Search Results - "DIEP, Caroline H"

Desmoplasia in Primary Tumors and Metastatic Lesions of Pancreatic Cancer by Whatcott, Clifford J, Diep, Caroline H, Jiang, Ping, Watanabe, Aprill, LoBello, Janine, Sima, Chao, Hostetter, Galen, Shepard, H Michael, Von Hoff, Daniel D, Han, Haiyong

“…Pancreatic ductal adenocarcinoma (PDAC) is characterized by high levels of fibrosis, termed desmoplasia, which is thought to hamper the efficacy of…”
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Progesterone induces progesterone receptor gene (PGR) expression via rapid activation of protein kinase pathways required for cooperative estrogen receptor alpha (ER) and progesterone receptor (PR) genomic action at ER/PR target genes by Diep, Caroline H., Ahrendt, Hannah, Lange, Carol A.

“…•Progestin (R5020) upregulates endogenous PR expression in ER+/PR+ cells.•R5020-dependent upregulation of PR levels are dependent on PR and ER activities.•ER…”
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Progesterone action in breast, uterine, and ovarian cancers by Diep, Caroline H, Daniel, Andrea R, Mauro, Laura J, Knutson, Todd P, Lange, Carol A

“…Progesterone and progesterone receptors (PRs) are essential for the development and cyclical regulation of hormone-responsive tissues including the breast and…”
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Glucocorticoid receptors are required effectors of TGFβ1-induced p38 MAPK signaling to advanced cancer phenotypes in triple-negative breast cancer by Perez Kerkvliet, Carlos, Dwyer, Amy R, Diep, Caroline H, Oakley, Robert H, Liddle, Christopher, Cidlowski, John A, Lange, Carol A

“…Altered signaling pathways typify breast cancer and serve as direct inputs to steroid hormone receptor sensors. We previously reported that phospho-Ser134-GR…”
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Down-regulation of Yes Associated Protein 1 expression reduces cell proliferation and clonogenicity of pancreatic cancer cells by Diep, Caroline H, Zucker, Kelly M, Hostetter, Galen, Watanabe, Aprill, Hu, Chengcheng, Munoz, Ruben M, Von Hoff, Daniel D, Han, Haiyong

“…The Hippo pathway regulates organ size by inhibiting cell proliferation and promoting cell apoptosis upon its activation. The Yes Associated Protein 1 (YAP1)…”
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Navigating a plethora of progesterone receptors: Comments on the safety/risk of progesterone supplementation in women with a history of breast cancer or at high-risk for developing breast cancer by Diep, Caroline H, Mauro, Laura J, Lange, Carol A

“…Progesterone and progestin agonists are potent steroid hormones. There are at least three major types of progesterone receptor (PR) families that interact with…”
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Phosphorylated Progesterone Receptor Isoforms Mediate Opposing Stem Cell and Proliferative Breast Cancer Cell Fates by Truong, Thu H, Dwyer, Amy R, Diep, Caroline H, Hu, Hsiangyu, Hagen, Kyla M, Lange, Carol A

“…Abstract Progesterone receptors (PRs) are key modifiers of estrogen receptor (ER) target genes and drivers of luminal breast cancer progression. Total PR…”
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Active FOXO1 Is a Key Determinant of Isoform-Specific Progesterone Receptor Transactivation and Senescence Programming by Diep, Caroline H, Knutson, Todd P, Lange, Carol A

“…Progesterone promotes differentiation coupled to proliferation and prosurvival in the breast, but inhibits estrogen-driven growth in the reproductive tract and…”
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Progesterone Receptors Promote Quiescence and Ovarian Cancer Cell Phenotypes via DREAM in p53-Mutant Fallopian Tube Models by Mauro, Laura J, Seibel, Megan I, Diep, Caroline H, Spartz, Angela, Perez Kerkvliet, Carlos, Singhal, Hari, Swisher, Elizabeth M, Schwartz, Lauren E, Drapkin, Ronny, Saini, Siddharth, Sesay, Fatmata, Litovchick, Larisa, Lange, Carol A

“…Abstract Context The ability of ovarian steroids to modify ovarian cancer (OC) risk remains controversial. Progesterone is considered to be protective; recent…”
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Synergistic Effect between Erlotinib and MEK Inhibitors in KRAS Wild-Type Human Pancreatic Cancer Cells by DIEP, Caroline H, MUNOZ, Ruben M, CHOUDHARY, Ashish, VON HOFF, Daniel D, HAIYONG HAN

“…The combination of erlotinib and gemcitabine has shown a small but statistically significant survival advantage when compared with gemcitabine alone in…”
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Progesterone receptors induce FOXO1-dependent senescence in ovarian cancer cells by Diep, Caroline, Charles, Nathan, Blake Gilks, C., Kalloger, Steve, Argenta, Peter, Lange, Carol A.

“…Loss of nuclear progesterone receptors (PR) and low circulating progesterone levels are associated with increased ovarian cancer (OC) risk. However, PR are…”
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Progesterone Receptor–Cyclin D1 Complexes Induce Cell Cycle–Dependent Transcriptional Programs in Breast Cancer Cells by Dressing, Gwen E, Knutson, Todd P, Schiewer, Matthew J, Daniel, Andrea R, Hagan, Christy R, Diep, Caroline H, Knudsen, Karen E, Lange, Carol A

“…The progesterone receptor (PR) and its coactivators are direct targets of activated cyclin-dependent kinases (CDKs) in response to peptide growth factors,…”
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Progesterone Receptor Signaling Promotes Cancer Associated Fibroblast Mediated Tumorigenicity in ER+ Breast Cancer by Diep, Caroline H, Spartz, Angela, Truong, Thu H, Dwyer, Amy R, El-Ashry, Dorraya, Lange, Carol A

“…Abstract Breast cancer progression involves intricate interactions between cancer cells and the tumor microenvironment (TME). This study elucidates the…”
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Abstract POSTER-BIOL-1311: Mechanisms of differential activities of progesterone receptor (PR) isoforms in ovarian cancer models by Diep, Caroline H., Lange, Carol A.

“…Progesterone is proliferative in the breast, but inhibitory in the reproductive tract and ovaries. Elevated circulating progesterone levels observed during…”
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Abstract 4752: Targeting senescence-induced pro-survival pathways in PR+ ovarian cancer cells by Diep, Caroline H., Lange, Carol A.

“…Despite major advances in surgical techniques and chemotherapeutics, over 90% of women with advanced ovarian cancer ultimately succumb to recurrent…”
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Chemistry-First Approach for Nomination of Personalized Treatment in Lung Cancer by McMillan, Elizabeth A., Ryu, Myung-Jeom, Diep, Caroline H., Mendiratta, Saurabh, Clemenceau, Jean R., Vaden, Rachel M., Kim, Ju-Hwa, Motoyaji, Takashi, Covington, Kyle R., Peyton, Michael, Huffman, Kenneth, Wu, Xiaofeng, Girard, Luc, Sung, Yeojin, Chen, Pei-Hsaun, Mallipeddi, Prema L., Lee, Joo Young, Hanson, Jordan, Voruganti, Sukesh, Yu, Yunku, Park, Sunho, Sudderth, Jessica, DeSevo, Christopher, Muzny, Donna M., Doddapaneni, HarshaVardhan, Gazdar, Adi, Gibbs, Richard A., Hwang, Tae-Hyun, Heymach, John V., Wistuba, Ignacio, Coombes, Kevin R., Williams, Noelle S., Wheeler, David A., MacMillan, John B., Deberardinis, Ralph J., Roth, Michael G., Posner, Bruce A., Minna, John D., Kim, Hyun Seok, White, Michael A.

“…Diversity in the genetic lesions that cause cancer is extreme. In consequence, a pressing challenge is the development of drugs that target patient-specific…”
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Glucocorticoid receptors are required effectors of TGF[beta]1-induced p38 MAPK signaling to advanced cancer phenotypes in triple-negative breast cancer by Perez Kerkvliet, Carlos, Dwyer, Amy R, Diep, Caroline H, Oakley, Robert H, Liddle, Christopher, Cidlowski, John A, Lange, Carol A

“…Background Altered signaling pathways typify breast cancer and serve as direct inputs to steroid hormone receptor sensors. We previously reported that…”
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Abstract 744: Progesterone receptors promote quiescence & ovarian cancer cell phenotypes via modulation of DREAM in p53-mutant fallopian tube models by Mauro, Laura J., Seibel, Megan I., Diep, Caroline H., Spartz, Angela, Kerkvliet, Carlos Perez, Singhal, Hari, Swisher, Elizabeth M., Schwartz, Lauren E., Drapkin, Ronny, Saini, Siddharth, Seesay, Fatmata, Litovchick, Larisa, Lange, Carol A.

“…The ability of ovarian steroids to modulate ovarian cancer (OC) risk remains controversial. High grade serous ovarian carcinoma (HGSC), the most aggressive OC…”
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Abstract 3084: Progesterone receptor mediated crosstalk between cancer associated fibroblasts (CAFs) and ER+/PR+ breast cancer cells through CAF-secreted FGF2 by Spartz, Angela K., Diep, Caroline H., Lange, Carol A., El-Ashry, Dorraya

“…Late recurring ER+ breast cancer emerges in post-menopausal women despite low/no hormone conditions. Cancer associated fibroblasts (CAFs) represent a major…”
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Abstract A39: FOXO1 is a key determinant of progesterone receptor isoform-specific senescence programming in ovarian cancer cells by Diep, Caroline H., Knutson, Todd P., Mauro, Laura J., Lange, Carol A.

“…Progesterone promotes proliferation and pro-survival in the breast, but inhibits growth in the reproductive tract and ovaries. Herein, using progesterone…”
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