Search Results - "DIBRA, Denada"

Universal Marker and Detection Tool for Human Sarcoma Circulating Tumor Cells by SATELLI, Arun, MITRA, Abhisek, LUDWIG, Joseph A, KLEINERMAN, Eugenie S, SHULIN LI, CUTRERA, Jeffry J, DEVARIE, Marcos, XUEQING XIA, INGRAM, Davis R, DIBRA, Denada, SOMAIAH, Neeta, TORRES, Keila E, RAVI, Vinod

“…To date, no specific marker exists for the detection of circulating tumor cells (CTC) from different types of sarcomas, though tools are available for…”
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A spontaneous model of spondyloarthropathies that develops bone loss and pathological bone formation: A process regulated by IL27RA-/- and mutant-p53 by Dibra, Denada, Xia, Xueqing, Gagea, Mihai, Lozano, Guillermina, Li, Shulin

“…Spondyloarthropathies, the second most frequently occurring form of chronic inflammatory arthritis, affects young adults in particular. However, a proper model…”
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Interleukin-30: A novel antiinflammatory cytokine candidate for prevention and treatment of inflammatory cytokine-induced liver injury by Dibra, Denada, Cutrera, Jeffry, Xia, Xueqing, Kallakury, Bhaskar, Mishra, Lopa, Li, Shulin

“…The liver is the major metabolic organ and is subjected to constant attacks from chronic viral infection, uptake of therapeutic drugs, life behavior…”
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Discovery of a Linear Peptide for Improving Tumor Targeting of Gene Products and Treatment of Distal Tumors by IL-12 Gene Therapy by Cutrera, Jeffry, Dibra, Denada, Xia, Xueqing, Hasan, Azeem, Reed, Scott, Li, Shulin

“…Like many effective therapeutics, interleukin-12 (IL-12) therapy often causes side effects. Tumor targeted delivery may improve the efficacy and decrease the…”
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Lack of Immunomodulatory Interleukin-27 Enhances Oncogenic Properties of Mutant p53 In Vivo by Dibra, Denada, Mitra, Abhisek, Newman, Melisa, Xia, Xueqing, Cutrera, Jeffry J, Gagea, Mihai, Kleinerman, Eugenie S, Lozano, Guillermina, Li, Shulin

“…p53 is mutated in about 50% of human cancers, mostly through missense mutations. Expression of mutant p53 is associated with poor clinical outcomes or…”
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WSX1 expression in tumors induces immune tolerance via suppression of effector immune cells by Dibra, Denada, Cutrera, Jeffry, Xia, Xueqing, Li, Shulin

“…Crosstalk between tumor cells and the cognate microenvironment plays a crucial role in tumor initiation and progression. However, only a few genes are known to…”
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Expression of WSX1 in Tumors Sensitizes IL-27 Signaling-Independent Natural Killer Cell Surveillance by DIBRA, Denada, CUTRERA, Jeffry J, XUEQING XIA, BIRKENBACH, Mark P, SHULIN LI

“…It is well known that the interleukin (IL)-27 receptor WSX1 is expressed in immune cells and induces an IL-27-dependent immune response. Opposing this…”
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Intricacies for Posttranslational Tumor-Targeted Cytokine Gene Therapy by Cutrera, Jeffry, Dibra, Denada, Satelli, Arun, Xia, Xuexing, Li, Shulin

“…The safest and most effective cytokine therapies require the favorable accumulation of the cytokine in the tumor environment. While direct treatment into the…”
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Triple-negative breast tumors are dependent on mutant p53 for growth and survival by Dibra, Denada, Moyer, Sydney M, El-Naggar, Adel K, Qi, Yuan, Su, Xiaoping, Lozano, Guillermina

“…The tumor suppressor gene is mutated early in the majority of patients with triple-negative breast cancer (TNBC). The most frequent alterations are missense…”
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FGL2 as a Multimodality Regulator of Tumor-Mediated Immune Suppression and Therapeutic Target in Gliomas by Yan, Jun, Kong, Ling-Yuan, Hu, Jiemiao, Gabrusiewicz, Konrad, Dibra, Denada, Xia, Xueqing, Heimberger, Amy B, Li, Shulin

“…Fibrinogen-like protein 2 (FGL2) may promote glioblastoma multiforme (GBM) cancer development by inducing multiple immune-suppression mechanisms. The…”
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Molecular mechanisms of oncogene-induced inflammation and inflammation-sustained oncogene activation in gastrointestinal tumors: An underappreciated symbiotic relationship by Dibra, Denada, Mishra, Lopa, Li, Shulin

“…Inflammation plays an integral part in tumor initiation. Specifically, patients with colitis, pancreatitis, or hepatitis have an increased susceptibility to…”
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The cell-to-cell coordination between activated T cells and CpG-stimulated macrophages synergistically induce elevated levels of IL-10 via NF-κB1, STAT3, and CD40/CD154 by Dibra, Denada, Li, Shulin

“…Studies into the regulation of interleukin-10 (IL-10), have focused only on the molecular or single-cell level. The cues that induce IL-10 in the context of…”
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Mutant p53 in concert with an interleukin‐27 receptor alpha deficiency causes spontaneous liver inflammation, fibrosis, and steatosis in mice by Dibra, Denada, Xia, Xueqing, Mitra, Abhisek, Cutrera, Jeffry J., Lozano, Guillermina, Li, Shulin

“…The cellular and molecular etiology of unresolved chronic liver inflammation remains obscure. Whereas mutant p53 has gain‐of‐function properties in tumors, the…”
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A spontaneous model of spondyloarthropathies that develops bone loss and pathological bone formation: A process regulated by IL27RA.sup.-/- and mutant-p53 by Dibra, Denada, Xia, Xueqing, Gagea, Mihai, Lozano, Guillermina, Li, Shulin

“…Spondyloarthropathies, the second most frequently occurring form of chronic inflammatory arthritis, affects young adults in particular. However, a proper model…”
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Coordination between TLR9 signaling in macrophages and CD3 signaling in T cells induces robust expression of IL-30 by Dibra, Denada, Cutrera, Jeffry J, Li, Shulin

“…IL-30, the p28 subunit of IL-27, interacts with EBV-induced gene 3 to form IL-27, which modulates both proinflammatory and anti-inflammatory responses during…”
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p53R245W Mutation Fuels Cancer Initiation and Metastases in NASH-driven Liver Tumorigenesis by Dibra, Denada, Gagea, Mihai, Qi, Yuan, Chau, Gilda P, Su, Xiaoping, Lozano, Guillermina

“…Obesity is a significant global health concern. Non-alcoholic fatty liver disease and non-alcoholic steatohepatitis (NASH) are common risk factors for…”
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Abstract 1082: IL27 promotes papilloma formation via inducing a pro-inflammatory milieu in the skin by Dibra, Denada, Xia, Xueqing, Newman, Melissa, Keenan, Camille, Li, Shulin

“…Ras activation plays an important role in Squamous Cell Carcinomas (SCC) development. Additionally, there is large evidence confirming the role of inflammation…”
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Coordination between TLR9 Signaling in Macrophages and CD3 Signaling in T cells Induces Robust Expression of IL301 by Dibra, Denada, Cutrera, Jeffry J., Li, Shulin

“…Interleukin 30 (IL30), the p28 subunit of IL27, interacts with Epstein-Barr virus induced gene 3 to form IL27, which modulates both pro- and anti-inflammatory…”
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Mutant p53 in concert with an IL27 Receptor α deficiency causes spontaneous liver inflammation, fibrosis, and steatosis by Dibra, Denada, Xia, Xueqing, Mitra, Abhisek, Cutrera, Jeffry J., Lozano, Guillermina, Li, Shulin

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Mutant p53 protects triple-negative breast adenocarcinomas from ferroptosis in vivo by Dibra, Denada, Xiong, Shunbin, Moyer, Sydney M, El-Naggar, Adel K, Qi, Yuan, Su, Xiaoping, Kong, Elisabeth K, Korkut, Anil, Lozano, Guillermina

“…The tumor suppressor gene is mutated early in most of the patients with triple-negative breast cancer (TNBC). The most frequent alterations are missense…”
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