Search Results - "DIOGENES, Maria J"

Challenges of BDNF-based therapies: From common to rare diseases by Miranda-Lourenço, Catarina, Ribeiro-Rodrigues, Leonor, Fonseca-Gomes, João, Tanqueiro, Sara R., Belo, Rita F., Ferreira, Catarina B., Rei, Nádia, Ferreira-Manso, Mafalda, de Almeida-Borlido, Carolina, Costa-Coelho, Tiago, Freitas, Céline Felicidade, Zavalko, Svitlana, Mouro, Francisco M., Sebastião, Ana M., Xapelli, Sara, Rodrigues, Tiago M., Diógenes, Maria J.

“…[Display omitted] Neurotrophins are a well-known family of neurotrophic factors that play an important role both in the central and peripheral nervous systems,…”
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Rare Diseases of Neurodevelopment: Maintain the Mystery or Use a Dazzling Tool for Investigation? The Case of Rett Syndrome by Ruffolo, Gabriele, Cifelli, Pierangelo, Miranda-Lourenço, Catarina, De Felice, Eleonora, Limatola, Cristina, Sebastião, Ana M., Diógenes, Maria J., Aronica, Eleonora, Palma, Eleonora

“…The investigation on neurotransmission function during normal and pathologic development is a pivotal component needed to understand the basic mechanisms…”
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Enhancement of LTP in Aged Rats is Dependent on Endogenous BDNF by DIOGENES, Maria J, COSTENLA, Ana R, LOPES, Luisa V, JERONIMO-SANTOS, Andre, SOUSA, Vasco C, FONTINHA, Bruno M, RIBEIRO, Joaquim A, SEBASTIAO, Ana M

“…Long-term potentiation (LTP), considered the neurophysiological basis for learning and memory, is facilitated by brain-derived neurotrophic factor (BDNF), an…”
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Neuritic growth impairment and cell death by unconjugated bilirubin is mediated by NO and glutamate, modulated by microglia, and prevented by glycoursodeoxycholic acid and interleukin-10 by Silva, Sandra L., Vaz, Ana R., Diógenes, Maria J., van Rooijen, Nico, Sebastião, Ana M., Fernandes, Adelaide, Silva, Rui F.M., Brites, Dora

“…Neuronal oxidative damage and cell death by unconjugated bilirubin (UCB) showed to be mediated by overstimulation of glutamate receptors and nitric oxide (NO)…”
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Purine nucleosides in neuroregeneration and neuroprotection by Ribeiro, Filipa F., Xapelli, Sara, Miranda-Lourenço, Catarina, Tanqueiro, Sara R., Fonseca-Gomes, João, Diógenes, Maria J., Ribeiro, Joaquim A., Sebastião, Ana M.

“…In the present review, we stress the importance of the purine nucleosides, adenosine and guanosine, in protecting the nervous system, both centrally and…”
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Sustained NMDA receptor hypofunction impairs brain-derived neurotropic factor signalling in the PFC, but not in the hippocampus, and disturbs PFC-dependent cognition in mice by Tanqueiro, Sara, Mouro, Francisco, Ferreira, Catarina B., Freitas, Céline, Fonseca-Gomes, João, Simões do Couto, Frederico, Sebastião, Ana M, Dawson, Neil, de Oliveira Diógenes Nogueira, Maria José

“…Copyright © 2021, © SAGE Publications Background: Cognitive deficits profoundly impact on the quality of life of patients with schizophrenia. Alterations in…”
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Adenosine inhibits human astrocyte proliferation independently of adenosine receptor activation by Marcelino, Helena, Nogueira, Vanda C., Santos, Cecília R.A., Quelhas, Patrícia, Carvalho, Tiago M.A., Fonseca‐Gomes, João, Tomás, Joana, Diógenes, Maria J., Sebastião, Ana M., Cascalheira, José F.

“…Brain adenosine concentrations can reach micromolar concentrations in stressful situations such as stroke, neurodegenerative diseases or hypoxic regions of…”
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Adenosine Kinase Deficiency in the Brain Results in Maladaptive Synaptic Plasticity by Sandau, Ursula S, Colino-Oliveira, Mariana, Jones, Abbie, Saleumvong, Bounmy, Coffman, Shayla Q, Liu, Long, Miranda-Lourenço, Catarina, Palminha, Cátia, Batalha, Vânia L, Xu, Yiming, Huo, Yuqing, Diógenes, Maria J, Sebastião, Ana M, Boison, Detlev

“…Adenosine kinase (ADK) deficiency in human patients (OMIM:614300) disrupts the methionine cycle and triggers hypermethioninemia, hepatic encephalopathy,…”
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Enhanced role of adenosine A(2A) receptors in the modulation of LTP in the rat hippocampus upon ageing by Costenla, Ana R, Diógenes, Maria J, Canas, Paula M, Rodrigues, Ricardo J, Nogueira, Célia, Maroco, João, Agostinho, Paula M, Ribeiro, Joaquim A, Cunha, Rodrigo A, de Mendonça, Alexandre

“…Adenosine neuromodulation depends on a balanced activation of inhibitory A₁ (A₁R) and facilitatory A(₂A) receptors (A(₂A) R). Both A₁ R and A(₂A) R modulate…”
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Inhibition of NMDA Receptors Prevents the Loss of BDNF Function Induced by Amyloid β by Tanqueiro, Sara R, Ramalho, Rita M, Rodrigues, Tiago M, Lopes, Luísa V, Sebastião, Ana M, Diógenes, Maria J

“…Brain-derived neurotrophic factor (BDNF) plays important functions in cell survival and differentiation, neuronal outgrowth and plasticity. In Alzheimer's…”
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Neural stem cells and cannabinoids in the spotlight as potential therapy for epilepsy by Lourenço, Diogo, Ribeiro Rodrigues, Leonor, Sebastião, Ana M, de Oliveira Diógenes Nogueira, Maria José, Xapelli, Sara

“…© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative…”
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Astrocytes control hippocampal synaptic plasticity through the vesicular-dependent release of D-serine by Abreu, Daniela Sofia, Gomes, Joana I, Ribeiro, Filipa F, Diógenes, Maria J, Sebastião, Ana M, Vaz, Sandra H

“…Astrocytes, the most abundant glial cells in the central nervous system (CNS), sense synaptic activity and respond through the release of gliotransmitters, a…”
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Adenosinergic System and BDNF Signaling Changes as a Cross-Sectional Feature of RTT: Characterization of Mecp2 Heterozygous Mouse Females by Miranda-Lourenço, Catarina, Rosa, Jéssica, Rei, Nádia, Belo, Rita F, Lopes, Ana Luísa, Silva, Diogo, Vieira, Cátia, Magalhães-Cardoso, Teresa, Viais, Ricardo, Correia-de-Sá, Paulo, Sebastião, Ana M, Diógenes, Maria J

“…Rett Syndrome is an X-linked neurodevelopmental disorder (RTT; OMIM#312750) associated to mutations. MeCP2 dysfunction is seen as one cause for the…”
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Impaired TrkB receptor signaling contributes to memory impairment in APP/PS1 mice by Kemppainen, Susanna, Rantamäki, Tomi, Jerónimo-Santos, André, Lavasseur, Gregoire, Autio, Henri, Karpova, Nina, Kärkkäinen, Elisa, Stavén, Saara, Miranda, Hugo Vicente, Outeiro, Tiago F, Diógenes, Maria J, Laroche, Serge, Davis, Sabrina, Sebastião, Ana M, Castrén, Eero, Tanila, Heikki

“…Abstract Brain-derived neurotrophic factor (BDNF) plays an important role in neuronal plasticity, learning, and memory. Levels of BDNF and its main receptor…”
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Editorial: Glial and Neural Stem Cells as New Therapeutic Targets for Neurodegenerative Disorders by Xapelli, Sara, Diógenes, Maria J, Crunelli, Vincenzo, Fitzsimons, Carlos P, Vaz, Sandra H

“…[...]NSPC-based therapy is, to date, not yet a satisfactory strategy due to poor survival and differentiation levels, as well as reduced synaptic plasticity…”
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High-caloric diet Induces memory impairment and disrupts synaptic plasticity in aged rats by Paulo, Sara, Miranda Lourenço, Catarina, Belo, Rita, Rodrigues, Rui S, Fonseca-Gomes, João, Tanqueiro, Sara, Geraldes, Vera, rocha, isabel, Sebastião, Ana M, Xapelli, Sara, de Oliveira Diógenes Nogueira, Maria José

“…© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative…”
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Modulation of brain-derived neurotrophic factor (BDNF) actions in the nervous system by adenosine A(2A) receptors and the role of lipid rafts by Sebastião, Ana M, Assaife-Lopes, Natália, Diógenes, Maria J, Vaz, Sandra H, Ribeiro, Joaquim A

“…In this paper we review some novel aspects related to the way adenosine A(2A) receptors (A(2A)R) modulate the action of BDNF or its high-affinity receptors,…”
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TrkB-ICD fragment, originating from BDNF receptor cleavage, is translocated to cell nucleus and phosphorylates nuclear and axonal proteins by Fonseca-Gomes, João, Jerónimo-Santos, André, Lesnikova, Angelina, Casarotto, Plinio, Castrén, Eero, Sebastião, Ana M, de Oliveira Diógenes Nogueira, Maria José

“…Copyright © 2019 Fonseca-Gomes, Jerónimo-Santos, Lesnikova, Casarotto, Castrén, Sebastião and Diógenes. This is an open-access article distributed under the…”
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Enhanced role of adenosine A2A receptors in the modulation of LTP in the rat hippocampus upon ageing by Costenla, Ana R., Diógenes, Maria J., Canas, Paula M., Rodrigues, Ricardo J., Nogueira, Célia, Maroco, João, Agostinho, Paula M., Ribeiro, Joaquim A., Cunha, Rodrigo A., de Mendonça, Alexandre

“…© 2011 The Authors. European Journal of Neuroscience © 2011 Federation of European Neuroscience Societies and Blackwell Publishing Ltd Adenosine…”
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Modulation of brain-derived neurotrophic factor (BDNF) actions in the nervous system by adenosine A2A receptors and the role of lipid rafts by Sebastião, Ana M., Assaife-Lopes, Natália, Diógenes, Maria J., Vaz, Sandra H., Ribeiro, Joaquim A.

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