Perioperative High-dose Rate Brachytherapy Using a Bendy Applicator (Flab): Treatment Results of 74 Patients

Background: Radiotherapy plays a pivotal role in tumor treatment. Brachytherapy as an additional radiation technique allows local dose increments in areas at high risk of local failure. Patients and Methods: Our past 15-year experience with tissue-equivalent bendy applicator brachytherapy at the Uni...

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Bibliographic Details
Published in:	Anticancer research Vol. 28; no. 6B; pp. 3885 - 3890
Main Authors:	BÖPOLLING, Tobias, SCHÜLLER, Patrick, WILLICH, Normann, KÖNEMANN, Stefan, DISTELMAIER, Bernd, SCHUCK, Andreas, ERNST, Iris, GOSHEGER, Georg, WINKELMANN, Winfried, DIRKSEN, Uta, JÜRGENS, Heribert, KRONHOLZ, Hans-Lars
Format:	Journal Article
Language:	English
Published:	Attiki International Institute of Anticancer Research 01-11-2008
Subjects:	Adolescent Adult Aged Aged, 80 and over Biological and medical sciences Brachytherapy - adverse effects Brachytherapy - instrumentation Brachytherapy - methods Child Child, Preschool Combined Modality Therapy Dose-Response Relationship, Radiation Female Humans Male Medical sciences Middle Aged Perioperative Care Radiotherapy Dosage Retrospective Studies Sarcoma - radiotherapy Sarcoma - surgery Sarcoma, Ewing - radiotherapy Sarcoma, Ewing - surgery Soft Tissue Neoplasms - radiotherapy Soft Tissue Neoplasms - surgery Survival Rate Tumors Young Adult Human Sarcoma flab Malignant tumor Radiotherapy Dose rate perioperative Applicator Cancerology Treatment bendy applicator Curietherapy High dose Cancer HDR brachytherapy
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Summary:	Background: Radiotherapy plays a pivotal role in tumor treatment. Brachytherapy as an additional radiation technique allows local dose increments in areas at high risk of local failure. Patients and Methods: Our past 15-year experience with tissue-equivalent bendy applicator brachytherapy at the University Hospital MÃ¼nster, Germany was reviewed. A series of 74 consecutive patients who had mainly been treated for sarcomas with perioperative brachytherapy was analyzed with a focus on local relapse-free survival and side-effects. Results: The 5-year local control rate was 73% in primary treatment situations with a significant influence of additional external irradiation, surgical margin depth and tumor entity. Late sequelae of combined modality treatment were observed in 40 patients (54%) and mainly concerned wound healing (n=18, 24%). Conclusion: A high-risk collective, in view of local failure, showed adequate local control rates as well as acceptable late sequelae. Flab brachytherapy is a good treatment option to achieve local radiation dose increments in patients at high risk of local failure.
ISSN:	0250-7005 1791-7530