Search Results - "DINSDALE, D."

The autophagy-associated factors DRAM1 and p62 regulate cell migration and invasion in glioblastoma stem cells by Galavotti, S, Bartesaghi, S, Faccenda, D, Shaked-Rabi, M, Sanzone, S, McEvoy, A, Dinsdale, D, Condorelli, F, Brandner, S, Campanella, M, Grose, R, Jones, C, Salomoni, P

“…The aggressiveness of glioblastoma multiforme (GBM) is defined by local invasion and resistance to therapy. Within established GBM, a subpopulation of…”
Get full text

Metabolic reprogramming during neuronal differentiation by Agostini, M, Romeo, F, Inoue, S, Niklison-Chirou, M V, Elia, A J, Dinsdale, D, Morone, N, Knight, R A, Mak, T W, Melino, G

“…Newly generated neurons pass through a series of well-defined developmental stages, which allow them to integrate into existing neuronal circuits. After exit…”
Get full text

Bcl-2 inhibitors: small molecules with a big impact on cancer therapy by Vogler, M, Dinsdale, D, Dyer, M J S, Cohen, G M

“…Despite tremendous advances over the last 15 years in understanding fundamental mechanisms of apoptosis, this has failed to translate into improved cancer…”
Get full text

Evaluation and critical assessment of putative MCL-1 inhibitors by Varadarajan, S, Vogler, M, Butterworth, M, Dinsdale, D, Walensky, L D, Cohen, G M

“…High levels of BCL-2 family proteins are implicated in a failed/ineffective apoptotic programme, often resulting in diseases, including cancer. Owing to their…”
Get full text

Switching from aerobic glycolysis to oxidative phosphorylation modulates the sensitivity of mantle cell lymphoma cells to TRAIL by Robinson, G L, Dinsdale, D, MacFarlane, M, Cain, K

“…TRAIL (TNF (tumour necrosis factor)-related apoptosis-inducing ligand) a putative anti-cancer cytokine induces apoptosis through DISC (death-inducing…”
Get full text

Metabolic effects of TiO2 nanoparticles, a common component of sunscreens and cosmetics, on human keratinocytes by Tucci, P, Porta, G, Agostini, M, Dinsdale, D, Iavicoli, I, Cain, K, Finazzi-Agró, A, Melino, G, Willis, A

“…The long-term health risks of nanoparticles remain poorly understood, which is a serious concern given their prevalence in the environment from increased…”
Get full text

Genetic analysis of mitochondrial protein misfolding in Drosophila melanogaster by Pimenta de Castro, I, Costa, A C, Lam, D, Tufi, R, Fedele, V, Moisoi, N, Dinsdale, D, Deas, E, Loh, S H Y, Martins, L M

“…Protein misfolding has a key role in several neurological disorders including Parkinson's disease. Although a clear mechanism for such proteinopathic diseases…”
Get full text

Different forms of cell death induced by putative BCL2 inhibitors by Vogler, M, Weber, K, Dinsdale, D, Schmitz, I, Schulze-Osthoff, K, Dyer, M J S, Cohen, G M

“…Several inhibitors of BCL2 proteins have been identified that induce apoptosis in a variety of tumor cells, indicating their potential in cancer therapy. We…”
Get full text

Differential roles of p63 isoforms in epidermal development: selective genetic complementation in p63 null mice by Candi, E, Rufini, A, Terrinoni, A, Dinsdale, D, Ranalli, M, Paradisi, A, De Laurenzi, V, Spagnoli, L G, Catani, M V, Ramadan, S, Knight, R A, Melino, G

“…Epidermal development requires the transcription factor p63, as p63-/- mice are born dead, without skin. The gene expresses two proteins, one with an…”
Get full text

Molecular profiling reveals primary mesothelioma cell lines recapitulate human disease by Chernova, T, Sun, X M, Powley, I R, Galavotti, S, Grosso, S, Murphy, F A, Miles, G J, Cresswell, L, Antonov, A V, Bennett, J, Nakas, A, Dinsdale, D, Cain, K, Bushell, M, Willis, A E, MacFarlane, M

“…Malignant mesothelioma (MM) is an aggressive, fatal tumor strongly associated with asbestos exposure. There is an urgent need to improve MM patient outcomes…”
Get full text

Lung exposure to nanoparticles modulates an asthmatic response in a mouse model by HUSSAIN, S, VANOIRBEEK, J. A. J, NEMERY, B, HOET, P. H. M, LUYTS, K, DE VOOGHT, V, VERBEKEN, E, THOMASSEN, L. C. J, MARTENS, J. A, DINSDALE, D, BOLAND, S, MARANO, F

“…The aim of this study was to investigate the modulation of an asthmatic response by titanium dioxide (TiO₂) or gold (Au) nanoparticles (NPs) in a murine model…”
Get full text

Passage of inhaled particles into the blood circulation in humans by NEMMAR, A, HOET, P. H. M, VANQUICKENBORNE, B, DINSDALE, D, THOMEER, M, HOYLAERTS, M. F, VANBILLOEN, H, MORTELMANS, L, NEMERY, B

“…Pollution by particulates has been consistently associated with increased cardiovascular morbidity and mortality. However, the mechanisms responsible for these…”
Get full text

A novel cellular stress response characterised by a rapid reorganisation of membranes of the endoplasmic reticulum by Varadarajan, S, Bampton, E T W, Smalley, J L, Tanaka, K, Caves, R E, Butterworth, M, Wei, J, Pellecchia, M, Mitcheson, J, Gant, T W, Dinsdale, D, Cohen, G M

“…Canonical endoplasmic reticulum (ER) stress, which occurs in many physiological and disease processes, results in activation of the unfolded protein response…”
Get full text

Enhanced peripheral thrombogenicity after lung inflammation is mediated by platelet–leukocyte activation: role of P‐selectin by NEMMAR, A., HOET, P. H. M., VANDERVOORT, P., DINSDALE, D., NEMERY, B., HOYLAERTS, M. F.

“…Background: Inhaled ultrafine particles trigger peripheral thrombotic complications. Methods: We have analyzed the systemic prothrombotic risk following lung…”
Get full text

Alteration of the nuclear pore complex in Ca2+-mediated cell death by Bano, D, Dinsdale, D, Cabrera-Socorro, A, Maida, S, Lambacher, N, Mccoll, B, Ferrando-May, E, Hengartner, M O, Nicotera, P

“…Cell death requires coordinated intracellular signalling before disassembly of cell architecture by degradative enzymes. Although the death signalling cascades…”
Get full text

A novel paradigm for rapid ABT-737-induced apoptosis involving outer mitochondrial membrane rupture in primary leukemia and lymphoma cells by Vogler, M, Dinsdale, D, Sun, X-M, Young, K W, Butterworth, M, Nicotera, P, Dyer, M J S, Cohen, G M

“…Primary chronic lymphocytic leukemia (CLL) cells are exquisitely sensitive to ABT-737, a small molecule BCL2-antagonist, which induces many of the classical…”
Get full text

Role of NOXA and its ubiquitination in proteasome inhibitor-induced apoptosis in chronic lymphocytic leukemia cells by BAOU, Maria, KOHLHAAS, Susan L, BUTTERWORTH, Michael, VOGLER, Meike, DINSDALE, David, WALEWSKA, Renata, MAJID, Aneela, ELDERING, Eric, DYER, Martin J. S, COHEN, Gerald M

“…Bortezomib has been successfully used in the treatment of multiple myeloma and has been proposed as a potential treatment for chronic lymphocytic leukemia. In…”
Get full text

Drosophila ref(2)P is required for the parkin-mediated suppression of mitochondrial dysfunction in pink1 mutants by de Castro, I P, Costa, A C, Celardo, I, Tufi, R, Dinsdale, D, Loh, S H Y, Martins, L M

“…Autophagy is a critical regulator of organellar homeostasis, particularly of mitochondria. Upon the loss of membrane potential, dysfunctional mitochondria are…”
Get full text

Alteration of the nuclear pore complex in Ca -mediated cell death by Bano, D, Dinsdale, D, Cabrera-Socorro, A, Maida, S, Lambacher, N, McColl, B, Ferrando-May, E, Hengartner, M O, Nicotera, P

“…Cell death requires coordinated intracellular signalling before disassembly of cell architecture by degradative enzymes. Although the death signalling cascades…”
Get full text

FLASH Is an Essential Component of Cajal Bodies by Barcaroli, D., Dinsdale, D., Neale, M. H., Bongiorno-Borbone, L., Ranalli, M., Munarriz, E., Sayan, A. E., McWilliam, J. M., Smith, T. M., Fava, E., Knight, R. A., Melino, G., De Laurenzi, V.

“…Cajal bodies are small nuclear organelles with a number of nuclear functions. Here we show that FLICE-associated huge protein (FLASH), originally described as…”
Get full text