Search Results - "DI XIA"

Hyperphosphorylated tau causes reduced hippocampal CA1 excitability by relocating the axon initial segment by Hatch, Robert John, Wei, Yan, Xia, Di, Götz, Jürgen

“…Hyperphosphorylated tau has a critical role in tauopathies such as Alzheimer’s disease and frontotemporal dementia, impairing neuronal function and eventually…”
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Altered Intersubunit Communication Is the Molecular Basis for Functional Defects of Pathogenic p97 Mutants by Tang, Wai Kwan, Xia, Di

“…The human AAA ATPase p97 is a molecular chaperone essential in cellular proteostasis. Single amino acid substitutions in p97 have been linked to a clinical…”
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The role of YAP/TAZ activity in cancer metabolic reprogramming by Zhang, Xiaodong, Zhao, Haiying, Li, Yan, Xia, Di, Yang, Liang, Ma, Yingbo, Li, Hangyu

“…In contrast to normal cells, which use the aerobic oxidation of glucose as their main energy production method, cancer cells prefer to use anaerobic glycolysis…”
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Structural Basis of p97 Inhibition by the Site-Selective Anticancer Compound CB-5083 by Tang, Wai Kwan, Odzorig, Taivan, Jin, Whitney, Xia, Di

“…Inhibition of p97, a key player in the ubiquitin-proteasome degradation pathway, has been proposed as a treatment of cancer. This concept was nearly realized…”
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Induction of apoptosis and ferroptosis by a tumor suppressing magnetic field through ROS-mediated DNA damage by Yuan, Lin-Qing, Wang, Can, Lu, Dong-Fang, Zhao, Xia-Di, Tan, Lin-Hua, Chen, Xi

“…Magnetic field (MF) is being used in antitumor treatment; however, the underlying biological mechanisms remain unclear. In this study, the potency and…”
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Role of the D1-D2 Linker of Human VCP/p97 in the Asymmetry and ATPase Activity of the D1-domain by Tang, Wai Kwan, Xia, Di

“…Human AAA + protein p97 consists of an N-domain and two tandem ATPase domains D1 and D2, which are connected by the N-D1 and the D1-D2 linkers. Inclusion of…”
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Hypoxia-induced P4HA1 overexpression promotes post-ischemic angiogenesis by enhancing endothelial glycolysis through downregulating FBP1 by Xu, Yating, Xia, Di, Huang, Kai, Liang, Minglu

“…Angiogenesis is essential for tissue repair in ischemic diseases, relying on glycolysis as its primary energy source. Prolyl 4-hydroxylase subunit alpha 1…”
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Faster Deep Inertial Pose Estimation with Six Inertial Sensors by Xia, Di, Zhu, Yeqing, Zhang, Heng

“…We propose a novel pose estimation method that can predict the full-body pose from six inertial sensors worn by the user. This method solves problems…”
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Sensing and Transmitting Intracellular Amino Acid Signals through Reversible Lysine Aminoacylations by He, Xia-Di, Gong, Wei, Zhang, Jia-Nong, Nie, Ji, Yao, Cui-Fang, Guo, Fu-Shen, Lin, Yan, Wu, Xiao-Hui, Li, Feng, Li, Jie, Sun, Wei-Cheng, Wang, En-Duo, An, Yan-Peng, Tang, Hui-Ru, Yan, Guo-Quan, Yang, Peng-Yuan, Wei, Yun, Mao, Yun-Zi, Lin, Peng-Cheng, Zhao, Jian-Yuan, Xu, Yanhui, Xu, Wei, Zhao, Shi-Min

“…Amino acids are known regulators of cellular signaling and physiology, but how they are sensed intracellularly is not fully understood. Herein, we report that…”
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A concerted ATPase cycle of the protein transporter AAA-ATPase Bcs1 by Pan, Yangang, Zhan, Jingyu, Jiang, Yining, Xia, Di, Scheuring, Simon

“…Bcs1, a homo-heptameric transmembrane AAA-ATPase, facilitates folded Rieske iron-sulfur protein translocation across the inner mitochondrial membrane…”
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Mutations in the Human AAA + Chaperone p97 and Related Diseases by Tang, Wai Kwan, Xia, Di

“…A number of neurodegenerative diseases have been linked to mutations in the human protein p97, an abundant cytosolic AAA (ATPase associated with various…”
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A Mighty "Protein Extractor" of the Cell: Structure and Function of the p97/CDC48 ATPase by Ye, Yihong, Tang, Wai Kwan, Zhang, Ting, Xia, Di

“…p97/VCP (known as Cdc48 in or TER94 in ) is one of the most abundant cytosolic ATPases. It is highly conserved from archaebacteria to eukaryotes. In…”
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Identification of Hub Biomarkers and Immune-Related Pathways Participating in the Progression of Antineutrophil Cytoplasmic Antibody-Associated Glomerulonephritis by Xia, Meng-Di, Yu, Rui-Ran, Chen, Dong-Ming

“…Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a systemic autoimmune disease that generally induces the progression of rapidly…”
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Laminar and turbulent groundwater flows in confined two- and three-dimensional discrete fracture networks by Fang, Hong, Zhu, Jianting, Qiu, Jinrong, Su, Yaoming, Xia, Di

“…Using laminar or turbulent flow equations indiscriminately to describe groundwater flows in fracture networks may result in large errors. We propose a new…”
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Enoyl-CoA hydratase-1 regulates mTOR signaling and apoptosis by sensing nutrients by Zhang, Ya-Kun, Qu, Yuan-Yuan, Lin, Yan, Wu, Xiao-Hui, Chen, Hou-Zao, Wang, Xu, Zhou, Kai-Qiang, Wei, Yun, Guo, Fushen, Yao, Cui-Fang, He, Xia-Di, Liu, Li-Xia, Yang, Chen, Guan, Zong-Yuan, Wang, Shi-Dong, Zhao, Jianyuan, Liu, De-Pei, Zhao, Shi-Min, Xu, Wei

“…The oncogenic mechanisms of overnutrition, a confirmed independent cancer risk factor, remain poorly understood. Herein, we report that enoyl-CoA hydratase-1…”
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Bcs1, a novel target for fungicide by Zhan, Jingyu, Xia, Di

“…The mitochondrial respiratory chain has long been a primary target for the development of fungicides for its indispensable role in various cellular functions…”
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Mitochondrial cytochrome bc1 complex as validated drug target: A structural perspective by Esser, Lothar, Xia, Di

“…Mitochondrial respiratory chain Complex III, also known as cytochrome bc1 complex or cyt bc1, is a validated target not only for antibiotics but also for…”
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Dissimilatory iron and sulfate reduction by native microbial communities using lactate and citrate as carbon sources and electron donors by Xia, Di, Yi, Xiaoyun, Lu, Yang, Huang, Weilin, Xie, Yingying, Ye, Han, Dang, Zhi, Tao, Xueqin, Li, Li, Lu, Guining

“…The bacterial (dissimilatory) iron and sulfate reduction (BIR and BSR) are intimately linked to the biogeochemical cycling of C, Fe, and S in acid mine…”
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Mobility and subcellular localization of endogenous, gene-edited Tau differs from that of over-expressed human wild-type and P301L mutant Tau by Xia, Di, Gutmann, Julia M., Götz, Jürgen

“…Alzheimer’s disease (AD) and a subset of frontotemporal dementia termed FTLD-Tau are characterized by a massive, yet incompletely characterized and understood…”
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Clinical characteristics, susceptibility profiles, and treatment of nocardiosis: a multicenter retrospective study in 2015-2021 by Yang, Jing, Ren, Hong-tao, Wang, Jie, Dong, Ai-ying, Chen, Yu-lan, Hu, Di-xia, Wang, Hao, Ji, Hong-meng, Wen, Hai-nan, Chen, Ying, Shi, Dong-yan

“…•Pulmonary nocardiosis was the most common type of Nocardia infection.•The most common basic disease was chronic lung disease in pulmonary…”
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