Search Results - "DIMARCHI, R"

Fibroblast growth factor 21 night watch: advances and uncertainties in the field by Kharitonenkov, A., DiMarchi, R.

“…Fibroblast growth factor (FGF) 21 belongs to a hormone‐like subgroup within the FGF superfamily. The members of this subfamily, FGF19, FGF21 and FGF23, are…”
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The New Biology and Pharmacology of Glucagon by Müller, T D, Finan, B, Clemmensen, C, DiMarchi, R D, Tschöp, M H

“…In the last two decades we have witnessed sizable progress in defining the role of gastrointestinal signals in the control of glucose and energy homeostasis…”
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Anti-Obesity Therapy: from Rainbow Pills to Polyagonists by Müller, T D, Clemmensen, C, Finan, B, DiMarchi, R D, Tschöp, M H

“…With their ever-growing prevalence, obesity and diabetes represent major health threats of our society. Based on estimations by the World Health Organization,…”
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Glucagon-like peptide 1 (GLP-1) by Müller, T.D., Finan, B., Bloom, S.R., D'Alessio, D., Drucker, D.J., Flatt, P.R., Fritsche, A., Gribble, F., Grill, H.J., Habener, J.F., Holst, J.J., Langhans, W., Meier, J.J., Nauck, M.A., Perez-Tilve, D., Pocai, A., Reimann, F., Sandoval, D.A., Schwartz, T.W., Seeley, R.J., Stemmer, K., Tang-Christensen, M., Woods, S.C., DiMarchi, R.D., Tschöp, M.H.

“…The glucagon-like peptide-1 (GLP-1) is a multifaceted hormone with broad pharmacological potential. Among the numerous metabolic effects of GLP-1 are the…”
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Peptide‐based multi‐agonists: a new paradigm in metabolic pharmacology by Brandt, S. J., Müller, T. D., DiMarchi, R. D., Tschöp, M. H., Stemmer, K.

“…Obesity and its comorbidities, such as type 2 diabetes, are pressing worldwide health concerns. Available anti‐obesity treatments include weight loss…”
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Prevention of Vascular and Neural Dysfunction in Diabetic Rats by C-Peptide by Ido, Y., Vindigni, A., Chang, K., Stramm, L., Chance, R., Heath, W. F., DiMarchi, R. D., Di Cera, E., Williamson, J. R.

“…C-peptide, a cleavage product from the processing of proinsulin to insulin, has been considered to possess little if any biological activity other than its…”
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Crystal structure of the obese protein leptin-E100 by ZHANG, F, BASINSKI, M. B, SCHONER, B. E, SMITH, D. P, ZHANG, X. Y, WERY, J.-P, SCHEVITZ, R. W, BEALS, J. M, BRIGGS, S. L, CHURGAY, L. M, CLAWSON, D. K, DIMARCHI, R. D, FURMAN, T. C, HALE, J. E, HSIUNG, H. M

“…Mutations in the obese gene (OB) or in the gene encoding the OB receptor(OB-R) result in obesity, infertility and diabetes in a variety of mouse phenotypes…”
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Modifications in the B10 and B26-30 regions of the B chain of human insulin alter affinity for the human IGF-I receptor more than for the insulin receptor by Slieker, L J, Brooke, G S, DiMarchi, R D, Flora, D B, Green, L K, Hoffmann, J A, Long, H B, Fan, L, Shields, J E, Sundell, K L, Surface, P L, Chance, R E

“…Inversion of the natural sequence of the B chain of human insulin (HI) from ProB28LysB29 to LysB28ProB29 generates an insulin analogue with reduced tendency to…”
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The rapid identification of HIV protease inhibitors through the synthesis and screening of defined peptide mixtures by Owens, R A, Gesellchen, P D, Houchins, B J, DiMarchi, R D

“…Small peptides with activity as enzyme inhibitors, hormone antagonists, or other peptide mimetics, can be identified by synthesizing and screening large…”
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Altering the association properties of insulin by amino acid replacement by Brems, D N, Alter, L A, Beckage, M J, Chance, R E, DiMarchi, R D, Green, L K, Long, H B, Pekar, A H, Shields, J E, Frank, B H

“…The importance of ProB28 and LysB29 on the self-association of insulin was established by systematically truncating the C terminus of the B chain. The…”
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8627 Viral Hormones: The Role Of Viral Insulin/IGF-1 Like Peptides In Host-Pathogen Interactions by Chuard, A, Nesarajah, K, Danazumi, K, Reiners, K, Zhang, F, DiMarchi, R, Altindis, E

“…Disclosure: A. Chuard: None. Viruses, encode proteins that are similar to host proteins to manipulate the host. Until our recent discovery of viral hormones,…”
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Preparation of an insulin with improved pharmacokinetics relative to human insulin through consideration of structural homology with insulin-like growth factor I by DiMarchi, R D, Chance, R E, Long, H B, Shields, J E, Slieker, L J

“…The Diabetes Control and Complications Trial has emphasized the need for improved control of blood glucose as a means to diminish long-term complications of…”
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Basal activity profiles of NPH and [Nε-palmitoyl Lys (B29)] human insulins in subjects with IDDM by RADZIUK, J, PYE, S, BRADLEY, B, BRAATEN, J, VIGNATI, L, ROACH, P, BOWSHER, R, DIMARCHI, R, CHANCE, R

“…[Nepsilon-palmitoyl Lys (B29)] human insulin is a fatty acid-acylated derivative of insulin with extended action compared to unmodified insulin when infused…”
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GLP-1 and estrogen conjugate acts in the supramammillary nucleus to reduce food-reward and body weight by Vogel, Heike, Wolf, Stefanie, Rabasa, Cristina, Rodriguez-Pacheco, Francisca, Babaei, Carina S., Stöber, Franziska, Goldschmidt, Jürgen, DiMarchi, Richard D., Finan, Brian, Tschöp, Matthias H., Dickson, Suzanne L., Schürmann, Annette, Skibicka, Karolina P.

“…The obesity epidemic continues unabated and currently available pharmacological treatments are not sufficiently effective. Combining gut/brain peptide, GLP-1,…”
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Isotype responses of infected, virus-vaccinated and peptide-vaccinated cattle to foot-and-mouth disease virus by Mulcahy, G, Gale, C, Robertson, P, Iyisan, S, DiMarchi, R D, Doel, T R

“…An ELISA to measure bovine serum immunoglobulin isotypes (IgG1, IgG2, IgM and IgA) specific for foot-and-mouth disease virus (FMDV) or for synthetic FMDV…”
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IGF-I--stimulated glucose transport in human skeletal muscle and IGF-I resistance in obesity and NIDDM by G L Dohm, C W Elton, M S Raju, N D Mooney, R DiMarchi, W J Pories, E G Flickinger, S M Atkinson, Jr, J F Caro

“…IGF-I--stimulated glucose transport in human skeletal muscle and IGF-I resistance in obesity and NIDDM. G L Dohm , C W Elton , M S Raju , N D Mooney , R…”
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Metabolic effects of IGF-I in diabetic rats by Rossetti, L., Frontoni, S., Dimarchi, R., DeFronzo, R. A., Giaccari, A.

“…Metabolic effects of IGF-I in diabetic rats. L Rossetti , S Frontoni , R Dimarchi , R A DeFronzo and A Giaccari Department of Medicine, University of Texas…”
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12389 Viral Insulin/IGF-1-like Peptides: A New Dimension In Understanding The Insulin/IGF System by Chrudinova, M, Chuard, A, Zhang, F, Dogru, Y D, De Meyts, P, Kim, J K, Kirk, N, Jiracek, J, DiMarchi, R D, Altindis, E

“…Disclosure: M. Chrudinova: None. A. Chuard: None. F. Zhang: None. Y.D. Dogru: None. P. De Meyts: None. J.K. Kim: None. N. Kirk: None. J. Jiracek: None. R.D…”
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Mouse protection test as a predictor of the protective capacity of synthetic foot-and-mouth disease vaccines by Mulcahy, G, Pullen, L A, Gale, C, DiMarchi, R D, Doel, T R

“…A passive immunity test (MPT) in suckling mice for the quantification of protective anti-foot-and-mouth disease virus (FMDV) antibodies in serum is described…”
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Human and rat amylin have no effects on insulin secretion in isolated rat pancreatic islets by Broderick, C L, Brooke, G S, DiMarchi, R D, Gold, G

“…Amylin, an islet amyloid peptide secreted by the pancreatic beta cell, has been proposed as a humoral regulator of islet insulin secretion. Four separate…”
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