly involved in the cellular response to DNA damage. PARP-1 is the chief human PARP enzyme involved in the…”
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PARP-1 and its associated nucleases in DNA damage response by Wang, Yijie, Luo, Weibo, Wang, Yingfei

“…Poly(ADP-ribose) (PAR) polymerase-1 (PARP-1) acts as a DNA damage sensor. It recognizes DNA damage and facilitates DNA repair by recruiting DNA repair…”
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Multiple functions of p27 in cell cycle, apoptosis, epigenetic modification and transcriptional regulation for the control of cell growth: A double-edged sword protein by Abbastabar, Maryam, Kheyrollah, Maryam, Azizian, Khalil, Bagherlou, Nazanin, Tehrani, Sadra Samavarchi, Maniati, Mahmood, Karimian, Ansar

“…The cell cycle is controlled by precise mechanisms to prevent malignancies such as cancer, and the cell needs these tight and advanced controls. Cyclin…”
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DNA repair mechanisms in dividing and non-dividing cells by Iyama, Teruaki, Wilson, David M.

“…•A review of the contribution of the different DNA repair mechanisms in dividing and non-dividing cells is provided.•The most recent findings on the molecular…”
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XRCC1 protein; Form and function by Caldecott, Keith W.

“…The human gene that encodes XRCC1 was cloned nearly thirty years ago but experimental analysis of this fascinating protein is still unveiling new insights into…”
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Nucleotide excision repair in humans by Spivak, Graciela

“…•NER is a mechanism for removal of a variety of structurally unrelated DNA lesions.•NER is prevalent in bacteria, archea, yeast, and in all higher…”
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Preserving replication fork integrity and competence via the homologous recombination pathway by Ait Saada, Anissia, Lambert, Sarah A.E., Carr, Antony M.

“…Flaws in the DNA replication process have emerged as a leading driver of genome instability in human diseases. Alteration to replication fork progression is a…”
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RNases H: Structure and mechanism by Hyjek, Malwina, Figiel, Małgorzata, Nowotny, Marcin

“…RNases H are a family of endonucleases that hydrolyze RNA residues in various nucleic acids. These enzymes are present in all branches of life, and their…”
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Histone ubiquitination in the DNA damage response by Uckelmann, Michael, Sixma, Titia K.

“…DNA double strand breaks need to be repaired in an organized fashion to preserve genomic integrity. In the organization of faithful repair, histone…”
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Cancer type-dependent correlations between TP53 mutations and antitumor immunity by Li, Lin, Li, Mengyuan, Wang, Xiaosheng

“…[Display omitted] •The correlation between TP53 mutation and tumor immunity is cancer type dependent.•The correlation between TP53 mutation and immunotherapy…”
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Base excision repair: A critical player in many games by Wallace, Susan S.

“…This perspective reviews the many dimensions of base excision repair from a 10,000 foot vantage point and provides one person's view on where the field is…”
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DNA mismatch repair and the DNA damage response by Li, Zhongdao, Pearlman, Alexander H., Hsieh, Peggy

“…This review discusses the role of DNA mismatch repair (MMR) in the DNA damage response (DDR) that triggers cell cycle arrest and, in some cases, apoptosis…”
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USP7: Structure, substrate specificity, and inhibition by Pozhidaeva, Alexandra, Bezsonova, Irina

“…Turnover of cellular proteins is regulated by Ubiquitin Proteasome System (UPS). Components of this pathway, including the proteasome, ubiquitinating enzymes…”
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New insights into abasic site repair and tolerance by Thompson, Petria S., Cortez, David

“…Thousands of apurinic/apyrimidinic (AP or abasic) sites form in each cell, each day. This simple DNA lesion can have profound consequences to cellular…”
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Not breathing is not an option: How to deal with oxidative DNA damage by Markkanen, Enni

“…Oxidative DNA damage constitutes a major threat to genetic integrity, and has thus been implicated in the pathogenesis of a wide variety of diseases, including…”
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DNA repair in personalized brain cancer therapy with temozolomide and nitrosoureas by Kaina, Bernd, Christmann, Markus

“…Alkylating agents have been used since the 60ties in brain cancer chemotherapy. Their target is the DNA and, although the DNA of normal and cancer cells is…”
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Recent advances in γH2AX biomarker-based genotoxicity assays: A marker of DNA damage and repair by Rahmanian, Nazanin, Shokrzadeh, Mohammad, Eskandani, Morteza

“…The phosphorylation of histone variant H2AX and formation of γH2AX is a primary response to the DNA double-strand breaks (DSBs). Detection of γH2AX is a robust…”
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