Search Results - "DI Stefano, Giuseppina"

Biocomplexity and Fractality in the Search of Biomarkers of Aging and Pathology: Focus on Mitochondrial DNA and Alzheimer's Disease by Zaia, Annamaria, Maponi, Pierluigi, Di Stefano, Giuseppina, Casoli, Tiziana

“…Alzheimer's disease (AD) represents one major health concern for our growing elderly population. It accounts for increasing impairment of cognitive capacity…”
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Lactate Can Modulate the Antineoplastic Effects of Doxorubicin and Relieve the Drug's Oxidative Damage on Cardiomyocytes by Rossi, Valentina, Govoni, Marzia, Di Stefano, Giuseppina

“…Doxorubicin (DOXO) is currently administered as the first-choice therapy for a variety of malignancies. Cancer cells exhibit enhanced glycolysis and lactate…”
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A novel method for coupling doxorubicin to lactosaminated human albumin by an acid sensitive hydrazone bond: synthesis, characterization and preliminary biological properties of the conjugate by Stefano, Giuseppina Di, Lanza, Marcella, Kratz, Felix, Merina, Luca, Fiume, Luigi

“…The expression of the asialoglycoprotein receptor on the cells of the large majority of the well differentiated hepatocellular carcinomas can be exploited to…”
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Human lactate dehydrogenase A undergoes allosteric transitions under pH conditions inducing the dissociation of the tetrameric enzyme by Pasti, Alberto Pietro, Rossi, Valentina, Di Stefano, Giuseppina, Brigotti, Maurizio, Hochkoeppler, Alejandro

“…The aerobic energetic metabolism of eukaryotic cells relies on the glycolytic generation of pyruvate, which is subsequently channelled to the oxidative…”
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One-month strawberry-rich anthocyanin supplementation ameliorates cardiovascular risk, oxidative stress markers and platelet activation in humans by Alvarez-Suarez, José M., Giampieri, Francesca, Tulipani, Sara, Casoli, Tiziana, Di Stefano, Giuseppina, González-Paramás, Ana M., Santos-Buelga, Celestino, Busco, Franco, Quiles, Josè L., Cordero, Mario D., Bompadre, Stefano, Mezzetti, Bruno, Battino, Maurizio

“…Strawberries are an important fruit in the Mediterranean diet because of their high content of essential nutrients and beneficial phytochemicals, which seem to…”
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Galloflavin (CAS 568-80-9): A Novel Inhibitor of Lactate Dehydrogenase by Manerba, Marcella, Vettraino, Marina, Fiume, Luigi, Di Stefano, Giuseppina, Sartini, Andrea, Giacomini, Elisa, Buonfiglio, Rosa, Roberti, Marinella, Recanatini, Maurizio

“…One of the most prominent alterations in cancer cells is their strict dependence on the glycolytic pathway for ATP generation. This observation led to the…”
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Peptides inhibiting the assembly of monomeric human l‐lactate dehydrogenase into catalytically active homotetramer decrease the synthesis of lactate in cultured cells by Stefan, Alessandra, Gentilucci, Luca, Ruffolo, Francesca, Rossi, Valentina, Sordi, Sofia, He, Tingting, Stefano, Giuseppina, Santino, Federica, Brigotti, Maurizio, Scotti, Claudia, Iamele, Luisa, Jonge, Hugo, Piaz, Fabrizio Dal, Santarcangelo, Danilo Rocco, Hochkoeppler, Alejandro

“…The energetic metabolism of cancer cells relies on a substantial commitment of pyruvate to the catalytic action of lactate‐generating dehydrogenases. This…”
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The activation of lactate dehydrogenase induced by mTOR drives neoplastic change in breast epithelial cells by Manerba, Marcella, Di Ianni, Lorenza, Govoni, Marzia, Comparone, Antonietta, Di Stefano, Giuseppina

“…mTOR kinase and the A isoform of lactate dehydrogenase (LDH-A) are key players controlling the metabolic characteristics of cancer cells. By using cultured…”
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Lactate-Induced HBEGF Shedding and EGFR Activation: Paving the Way to a New Anticancer Therapeutic Opportunity by Rossi, Valentina, Hochkoeppler, Alejandro, Govoni, Marzia, Di Stefano, Giuseppina

“…Cancer cells can release EGF-like peptides, acquiring the capacity of autocrine stimulation via EGFR-mediated signaling. One of these peptides (HBEGF) was…”
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The Mechanistic Understanding of RAD51 Defibrillation: A Critical Step in BRCA2-Mediated DNA Repair by Homologous Recombination by Schipani, Fabrizio, Manerba, Marcella, Marotta, Roberto, Poppi, Laura, Gennari, Arianna, Rinaldi, Francesco, Armirotti, Andrea, Farabegoli, Fulvia, Roberti, Marinella, Di Stefano, Giuseppina, Rocchia, Walter, Girotto, Stefania, Tirelli, Nicola, Cavalli, Andrea

“…The cytotoxic action of anticancer drugs can be potentiated by inhibiting DNA repair mechanisms. RAD51 is a crucial protein for genomic stability due to its…”
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Impact of potentially inappropriate medications and polypharmacy on 3-month readmission among older patients discharged from acute care hospital: a prospective study by Fabbietti, Paolo, Di Stefano, Giuseppina, Moresi, Raffaella, Cassetta, Laura, Di Rosa, Mirko, Fimognari, Filippo, Bambara, Valentina, Ruotolo, Giovanni, Castagna, Alberto, Ruberto, Carmen, Lattanzio, Fabrizia, Corsonello, Andrea

“…Background Polypharmacy and potentially inappropriate medications (PIMs) are known to affect several negative outcomes in older patients. However, studies…”
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Uterine Myomas: Extravascular Treatment by Ierardi, Anna Maria, Carnevale, Aldo, Pellegrino, Fabio, Stefano, Giuseppina Di, Bonelli, Cristian, Renzulli, Matteo, Giganti, Melchiore, Carrafiello, Gianpaolo

“…Uterine fibroids are common benign tumors that affect the female reproductive tract. They are responsible for considerable morbidity and deterioration of life…”
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Effect of sorafenib on the energy metabolism of hepatocellular carcinoma cells by Fiume, Luigi, Manerba, Marcella, Vettraino, Marina, Di Stefano, Giuseppina

“…Recent data demonstrated that sorafenib impaired the oxidative phosphorylation of a rat myogenic cell line and suggested that this biochemical lesion can…”
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Altered glycosylation profile of purified plasma ACT from Alzheimer's disease by Ianni, Manuela, Manerba, Marcella, Di Stefano, Giuseppina, Porcellini, Elisa, Chiappelli, Martina, Carbone, Ilaria, Licastro, Federico

“…Alzheimer's disease (AD) is one of the most frequent cause of neurodegenerative disorder in the elderly. Inflammation has been implicated in brain degenerative…”
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The relevance of geriatric assessments on the association between chronic kidney disease stages and mortality among older people: a secondary analysis of a multicentre cohort study by Corsonello, Andrea, Soraci, Luca, Ärnlöv, Johan, Carlsson, Axel C, Roller-Wirnsberger, Regina, Wirnsberger, Gerhard, Mattace-Raso, Francesco, Tap, Lisanne, Formiga, Francesc, Moreno-González, Rafael, Kostka, Tomasz, Guligowska, Agnieszka, Artzi-Medvedik, Rada, Melzer, Itshak, Weingart, Christian, Sieber, Cornell, Lattanzio, Fabrizia

“…Abstract Background age-adapted definition of chronic kidney disease (CKD) does not take individual risk factors into account. We aimed at investigating…”
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NAD metabolism and functions: a common therapeutic target for neoplastic, metabolic and neurodegenerative diseases by Di Stefano, Giuseppina, Manerba, Marcella, Vettraino, Marina

“…In recent years the study of nicotinamide adenine dinucleotide (NAD) biochemistry has been the focus of attention for many researchers. Although the role of…”
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Effects of robot-assisted gait training on postural instability in Parkinson's disease: a systematic review by Picelli, Alessandro, Capecci, Marianna, Filippetti, Mirko, Varalta, Valentina, Fonte, Cristina, DI Censo, Rita, Zadra, Alessandro, Chignola, Irene, Scarpa, Stefano, Amico, Angelo P, Antenucci, Roberto, Baricich, Alessio, Benanti, Paolo, Bissolotti, Luciano, Boldrini, Paolo, Bonaiuti, Donatella, Castelli, Enrico, Cavalli, Loredana, DI Stefano, Giuseppina, Draicchio, Francesco, Falabella, Vincenzo, Galeri, Silvia, Gimigliano, Francesca, Grigioni, Mauro, Jonsdottir, Johanna, Lentino, Carmelo, Massai, Perla, Mazzoleni, Stefano, Mazzon, Stefano, Molteni, Franco, Morelli, Sandra, Morone, Giovanni, Panzeri, Daniele, Petrarca, Maurizio, Posteraro, Federico, Senatore, Michele, Taglione, Elisa, Turchetti, Giuseppe, Bowman, Thomas, Nardone, Antonio

“…Postural instability is a cardinal feature of Parkinson's disease, together with rest tremor, rigidity and bradykinesia. It is a highly disabling symptom that…”
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Inhibition of lactic dehydrogenase as a way to increase the anti-proliferative effect of multi-targeted kinase inhibitors by Fiume, Luigi, Vettraino, Marina, Manerba, Marcella, Di Stefano, Giuseppina

“…Reduction of ATP levels by oxamic acid potentiates the effect of sorafenib on human hepatocellular carcinoma cells causing an early manifestation of cell…”
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Association between kidney function, nutritional status and anthropometric measures in older people by Guligowska, Agnieszka, Corsonello, Andrea, PigÅowska, MaÅgorzata, Roller-Wirnsberger, Regina, Wirnsberger, Gerhard, Ãrnlöv, Johan, Carlsson, Axel C, Tap, Lisanne, Mattace-Raso, Francesco, Formiga, Francesc, Moreno-Gonzalez, Rafael, Freiberger, Ellen, Sieber, Cornel, Gregorio, Pedro Gil, Martínez, Sara Laínez, Artzi-Medvedik, Rada, Yehoshua, Ilan, Fabbietti, Paolo, Lattanzio, Fabrizia, Kostka, Tomasz, Bustacchini, Silvia, Bolognini, Silvia, D'Ascoli, Paola, Moresi, Raffaella, Di Stefano, Giuseppina, Giammarchi, Cinzia, Bonfigli, Anna Rita, Galeazzi, Roberta, Lenci, Federica, Bella, Stefano Della, Bordoni, Enrico, Provinciali, Mauro, Giacconi, Robe, Giuli, Cinzia, Postacchini, Demetrio, Garasto, Sabrina, Cozza, Annalisa, Guarasci, Francesco, D'Alia, Sonia, Firmani, Romano, Nacciariti, Moreno, Di Rosa, Mirko, Wirnsberger, Gerhard Hubert, Roller-Wirnsberger, Regina Elisabeth, Herzog, Carolin, Lindner, Sonja, Ziere, Gijsbertus, Goudzwaard, Jeannette, Kroc, Åukasz, SoÅtysik, BartÅomiej K, Wójcik, Agnieszka, ChrzÄstek, Zuzanna, Sosowska, Natalia, TelÄżka, Anna, Kostka, Joanna, Fife, Elizaveta, Smyj, Katarzyna, Zel, Kinga, Melzer, Yehudit, Clarfield, Mark, Melzer, Itshak, Moreno-González, Rafael, Corbella, Xavier, Martínez, Yurema, Polo, Carolina, Cruzado, Josep Maria, Alonso, Mónica González, Herrero Calvo, Jose A, Molina, Fernando Tornero, Fuentes, Lara Guardado, García, Pamela Carrillo, Pérez, María Mombiedro, Renz, Alexandra, Muck, Susanne, Theobaldy, Stephan, Bekmann, Andreas, Kaltsa, Revekka, Britting, Sabine, Kob, Robert, Weingart, Christian, Carlsson, Axel, Feldreich, Tobias

“…Background Different mechanisms connect the nutritional status with the occurrence and the course of chronic kidney disease (CKD). The end-stage renal disease…”
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Balance Rehabilitation through Robot-Assisted Gait Training in Post-Stroke Patients: A Systematic Review and Meta-Analysis by Loro, Alberto, Borg, Margherita Beatrice, Battaglia, Marco, Amico, Angelo Paolo, Antenucci, Roberto, Benanti, Paolo, Bertoni, Michele, Bissolotti, Luciano, Boldrini, Paolo, Bonaiuti, Donatella, Bowman, Thomas, Capecci, Marianna, Castelli, Enrico, Cavalli, Loredana, Cinone, Nicoletta, Cosenza, Lucia, Di Censo, Rita, Di Stefano, Giuseppina, Draicchio, Francesco, Falabella, Vincenzo, Filippetti, Mirko, Galeri, Silvia, Gimigliano, Francesca, Grigioni, Mauro, Invernizzi, Marco, Jonsdottir, Johanna, Lentino, Carmelo, Massai, Perla, Mazzoleni, Stefano, Mazzon, Stefano, Molteni, Franco, Morelli, Sandra, Morone, Giovanni, Nardone, Antonio, Panzeri, Daniele, Petrarca, Maurizio, Posteraro, Federico, Santamato, Andrea, Scotti, Lorenza, Senatore, Michele, Spina, Stefania, Taglione, Elisa, Turchetti, Giuseppe, Varalta, Valentina, Picelli, Alessandro, Baricich, Alessio

“…Balance impairment is a common disability in post-stroke survivors, leading to reduced mobility and increased fall risk. Robotic gait training (RAGT) is…”
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