Search Results - "DIGGANS, James"

Next Steps for Access to Safe, Secure DNA Synthesis by Diggans, James, Leproust, Emily

“…The DNA synthesis industry has, since the invention of gene-length synthesis, worked proactively to ensure synthesis is carried out securely and safely…”
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The impact of benign gene expression classifier test results on the endocrinologist-patient decision to operate on patients with thyroid nodules with indeterminate fine-needle aspiration cytopathology by Duick, Daniel S, Klopper, Joshua P, Diggans, James C, Friedman, Lyssa, Kennedy, Giulia C, Lanman, Richard B, McIver, Bryan

“…Seventy-five percent of thyroid nodules with indeterminate fine-needle aspiration (FNA) cytology are found to be benign postoperatively. A novel genomic test,…”
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A Prospective Assessment Defining the Limitations of Thyroid Nodule Pathologic Evaluation by CIBAS, Edmund S, BALOCH, Zubair W, LANMAN, Richard B, MANDEL, Susan J, SINDY, Nicole, STEWARD, David L, ZEIGER, Martha A, HAUGEN, Bryan R, ALEXANDER, Erik K, FELLEGARA, Giovanni, LIVOLSI, Virginia A, RAAB, Stephen S, ROSAI, Juan, DIGGANS, James, FRIEDMAN, Lyssa, KENNEDY, Giulia C, KLOOS, Richard T

“…Clinical management of thyroid neoplasms is based on light microscopic diagnosis, but its accuracy and precision are poorly defined. To assess inter- and…”
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Safety by design: Biosafety and biosecurity in the age of synthetic genomics by Hoffmann, Stefan A., Diggans, James, Densmore, Douglas, Dai, Junbiao, Knight, Tom, Leproust, Emily, Boeke, Jef D., Wheeler, Nicole, Cai, Yizhi

“…Technologies to profoundly engineer biology are becoming increasingly affordable, powerful, and accessible to a widening group of actors. While offering…”
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Making Security Viral: Shifting Engineering Biology Culture and Publishing by Mackelprang, Rebecca, Adamala, Katarzyna P, Aurand, Emily R, Diggans, James C, Ellington, Andrew D, Evans, Samuel Weiss, Fortman, J. L. Clem, Hillson, Nathan J, Hinman, Albert W, Isaacs, Farren J, Medford, June I, Mamaghani, Shadi, Moon, Tae Seok, Palmer, Megan J, Peccoud, Jean, Vitalis, Elizabeth A, Hook-Barnard, India, Friedman, Douglas C

“…The ability to construct, synthesize, and edit genes and genomes at scale and with speed enables, in synergy with other tools of engineering biology,…”
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Open-target sparse sensing of biological agents using DNA microarray by Mohtashemi, Mojdeh, Walburger, David K, Peterson, Matthew W, Sutton, Felicia N, Skaer, Haley B, Diggans, James C

“…Current biosensors are designed to target and react to specific nucleic acid sequences or structural epitopes. These 'target-specific' platforms require…”
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Ensuring the Responsible Use of Synthetic DNA by Diggans, James

“…The design, build, test, and learn cycle of synthetic biology has created new opportunities to leverage living systems to manufacture high-value compounds at…”
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Next Steps to Grow the Bioeconomy by Smith, Erin, Diggans, James

“…The bioeconomy in the United States represents a significant proportion of total economic output and is poised to grow even more rapidly over the next decade…”
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Preoperative Diagnosis of Benign Thyroid Nodules with Indeterminate Cytology by Alexander, Erik K, Kennedy, Giulia C, Baloch, Zubair W, Cibas, Edmund S, Chudova, Darya, Diggans, James, Friedman, Lyssa, Kloos, Richard T, LiVolsi, Virginia A, Mandel, Susan J, Raab, Stephen S, Rosai, Juan, Steward, David L, Walsh, P. Sean, Wilde, Jonathan I, Zeiger, Martha A, Lanman, Richard B, Haugen, Bryan R

“…A significant fraction of fine-needle aspirates obtained from thyroid nodules are read as indeterminate. A new molecular test accurately predicts whether a…”
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Shaping the future US bioeconomy through safety, security, sustainability, and social responsibility by Attal-Juncqua, Aurelia, Dods, Galen, Crain, Nicole, Diggans, James, Dodds, David, Evans, Steve, Fackler, Nick, Flyangolts, Kevin, Gibson, Kathleen, Kosal, Margaret E., Kunjapur, Aditya, Read, Russ, Renda, Brian, Scown, Corinne D., Tchedre, Kissaou, Ternus, Krista, Vitalis, Beth, Gronvall, Gigi

“…Biomanufacturing practitioners and researchers describe the norms that should govern the growing, global field, to include safety, security, sustainability,…”
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Beyond Biosecurity by Taxonomic Lists: Lessons, Challenges, and Opportunities by Millett, Piers, Alexanian, Tessa, Brink, Kathryn R, Carter, Sarah R, Diggans, James, Palmer, Megan J, Ritterson, Ryan, Sandbrink, Jonas B, Wheeler, Nicole E

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Classification of usual interstitial pneumonia in patients with interstitial lung disease: assessment of a machine learning approach using high-dimensional transcriptional data by Kim, Su Yeon, PhD, Diggans, James, PhD, Pankratz, Dan, PhD, Huang, Jing, PhD, Pagan, Moraima, PhD, Sindy, Nicole, MBS, Tom, Ed, BA, Anderson, Jessica, MS, Choi, Yoonha, PhD, Lynch, David A, Prof, Steele, Mark P, Prof, Flaherty, Kevin R, MD, Brown, Kevin K, Prof, Farah, Humam, MD, Bukstein, Michael J, MD, Pardo, Annie, Prof, Selman, Moisés, MD, Wolters, Paul J, MD, Nathan, Steven D, Prof, Colby, Thomas V, Prof, Myers, Jeffrey L, Prof, Katzenstein, Anna-Luise A, Prof, Raghu, Ganesh, Prof, Kennedy, Giulia C, Dr

“…Summary Background Idiopathic pulmonary fibrosis is a progressive fibrotic lung disease that distorts pulmonary architecture, leading to hypoxia, respiratory…”
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Augmenting pre-operative risk of recurrence stratification in differentiated thyroid carcinoma using machine learning and high dimensional transcriptional data from thyroid FNA by Sherman, Steven I., Pagan, Moraima, Huang, Jing, Lin, Bamboo, Diggans, James, Tom, Ed, Haugen, Bryan, Tuttle, R. Michael, Kennedy, Giulia

“…Abstract only…”
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Guiding Ethical Principles in Engineering Biology Research by Mackelprang, Rebecca, Aurand, Emily R., Bovenberg, Roel A. L., Brink, Kathryn R., Charo, R. Alta, Delborne, Jason A., Diggans, James, Ellington, Andrew D., Fortman, Jeffrey L. “Clem”, Isaacs, Farren J., Medford, June I., Murray, Richard M., Noireaux, Vincent, Palmer, Megan J., Zoloth, Laurie, Friedman, Douglas C.

“…Engineering biology is being applied toward solving or mitigating some of the greatest challenges facing society. As with many other rapidly advancing…”
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Machine learning from concept to clinic: reliable detection of BRAF V600E DNA mutations in thyroid nodules using high-dimensional RNA expression data by Diggans, James, Kim, Su Yeon, Hu, Zhanzhi, Pankratz, Daniel, Wong, Mei, Reynolds, Jessica, Tom, Ed, Pagan, Moraima, Monroe, Robert, Rosai, Juan, Livolsi, Virginia A, Lanman, Richard B, Kloos, Richard T, Walsh, P Sean, Kennedy, Giulia C

“…The promise of personalized medicine will require rigorously validated molecular diagnostics developed on minimally invasive, clinically relevant samples…”
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Engineering MicrobiomesLooking Ahead by Lee, Eric D, Aurand, Emily R, Friedman, Douglas C

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Defining the Synthetic Biology Supply Chain by Frazar, Sarah L, Hund, Gretchen E, Bonheyo, George T, Diggans, James, Bartholomew, Rachel A, Gehrig, Lindsey, Greaves, Mark

“…Several recent articles have described risks posed by synthetic biology and spurred vigorous discussion in the scientific, commercial, and government…”
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Complete Genomic Sequence of the Amsacta moorei Entomopoxvirus: Analysis and Comparison with Other Poxviruses by Bawden, Alison L., Glassberg, Kathryn J., Diggans, James, Shaw, Regina, Farmerie, William, Moyer, Richard W.

“…The genome of the genus B entomopoxvirus from Amsacta moorei (AmEPV) was sequenced and found to contain 232,392 bases with 279 unique open reading frames…”
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Biothreat detection by random oligomer -based microarray by Diggans, James C

“…Current biosensors are primarily based upon previous observations: they detect organisms known to be pathogenic. Future biowarfare agents, however, are likely…”
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Biothreat detection by random oligomer-based microarray by Diggans, James C

“…Current biosensors are primarily based upon previous observations: they detect organisms known to be pathogenic. Future biowarfare agents, however, are likely…”
Get full text