Search Results - "DIMRI, Manjari"

A Positive Feedback Loop Regulates the Expression of Polycomb Group Protein BMI1 via WNT Signaling Pathway by Cho, Joon-Ho, Dimri, Manjari, Dimri, Goberdhan P.

“…Polycomb group protein BMI1 plays an important role in cellular homeostasis by maintaining a balance between proliferation and senescence. It is often…”
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A miR-200c/141-BMI1 autoregulatory loop regulates oncogenic activity of BMI1 in cancer cells by Dimri, Manjari, Kang, Mingu, Dimri, Goberdhan P

“…MicroRNAs (miRNAs) are known to function as oncomiRs or tumor suppressors and are important noncoding RNA regulators of oncogenesis. The miR-200c/141 locus on…”
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Oxidative stress, cellular senescence and ageing by Pole, Akshaj, Dimri, Manjari, P. Dimri, Goberdhan

“…Almost a half century ago, the free radical theory of ageing proposed that the reactive oxygen species (ROS) is a key component which contributes to the…”
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Dietary omega-3 polyunsaturated fatty acids suppress expression of EZH2 in breast cancer cells by Dimri, Manjari, Bommi, Prashant V., Sahasrabuddhe, Anagh A., Khandekar, Janardan D., Dimri, Goberdhan P.

“…The polycomb group (PcG) protein, enhancer of zeste homologue 2 (EZH2), is overexpressed in several human malignancies including breast cancer. Aberrant…”
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Insights into the HIV Latency and the Role of Cytokines by Hokello, Joseph, Sharma, Adhikarimayum Lakhikumar, Dimri, Manjari, Tyagi, Mudit

“…Human immunodeficiency virus-1 (HIV-1) has the ability to infect latently at the level of individual CD4+ cells. Latent HIV-1 proviruses are transcriptionally…”
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A comprehensive, multi-scale dynamical model of ErbB receptor signal transduction in human mammary epithelial cells by Helikar, Tomáš, Kochi, Naomi, Kowal, Bryan, Dimri, Manjari, Naramura, Mayumi, Raja, Srikumar M, Band, Vimla, Band, Hamid, Rogers, Jim A

“…The non-receptor tyrosine kinase Src and receptor tyrosine kinase epidermal growth factor receptor (EGFR/ErbB1) have been established as collaborators in…”
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The polycomb group protein BMI1 is a transcriptional target of HDAC inhibitors by Bommi, Prashant V., Dimri, Manjari, Sahasrabuddhe, Anagh A., Khandekar, Janardan, Dimri, Goberdhan P.

“…Polycomb group (PcG) proteins are overexpressed in several human malignancies including breast cancer.  In particular, aberrant expression of BMI1 and EZH2 has…”
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βTrCP regulates BMI1 protein turnover via ubiquitination and degradation by Sahasrabuddhe, Anagh A., Dimri, Manjari, Bommi, Prashant V., Dimri, Goberdhan P.

“…The polycomb group protein BMI1 has been linked to proliferation, senescence, cancer progression and stem cell phenotype. At present, very little is known…”
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Endosomal-sorting complexes required for transport (ESCRT) pathway-dependent endosomal traffic regulates the localization of active Src at focal adhesions by Tu, Chun, Ortega-Cava, Cesar F., Winograd, Paul, Stanton, Marissa Jo, Reddi, Alagarsamy Lakku, Dodge, Ingrid, Arya, Ranjana, Dimri, Manjari, Clubb, Robert J., Naramura, Mayumi, Wagner, Kay-Uwe, Band, Vimla, Band, Hamid

“…Active Src localization at focal adhesions (FAs) is essential for cell migration. How this pool is linked mechanistically to the large pool of Src at late…”
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A combination of Trastuzumab and 17-AAG induces enhanced ubiquitinylation and lysosomal pathway-dependent ErbB2 degradation and cytotoxicity in ErbB2-overexpressing breast cancer cells by Raja, Srikumar M., Clubb, Robert J., Bhattacharyya, Mitra, Dimri, Manjari, Cheng, Hao, Pan, Wei, Ortega-Cava, Cesar, Lakku-Reddi, Alagarsamy, Naramura, Mayumi, Band, Vimla, Band, Hamid

“…ErbB2 (or Her2/Neu) overexpression in breast cancer signifies poorer prognosis, yet it has provided an avenue for targeted therapy as demonstrated by the…”
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Deletion analysis of BMI1 oncoprotein identifies its negative regulatory domain by Yadav, Ajay K, Sahasrabuddhe, Anagh A, Dimri, Manjari, Bommi, Prashant V, Sainger, Rachana, Dimri, Goberdhan P

“…The polycomb group (PcG) protein BMI1 is an important regulator of development. Additionally, aberrant expression of BMI1 has been linked to cancer stem cell…”
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Negative Regulation of EGFR-Vav2 Signaling Axis by Cbl Ubiquitin Ligase Controls EGF Receptor-mediated Epithelial Cell Adherens Junction Dynamics and Cell Migration by Duan, Lei, Raja, Srikumar M., Chen, Gengsheng, Virmani, Sumeet, Williams, Stetson H., Clubb, Robert J., Mukhopadhyay, Chandrani, Rainey, Mark A., Ying, Guoguang, Dimri, Manjari, Chen, Jing, Reddi, Alagarsamy L., Naramura, Mayumi, Band, Vimla, Band, Hamid

“…The E3 ubiquitin ligase Casitas B lymphoma protein (Cbl) controls the ubiquitin-dependent degradation of EGF receptor (EGFR), but its role in regulating…”
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Cbl-mediated Ubiquitinylation Is Required for Lysosomal Sorting of Epidermal Growth Factor Receptor but Is Dispensable for Endocytosis by Duan, Lei, Miura, Yuko, Dimri, Manjari, Majumder, Biswanath, Dodge, Ingrid L., Reddi, Alagarsamy L., Ghosh, Amiya, Fernandes, Norvin, Zhou, Pengcheng, Mullane-Robinson, Karen, Rao, Navin, Donoghue, Stephen, Rogers, Rick A., Bowtell, David, Naramura, Mayumi, Gu, Hua, Band, Vimla, Band, Hamid

“…Ligand-induced down-regulation controls the signaling potency of the epidermal growth factor receptor (EGFR/ErbB1). Overexpression studies have identified…”
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An Essential Role of Human Ada3 in p53 Acetylation by Nag, Alo, Germaniuk-Kurowska, Aleksandra, Dimri, Manjari, Sassack, Michael A., Gurumurthy, Channabasavaiah Basavaraju, Gao, Qingshen, Dimri, Goberdhan, Band, Hamid, Band, Vimla

“…The p53 tumor suppressor protein functions as a critical component of genotoxic stress response by regulating the expression of effector gene products that…”
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Distinct Roles for Rho Versus Rac/Cdc42 GTPases Downstream of Vav2 in Regulating Mammary Epithelial Acinar Architecture by Duan, Lei, Chen, Gengsheng, Virmani, Sumeet, Ying, GuoGuang, Raja, Srikumar M., Chung, Byung Min, Rainey, Mark A., Dimri, Manjari, Ortega-Cava, Cesar F., Zhao, Xiangshan, Clubb, Robert J., Tu, Chun, Reddi, Alagarsamy L., Naramura, Mayumi, Band, Vimla, Band, Hamid

“…Non-malignant mammary epithelial cells (MECs) undergo acinar morphogenesis in three-dimensional Matrigel culture, a trait that is lost upon oncogenic…”
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MicroRNA-31 Is a Transcriptional Target of Histone Deacetylase Inhibitors and a Regulator of Cellular Senescence by Cho, Joon-Ho, Dimri, Manjari, Dimri, Goberdhan P.

“…MicroRNAs (miRNAs) have emerged as important regulators of tumorigenesis. Several miRNAs, which can function either as oncomiRs or tumor suppressive miRs are…”
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The original colorimetric method to detect cellular senescence by Dimri, Manjari, Dimri, Goberdhan P

“…Cellular senescence, whereby cells cease to proliferate, is known to contribute to the aging process and age-related pathologies. It is elicited either by…”
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Timosaponin A‐III inhibits oncogenic phenotype via regulation of PcG protein BMI1 in breast cancer cells by Gergely, Joseph E., Dorsey, Armond E., Dimri, Goberdhan P., Dimri, Manjari

“…Polycomb group (PcG) protein BMI1 is an important regulator of oncogenic phenotype and is often overexpressed in several human malignancies including breast…”
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PLK1 Inhibition Down-regulates Polycomb Group Protein BMI1 via Modulation of the miR-200c/141 Cluster by Dimri, Manjari, Cho, Joon-Ho, Kang, Mingu, Dimri, Goberdhan P.

“…The polycomb group protein BMI1 is an important regulator of cancer stem cell (CSC) phenotype and is often overexpressed in cancer cells. Its overexpression…”
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Abstract 1794: Cross-regulation of polycomb group protein BMI1 and WNT inhibitors by Cho, Joon-Ho, Dimri, Manjari, Dimri, Goberdhan P.

“…Abstract Polycomb group (PcG) proteins are evolutionarily conserved gene silencers, which determine cell fate decisions during development. These proteins are…”
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