Search Results - "DINCALCI, M"

Mechanism of action of trabectedin in desmoplastic small round cell tumor cells by Uboldi, S, Craparotta, I, Colella, G, Ronchetti, E, Beltrame, L, Vicario, S, Marchini, S, Panini, N, Dagrada, G, Bozzi, F, Pilotti, S, Galmarini, C M, D'Incalci, M, Gatta, R

“…Desmoplastic small round cell tumor (DSRCT) is a rare and highly aggressive disease, that can be described as a member of the family of small round blue cell…”
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Flow-cytometric measurement of histone H1o in human cells by Srebreva, L, Ubezio, P, Civoli, F, D'Incalci, M

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Apoptosis Biochemical events and relevance to cancer chemotherapy by Sen, Soumitra, D'Incalci, Maurizio

“…Two distinct pathways for cell death exist. Compared to necrotic death, physiological or apoptotic cell death is an active suicidal process that consists of a…”
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Sensitivity of CHO mutant cell lines with specific defects in nucleotide excision repair to different anti‐cancer agents by Damia, Giovanna, Imperatori, Luigi, Stefanini, Miria, D'Incalci, Maurizio

“…Nucleotide excision repair (NER) is one of the major DNA repair systems in mammalian cells, able to remove a broad spectrum of unrelated lesions. In this…”
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p53 status does not affect sensitivity of human ovarian cancer cell lines to paclitaxel by DEBERNARDIS, D, SIRE, E. G, DE FEUDIS, P, VIKHANSKAYA, F, VALENTI, M, RUSSO, P, PARODI, S, D'INCALCI, M, BROGGINI, M

“…Nine human ovarian cancer cell lines that express wild-type (wt) or mutated p53 were used to evaluate the cytotoxicity induced by paclitaxel. The IC50…”
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DNA sequence-specific adenine alkylation by the novel antitumor drug tallimustine (FCE 24517), a benzoyl nitrogen mustard derivative of distamycin by Broggini, Massimo, Coley, Helen M., Mongelli, Nicola, Pesenti, Enrico, Wyatt, Michael D., Hartley, John A., Dlncaici, Maurizio

“…FCE 24517, a novel distamycin derivative possessing potent antitumor activity, is under initial clinical investigation in Europe. In spite of the presence of a…”
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Multidrug resistance-reversing agents increase vinblastine distribution in normal tissues expressing the P-glycoprotein but do not enhance drug penetration in brain and testis by Arboix, M, Paz, O G, Colombo, T, D'Incalci, M

“…The aim of this study was to assess whether P-glycoprotein (Pgp) inhibitors altered the blood-brain barrier and enhanced vinblastine (VBL) distribution in…”
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Introduction of wild-type p53 in a human ovarian cancer cell line not expressing endogenous p53 by Vikhanskaya, Faina, Erba, Eugenio, D'lncalci, Maurizio, Broggini, Massimo

“…Utilizing a temperature sensitive p53 mutant (pLTRp53cGval135) which expresses mutant p53 at 37°C and a wild-type like p53 at 32°C, we transfected a human…”
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DNA-minor-groove alkylators, a new class of anticancer agents by D'Incalci, M

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Distribution and activity of doxorubicin combined with SDZ PSC 833 in mice with P388 and P388/DOX leukaemia by COLOMBO, T, GONZALEZ PAZ, O, D'INCALCI, M

“…SDZ PSC 833 (PSC 833) is a non-immunosuppressive analogue of cyclosporin A and is a potent modifier of P-glycoprotein (P-gp)-mediated multidrug resistance. The…”
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Distamycin A and tallimustine inhibit TBP binding and basal in vitro transcription by Bellorini, Marianna, Moncollin, Vincent, D'lncalci, Maurizio, Mongelli, Nicola, Mantovani, Roberto

“…The antibiotic distamycin A is a DNA minor groove binding drug (MGB) that recognizes a stretch of a least four ATs. The alkylating benzoyl mustard derivative…”
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Expression of Genes of Potential Importance in the Response to Chemotherapy and DNA Repair in Patients with Ovarian Cancer by Codegoni, A.M., Broggini, M., Pitelli, M.R., Pantarotto, M., Torri, V., Mangioni, C., D'Incalci, M.

“…The expression of different genes potentially involved in DNA repair and in cell responses to chemotherapy was evaluated in 33 previously untreated ovarian…”
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The unique biological features of the marine product Yondelis (ET-743, trabectedin) are shared by its analog ET-637, which lacks the C ring by Erba, E, Cavallaro, E, Damia, G, Mantovani, R, Di Silvio, A, Di Francesco, A M, Riccardi, R, Cuevas, C, Faircloth, G T, D'Incalci, M

“…It was previously suggested that the peculiar mechanism of action of the novel anticancer drug Yondelis (ET-743, trabectedin) was due to part of the molecule,…”
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Decreased cytotoxic effects of doxorubicin in a human ovarian cancer-cell line expressing wild-type p53 and WAF1/CIP1 genes by Vikhanskaya, F, D'Incalci, M, Broggini, M

“…The cytotoxicity of Doxorubicin and cis-dichloro-diammine-platinum (DDP) was evaluated in clones, obtained from a human ovarian cancer cell line transfected…”
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DDP-induced cytotoxicity is not influenced by p53 in nine human ovarian cancer cell lines with different p53 status by DE FEUDIS, P, DEBERNARDIS, D, BROGGINI, M, BECCAGLIA, P, VALENTI, M, SIRE, E. G, ARZANI, D, STANZIONE, S, PARODI, S, D'INCALCI, M, RUSSO, P

“…Nine human ovarian cancer cell lines that express wild-type (wt) or mutated (mut) p53 were used to evaluate the cytotoxicity induced by cisplatin (DDP). The…”
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Selective DNA interaction of the novel distamycin derivative FCE 24517 by BROGGINI, M, ERBA, E, PONTI, M, BALLINARI, D, GERONI, C, SPREAFICO, F, D'INCALCI, M

“…N-Deformyl-N-(4-N-N,N-bis(2-chloroethylamino)benzoyl)distamy cin A (FCE 24517) is a novel cytotoxic and antitumor agent shortly to be investigated in phase I…”
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Measurement of the sequence specificity of covalent DNA modification by antineoplastic agents using Taq DNA polymerase by PONTI, M, FORROW, S. M, SOUHAMI, R. L, D'INCALCI, M, HARTLEY, J. A

“…A polymerase stop assay has been developed to determine the DNA nucleotide sequence specificity of covalent modification by antineoplastic agents using the…”
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Clinical pharmacokinetics of altretamine by DAMIA, G, D'INCALI, M

“…Altretamine (hexamethylmelamine) is an antitumour drug with demonstrated antitumour activity in refractory ovarian cancer. Due to its poor water solubility,…”
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Cell signaling and cancer treatment by Corda, D., D'Incalci, M.

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Distamycins inhibit the binding of OTF-1 and NFE-1 transfactors to their conserved DNA elements by Broggini, M, Ponti, M, Ottolenghi, S, D'Incalci, M, Mongelli, N, Mantovani, R

“…We investigated the effects of the antiviral agent distamycin A and of a distamycin derivative (FCE 24517) which possesses antineoplastic activity on the…”
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