Search Results - "DJABALLAH, Hakim"

Asparagine Plays a Critical Role in Regulating Cellular Adaptation to Glutamine Depletion by Zhang, Ji, Fan, Jing, Venneti, Sriram, Cross, Justin R., Takagi, Toshimitsu, Bhinder, Bhavneet, Djaballah, Hakim, Kanai, Masayuki, Cheng, Emily H., Judkins, Alexander R., Pawel, Bruce, Baggs, Julie, Cherry, Sara, Rabinowitz, Joshua D., Thompson, Craig B.

“…Many cancer cells consume large quantities of glutamine to maintain TCA cycle anaplerosis and support cell survival. It was therefore surprising when RNAi…”
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Systematic analysis of RNAi reports identifies dismal commonality at gene-level and reveals an unprecedented enrichment in pooled shRNA screens by Bhinder, Bhavneet, Djaballah, Hakim

“…RNA interference (RNAi) has opened promising avenues to better understand gene function. Though many RNAi screens report on the identification of genes, very…”
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Superoxide dismutase 1 (SOD1) is a target for a small molecule identified in a screen for inhibitors of the growth of lung adenocarcinoma cell lines by Somwar, Romel, Erdjument-Bromage, Hediye, Larsson, Erik, Shum, David, Lockwood, William W, Yang, Guangli, Sander, Chris, Ouerfelli, Ouathek, Tempst, Paul J, Djaballah, Hakim, Varmus, Harold E

“…We previously described four small molecules that reduced the growth of lung adenocarcinoma cell lines with either epidermal growth factor receptor (EGFR) or…”
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High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells by Desbordes, Sabrina C, Placantonakis, Dimitris G, Ciro, Anthony, Socci, Nicholas D, Lee, Gabsang, Djaballah, Hakim, Studer, Lorenz

“…High-throughput screening (HTS) of chemical libraries has become a critical tool in basic biology and drug discovery. However, its implementation and the…”
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Characterization of a small molecule inhibitor of disulfide reductases that induces oxidative stress and lethality in lung cancer cells by Johnson, Fraser D., Ferrarone, John, Liu, Alvin, Brandstädter, Christina, Munuganti, Ravi, Farnsworth, Dylan A., Lu, Daniel, Luu, Jennifer, Sihota, Tianna, Jansen, Sophie, Nagelberg, Amy, Shi, Rocky, Forcina, Giovanni C., Zhang, Xu, Cheng, Grace S.W., Spencer Miko, Sandra E., de Rappard-Yuswack, Georgia, Sorensen, Poul H., Dixon, Scott J., Guha, Udayan, Becker, Katja, Djaballah, Hakim, Somwar, Romel, Varmus, Harold, Morin, Gregg B., Lockwood, William W.

“…Phenotype-based screening can identify small molecules that elicit a desired cellular response, but additional approaches are required to characterize their…”
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A simple method for analyzing actives in random RNAi screens: introducing the "H Score" for hit nomination & gene prioritization by Bhinder, Bhavneet, Djaballah, Hakim

“…Due to the numerous challenges in hit identification from random RNAi screening, we have examined current practices with a discovery of a variety of…”
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Combining integrated genomics and functional genomics to dissect the biology of a cancer-associated, aberrant transcription factor, the ASPSCR1-TFE3 fusion oncoprotein by Kobos, Rachel, Nagai, Makoto, Tsuda, Masumi, Merl, Man Yee, Saito, Tsuyoshi, Laé, Marick, Mo, Qianxing, Olshen, Adam, Lianoglou, Steven, Leslie, Christina, Ostrovnaya, Irina, Antczak, Christophe, Djaballah, Hakim, Ladanyi, Marc

“…Oncogenic rearrangements of the TFE3 transcription factor gene are found in two distinct human cancers. These include ASPSCR1–TFE3 in all cases of alveolar…”
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Death induced by CD95 or CD95 ligand elimination by Hadji, Abbas, Ceppi, Paolo, Murmann, Andrea E, Brockway, Sonia, Pattanayak, Abhinandan, Bhinder, Bhavneet, Hau, Annika, De Chant, Shirley, Parimi, Vamsi, Kolesza, Piotre, Richards, Joanne, Chandel, Navdeep, Djaballah, Hakim, Peter, Marcus E

“…CD95 (Fas/APO-1), when bound by its cognate ligand CD95L, induces cells to die by apoptosis. We now show that elimination of CD95 or CD95L results in a form of…”
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Proteasome Addiction Defined in Ewing Sarcoma Is Effectively Targeted by a Novel Class of 19S Proteasome Inhibitors by Shukla, Neerav, Somwar, Romel, Smith, Roger S, Ambati, Sri, Munoz, Stanley, Merchant, Melinda, D'Arcy, Padraig, Wang, Xin, Kobos, Rachel, Antczak, Christophe, Bhinder, Bhavneet, Shum, David, Radu, Constantin, Yang, Guangbin, Taylor, Barry S, Ng, Charlotte K Y, Weigelt, Britta, Khodos, Inna, de Stanchina, Elisa, Reis-Filho, Jorge S, Ouerfelli, Ouathek, Linder, Stig, Djaballah, Hakim, Ladanyi, Marc

“…Ewing sarcoma is a primitive round cell sarcoma with a peak incidence in adolescence that is driven by a chimeric oncogene created from the fusion of the EWSR1…”
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Modulation of γ-secretase specificity using small molecule allosteric inhibitors by Shelton, Christopher C, Zhu, Lei, Chau, Deming, Yang, Li, Wang, Rong, Djaballah, Hakim, Zheng, Hui, Li, Yue-Ming

“…γ-Secretase cleaves multiple substrates within the transmembrane domain that include the amyloid precursor protein as well as the Notch family of receptors…”
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Nanomolar Inhibitors of Trypanosoma brucei RNA Triphosphatase by Smith, Paul, Ho, C Kiong, Takagi, Yuko, Djaballah, Hakim, Shuman, Stewart

“…Eukaryal taxa differ with respect to the structure and mechanism of the RNA triphosphatase (RTPase) component of the mRNA capping apparatus. Protozoa, fungi,…”
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A 1536-well fluorescence polarization assay to screen for modulators of the MUSASHI family of RNA-binding proteins by Minuesa, Gerard, Antczak, Christophe, Shum, David, Radu, Constantin, Bhinder, Bhavneet, Li, Yueming, Djaballah, Hakim, Kharas, Michael G

“…RNA-binding proteins (RBPs) can act as stem cell modulators and oncogenic drivers, but have been largely ignored by the pharmaceutical industry as potential…”
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Discovery of a dicer-independent, cell-type dependent alternate targeting sequence generator: implications in gene silencing & pooled RNAi screens by Bhinder, Bhavneet, Shum, David, Li, Mu, Ibáñez, Glorymar, Vlassov, Alexander V, Magdaleno, Susan, Djaballah, Hakim

“…There is an acceptance that plasmid-based delivery of interfering RNA always generates the intended targeting sequences in cells, making it as specific as its…”
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Identification of Novel Antipoxviral Agents: Mitoxantrone Inhibits Vaccinia Virus Replication by Blocking Virion Assembly by LIANG DENG, PEIHONG DAI, CIRO, Anthony, SMEE, Donald F, DJABALLAH, Hakim, SHUMAN, Stewart

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Flaviviruses Are Sensitive to Inhibition of Thymidine Synthesis Pathways by Fischer, Matthew A, Smith, Jessica L, Shum, David, Stein, David A, Parkins, Christopher, Bhinder, Bhavneet, Radu, Constantin, Hirsch, Alec J, Djaballah, Hakim, Nelson, Jay A, Früh, Klaus

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Comparative analysis of RNAi screening technologies at genome-scale reveals an inherent processing inefficiency of the plasmid-based shRNA hairpin by Bhinder, Bhavneet, Shum, David, Djaballah, Hakim

“…RNAi screening in combination with the genome-sequencing projects would constitute the Holy Grail of modern genetics; enabling discovery and validation towards…”
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Modulators of the microRNA biogenesis pathway via arrayed lentiviral enabled RNAi screening for drug and biomarker discovery by Shum, David, Bhinder, Bhavneet, Djaballah, Hakim

“…MicroRNAs (miRNAs) are small endogenous and conserved non-coding RNA molecules that regulate gene expression. Although the first miRNA was discovered well over…”
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A synergetic screening approach with companion effector for combination therapy: application to retinoblastoma by Mahida, Jeni P, Antczak, Christophe, Decarlo, Daniel, Champ, Kathryn G, Francis, Jasmine H, Marr, Brian, Polans, Arthur S, Albert, Daniel M, Abramson, David H, Djaballah, Hakim

“…For many cancers, the lack of potency and the toxicity of current drugs limits the dose achievable in patients and the efficacy of treatment. Among them,…”
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A high-content biosensor-based screen identifies cell-permeable activators and inhibitors of EGFR function: implications in drug discovery by Antczak, Christophe, Mahida, Jeni P, Bhinder, Bhavneet, Calder, Paul A, Djaballah, Hakim

“…Early success of kinase inhibitors has validated their use as drugs. However, discovery efforts have also suffered from high attrition rates due to lack of…”
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A high content assay to assess cellular fitness by Antczak, Christophe, Mahida, Jeni P, Singh, Chanpreet, Calder, Paul A, Djaballah, Hakim

“…A universal process in experimental biology is the use of engineered cells; more often, stably or transiently transfected cells are generated for the purpose…”
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