Search Results - "DIETRICH, Nikolaj"

REST-mediated recruitment of polycomb repressor complexes in mammalian cells by Dietrich, Nikolaj, Lerdrup, Mads, Landt, Eskild, Agrawal-Singh, Shuchi, Bak, Mads, Tommerup, Niels, Rappsilber, Juri, Södersten, Erik, Hansen, Klaus

“…Polycomb Repressive Complex (PRC) 1 and PRC2 regulate genes involved in differentiation and development. However, the mechanism for how PRC1 and PRC2 are…”
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Polycomb Group Protein Displacement and Gene Activation through MSK-Dependent H3K27me3S28 Phosphorylation by Gehani, Simmi Suman, Agrawal-Singh, Shuchi, Dietrich, Nikolaj, Christophersen, Nicolaj Strøyer, Helin, Kristian, Hansen, Klaus

“…Epigenetic regulation of chromatin structure is essential for the expression of genes determining cellular specification and function. The Polycomb repressive…”
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The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells by Bracken, Adrian P, Kleine-Kohlbrecher, Daniela, Dietrich, Nikolaj, Pasini, Diego, Gargiulo, Gaetano, Beekman, Chantal, Theilgaard-Mönch, Kim, Minucci, Saverio, Porse, Bo T, Marine, Jean-Christophe, Hansen, Klaus H, Helin, Kristian

“…The p16INK4A and p14ARF proteins, encoded by the INK4A-ARF locus, are key regulators of cellular senescence, yet the mechanisms triggering their up-regulation…”
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Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus by Dietrich, Nikolaj, Bracken, Adrian P, Trinh, Emmanuelle, Schjerling, Charlotte K, Koseki, Haruhiko, Rappsilber, Juri, Helin, Kristian, Hansen, Klaus H

“…The Polycomb group (PcG) proteins are essential for embryogenesis, and their expression is often found deregulated in human cancer. The PcGs form two major…”
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A role for ADAM12 in breast tumor progression and stromal cell apoptosis by KVEIBORG, Marie, FRÖHLICH, Camilla, ALBRECHTSEN, Reidar, TISCHLER, Verena, DIETRICH, Nikolaj, HOLCK, Peter, KRONQVIST, Pauliina, RANK, Fritz, MERCURIO, Arthur M, WEWER, Ulla M

“…As in developmental and regenerative processes, cell survival is of fundamental importance in cancer. Thus, a tremendous effort has been devoted to dissecting…”
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ADAM12 induces actin cytoskeleton and extracellular matrix reorganization during early adipocyte differentiation by regulating β1 integrin function by Kawaguchi, Nobuko, Sundberg, Christina, Kveiborg, Marie, Moghadaszadeh, Behzad, Asmar, Meena, Dietrich, Nikolaj, Thodeti, Charles K., Nielsen, Finn C., Möller, Peter, Mercurio, Arthur M., Albrechtsen, Reidar, Wewer, Ulla M.

“…Changes in cell shape are a morphological hallmark of differentiation. In this study we report that the expression of ADAM12, a disintegrin and…”
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A model for transmission of the H3K27me3 epigenetic mark by Hansen, Klaus H, Helin, Kristian, Bracken, Adrian P, Pasini, Diego, Dietrich, Nikolaj, Gehani, Simmi S, Monrad, Astrid, Rappsilber, Juri, Lerdrup, Mads

“…The chromatin mark H3K27me3 is transmitted during cell division by recruitment and binding of the PRC2 complex, which maintains the mark and leads to…”
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β-Catenin Regulates Primitive Streak Induction through Collaborative Interactions with SMAD2/SMAD3 and OCT4 by Funa, Nina S., Schachter, Karen A., Lerdrup, Mads, Ekberg, Jenny, Hess, Katja, Dietrich, Nikolaj, Honoré, Christian, Hansen, Klaus, Semb, Henrik

“…Canonical Wnt and Nodal signaling are both required for induction of the primitive streak (PS), which guides organization of the early embryo. The Wnt effector…”
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Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions by Bracken, Adrian P, Dietrich, Nikolaj, Pasini, Diego, Hansen, Klaus H, Helin, Kristian

“…The Polycomb group (PcG) proteins form chromatin-modifying complexes that are essential for embryonic development and stem cell renewal and are commonly…”
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Corrigendum: The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells by Bracken, Adrian P., Kleine-Kohlbrecher, Daniela, Dietrich, Nikolaj, Pasini, Diego, Gargiulo, Gaetano, Beekman, Chantal, Theilgaard-Mönch, Kim, Minucci, Saverio, Porse, Bo T., Marine, Jean-Christophe, Hansen, Klaus H., Helin, Kristian

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Sym021, a promising anti-PD1 clinical candidate antibody derived from a new chicken antibody discovery platform by Gjetting, Torben, Gad, Monika, Fröhlich, Camilla, Lindsted, Trine, Melander, Maria C, Bhatia, Vikram K, Grandal, Michael M, Dietrich, Nikolaj, Uhlenbrock, Franziska, Galler, Gunther R, Strandh, Magnus, Lantto, Johan, Bouquin, Thomas, Horak, Ivan D, Kragh, Michael, Pedersen, Mikkel W, Koefoed, Klaus

“…Discovery of therapeutic antibodies is a field of intense development, where immunization of rodents remains a major source of antibody candidates. However,…”
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DNA methylation changes are a late event in acute promyelocytic leukemia and coincide with loss of transcription factor binding by Schoofs, Till, Rohde, Christian, Hebestreit, Katja, Klein, Hans-Ulrich, Göllner, Stefanie, Schulze, Isabell, Lerdrup, Mads, Dietrich, Nikolaj, Agrawal-Singh, Shuchi, Witten, Anika, Stoll, Monika, Lengfelder, Eva, Hofmann, Wolf-Karsten, Schlenke, Peter, Büchner, Thomas, Hansen, Klaus, Berdel, Wolfgang E., Rosenbauer, Frank, Dugas, Martin, Müller-Tidow, Carsten

“…The origin of aberrant DNA methylation in cancer remains largely unknown. In the present study, we elucidated the DNA methylome in primary acute promyelocytic…”
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Erratum: A model for transmission of the H3K27me3 epigenetic mark by Hansen, Klaus H., Bracken, Adrian P., Pasini, Diego, Dietrich, Nikolaj, Gehani, Simmi S., Monrad, Astrid, Rappsilber, Juri, Lerdrup, Mads, Helin, Kristian

“…Nature Cell Biol. 10, 1291–1300 (2008); published online 19 October 2008; corrected after print 28 October 2008 In the version of this article initially…”
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A model for transmission of the H3K27me3 epigenetic mark by Hansen, Klaus H, Bracken, Adrian P, Pasini, Diego, Dietrich, Nikolaj, Gehani, Simmi S, Monrad, Astrid, Rappsilber, Juri, Lerdrup, Mads, Helin, Kristian

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ADAM12 induces actin cytoskeleton and extracellular matrix reorganization during early adipocyte differentiation by regulating beta1 integrin function by Kawaguchi, Nobuko, Sundberg, Christina, Kveiborg, Marie, Moghadaszadeh, Behzad, Asmar, Meena, Dietrich, Nikolaj, Thodeti, Charles K, Nielsen, Finn C, Möller, Peter, Mercurio, Arthur M, Albrechtsen, Reidar, Wewer, Ulla M

“…Changes in cell shape are a morphological hallmark of differentiation. In this study we report that the expression of ADAM12, a disintegrin and…”
Get full text

Sym021, a promising anti-PD1 clinical candidate antibody derived from a new chicken antibody discovery platform by Gjetting, Torben, Gad, Monika, Fröhlich, Camilla, Lindsted, Trine, Melander, Maria C, Bhatia, Vikram K, Grandal, Michael M, Dietrich, Nikolaj, Uhlenbrock, Franziska, Galler, Gunther R, Strandh, Magnus, Lantto, Johan, Bouquin, Thomas, Horak, Ivan D, Kragh, Michael, Pedersen, Mikkel W, Koefoed, Klaus

“…Discovery of therapeutic antibodies is a field of intense development, where immunization of rodents remains a major source of antibody candidates. However,…”
Get full text