Search Results - "DIDRIKSEN, Michael"

Transcriptomic networks implicate neuronal energetic abnormalities in three mouse models harboring autism and schizophrenia-associated mutations by Gordon, Aaron, Forsingdal, Annika, Klewe, Ib Vestergaard, Nielsen, Jacob, Didriksen, Michael, Werge, Thomas, Geschwind, Daniel H.

“…Genetic risk for psychiatric illness is complex, so identification of shared molecular pathways where distinct forms of genetic risk might coincide is of…”
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Antagonism of dopamine D2 receptor/β-arrestin 2 interaction is a common property of clinically effective antipsychotics by Masri, Bernard, Salahpour, Ali, Didriksen, Michael, Ghisi, Valentina, Beaulieu, Jean-Martin, Gainetdinov, Raul R, Caron, Marc G

“…Since the unexpected discovery of the antipsychotic activity of chlorpromazine, a variety of therapeutic agents have been developed for the treatment of…”
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Interactive effects between hemizygous 15q13.3 microdeletion and peripubertal stress on adult behavioral functions by Giovanoli, Sandra, Werge, Thomas M, Mortensen, Preben B, Didriksen, Michael, Meyer, Urs

“…15q13.3 microdeletion is one of several gene copy number variants (CNVs) conferring increased risk of psychiatric and neurological disorders. This…”
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Differential resting-state patterns across networks are spatially associated with Comt and Trmt2a gene expression patterns in a mouse model of 22q11.2 deletion by Gass, Natalia, Peterson, Zeru, Reinwald, Jonathan, Sartorius, Alexander, Weber-Fahr, Wolfgang, Sack, Markus, Chen, Junfang, Cao, Han, Didriksen, Michael, Stensbøl, Tine Bryan, Klemme, Gabrielle, Schwarz, Adam J., Schwarz, Emanuel, Meyer-Lindenberg, Andreas, Nickl-Jockschat, Thomas

“…Copy number variations (CNV) involving multiple genes are ideal models to study polygenic neuropsychiatric disorders. Since 22q11.2 deletion is regarded as the…”
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BrainSeq: Neurogenomics to Drive Novel Target Discovery for Neuropsychiatric Disorders by Schubert, Christian R., O’Donnell, Patricio, Quan, Jie, Wendland, Jens R., Xi, Hualin S., Winslow, Ashley R., Domenici, Enrico, Essioux, Laurent, Kam-Thong, Tony, Airey, David C., Calley, John N., Collier, David A., Wang, Hong, Eastwood, Brian, Ebert, Philip, Liu, Yushi, Nisenbaum, Laura, Ruble, Cara, Scherschel, James E., Smith, Ryan Matthew, Qian, Hui-Rong, Merchant, Kalpana, Didriksen, Michael, Matsumoto, Mitsuyuki, Saito, Takeshi, Brandon, Nicholas J., Cross, Alan J., Wang, Qi, Manji, Husseini, Kolb, Hartmuth, Furey, Maura, Drevets, Wayne C., Shin, Joo Heon, Jaffe, Andrew E., Jia, Yankai, Straub, Richard E., Deep-Soboslay, Amy, Hyde, Thomas M., Kleinman, Joel E., Weinberger, Daniel R.

“…We outline an ambitious project to characterize the genetic and epigenetic regulation of multiple facets of transcription in distinct brain regions across the…”
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Cognition- and circuit-based dysfunction in a mouse model of 22q11.2 microdeletion syndrome: effects of stress by Tripathi, Anushree, Spedding, Michael, Schenker, Esther, Didriksen, Michael, Cressant, Arnaud, Jay, Therese M.

“…Genetic microdeletion at the 22q11 locus is associated with very high risk for schizophrenia. The 22q11.2 microdeletion (Df(h22q11)/+) mouse model shows…”
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Persistent gating deficit and increased sensitivity to NMDA receptor antagonism after puberty in a new mouse model of the human 22q11.2 microdeletion syndrome: a study in male mice by Didriksen, Michael, PhD, Fejgin, Kim, PhD, Birknow, Michelle R., MSc, Larsen, Peter H., PhD, Lauridsen, Jes B., PhD, Nielsen, Vibeke, BSc, Kallunki, Pekka, PhD, Christensen, Kenneth V., PhD, Stensbøl, Tine B., PhD, Egebjerg, Jan, PhD, Nielsen, Jacob, PhD, Nilsson, Simon R.O., PhD, Grayton, Hannah M., PhD, Gastambide, Francois, PhD, Celada, Pau, PhD, Artigas, Francesc, PhD, Santana, Noemi, PhD, Werge, Thomas M., PhD, Bastlund, Jesper F., PhD

“…Background The hemizygous 22q11.2 microdeletion is a common copy number variant in humans. The deletion confers high risk for neurodevelopmental disorders,…”
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Assessing the Cognitive Translational Potential of a Mouse Model of the 22q11.2 Microdeletion Syndrome by Nilsson, Simon Ro, Fejgin, Kim, Gastambide, Francois, Vogt, Miriam A, Kent, Brianne A, Nielsen, Vibeke, Nielsen, Jacob, Gass, Peter, Robbins, Trevor W, Saksida, Lisa M, Stensbøl, Tine B, Tricklebank, Mark D, Didriksen, Michael, Bussey, Timothy J

“…A chromosomal microdeletion at the 22q11.2 locus is associated with extensive cognitive impairments, schizophrenia and other psychopathology in humans…”
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A mouse model of the 15q13.3 microdeletion syndrome shows prefrontal neurophysiological dysfunctions and attentional impairment by Nilsson, Simon R. O., Celada, Pau, Fejgin, Kim, Thelin, Jonas, Nielsen, Jacob, Santana, Noemí, Heath, Christopher J., Larsen, Peter H., Nielsen, Vibeke, Kent, Brianne A., Saksida, Lisa M., Stensbøl, Tine B., Robbins, Trevor W., Bastlund, Jesper F., Bussey, Timothy J., Artigas, Francesc, Didriksen, Michael

“…Rationale A microdeletion at locus 15q13.3 is associated with high incidence rates of psychopathology, including schizophrenia. A mouse model of the 15q13.3…”
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Altered dopaminergic firing pattern and novelty response underlie ADHD-like behavior of SorCS2-deficient mice by Olsen, Ditte, Wellner, Niels, Kaas, Mathias, de Jong, Inge E. M., Sotty, Florence, Didriksen, Michael, Glerup, Simon, Nykjaer, Anders

“…Attention deficit hyperactivity disorder (ADHD) is the most frequently diagnosed neurodevelopmental disorder worldwide. Affected individuals present with…”
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A mouse model of the schizophrenia-associated 1q21.1 microdeletion syndrome exhibits altered mesolimbic dopamine transmission by Nielsen, Jacob, Fejgin, Kim, Sotty, Florence, Nielsen, Vibeke, Mørk, Arne, Christoffersen, Claus T., Yavich, Leonid, Lauridsen, Jes B., Clausen, Dorte, Larsen, Peter H., Egebjerg, Jan, Werge, Thomas M., Kallunki, Pekka, Christensen, Kenneth V., Didriksen, Michael

“…1q21.1 hemizygous microdeletion is a copy number variant leading to eightfold increased risk of schizophrenia. In order to investigate biological alterations…”
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Disruption of Neurogenesis on Gestational Day 17 in the Rat Causes Behavioral Changes Relevant to Positive and Negative Schizophrenia Symptoms and Alters Amphetamine-Induced Dopamine Release in Nucleus Accumbens by FLAGSTAD, Peter, MØRK, Arne, GLENTHØJ, Birte Y, VAN BEEK, Johan, MICHAEL-TITUS, Adina T, DIDRIKSEN, Michael

“…Gestational disruption of neurodevelopment has been proposed to lead to pathophysiological changes similar to those underlying schizophrenia. We induced such…”
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Cognitive Deficits Caused by Late Gestational Disruption of Neurogenesis in Rats: a Preclinical Model of Schizophrenia by FLAGSTAD, Peter, GLENTHØJ, Birte Y, DIDRIKSEN, Michael

“…Late gestational disruption of neurogenesis in rats has been shown to induce behavioral abnormalities thought to mimic aspects of positive and negative…”
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Comparison of quantitative trait loci methods: Total expression and allelic imbalance method in brain RNA-seq by Gådin, Jesper R, Buil, Alfonso, Colantuoni, Carlo, Jaffe, Andrew E, Nielsen, Jacob, Shin, Joo-Heon, Hyde, Thomas M, Kleinman, Joel E, Plath, Niels, Eriksson, Per, Brunak, Søren, Didriksen, Michael, Weinberger, Daniel R, Folkersen, Lasse

“…Of the 108 Schizophrenia (SZ) risk-loci discovered through genome-wide association studies (GWAS), 96 are not altering the sequence of any protein. Evidence…”
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Decrease in parvalbumin-expressing neurons in the hippocampus and increased phencyclidine-induced locomotor activity in the rat methylazoxymethanol (MAM) model of schizophrenia by Penschuck, Silke, Flagstad, Peter, Didriksen, Michael, Leist, Marcel, Michael-Titus, Adina T.

“…Treatment of rats with methylazoxymethanol (MAM) on gestational day (GD)17 disrupts corticolimbic development in the offspring (MAM‐GD17 rats) and leads to…”
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Genome-wide scans using archived neonatal dried blood spot samples by Hollegaard, Mads V, Grauholm, Jonas, Børglum, Anders, Nyegaard, Mette, Nørgaard-Pedersen, Bent, Ørntoft, Torben, Mortensen, Preben B, Wiuf, Carsten, Mors, Ole, Didriksen, Michael, Thorsen, Poul, Hougaard, David M

“…Identification of disease susceptible genes requires access to DNA from numerous well-characterised subjects. Archived residual dried blood spot samples from…”
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Individuals with 22q11.2 deletion syndrome show intact prediction but reduced adaptation in responses to repeated sounds: Evidence from Bayesian mapping by Larsen, Kit Melissa, Mørup, Morten, Birknow, Michelle Rosgaard, Fischer, Elvira, Olsen, Line, Didriksen, Michael, Baaré, William Frans Christiaan, Werge, Thomas Mears, Garrido, Marta Isabel, Siebner, Hartwig Roman

“…One of the most common copy number variants, the 22q11.2 microdeletion, confers an increased risk for schizophrenia. Since schizophrenia has been associated…”
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Nest building performance following MPTP toxicity in mice by Sager, Thomas Nikolaj, Kirchhoff, Jeppe, Mørk, Arne, Van Beek, Johan, Thirstrup, Kenneth, Didriksen, Michael, Lauridsen, Jes Brix

“…Systemic injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mice is one of the primary models used to evaluate neuroprotective and symptomatic…”
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Lu AF35700 reverses the phencyclidine-induced disruption of thalamo-cortical activity by blocking dopamine D1 and D2 receptors by Riga, Maurizio S., Paz, Veronica, Didriksen, Michael, Celada, Pau, Artigas, Francesc

“…Antipsychotic drugs of different chemical/pharmacological families show preferential dopamine (DA) D2 receptor (D2-R) vs. D1 receptor (D1-R) affinity, with the…”
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Can Animal Models of Copy Number Variants That Predispose to Schizophrenia Elucidate Underlying Biology? by Forsingdal, Annika, Jørgensen, Trine Nygaard, Olsen, Line, Werge, Thomas, Didriksen, Michael, Nielsen, Jacob

“…The diagnosis of schizophrenia rests on clinical criteria that cannot be assessed in animal models. Together with absence of a clear underlying pathology and…”
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