Search Results - "DIRKSEN, U"

Cell-to-cell heterogeneity of EWSR1-FLI1 activity determines proliferation/migration choices in Ewing sarcoma cells by Franzetti, G-A, Laud-Duval, K, van der Ent, W, Brisac, A, Irondelle, M, Aubert, S, Dirksen, U, Bouvier, C, de Pinieux, G, Snaar-Jagalska, E, Chavrier, P, Delattre, O

“…Ewing sarcoma is characterized by the expression of the chimeric EWSR1-FLI1 transcription factor. Proteomic analyses indicate that the decrease of EWSR1-FLI1…”
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Exploring long-term cancer survivors' care experiences and unmet needs: protocol for a qualitative study by Speckemeier, Christian, Maus, K, Bialobrzeski, A, Jaspers, B, Radbruch, L, Hahn, S, Wasem, J, Grünwald, V, Dirksen, U, Neumann, A

“…The number of cancer survivors has increased in recent decades, and the majority of them suffer from sequelae of their disease and treatment. This study, which…”
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Renal Ewing tumors by Zöllner, S., Dirksen, U., Jürgens, H., Ranft, A.

“…Renal Ewing's sarcoma/primitive neuroectodermal tumor (ES/PNET) is extremely rare. Clinical symptoms are nonspecific presenting abdominal pain, palpable mass,…”
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Easy-to-use clinical tool for survival estimation in Ewing sarcoma at diagnosis and after surgery by Bosma, S. E., Lancia, C., Rueten-Budde, A. J., Ranft, A., Gelderblom, H., Fiocco, M., van de Sande, M. A. J., Dijkstra, P. D. S., Dirksen, U.

“…Accurate survival estimations in Ewing sarcoma are necessary to develop risk- and response adaptive treatment strategies allowing for early decision-making. We…”
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Treatment-related fertility impairment in long-term female childhood, adolescent and young adult cancer survivors: investigating dose-effect relationships in a European case-control study (PanCareLIFE) by van den Berg, M H, van Dijk, M, Byrne, J, Berger, C, Dirksen, U, Winther, J F, Fossa, S D, Grabow, D, Grandage, V L, Haupt, R, van den Heuvel-Eibrink, M M, Kaiser, M, Kepak, T, van der Kooi, A L F, Kremer, L C M, Kruseova, J, Lambalk, C B, van Leeuwen, F E, Leiper, A, Modan-Moses, D, Spix, C, Twisk, J W R, Ronckers, C M, Kaatsch, P, van Dulmen-den Broeder, E

“…Which chemotherapeutic agents and body site-specific radiation fields are dose-dependently associated with an increased risk of fertility impairment in…”
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The ganglioside antigen G(D2) is surface-expressed in Ewing sarcoma and allows for MHC-independent immune targeting by Kailayangiri, S, Altvater, B, Meltzer, J, Pscherer, S, Luecke, A, Dierkes, C, Titze, U, Leuchte, K, Landmeier, S, Hotfilder, M, Dirksen, U, Hardes, J, Gosheger, G, Juergens, H, Rossig, C

“…Novel treatment strategies are needed to cure disseminated Ewing sarcoma. Primitive neuroectodermal features and a mesenchymal stem cell origin are both…”
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The CXCR4 antagonist Plerixafor (AMD3100) promotes Ewing sarcoma cell survival and migration in Ewing sarcoma cells in vitro by Dirksen, U, Berning, P, Schaefer, C, Potratz, J

“…An abstract of a study by Dirksen et al performing cell viability assays using Plerixafor, in combination with Dasatinib in A373, TC32, VH74, TC71, SKNMC Ewing…”
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Dynamics of fertility impairment and recovery after allogeneic haematopoietic stem cell transplantation in childhood and adolescence: results from a longitudinal study by Pfitzer, C., Orawa, H., Balcerek, M., Langer, T., Dirksen, U., Keslova, P., Zubarovskaya, N., Schuster, F. R., Jarisch, A., Strauss, G., Borgmann-Staudt, A.

“…Purpose Fertility impairment and recovery after haematopoietic stem cell transplantation (HSCT) have been reported in both sexes, but little is known about how…”
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Individual risk evaluation for local recurrence and distant metastasis in Ewing sarcoma: A multistate model: A multistate model for Ewing sarcoma by Bosma, S E, Rueten-Budde, A J, Lancia, C, Ranft, A, Dirksen, U, Krol, A D, Gelderblom, H, van de Sande, M A J, Dijkstra, P D S, Fiocco, M

“…We investigated the effects of surgical margins, histological response, and radiotherapy on local recurrence (LR), distant metastasis (DM), and survival in…”
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Identification of novel therapeutic targets in Ewing sarcoma using a pooled shRNA screening approach in a tumor cell-specific environment by Potratz, J, Schaefer, C, Clemens, D, Hotfilder, M, Dirksen, U

“…An abstract of a study by Dirksen et al aiming identification of novel therapeutic targets in Ewing sarcoma using a pooled shRNA screening approach in a tumor…”
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No difference in survival after HLA mismatched versus HLA matched allogeneic stem cell transplantation in Ewing sarcoma patients with advanced disease by Thiel, U., Schober, S. J., Ranft, A., Gassmann, H., Jabar, S., Gall, K., von Lüttichau, I., Wawer, A., Koscielniak, E., Diaz, M. A., Ussowicz, M., Kazantsev, I., Afanasyev, B., Merker, M., Klingebiel, T., Prete, A., Gruhn, B., Bader, P., Jürgens, H., Dirksen, U., Handgretinger, R., Burdach, S., Lang, P.

“…Patients with advanced Ewing sarcoma (AES) carry a poor prognosis. Retrospectively, we analyzed 66 AES patients treated with allogeneic stem cell…”
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Teenagers and young adults with cancer in Europe: from national programmes to a European integrated coordinated project by Stark, D., Bielack, S., Brugieres, L., Dirksen, U., Duarte, X., Dunn, S., Erdelyi, D.J., Grew, T., Hjorth, L., Jazbec, J., Kabickova, E., Konsoulova, A., Kowalczyk, J.R., Lassaletta, A., Laurence, V., Lewis, I., Monrabal, A., Morgan, S., Mountzios, G., Olsen, P.R., Renard, M., Saeter, G., van der Graaf, W.T., Ferrari, A.

“…Over 14 000 patients aged 15–24 are estimated to be diagnosed with cancer in the European Union (EU) each year. Teenagers and young adults (TYA) often fall…”
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Comprehensive assessments and related interventions to enhance the long-term outcomes of child, adolescent and young adult cancer survivors - presentation of the CARE for CAYA-Program study protocol and associated literature review by Salchow, J, Mann, J, Koch, B, von Grundherr, J, Jensen, W, Elmers, S, Straub, L A, Vettorazzi, E, Escherich, G, Rutkowski, S, Dwinger, S, Bergelt, C, Sokalska-Duhme, M, Bielack, S, Calaminus, G, Baust, K, Classen, C F, Rössig, C, Faber, J, Faller, H, Hilgendorf, I, Gebauer, J, Langer, T, Metzler, M, Schuster, S, Niemeyer, C, Puzik, A, Reinhardt, D, Dirksen, U, Sander, A, Köhler, M, Habermann, J K, Bokemeyer, C, Stein, A

“…Improved, multimodal treatment strategies have been shown to increase cure rates in cancer patients. Those who survive cancer as a child, adolescent or young…”
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Prevalence of the Hippo Effectors YAP1/TAZ in Tumors of Soft Tissue and Bone by Isfort, Ilka, Elges, Sandra, Cyra, Magdalene, Berthold, Ruth, Renner, Marcus, Mechtersheimer, Gunhild, Åman, Pierre, Larsson, Olle, Ratner, Nancy, Hafner, Susanne, Simmet, Thomas, Schliemann, Christoph, Rossig, Claudia, Dirksen, Uta, Grünewald, Inga, Wardelmann, Eva, Huss, Sebastian, Hartmann, Wolfgang, Trautmann, Marcel

“…Tumors of soft tissue and bone represent a heterogeneous group of neoplasias characterized by a wide variety of genetic aberrations. Albeit knowledge on…”
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Correction to: No difference in survival after HLA mismatched versus HLA matched allogeneic stem cell transplantation in Ewing sarcoma patients with advanced disease by Thiel, U., Schober, S. J., Ranft, A., Gassmann, H., Jabar, S., Gall, K., von Lüttichau, I., Wawer, A., Koscielniak, E., Diaz, M. A., Ussowicz, M., Kazantsev, I., Afanasyev, B., Merker, M., Klingebiel, T., Prete, A., Gruhn, B., Bader, P., Jürgens, H., Dirksen, U., Handgretinger, R., Burdach, S., Lang, P.

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1q gain and CDT2 overexpression underlie an aggressive and highly proliferative form of Ewing sarcoma by Mackintosh, C, Ordóñez, J L, García-Domínguez, D J, Sevillano, V, Llombart-Bosch, A, Szuhai, K, Scotlandi, K, Alberghini, M, Sciot, R, Sinnaeve, F, Hogendoorn, P C W, Picci, P, Knuutila, S, Dirksen, U, Debiec-Rychter, M, Schaefer, K-L, de Álava, E

“…Despite extensive characterization of the role of the EWS-ETS fusions, little is known about secondary genetic alterations and their clinical contribution to…”
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Management of Bone Tumours in Paediatric Oncology by Bölling, T, Hardes, J, Dirksen, U

“…Abstract The management of bone tumours in paediatric oncology requires careful multidisciplinary planning due to the need for multimodal therapy approaches…”
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Individual risk evaluation for local recurrence and distant metastasis in Ewing sarcoma: A multistate model by Bosma, S. E., Rueten‐Budde, A. J., Lancia, C., Ranft, A., Dirksen, U., Krol, A. D., Gelderblom, H., Sande, M. A. J., Dijkstra, P. D. S., Fiocco, M.

“…Background We investigated the effects of surgical margins, histological response, and radiotherapy on local recurrence (LR), distant metastasis (DM), and…”
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Effective childhood cancer treatment: The impact of large scale clinical trials in Germany and Austria by Rossig, C., Juergens, H., Schrappe, M., Moericke, A., Henze, G., von Stackelberg, A., Reinhardt, D., Burkhardt, B., Woessmann, W., Zimmermann, M., Gadner, H., Mann, G., Schellong, G., Mauz-Koerholz, C., Dirksen, U., Bielack, S., Berthold, F., Graf, N., Rutkowski, S., Calaminus, G., Kaatsch, P., Creutzig, U.

“…In Germany and Austria, more than 90% of pediatric cancer patients are enrolled into nationwide disease‐specific first‐line clinical trials or interim…”
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Pelvic reconstruction with compound osteosynthesis following hemipelvectomy: A clinical study by Gebert, C, Wessling, M, Gosheger, G, Aach, M, Streitbürger, A, Henrichs, M P, Dirksen, U, Hardes, J

“…To date, all surgical techniques used for reconstruction of the pelvic ring following supra-acetabular tumour resection produce high complication rates. We…”
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