Search Results - "DIKEN, Mustafa"

A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis by Krienke, Christina, Kolb, Laura, Diken, Elif, Streuber, Michael, Kirchhoff, Sarah, Bukur, Thomas, Akilli-Öztürk, Özlem, Kranz, Lena M, Berger, Hendrik, Petschenka, Jutta, Diken, Mustafa, Kreiter, Sebastian, Yogev, Nir, Waisman, Ari, Karikó, Katalin, Türeci, Özlem, Sahin, Ugur

“…The ability to control autoreactive T cells without inducing systemic immune suppression is the major goal for treatment of autoimmune diseases. The key…”
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Improving mRNA-Based Therapeutic Gene Delivery by Expression-Augmenting 3′ UTRs Identified by Cellular Library Screening by Orlandini von Niessen, Alexandra G., Poleganov, Marco A., Rechner, Corina, Plaschke, Arianne, Kranz, Lena M., Fesser, Stephanie, Diken, Mustafa, Löwer, Martin, Vallazza, Britta, Beissert, Tim, Bukur, Valesca, Kuhn, Andreas N., Türeci, Özlem, Sahin, Ugur

“…Synthetic mRNA has emerged as a powerful tool for the transfer of genetic information, and it is being explored for a variety of therapeutic applications. Many…”
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Specific hepatic delivery of procollagen α1(I) small interfering RNA in lipid‐like nanoparticles resolves liver fibrosis by Jiménez Calvente, Carolina, Sehgal, Alfica, Popov, Yury, Kim, Yong Ook, Zevallos, Victor, Sahin, Ugur, Diken, Mustafa, Schuppan, Detlef

“…Fibrosis accompanies the wound‐healing response to chronic liver injury and is characterized by excessive hepatic collagen accumulation dominated by collagen…”
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Exploiting the Mutanome for Tumor Vaccination by CASTLE, John C, KREITER, Sebastian, KOSLOWSKI, Michael, KUHN, Andreas N, BRITTEN, Cedrik M, HUBER, Christoph, TÜRECI, Ozlem, SAHIN, Ugur, DIEKMANN, Jan, LÖWER, Martin, DE ROEMER, Niels Van, DE GRAAF, Jos, SELMI, Abderraouf, DIKEN, Mustafa, BOEGEL, Sebastian, PARET, Claudia

“…Multiple genetic events and subsequent clonal evolution drive carcinogenesis, making disease elimination with single-targeted drugs difficult. The multiplicity…”
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Immunomic, genomic and transcriptomic characterization of CT26 colorectal carcinoma by Castle, John C, Loewer, Martin, Boegel, Sebastian, de Graaf, Jos, Bender, Christian, Tadmor, Arbel D, Boisguerin, Valesca, Bukur, Thomas, Sorn, Patrick, Paret, Claudia, Diken, Mustafa, Kreiter, Sebastian, Türeci, Özlem, Sahin, Ugur

“…Tumor models are critical for our understanding of cancer and the development of cancer therapeutics. Here, we present an integrated map of the genome,…”
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Reductive Decationizable Block Copolymers for Stimuli-Responsive mRNA Delivery by Nuhn, Lutz, Kaps, Leonard, Diken, Mustafa, Schuppan, Detlef, Zentel, Rudolf

“…Messenger ribonucleic acids (mRNAs) are considered as promising alternatives for transient gene therapy, but to overcome their poor pharmacokinetic properties,…”
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HPV16 RNA-LPX vaccine mediates complete regression of aggressively growing HPV-positive mouse tumors and establishes protective T cell memory by Grunwitz, Christian, Salomon, Nadja, Vascotto, Fulvia, Selmi, Abderaouf, Bukur, Thomas, Diken, Mustafa, Kreiter, Sebastian, Türeci, Özlem, Sahin, Ugur

“…HPV16 infections are associated with a variety of cancers and there is compelling evidence that the transforming activity of HPV16 critically depends on the…”
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Protein corona–mediated targeting of nanocarriers to B cells allows redirection of allergic immune responses by Shen, Limei, Tenzer, Stefan, Storck, Wiebke, Hobernik, Dominika, Raker, Verena Katherina, Fischer, Karl, Decker, Sandra, Dzionek, Andrzej, Krauthäuser, Susanne, Diken, Mustafa, Nikolaev, Alexej, Maxeiner, Joachim, Schuster, Petra, Kappel, Cinja, Verschoor, Admar, Schild, Hansjörg, Grabbe, Stephan, Bros, Matthias

“…Nanoparticle (NP)–based vaccines are attractive immunotherapy tools because of their capability to codeliver antigen and adjuvant to antigen-presenting cells…”
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Tumor vaccination using messenger RNA: prospects of a future therapy by Kreiter, Sebastian, Diken, Mustafa, Selmi, Abderraouf, Türeci, Özlem, Sahin, Ugur

“…Highlights ► Coding mRNA is emerging as an attractive option for antitumor vaccination. ► mRNA not only serves as an antigen format but also has an intrinsic…”
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pH-degradable, bisphosphonate-loaded nanogels attenuate liver fibrosis by repolarization of M2-type macrophages by Kaps, Leonard, Huppertsberg, Anne, Choteschovsky, Niklas, Klefenz, Adrian, Durak, Feyza, Schrörs, Babara, Diken, Mustafa, Eichler, Emma, Rosigkeit, Sebastian, Schmitt, Sascha, Leps, Christian, Schulze, Alicia, Foerster, Friedrich, Bockamp, Ernesto, De Geest, Bruno G, Koynov, Kaloian, Räder, Hans-Joachim, Tenzer, Stefan, Marini, Federico, Schuppan, Detlef, Nuhn, Lutz

“…Immune-suppressive (M2-type) macrophages can contribute to the progression of cancer and fibrosis. In chronic liver diseases, M2-type macrophages promote the…”
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FBXO32 promotes microenvironment underlying epithelial-mesenchymal transition via CtBP1 during tumour metastasis and brain development by Sahu, Sanjeeb Kumar, Tiwari, Neha, Pataskar, Abhijeet, Zhuang, Yuan, Borisova, Marina, Diken, Mustafa, Strand, Susanne, Beli, Petra, Tiwari, Vijay K.

“…The set of events that convert adherent epithelial cells into migratory cells are collectively known as epithelial–mesenchymal transition (EMT). EMT is…”
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Artificial intelligence and neoantigens: paving the path for precision cancer immunotherapy by Bulashevska, Alla, Nacsa, Zsófia, Lang, Franziska, Braun, Markus, Machyna, Martin, Diken, Mustafa, Childs, Liam, König, Renate

“…Cancer immunotherapy has witnessed rapid advancement in recent years, with a particular focus on neoantigens as promising targets for personalized treatments…”
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CRISPR/Cas9-mediated TGFβRII disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells in vitro by Alishah, Khadijeh, Birtel, Matthias, Masoumi, Elham, Jafarzadeh, Leila, Mirzaee, Hamid Reza, Hadjati, Jamshid, Voss, Ralf-Holger, Diken, Mustafa, Asad, Sedighe

“…CAR T-cell therapy has been recently unveiled as one of the most promising cancer therapies in hematological malignancies. However, solid tumors mount a…”
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A liposomal RNA vaccine inducing neoantigen-specific CD4+ T cells augments the antitumor activity of local radiotherapy in mice by Salomon, Nadja, Vascotto, Fulvia, Selmi, Abderaouf, Vormehr, Mathias, Quinkhardt, Juliane, Bukur, Thomas, Schrörs, Barbara, Löewer, Martin, Diken, Mustafa, Türeci, Özlem, Sahin, Ugur, Kreiter, Sebastian

“…Antigen-encoding, lipoplex-formulated RNA (RNA-LPX) enables systemic delivery to lymphoid compartments and selective expression in resident antigen-presenting…”
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MC38 colorectal tumor cell lines from two different sources display substantial differences in transcriptome, mutanome and neoantigen expression by Schrörs, Barbara, Hos, Brett J, Yildiz, Ikra G, Löwer, Martin, Lang, Franziska, Holtsträter, Christoph, Becker, Julia, Vormehr, Mathias, Sahin, Ugur, Ossendorp, Ferry, Diken, Mustafa

“…The cell line MC38 is a commonly used murine model for colorectal carcinoma. It has a high mutational burden, is sensitive to immune checkpoint immunotherapy…”
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Polysarcosine-Functionalized mRNA Lipid Nanoparticles Tailored for Immunotherapy by Wilhelmy, Christoph, Keil, Isabell Sofia, Uebbing, Lukas, Schroer, Martin A., Franke, Daniel, Nawroth, Thomas, Barz, Matthias, Sahin, Ugur, Haas, Heinrich, Diken, Mustafa, Langguth, Peter

“…Lipid nanoparticles (LNPs) have gained great attention as carriers for mRNA-based therapeutics, finding applications in various indications, extending beyond…”
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Inducible knockdown of procollagen I protects mice from liver fibrosis and leads to dysregulated matrix genes and attenuated inflammation by Molokanova, Olena, Schönig, Kai, Weng, Shih-Yen, Wang, Xiaoyu, Bros, Matthias, Diken, Mustafa, Ohngemach, Svetlana, Karsdal, Morten, Strand, Dennis, Nikolaev, Alexei, Eshkind, Leonid, Schuppan, Detlef

“…Organ fibrosis is characterized by a chronic wound-healing response, with excess deposition of extracellular matrix components. Here, collagen type I…”
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Monitoring Translation Activity of mRNA-Loaded Nanoparticles in Mice by Rosigkeit, Sebastian, Meng, Martin, Grunwitz, Christian, Gomes, Patricia, Kreft, Andreas, Hayduk, Nina, Heck, Rosario, Pickert, Geethanjali, Ziegler, Kira, Abassi, Yasmin, Röder, Jasmin, Kaps, Leonard, Vascotto, Fulvia, Beissert, Tim, Witzel, Sonja, Kuhn, Andreas, Diken, Mustafa, Schuppan, Detlef, Sahin, Ugur, Haas, Heinrich, Bockamp, Ernesto

“…Targeting mRNA to eukaryotic cells is an emerging technology for basic research and provides broad applications in cancer immunotherapy, vaccine development,…”
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Molecular in vivo imaging of gastric cancer in a human-murine xenograft model: targeting epidermal growth factor receptor by Hoetker, Michael S, Kiesslich, Ralf, MD, Diken, Mustafa, PhD, Moehler, Markus, MD, Galle, Peter R., MD, Li, Yanqing, MD, Goetz, Martin, MD

“…Background The prognosis of gastric cancer depends on early diagnosis. Targeted therapies against epidermal growth factor receptors (EGFRs) are currently…”
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PLGA Nanoparticles Co-encapsulating NY-ESO-1 Peptides and IMM60 Induce Robust CD8 and CD4 T Cell and B Cell Responses by Dölen, Yusuf, Gileadi, Uzi, Chen, Ji-Li, Valente, Michael, Creemers, Jeroen H A, Van Dinther, Eric A W, van Riessen, N Koen, Jäger, Eliezer, Hruby, Martin, Cerundolo, Vincenzo, Diken, Mustafa, Figdor, Carl G, de Vries, I Jolanda M

“…Tumor-specific neoantigens can be highly immunogenic, but their identification for each patient and the production of personalized cancer vaccines can be…”
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