Search Results - "DIXON, J"

Ferroptosis: bug or feature? by Dixon, Scott J.

“…Summary Ferroptosis is an iron‐dependent, oxidative form of non‐apoptotic cell death. This form of cell death does not share morphological, biochemical, or…”
Get full text

GPX4 at the Crossroads of Lipid Homeostasis and Ferroptosis by Forcina, Giovanni C., Dixon, Scott J.

“…Oxygen is necessary for aerobic metabolism but can cause the harmful oxidation of lipids and other macromolecules. Oxidation of cholesterol and phospholipids…”
Get full text

The role of iron and reactive oxygen species in cell death by Dixon, Scott J, Stockwell, Brent R

“…Iron is essential for biological systems but can also damage or kill cells, leading to a variety of disease states. A review of mechanisms leading to Fe- and…”
Get full text

The principle of maximal transcendentality and the four-loop collinear anomalous dimension by Dixon, Lance J.

“…A bstract We use the principle of maximal transcendentality and the universal nature of subleading infrared poles to extract the analytic value of the…”
Get full text

Pathophysiology of Traumatic Brain Injury by Dixon, Kirsty J., PhD

“…Traumatic brain injury (TBI) has become the signature injury of the military conflict in Iraq and Afghanistan and also has a high rate of occurrence in…”
Get full text

Endocrine resistance in breast cancer – An overview and update by Clarke, Robert, Tyson, John J., Dixon, J. Michael

“…Tumors that express detectable levels of the product of the ESR1 gene (estrogen receptor-α; ERα) represent the single largest molecular subtype of breast…”
Get full text

The Hallmarks of Ferroptosis by Dixon, Scott J, Stockwell, Brent R

“…Ferroptosis is a nonapoptotic, iron-dependent form of cell death that can be activated in cancer cells by natural stimuli and synthetic agents. Three essential…”
Get full text

Understanding the role of cysteine in ferroptosis: progress & paradoxes by Poltorack, Carson D., Dixon, Scott J.

“…Cysteine is a conditionally essential amino acid required for the synthesis of proteins and many important intracellular metabolites. Cysteine depletion can…”
Get full text

Microplastics: An introduction to environmental transport processes by Horton, Alice A., Dixon, Simon J.

“…Microplastic pollution is widespread across the globe, pervading land, water, and air. These environments are commonly considered independently, however, in…”
Get full text

Breast-conserving surgery with or without irradiation in women aged 65 years or older with early breast cancer (PRIME II): a randomised controlled trial by Kunkler, Ian H, Prof, Williams, Linda J, PhD, Jack, Wilma J L, MBChB, Cameron, David A, Prof, Dixon, J Michael, Prof

“…Summary Background For most older women with early breast cancer, standard treatment after breast-conserving surgery is adjuvant whole-breast radiotherapy and…”
Get full text

Bariatric surgery: an IDF statement for obese Type 2 diabetes by Dixon, J. B., Zimmet, P., Alberti, K. G., Rubino, F.

“…Diabet. Med. 28, 628–642 (2011) The International Diabetes Federation Taskforce on Epidemiology and Prevention of Diabetes convened a consensus working group…”
Get full text

Dietary Lipids Induce Ferroptosis in Caenorhabditiselegans and Human Cancer Cells by Perez, Marcos A., Magtanong, Leslie, Dixon, Scott J., Watts, Jennifer L.

“…Dietary lipids impact development, homeostasis, and disease, but links between specific dietary fats and cell fates are poorly understood. Ferroptosis is an…”
Get full text

Lymphatic lipid transport: sewer or subway? by Dixon, J. Brandon

“…The lymphatics began receiving attention in the scientific community as early as 1622, when Gasparo Aselli noted the appearance of milky-white vessels in the…”
Get full text

Ferroptosis occurs through an osmotic mechanism and propagates independently of cell rupture by Riegman, Michelle, Sagie, Liran, Galed, Chen, Levin, Tom, Steinberg, Noah, Dixon, Scott J., Wiesner, Ulrich, Bradbury, Michelle S., Niethammer, Philipp, Zaritsky, Assaf, Overholtzer, Michael

“…Ferroptosis is a regulated form of necrotic cell death that is caused by the accumulation of oxidized phospholipids, leading to membrane damage and cell lysis…”
Get full text

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis by Bersuker, Kirill, Hendricks, Joseph M., Li, Zhipeng, Magtanong, Leslie, Ford, Breanna, Tang, Peter H., Roberts, Melissa A., Tong, Bingqi, Maimone, Thomas J., Zoncu, Roberto, Bassik, Michael C., Nomura, Daniel K., Dixon, Scott J., Olzmann, James A.

“…Ferroptosis is a form of regulated cell death that is caused by the iron-dependent peroxidation of lipids 1 , 2 . The glutathione-dependent lipid…”
Get full text

Iridium-catalyzed reductive Ugi-type reactions of tertiary amides by Xie, Lan-Gui, Dixon, Darren J.

“…Amides are ubiquitous in the fine chemical, agrochemical and pharmaceutical industries, but are rarely exploited as substrates for homologous amine synthesis…”
Get full text

A three-point form factor through five loops by Dixon, Lance J., McLeod, Andrew J., Wilhelm, Matthias

“…A bstract We bootstrap the three-point form factor of the chiral part of the stress­tensor supermultiplet in planar N = 4 super-Yang-Mills theory, obtaining…”
Get full text

The four-loop six-gluon NMHV ratio function by Dixon, Lance J., von Hippel, Matt, McLeod, Andrew J.

“…A bstract We use the hexagon function bootstrap to compute the ratio function which characterizes the next-to-maximally-helicity-violating (NMHV) six-point…”
Get full text

Prominin2 Drives Ferroptosis Resistance by Stimulating Iron Export by Brown, Caitlin W., Amante, John J., Chhoy, Peter, Elaimy, Ameer L., Liu, Haibo, Zhu, Lihua Julie, Baer, Christina E., Dixon, Scott J., Mercurio, Arthur M.

“…Ferroptosis, regulated cell death characterized by the iron-dependent accumulation of lethal lipid reactive oxygen species, contributes to tissue homeostasis…”
Get full text

Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis by Shimada, Kenichi, Skouta, Rachid, Kaplan, Anna, Yang, Wan Seok, Hayano, Miki, Dixon, Scott J, Brown, Lewis M, Valenzuela, Carlos A, Wolpaw, Adam J, Stockwell, Brent R

“…Editorial Summary Modulatory profiling of lethal small-molecule compounds identified FIN56 as an inducer of ferroptosis. FIN56 promotes the degradation of…”
Get full text