Search Results - "DICKSON, Robert B"

A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes by Neve, Richard M., Chin, Koei, Fridlyand, Jane, Yeh, Jennifer, Baehner, Frederick L., Fevr, Tea, Clark, Laura, Bayani, Nora, Coppe, Jean-Philippe, Tong, Frances, Speed, Terry, Spellman, Paul T., DeVries, Sandy, Lapuk, Anna, Wang, Nick J., Kuo, Wen-Lin, Stilwell, Jackie L., Pinkel, Daniel, Albertson, Donna G., Waldman, Frederic M., McCormick, Frank, Dickson, Robert B., Johnson, Michael D., Lippman, Marc, Ethier, Stephen, Gazdar, Adi, Gray, Joe W.

“…Recent studies suggest that thousands of genes may contribute to breast cancer pathophysiologies when deregulated by genomic or epigenomic events. Here, we…”
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Matriptase activates stromelysin (MMP‐3) and promotes tumor growth and angiogenesis by Jin, Xinlian, Yagi, Motoki, Akiyama, Nagisa, Hirosaki, Tomomi, Higashi, Shouichi, Lin, Chen‐Yong, Dickson, Robert B., Kitamura, Hitoshi, Miyazaki, Kaoru

“…Matriptase/MT‐SP1, a type II membrane serine protease widely expressed in normal epithelial cells and human carcinoma cells, is thought to be involved in…”
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A Novel Biomarker for Staging Human Prostate Adenocarcinoma: Overexpression of Matriptase with Concomitant Loss of its Inhibitor, Hepatocyte Growth Factor Activator Inhibitor-1 by SALEEM, Mohammad, VAQAR MUSTAFA ADHAMI, WEIXIONG ZHONG, LONGLEY, B. Jack, LIN, Chen-Yong, DICKSON, Robert B, REAGAN-SHAW, Shannon, JARRARD, David F, MUKHTAR, Hasan

“…Background: Matriptase, a type II transmembrane serine protease is involved in angiogenesis, degradation of extracellular matrix, and in the progression of…”
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Autoactivation of matriptase in vitro: requirement for biomembrane and LDL receptor domain by Lee, Ming-Shyue, Tseng, I-Chu, Wang, Youhong, Kiyomiya, Ken-ichi, Johnson, Michael D, Dickson, Robert B, Lin, Chen-Yong

“…In live cells, autoactivation of matriptase, a membrane-bound serine protease, can be induced by lysophospholipids, androgens, and the polyanionic compound…”
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HAI-1 regulates activation and expression of matriptase, a membrane-bound serine protease by Oberst, Michael D, Chen, Li-Yuan L, Kiyomiya, Ken-Ichi, Williams, Cicely A, Lee, Ming-Shyue, Johnson, Michael D, Dickson, Robert B, Lin, Chen-Yong

“…Hepatocyte growth factor activator inhibitor-1 (HAI-1) was initially identified as cognate inhibitor of matriptase, a membrane-bound serine protease…”
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The Activation of Matriptase Requires Its Noncatalytic Domains, Serine Protease Domain, and Its Cognate Inhibitor by Oberst, Michael D., Williams, Cicely A., Dickson, Robert B., Johnson, Michael D., Lin, Chen-Yong

“…The activation of matriptase requires proteolytic cleavage at a canonical activation motif that converts the enzyme from a one-chain zymogen to an active,…”
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Calmodulin-mediated Activation of Akt Regulates Survival of c-Myc-overexpressing Mouse Mammary Carcinoma Cells by Deb, Tushar B., Coticchia, Christine M., Dickson, Robert B.

“…c-Myc-overexpressing mammary epithelial cells are proapoptotic; their survival is strongly promoted by epidermal growth factor (EGF). We now demonstrate that…”
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Characterization of Matriptase Expression in Normal Human Tissues by Oberst, Michael D, Singh, Baljit, Ozdemirli, Metin, Dickson, Robert B, Johnson, Michael D, Lin, Chen-Yong

“…Matriptase is a type II transmembrane serine protease that has been implicated in the progression of epithelium-derived tumors. The role of this protease in…”
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Roles of androgens in the development, growth, and carcinogenesis of the mammary gland by Liao, Dezhong J, Dickson, Robert B

“…Androgens influence the development and growth of the mammary gland in women. Treatment of animals and cultured cells with androgens has either inhibitory or…”
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Prognostic relevance of c-MYC gene amplification and polysomy for chromosome 8 in suboptimally-resected, advanced stage epithelial ovarian cancers: A Gynecologic Oncology Group study by Darcy, Kathleen M, Brady, William E, Blancato, Jan K, Dickson, Robert B, Hoskins, William J, McGuire, William P, Birrer, Michael J

“…Abstract Objective The Gynecologic Oncology Group (GOG) examined the prognostic relevance of c-MYC amplification and polysomy 8 in epithelial ovarian cancer…”
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Pentameric procyanidin from Theobroma cacao selectively inhibits growth of human breast cancer cells by Ramljak, Danica, Romanczyk, Leo J, Metheny-Barlow, Linda J, Thompson, Nicole, Knezevic, Vladimir, Galperin, Mikhail, Ramesh, Arun, Dickson, Robert B

“…A naturally occurring, cocoa-derived pentameric procyanidin (pentamer) was previously shown to cause G 0 /G 1 cell cycle arrest in human breast cancer cells by…”
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Matriptase and HAI-1 Are Expressed by Normal and Malignant Epithelial Cells in Vitro and in Vivo by Oberst, Michael, Anders, Joanna, Xie, Bin, Singh, Baljit, Ossandon, Miguel, Johnson, Michael, Dickson, Robert B., Lin, Chen-Yong

“…Matriptase and its cognate, Kunitz-type serine protease inhibitor, HAI-1, comprise a newly characterized extracellular matrix-degrading protease system that…”
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Simultaneous activation and hepatocyte growth factor activator inhibitor 1-mediated inhibition of matriptase induced at activation foci in human mammary epithelial cells by Lee, Ming-Shyue, Kiyomiya, Ken-ichi, Benaud, Christelle, Dickson, Robert B, Lin, Chen-Yong

“…Activation of single-chain, latent matriptase, a type II transmembrane serine protease, depends on the weak proteolytic activity of its own zymogen as well as…”
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Type II transmembrane serine proteases by Szabo, Roman, Wu, Qingyu, Dickson, Robert B, Netzel-Arnett, Sarah, Antalis, Toni M, Bugge, Thomas H

“…The recent availability of human and mouse genome sequences and expressed sequence tag databases facilitated the identification of a large new family of…”
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Inhibition of Tumor Invasion by Genomic Down-regulation of Matriptase through Suppression of Activation of Receptor-bound Pro-urokinase by Suzuki, Mika, Kobayashi, Hiroshi, Kanayama, Naohiro, Saga, Yasushi, Suzuki, Mitsuaki, Lin, Chen-Yong, Dickson, Robert B., Terao, Toshihiko

“…Urokinase-type plasminogen activator (uPA) degrades the extracellular matrix and plays critical roles in tumor invasion and metastasis. Matriptase, a…”
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Indole‐3‐carbinol activates the ATM signaling pathway independent of DNA damage to stabilize p53 and induce G1 arrest of human mammary epithelial cells by Brew, Christine T., Aronchik, Ida, Hsu, Jocelyn C., Sheen, Joon‐Ho, Dickson, Robert B., Bjeldanes, Leonard F., Firestone, Gary L.

“…The phytochemical indole‐3‐carbinol (I3C), from cruciferous vegetables such as broccoli, has been shown to elicit a potent anti‐proliferative response in human…”
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Sphingosine 1-Phosphate, Present in Serum-derived Lipoproteins, Activates Matriptase by Benaud, Christelle, Oberst, Michael, Hobson, John P., Spiegel, Sarah, Dickson, Robert B., Lin, Chen-Yong

“…We describe here a novel biological function of sphingosine 1-phosphate (S1P): the activation of a serine protease, matriptase. Matriptase is a type II…”
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Coexpression of β1,6-N-Acetylglucosaminyltransferase V Glycoprotein Substrates Defines Aggressive Breast Cancers with Poor Outcome by SIDDIQUI, Summar F, PAWELEK, John, HANDERSON, Tamara, LIN, Chen-Yong, DICKSON, Robert B, RIMM, David L, CAMP, Robert L

“…β1,6- N -Acetylglucosaminyltransferase-V (GnT-V) catalyzes the addition of complex oligosaccharide side chains to glycoproteins, regulating the expression and…”
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Identification of membrane‐bound serine proteinase matriptase as processing enzyme of insulin‐like growth factor binding protein‐related protein‐1 (IGFBP‐rP1/angiomodulin/mac25) by Ahmed, Sanjida, Jin, Xinlian, Yagi, Motoki, Yasuda, Chie, Sato, Yuichiro, Higashi, Shouichi, Lin, Chen‐Yong, Dickson, Robert B., Miyazaki, Kaoru

“…Insulin‐like growth factor (IGF) binding protein‐related protein‐1 (IGFBP‐rP1) modulates cellular adhesion and growth in an IGF/insulin‐dependent or…”
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Of mice and Myc: c-Myc and mammary tumorigenesis by Jamerson, M Hunter, Johnson, Michael D, Dickson, Robert B

“…The proto-oncogene c- myc is involved in regulating proliferation and apoptosis, and its deregulation via genomic and postgenomic mechanisms, contributes to…”
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