Search Results - "DINKELBORG, LUDGER M"

Specific PET Imaging of xC― Transporter Activity Using a 18F-Labeled Glutamate Derivative Reveals a Dominant Pathway in Tumor Metabolism by KOGLIN, Norman, MUELLER, Andre, BERNDT, Mathias, SCHMITT-WILLICH, Heribert, TOSCHI, Luisella, STEPHENS, Andrew W, GEKELER, Volker, FRIEBE, Matthias, DINKELBORG, Ludger M

“…(18)F-labeled small molecules targeting adaptations of tumor metabolism possess the potential for early tumor detection with high sensitivity and specificity…”
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Pilot Preclinical and Clinical Evaluation of (4S)-4-(3-[18F]Fluoropropyl)-L-Glutamate (18F-FSPG) for PET/CT Imaging of Intracranial Malignancies by Mittra, Erik S, Koglin, Norman, Mosci, Camila, Kumar, Meena, Hoehne, Aileen, Keu, Khun Visith, Iagaru, Andrei H, Mueller, Andre, Berndt, Mathias, Bullich, Santiago, Friebe, Matthias, Schmitt-Willich, Heribert, Gekeler, Volker, Fels, Lüder M, Bacher-Stier, Claudia, Moon, Dae Hyuk, Chin, Frederick T, Stephens, Andrew W, Dinkelborg, Ludger M, Gambhir, Sanjiv S

“…(S)-4-(3-[18F]Fluoropropyl)-L-glutamic acid (18F-FSPG) is a novel radiopharmaceutical for Positron Emission Tomography (PET) imaging. It is a glutamate…”
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18F-Radiolabeling of Aromatic Compounds Using Triarylsulfonium Salts by Mu, Linjing, Fischer, Cindy R., Holland, Jason P., Becaud, Jessica, Schubiger, P. August, Schibli, Roger, Ametamey, Simon M., Graham, Keith, Stellfeld, Timo, Dinkelborg, Ludger M., Lehmann, Lutz

“…A new method for the 18F‐radiolabeling of aromatic compounds based on the aromatic nucleophilic substitution (SNAr) reaction using triarylsulfonium salts has…”
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Gene expression levels of matrix metalloproteinases in human atherosclerotic plaques and evaluation of radiolabeled inhibitors as imaging agents for plaque vulnerability by Müller, Adrienne, Krämer, Stefanie D, Meletta, Romana, Beck, Katharina, Selivanova, Svetlana V, Rancic, Zoran, Kaufmann, Philipp A, Vos, Bernhard, Meding, Jörg, Stellfeld, Timo, Heinrich, Tobias K, Bauser, Marcus, Hütter, Joachim, Dinkelborg, Ludger M, Schibli, Roger, Ametamey, Simon M

“…Abstract Introduction Atherosclerotic plaque rupture is the primary cause for myocardial infarction and stroke. During plaque progression macrophages and mast…”
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Radioimmunotherapy of Solid Tumors by Targeting Extra Domain B Fibronectin: Identification of the Best-Suited Radioimmunoconjugate by BERNDORFF, Dietmar, BORKOWSKI, Sandra, SIEGER, Stephanie, ROTHER, Axel, FRIEBE, Matthias, VITI, Francesca, HILGER, Christoph S, CYR, John E, DINKELBORG, Ludger M

“…Purpose: The expression of extra domain B (ED-B) fibronectin is always associated with angiogenic processes and can be exclusively observed in tissues…”
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Molecular imaging in drug development by Gambhir, Sanjiv S, Willmann, Jürgen K, van Bruggen, Nicholas, Dinkelborg, Ludger M

“…Key Points Drug development is a costly, time-intensive and high-risk endeavour, with only two to three approvals for novel therapeutics in new drug classes…”
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Bispecific Antibody Pretargeting of Tumor Neovasculature for Improved Systemic Radiotherapy of Solid Tumors by MOOSMAYER, Dieter, BERNDORFF, Dietmar, DINKELBORG, Ludger M, CHANG, Chien-Hsing, SHARKEY, Robert M, ROTHER, Axel, BORKOWSKI, Sandra, ROSSI, Edmund A, MCBRIDE, William J, CARDILLO, Thomas M, GOLDENBERG, David M

“…Purpose: Extra domain B (ED-B) fibronectin is a specific tumor matrix marker for targeting angiogenesis in solid tumors. In this study, the radiotherapeutic…”
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Aβ imaging with 18F-florbetaben in prodromal Alzheimer's disease: a prospective outcome study by Ong, Kevin T, Villemagne, Victor L, Bahar-Fuchs, Alex, Lamb, Fiona, Langdon, Narelle, Catafau, Ana M, Stephens, Andrew W, Seibyl, John, Dinkelborg, Ludger M, Reininger, Cornelia B, Putz, Barbara, Rohde, Beate, Masters, Colin L, Rowe, Christopher C

“…Background We assessed the clinical utility of β-amyloid (Aβ) imaging with 18F-florbetaben (FBB) in mild cognitive impairment (MCI) by evaluating its…”
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18 F-FSPG PET/CT Imaging of System x C - Transporter Activity in Patients with Primary and Metastatic Brain Tumors by Wardak, Mirwais, Sonni, Ida, Fan, Audrey P, Minamimoto, Ryogo, Jamali, Mehran, Hatami, Negin, Zaharchuk, Greg, Fischbein, Nancy, Nagpal, Seema, Li, Gordon, Koglin, Norman, Berndt, Mathias, Bullich, Santiago, Stephens, Andrew W, Dinkelborg, Ludger M, Abel, Ty, Manning, H Charles, Rosenberg, Jarrett, Chin, Frederick T, Gambhir, Sanjiv Sam, Mittra, Erik S

“…Background The PET tracer (4S)-4-(3-[ F]fluoropropyl)-l-glutamate ( F-FSPG) targets the system x cotransporter, which is overexpressed in various tumors…”
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18F-FSPG PET/CT Imaging of System xC- Transporter Activity in Patients with Primary and Metastatic Brain Tumors by Wardak, Mirwais, Sonni, Ida, Fan, Audrey P, Minamimoto, Ryogo, Jamali, Mehran, Hatami, Negin, Zaharchuk, Greg, Fischbein, Nancy, Nagpal, Seema, Li, Gordon, Koglin, Norman, Berndt, Mathias, Bullich, Santiago, Stephens, Andrew W, Dinkelborg, Ludger M, Abel, Ty, Manning, H Charles, Rosenberg, Jarrett, Chin, Frederick T, Gambhir, Sanjiv Sam, Mittra, Erik S

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Exploratory Clinical Trial of (4S)-4-(3-[18F]fluoropropyl)-L-glutamate for Imaging xC― Transporter Using Positron Emission Tomography in Patients with Non―Small Cell Lung or Breast Cancer by BAEK, Sora, CHOI, Chang-Min, HULTSCH, Christina, SCHATZ, Christoph A, DINKELBORG, Ludger M, MITTRA, Erik S, GAMBHIR, Sanjiv S, DAE HYUK MOON, SEI HYUN AHN, JONG WON LEE, GONG, Gyungyub, RYU, Jin-Sook, SEUNG JUN OH, BACHER-STIER, Claudia, FELS, Luder, KOGLIN, Norman

“…(4S)-4-(3-[(18)F]fluoropropyl)-l-glutamate (BAY 94-9392, alias [(18)F]FSPG) is a new tracer to image x(C)(-) transporter activity with positron emission…”
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Evaluation of Dosimetry, Quantitative Methods, and Test–Retest Variability of 18F-PI-2620 PET for the Assessment of Tau Deposits in the Human Brain by Bullich, Santiago, Barret, Olivier, Constantinescu, Cristian, Sandiego, Christine, Mueller, Andre, Berndt, Mathias, Papin, Caroline, Perrotin, Audrey, Koglin, Norman, Kroth, Heiko, Pfeifer, Andrea, Tamagnan, Gilles, Madonia, Jennifer, Seibyl, John P, Marek, Kenneth, De Santi, Susan, Dinkelborg, Ludger M, Stephens, Andrew W

“…18F-PI-2620 is a next-generation tau PET tracer that has demonstrated ability to image the spatial distribution of suspected tau pathology. The objective of…”
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Tau PET imaging with 18F-PI-2620 in Patients with Alzheimer Disease and Healthy Controls: A First-in-Humans Study by Mueller, Andre, Bullich, Santiago, Barret, Olivier, Madonia, Jennifer, Berndt, Mathias, Papin, Caroline, Perrotin, Audrey, Koglin, Norman, Kroth, Heiko, Pfeifer, Andrea, Tamagnan, Gilles, Seibyl, John P, Marek, Kenneth, De Santi, Susan, Dinkelborg, Ludger M, Stephens, Andrew W

“…18F-PI-2620 is a PET tracer with high binding affinity for aggregated tau, a key pathologic feature of Alzheimer disease (AD) and other neurodegenerative…”
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Tau PET imaging with 18 F-PI-2620 in Patients with Alzheimer Disease and Healthy Controls: A First-in-Humans Study by Mueller, Andre, Bullich, Santiago, Barret, Olivier, Madonia, Jennifer, Berndt, Mathias, Papin, Caroline, Perrotin, Audrey, Koglin, Norman, Kroth, Heiko, Pfeifer, Andrea, Tamagnan, Gilles, Seibyl, John P, Marek, Kenneth, De Santi, Susan, Dinkelborg, Ludger M, Stephens, Andrew W

“…F-PI-2620 is a PET tracer with high binding affinity for aggregated tau, a key pathologic feature of Alzheimer disease (AD) and other neurodegenerative…”
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Evaluation of Dosimetry, Quantitative Methods, and Test-Retest Variability of 18 F-PI-2620 PET for the Assessment of Tau Deposits in the Human Brain by Bullich, Santiago, Barret, Olivier, Constantinescu, Cristian, Sandiego, Christine, Mueller, Andre, Berndt, Mathias, Papin, Caroline, Perrotin, Audrey, Koglin, Norman, Kroth, Heiko, Pfeifer, Andrea, Tamagnan, Gilles, Madonia, Jennifer, Seibyl, John P, Marek, Kenneth, De Santi, Susan, Dinkelborg, Ludger M, Stephens, Andrew W

“…F-PI-2620 is a next-generation tau PET tracer that has demonstrated ability to image the spatial distribution of suspected tau pathology. The objective of this…”
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(S)-4-(3-18F-fluoropropyl)-L-glutamic acid: an 18F-labeled tumor-specific probe for PET/CT imaging--dosimetry by Smolarz, Kamilla, Krause, Bernd Joachim, Graner, Frank-Philipp, Wagner, Franziska Martina, Hultsch, Christina, Bacher-Stier, Claudia, Sparks, Richard B, Ramsay, Susan, Fels, Lüder M, Dinkelborg, Ludger M, Schwaiger, Markus

“…The glutamic acid derivative (S)-4-(3-(18)F-Fluoropropyl)-l-glutamic acid ((18)F-FSPG, alias BAY 94-9392), a new PET tracer for the detection of malignant…”
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Commentary to 18F-GP1, a Novel PET Tracer Designed for High-Sensitivity, Low-Background Detection of Thrombi: Imaging Activated Platelets in Clots—Are We Getting There? by Stephens, Andrew W., Koglin, Norman, Dinkelborg, Ludger M.

“…Thrombus formation can lead to heart attacks, stroke and pulmonary embolism, which are major causes of mortality. Current standard diagnostic imaging methods…”
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Commentary to 18 F-GP1, a Novel PET Tracer Designed for High-Sensitivity, Low-Background Detection of Thrombi: Imaging Activated Platelets in Clots-Are We Getting There? by Stephens, Andrew W, Koglin, Norman, Dinkelborg, Ludger M

“…Thrombus formation can lead to heart attacks, stroke and pulmonary embolism, which are major causes of mortality. Current standard diagnostic imaging methods…”
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Exploratory Clinical Investigation of (4S)-4-(3-18F-Fluoropropyl)-L-Glutamate PET of Inflammatory and Infectious Lesions by Chae, Sun Young, Choi, Chang-Min, Shim, Tae Sun, Park, Yangsoon, Park, Chan-Sik, Lee, Hyo Sang, Lee, Sang Ju, Oh, Seung Jun, Kim, Seog-Young, Baek, Sora, Koglin, Norman, Stephens, Andrew W, Dinkelborg, Ludger M, Moon, Dae Hyuk

“…We explored system [Formula: see text] transporter activity and the detection of inflammatory or infectious lesions using…”
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Preclinical evaluation of BAY 1075553, a novel (18)F-labelled inhibitor of prostate-specific membrane antigen for PET imaging of prostate cancer by Lesche, Ralf, Kettschau, Georg, Gromov, Alexey V, Böhnke, Niels, Borkowski, Sandra, Mönning, Ursula, Hegele-Hartung, Christa, Döhr, Olaf, Dinkelborg, Ludger M, Graham, Keith

“…Prostate-specific membrane antigen (PSMA) is a transmembrane protein overexpressed in prostate cancer and is therefore being explored as a biomarker for…”
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