Search Results - "DIEHL, A. M"

Metformin in the treatment of non‐alcoholic steatohepatitis: a pilot open label trial by Nair, S., Diehl, A. M., Wiseman, M., Farr, G. H., Perrillo, R. P.

“…Summary Background : Insulin sensitizing agents may be useful in treatment of non‐alcoholic fatty liver disease. Aim : A pilot study to evaluate the efficacy…”
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Cytokines and the pathogenesis of non-alcoholic steatohepatitis by Diehl, A M, Li, Z P, Lin, H Z, Yang, S Q

“…[...]intra-abdominal fat provides an immediate source of free fatty acids that are delivered directly into the portal vein. 11 In mice, situations that…”
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Caspase-2 promotes obesity, the metabolic syndrome and nonalcoholic fatty liver disease by Machado, M V, Michelotti, G A, Jewell, M L, Pereira, T A, Xie, G, Premont, R T, Diehl, A M

“…Obesity and its resulting metabolic disturbances are major health threats. In response to energy surplus, overtaxed adipocytes release fatty acids and…”
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Myofibroblastic cells function as progenitors to regenerate murine livers after partial hepatectomy by Swiderska-Syn, M, Syn, W K, Xie, G, Krüger, L, Machado, M V, Karaca, G, Michelotti, G A, Choi, S S, Premont, R T, Diehl, A M

“…Smoothened (SMO), a coreceptor of the Hedgehog (Hh) pathway, promotes fibrogenic repair of chronic liver injury. We investigated the roles of SMO+…”
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Non-alcoholic fatty liver disease: lumen–liver interactions and possible role for probiotics by Solga, Steven F., Diehl, A.M.

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Osteopontin neutralisation abrogates the liver progenitor cell response and fibrogenesis in mice by Coombes, J D, Swiderska-Syn, M, Dollé, L, Reid, D, Eksteen, B, Claridge, L, Briones-Orta, M A, Shetty, S, Oo, Y H, Riva, A, Chokshi, S, Papa, S, Mi, Z, Kuo, P C, Williams, R, Canbay, A, Adams, D H, Diehl, A M, van Grunsven, L A, Choi, S S, Syn, W K

“…Chronic liver injury triggers a progenitor cell repair response, and liver fibrosis occurs when repair becomes deregulated. Previously, we reported that…”
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Quantitative comparison and evaluation of software packages for assessment of abdominal adipose tissue distribution by magnetic resonance imaging by Bonekamp, S, Ghosh, P, Crawford, S, Solga, S.F, Horska, A, Brancati, F.L, Diehl, A.M, Smith, S, Clark, J.M

“…Objective: To examine five available software packages for the assessment of abdominal adipose tissue with magnetic resonance imaging, compare their features…”
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Animal models of steatosis by Koteish, A, Diehl, A M

“…The lipid content of hepatocytes is regulated by the integrated activities of cellular enzymes that catalyze lipid uptake, synthesis, oxidation, and export…”
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Hepatic fibrogenesis requires sympathetic neurotransmitters by Oben, J A, Roskams, T, Yang, S, Lin, H, Sinelli, N, Torbenson, M, Smedh, U, Moran, T H, Li, Z, Huang, J, Thomas, S A, Diehl, A M

“…Background and aims: Hepatic stellate cells (HSC) are activated by liver injury to become proliferative fibrogenic myofibroblasts. This process may be…”
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Leptin regulates proinflammatory immune responses by Loffreda, S. (John Hopkins University, Baltimore, MD.), Yang, S.Q, Lin, H.Z, Karp, C.L, Brengman, M.L, Wang, D.J, Klein, A.S, Bulkley, G.B, Bao, C, Noble, P.W

“…Obesity is associated with an increased incidence of infection, diabetes, and cardiovascular disease, which together account for most obesity-related morbidity…”
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Inhibition of bone morphogenetic protein signaling reduces viability, growth and migratory potential of non-small cell lung carcinoma cells by Mihajlović, Jelena, Diehl, Laura A. M., Hochhaus, Andreas, Clement, Joachim H.

“…Purpose BMP signaling has an oncogenic and tumor-suppressing activity in lung cancer that makes the prospective therapeutic utility of BMP signaling in lung…”
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Alterations in Liver ATP Homeostasis in Human Nonalcoholic Steatohepatitis: A Pilot Study by Cortez-Pinto, Helena, Chatham, John, Chacko, V. P, Arnold, Cheryl, Rashid, Asif, Diehl, Anna Mae

“…CONTEXT The mechanisms that drive progression from fatty liver to steatohepatitis and cirrhosis are unknown. In animal models, obese mice with fatty livers are…”
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Breath biomarkers and non-alcoholic fatty liver disease: Preliminary observations by Solga, S. F., Alkhuraishe, A., Cope, K., Tabesh, A., Clark, J. M., Torbenson, M., Schwartz, P., Magnuson, T., Diehl, A. M., Risby, T. H.

“…Abstract Breath biomarkers have the potential to offer information that is similar to conventional clinical tests or they are entirely unique. Preliminary data…”
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Insulin resistance and steatosis in hepatitis C virus infection by Zekry, A, McHutchison, J G, Diehl, A M

“…The relationship between hepatitis C virus (HCV), steatosis, and insulin resistance is genotype specific, and steatosis and insulin resistance are closely…”
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Fatty liver, hypertension, and the metabolic syndrome by Diehl, A M

“…The prevalence of fatty liver in non-obese non-diabetic hypertensive patients is at least twice that of the general population and may be related to increases…”
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Altered hepatic lymphocyte subpopulations in obesity‐related murine fatty livers: Potential mechanism for sensitization to liver damage by Guebre‐Xabier, Mimi, Yang, ShiQi, Lin, Hui Zhi, Schwenk, Robert, Krzych, Ursula, Diehl, Anna Mae

“…Although obesity‐related fatty livers are vulnerable to damage from endotoxin, the mechanisms involved remain obscure. The purpose of this study was to…”
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A 30-kDa Alternative Translation Product of the CCAAT/Enhancer Binding Protein α Message: Transcriptional Activator Lacking Antimitotic Activity by Lin, Fang-Tsyr, MacDougald, Ormond A., Diehl, Anna Mae, Lane, M. Daniel

“…Full-length (42 kDa) CCAAT/enhancer binding protein α (C/EBPα) (p42) has been implicated in the transcriptional activation of adipocyte genes including the…”
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Chronic Ethanol Consumption Induces the Production of Tumor Necrosis Factor-α and Related Cytokines in Liver and Adipose Tissue by Lin, H. Z., Yang, S. Q., Zeldin, G., Diehl, A. M.

“…Increases in monocyte/macrophage production of the proinflammatory cytokine, tumor necrosis factor‐α (TNF‐α), parallel the evolution of liver injury in rats…”
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Reduced lipoapoptosis, hedgehog pathway activation and fibrosis in caspase-2 deficient mice with non-alcoholic steatohepatitis by Machado, M V, Michelotti, G A, Pereira, T de Almeida, Boursier, J, Kruger, L, Swiderska-Syn, M, Karaca, G, Xie, G, Guy, C D, Bohinc, B, Lindblom, K R, Johnson, E, Kornbluth, S, Diehl, A M

“…Caspase-2 is an initiator caspase involved in multiple apoptotic pathways, particularly in response to specific intracellular stressors (eg, DNA damage, ER…”
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NAFLD and extrahepatic cancers: have a look at the colon by Tilg, Herbert, Diehl, Anna Mae

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