Search Results - "DIETZE, E. C"

Interferon regulatory factor-1 regulates reconstituted extracellular matrix (rECM)-mediated apoptosis in human mammary epithelial cells by BOWIE, M. L, TROCH, M. M, DELROW, J, DIETZE, E. C, BEAN, G. R, IBARRA, C, PANDIYAN, G, SEEWALDT, V. L

“…Interactions between extracellular matrix (ECM) and mammary epithelial cells are critical for mammary gland homeostasis and apoptotic signaling. Interferon…”
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Pressure‐dependent ionization of Tyr 9 in glutathione S‐transferase A1‐1: Contribution of the C‐terminal helix to a “soft” active site by Atkins, William M., Dietze, Eric C., Ibarra, Catherine

“…The glutathione S‐transferase (GST) isozyme A1‐1 contains at its active site a catalytic tyrosine, Tyr 9, which hydrogen bonds to, and stabilizes, the thiolate…”
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Suppression of pRB expression in normal human mammary epithelial cells is associated with resistance to all-trans-retinoic acid but not N-(4-hydroxylphenyl)-retinamide by DIETZE, Eric C, YEE, Lisa, SEEWALDT, Victoria L

“…Despite the widespread clinical use of synthetic and naturally occurring retinoids, the down stream targets of retinoids have not been fully characterized. We…”
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Spectrophotometric substrates for cytosolic epoxide hydrolase by Dietze, E C, Kuwano, E, Hammock, B D

“…In this study, we demonstrate the utility of a broad class of spectrophotometric substrates for the assay of cytosolic epoxide hydrolase purified from murine…”
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Interferon-regulatory factor-1 is critical for tamoxifen-mediated apoptosis in human mammary epithelial cells by BOWIE, Michelle L, DIETZE, Eric C, DELROW, Jeffery, BEAN, Gregory R, TROCH, Michelle M, MARJORAM, Robin J, SEEWALDT, Victoria L

“…Unlike estrogen receptor-positive (ER(+)) breast cancers, normal human mammary epithelial cells (HMECs) typically express low nuclear levels of ER (ER poor)…”
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Tamoxifen but Not 4-Hydroxytamoxifen Initiates Apoptosis in p53(−) Normal Human Mammary Epithelial Cells by Inducing Mitochondrial Depolarization by Dietze, Eric C., Caldwell, L. Elizabeth, Grupin, Svetlana L., Mancini, Mariangela, Seewaldt, Victoria L.

“…Despite the widespread clinical use of tamoxifen as a breast cancer prevention agent, the molecular mechanism of tamoxifen chemoprevention is poorly…”
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CBP/p300 induction is required for retinoic acid sensitivity in human mammary cells by Dietze, Eric C, Troch, Michelle M, Bowie, Michelle L, Yee, Lisa, Bean, Gregory R, Seewaldt, Victoria L

“…The coactivators CBP and p300 are recruited by retinoic acid receptors (RARs) during retinoid mediated transcriptional regulation. To assess the role of…”
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Tamoxifen and tamoxifen ethyl bromide induce apoptosis in acutely damaged mammary epithelial cells through modulation of AKT activity by DIETZE, Eric C, TROCH, Michelle M, BEAN, Gregory R, HEFFNER, Joshua B, BOWIE, Michelle L, ROSENBERG, Paul, RATLIFF, Brooke, SEEWALDT, Victoria L

“…Normal human mammary epithelial cells (HMECs), unlike estrogen receptor-positive (ER+) breast cancers, typically express low nuclear levels of ER (ER-'poor')…”
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Suppression of p53 Function in Normal Human Mammary Epithelial Cells Increases Sensitivity to Extracellular Matrix-Induced Apoptosis by Seewaldt, Victoria L., Mrózek, Krzysztof, Sigle, Randy, Dietze, Eric C., Heine, Kevin, Hockenbery, David M., Hobbs, Katherine B., Caldwell, L. Elizabeth

“…Little is known about the fate of normal human mammary epithelial cells (HMECs) that lose p53 function in the context of extracellular matrix (ECM)-derived…”
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Inactivation of Glyceraldehyde-3-phosphate Dehydrogenase by a Reactive Metabolite of Acetaminophen and Mass Spectral Characterization of an Arylated Active Site Peptide by Dietze, Eric C., Schäfer, Andrea, Omichinski, James G., Nelson, Sidney D.

“…Acetaminophen (4‘-hydroxyacetanilide, APAP) is a widely used analgesic and antipyretic drug that can cause hepatic necrosis under some circumstances via…”
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Localization of the C-terminus of rat glutathione S-transferase A1-1: Crystal structure of mutants W21F and W21F/F220Y by Adman, Elinor T., Le Trong, Isolde, Stenkamp, Ronald E., Nieslanik, Brenda S., Dietze, Eric C., Tai, Guoying, Ibarra, Catherine, Atkins, William M.

“…Twelve C‐terminal residues of human glutathione S‐transferase A1‐1 form a helix in the presence of glutathione‐conjugate, or substrate alone, and partly cover…”
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Human papillomavirus type 16 E6 inactivation of p53 in normal human mammary epithelial cells promotes tamoxifen-mediated apoptosis by SEEWALDT, Victoria L, MROZEK, Krzysztof, DIETZE, Eric C, PARKER, Molly, CALDWELL, L. Elizabeth

“…Aberrant p53 expression is frequently observed in mammary epithelial cells obtained from women at high risk for developing breast cancer and is a predictor for…”
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Ligand Effects on the Fluorescence Properties of Tyrosine-9 in Alpha 1-1 Glutathione S-Transferase by Dietze, Eric C, Wang, Regina W, Lu, Anthony Y. H, Atkins, William M

“…A conserved tyrosine plays a critical role in catalysis by mammalian glutathione S-transferases (GSTs) of the alpha-, mu-, and pi-classes, by forming a…”
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Thiol Ester Hydrolysis Catalyzed by Glutathione S-Transferase A1-1 by Dietze, Eric C, Grillo, Mark P, Kalhorn, Thomas, Nieslanik, Brenda S, Jochheim, Claudia M, Atkins, William M

“…rGSTA1-1 has been shown to catalyze the hydrolysis of the thiol ester glutathionyl ethacrynate (E-SG). In contrast, neither the retro-Michael addition with the…”
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Rational Modulation of the Catalytic Activity of A1-1 Glutathione S-Transferase:  Evidence for Incorporation of an On-Face (π···HO−Ar) Hydrogen Bond at Tyrosine-9 by Dietze, Eric C, Ibarra, Catherine, Dabrowski, Michael J, Bird, Andrew, Atkins, William M

“…The alpha-, pi-, and mu-class glutathione S-transferases utilize a hydrogen bond between a conserved tyrosine and glutathione (GSH) to stabilize the…”
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Inhibition of cytosolic epoxide hydrolase by trans-3-phenylglycidols by Dietze, E C, Kuwano, E, Casas, J, Hammock, B D

“…The inhibition of murine cytosolic epoxide hydrolase has been studied with both racemic and enantiomerically pure trans-3-phenylglycidols. These compounds are…”
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Inhibition of epoxide hydrolase from human, monkey, bovine, rabbit and murine liver by trans-3-phenylglycidols by Dietze, E C, Casas, J, Kuwano, E, Hammock, B D

“…1. trans-3-Phenylglycidols were potent inhibitors of cytosolic epoxide hydrolases in all species tested. 2. The order of inhibitor potency varied from species…”
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The interaction of cytosolic epoxide hydrolase with chiral epoxides by Dietze, E C, Kuwano, E, Hammock, B D

“…1. The kinetic parameters of the cytosolic epoxide hydrolase were examined with two sets of spectrophotometric substrates. The (2S,3S)- and (2R,3R)-enantiomers…”
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Inhibition of human and murine cytosolic epoxide hydrolase by group-selective reagents by Dietze, E C, Stephens, J, Magdalou, J, Bender, D M, Moyer, M, Fowler, B, Hammock, B D

“…1. Human and murine cytosolic epoxide hydrolase were inhibited by thiol-, imidazole- and carboxyl-selective reagents. They were not inhibited by amino-,…”
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Supramolecular Self-Assembly of Glutamine Synthetase: Mutagenesis of a Novel Intermolecular Metal Binding Site Required for Dodecamer Stacking by Dabrowski, Michael J, Yanchunas, Joseph, Villafranca, Beth Cader, Dietze, Eric C, Schurke, Peter, Atkins, William M

“…Dodecameric glutamine synthetase (GS) from Escherichia coli assembles into highly ordered supramolecular protein tubes in the presence of several divalent…”
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