Search Results - "DILLMAN, Allissa"

Acetylation of Cytidine in mRNA Promotes Translation Efficiency by Arango, Daniel, Sturgill, David, Alhusaini, Najwa, Dillman, Allissa A., Sweet, Thomas J., Hanson, Gavin, Hosogane, Masaki, Sinclair, Wilson R., Nanan, Kyster K., Mandler, Mariana D., Fox, Stephen D., Zengeya, Thomas T., Andresson, Thorkell, Meier, Jordan L., Coller, Jeffery, Oberdoerffer, Shalini

“…Generation of the “epitranscriptome” through post-transcriptional ribonucleoside modification embeds a layer of regulatory complexity into RNA structure and…”
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APOE4 is Associated with Differential Regional Vulnerability to Bioenergetic Deficits in Aged APOE Mice by Area-Gomez, Estela, Larrea, Delfina, Pera, Marta, Agrawal, Rishi R., Guilfoyle, David N., Pirhaji, Leila, Shannon, Kathleen, Arain, Hirra A., Ashok, Archana, Chen, Qiuying, Dillman, Allissa A., Figueroa, Helen Y., Cookson, Mark R., Gross, Steven S., Fraenkel, Ernest, Duff, Karen E., Nuriel, Tal

“…The ε4 allele of apolipoprotein E ( APOE ) is the dominant genetic risk factor for late-onset Alzheimer’s disease (AD). However, the reason for the association…”
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The Endosomal-Lysosomal Pathway Is Dysregulated by APOE4 Expression in Vivo by Nuriel, Tal, Peng, Katherine Y, Ashok, Archana, Dillman, Allissa A, Figueroa, Helen Y, Apuzzo, Justin, Ambat, Jayanth, Levy, Efrat, Cookson, Mark R, Mathews, Paul M, Duff, Karen E

“…Possession of the ε4 allele of apolipoprotein E ( ) is the major genetic risk factor for late-onset Alzheimer's disease (AD). Although numerous hypotheses have…”
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The G2385R risk factor for Parkinson's disease enhances CHIP-dependent intracellular degradation of LRRK2 by Rudenko, Iakov N, Kaganovich, Alice, Langston, Rebekah G, Beilina, Aleksandra, Ndukwe, Kelechi, Kumaran, Ravindran, Dillman, Allissa A, Chia, Ruth, Cookson, Mark R

“…Autosomal dominant mutations in ( ) are associated with Parkinson's disease (PD). Most pathogenic mutations result in amino acid substitutions in the central…”
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Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain by Gibbs, J Raphael, van der Brug, Marcel P, Hernandez, Dena G, Traynor, Bryan J, Nalls, Michael A, Lai, Shiao-Lin, Arepalli, Sampath, Dillman, Allissa, Rafferty, Ian P, Troncoso, Juan, Johnson, Robert, Zielke, H Ronald, Ferrucci, Luigi, Longo, Dan L, Cookson, Mark R, Singleton, Andrew B

“…A fundamental challenge in the post-genome era is to understand and annotate the consequences of genetic variation, particularly within the context of human…”
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MAPT expression and splicing is differentially regulated by brain region: relation to genotype and implication for tauopathies by TRABZUNI, Daniah, WRAY, Selina, AREPALLI, Sampath, SINGLETON, Andrew B, COOKSON, Mark R, PITTMAN, Alan M, DE SILVA, Rohan, WEALE, Michael E, HARDY, John, RYTEN, Mina, VANDROVCOVA, Jana, RAMASAMY, Adaikalavan, WALKER, Robert, SMITH, Colin, LUK, Connie, RAPHAEL GIBBS, J, DILLMAN, Allissa, HERNANDEZ, Dena G

“…The MAPT (microtubule-associated protein tau) locus is one of the most remarkable in neurogenetics due not only to its involvement in multiple…”
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mRNA expression, splicing and editing in the embryonic and adult mouse cerebral cortex by Dillman, Allissa A, Hauser, David N, Gibbs, J Raphael, Nalls, Michael A, McCoy, Melissa K, Rudenko, Iakov N, Galter, Dagmar, Cookson, Mark R

“…Using whole-transcriptome RNA sequencing at single-nucleotide resolution, this Resource article describes the mRNAs, RNA editing, splice variants and…”
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Transcriptomic profiling of the human brain reveals that altered synaptic gene expression is associated with chronological aging by Dillman, Allissa A., Majounie, Elisa, Ding, Jinhui, Gibbs, J. Raphael, Hernandez, Dena, Arepalli, Sampath, Traynor, Bryan J., Singleton, Andrew B., Galter, Dagmar, Cookson, Mark R.

“…Aging is a biologically universal event, and yet the key events that drive aging are still poorly understood. One approach to generate new hypotheses about…”
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Hexokinases link DJ-1 to the PINK1/parkin pathway by Hauser, David N, Mamais, Adamantios, Conti, Melissa M, Primiani, Christopher T, Kumaran, Ravindran, Dillman, Allissa A, Langston, Rebekah G, Beilina, Alexandra, Garcia, Joseph H, Diaz-Ruiz, Alberto, Bernier, Michel, Fiesel, Fabienne C, Hou, Xu, Springer, Wolfdieter, Li, Yan, de Cabo, Rafael, Cookson, Mark R

“…Early onset Parkinson's disease is caused by variants in PINK1, parkin, and DJ-1. PINK1 and parkin operate in pathways that preserve mitochondrial integrity,…”
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Post-translational decrease in respiratory chain proteins in the Polg mutator mouse brain by Hauser, David N, Dillman, Allissa A, Ding, Jinhui, Li, Yan, Cookson, Mark R

“…Mitochondrial DNA damage is thought to be a causal contributor to aging as mice with inactivating mutations in polymerase gamma (Polg) develop a progeroid…”
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An international consensus on effective, inclusive, and career-spanning short-format training in the life sciences and beyond by Williams, Jason J, Tractenberg, Rochelle E, Batut, Bérénice, Becker, Erin A, Brown, Anne M, Burke, Melissa L, Busby, Ben, Cooch, Nisha K, Dillman, Allissa A, Donovan, Samuel S, Doyle, Maria A, van Gelder, Celia W. G, Hall, Christina R, Hertweck, Kate L, Jordan, Kari L, Jungck, John R, Latour, Ainsley R, Lindvall, Jessica M, Lloret-Llinares, Marta, McDowell, Gary S, Morris, Rana, Mourad, Teresa, Nisselle, Amy, Ordóñez, Patricia, Paladin, Lisanna, Palagi, Patricia M, Sukhai, Mahadeo A, Teal, Tracy K, Woodley, Louise

“…Science, technology, engineering, mathematics, and medicine (STEMM) fields change rapidly and are increasingly interdisciplinary. Commonly, STEMM practitioners…”
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Jupyter notebook-based tools for building structured datasets from the Sequence Read Archive [version 2; peer review: 2 approved] by Bernstein, Matthew N, Gladstein, Ariella, Latt, Khun Zaw, Clough, Emily, Busby, Ben, Dillman, Allissa

“…The Sequence Read Archive (SRA) is a large public repository that stores raw next-generation sequencing data from thousands of diverse scientific…”
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Differences in Stability, Activity and Mutation Effects Between Human and Mouse Leucine-Rich Repeat Kinase 2 by Langston, Rebekah G., Rudenko, Iakov N., Kumaran, Ravindran, Hauser, David N., Kaganovich, Alice, Ponce, Luis Bonet, Mamais, Adamantios, Ndukwe, Kelechi, Dillman, Allissa A., Al-Saif, Amr M., Beilina, Aleksandra, Cookson, Mark R.

“…Mutations in the Leucine-rich repeat kinase 2 ( LRRK2 ) gene have been implicated in the pathogenesis of Parkinson’s disease (PD). Identification of…”
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geneHummus: an R package to define gene families and their expression in legumes and beyond by Die, Jose V, Elmassry, Moamen M, LeBlanc, Kimberly H, Awe, Olaitan I, Dillman, Allissa, Busby, Ben

“…During the last decade, plant biotechnological laboratories have sparked a monumental revolution with the rapid development of next sequencing technologies at…”
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Integration of GWAS SNPs and tissue specific expression profiling reveal discrete eQTLs for human traits in blood and brain by Hernandez, Dena G, Nalls, Mike A, Moore, Matthew, Chong, Sean, Dillman, Allissa, Trabzuni, Daniah, Gibbs, J. Raphael, Ryten, Mina, Arepalli, Sampath, Weale, Michael E, Zonderman, Alan B, Troncoso, Juan, O'Brien, Richard, Walker, Robert, Smith, Colin, Bandinelli, Stefania, Traynor, Bryan J, Hardy, John, Singleton, Andrew B, Cookson, Mark R

“…Abstract Genome-wide association studies have nominated many genetic variants for common human traits, including diseases, but in many cases the underlying…”
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Cell population-specific expression analysis of human cerebellum by Kuhn, Alexandre, Kumar, Azad, Beilina, Alexandra, Dillman, Allissa, Cookson, Mark R, Singleton, Andrew B

“…Interpreting gene expression profiles obtained from heterogeneous samples can be difficult because bulk gene expression measures are not resolved to individual…”
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TET-Catalyzed 5-Carboxylcytosine Promotes CTCF Binding to Suboptimal Sequences Genome-wide by Nanan, Kyster K., Sturgill, David M., Prigge, Maria F., Thenoz, Morgan, Dillman, Allissa A., Mandler, Mariana D., Oberdoerffer, Shalini

“…The mechanisms supporting dynamic regulation of CTCF-binding sites remain poorly understood. Here we describe the TET-catalyzed 5-methylcytosine derivative,…”
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Variation in tau isoform expression in different brain regions and disease states by Majounie, Elisa, Cross, William, Newsway, Victoria, Dillman, Allissa, Vandrovcova, Jana, Morris, Christopher M, Nalls, Michael A, Ferrucci, Luigi, Owen, Michael J, O'Donovan, Michael C, Cookson, Mark R, Singleton, Andrew B, de Silva, Rohan, Morris, Huw R

“…Abstract Progressive supranuclear palsy (PSP) is the most common atypical parkinsonian disorder. Abnormal tau inclusions, in selected regions of the brain, are…”
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Age-associated changes in gene expression in human brain and isolated neurons by Kumar, Azad, Gibbs, J. Raphael, Beilina, Alexandra, Dillman, Allissa, Kumaran, Ravindran, Trabzuni, Daniah, Ryten, Mina, Walker, Robert, Smith, Colin, Traynor, Bryan J, Hardy, John, Singleton, Andrew B, Cookson, Mark R

“…Abstract Previous studies have suggested that there are genes whose expression levels are associated with chronological age. However, which genes show…”
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Transcriptomic changes in brain development by Dillman, Allissa A, Cookson, Mark R

“…The transcriptome changes hugely during development of the brain. Whole genes, alternate exons, and single base pair changes related to RNA editing all show…”
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