Search Results - "DI MARTINO, L."

Analysis of intraspecific seed diversity in Astragalus aquilanus (Fabaceae), an endemic species of Central Apennine by Di Cecco, V, Di Musciano, M, D'Archivio, A A, Frattaroli, A R, Di Martino, L

“…This work aims to study seeds of the endemic species Astragalus aquilanus from four different populations of central Italy. We investigated seed…”
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Genetic deletion of the bacterial sensor NOD2 improves murine Crohn’s disease-like ileitis independent of functional dysbiosis by Corridoni, D, Rodriguez-Palacios, A, Di Stefano, G, Di Martino, L, Antonopoulos, D A, Chang, E B, Arseneau, K O, Pizarro, T T, Cominelli, F

“…Although genetic polymorphisms in NOD2 (nucleotide-binding oligomerization domain-containing 2) have been associated with the pathogenesis of Crohn’s disease…”
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Pyridoxal 5'-phosphate is a slow tight binding inhibitor of E. coli pyridoxal kinase by Ghatge, Mohini S, Contestabile, Roberto, di Salvo, Martino L, Desai, Jigar V, Gandhi, Amit K, Camara, Christina M, Florio, Rita, González, Isabel N, Parroni, Alessia, Schirch, Verne, Safo, Martin K

“…Pyridoxal 5'-phosphate (PLP) is a cofactor for dozens of B(6) requiring enzymes. PLP reacts with apo-B(6) enzymes by forming an aldimine linkage with the…”
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The MocR‐like transcription factors: pyridoxal 5′‐phosphate‐dependent regulators of bacterial metabolism by Tramonti, Angela, Nardella, Caterina, Salvo, Martino L., Pascarella, Stefano, Contestabile, Roberto

“…Many biological functions played by current proteins were not created by evolution from scratch, rather they were obtained combining already available protein…”
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Characterization of Novel Pathogenic Variants Causing Pyridox(am)ine 5'-Phosphate Oxidase-Dependent Epilepsy by Barile, Anna, Mills, Philippa, di Salvo, Martino L, Graziani, Claudio, Bunik, Victoria, Clayton, Peter, Contestabile, Roberto, Tramonti, Angela

“…Several variants of the enzyme pyridox(am)ine 5'-phosphate oxidase (PNPO), responsible for a rare form of vitamin B -dependent neonatal epileptic…”
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How pyridoxal 5′‐phosphate differentially regulates human cytosolic and mitochondrial serine hydroxymethyltransferase oligomeric state by Giardina, Giorgio, Brunotti, Paolo, Fiascarelli, Alessio, Cicalini, Alessandra, Costa, Mauricio G. S, Buckle, Ashley M, Salvo, Martino L, Giorgi, Alessandra, Marani, Marina, Paone, Alessio, Rinaldo, Serena, Paiardini, Alessandro, Contestabile, Roberto, Cutruzzolà, Francesca

“…Adaptive metabolic reprogramming gives cancer cells a proliferative advantage. Tumour cells extensively use glycolysis to sustain anabolism and produce serine,…”
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Molecular characterization of pyridoxine 5′-phosphate oxidase and its pathogenic forms associated with neonatal epileptic encephalopathy by Barile, Anna, Nogués, Isabel, di Salvo, Martino L., Bunik, Victoria, Contestabile, Roberto, Tramonti, Angela

“…Defects of vitamin B 6 metabolism are responsible for severe neurological disorders, such as pyridoxamine 5′-phosphate oxidase deficiency (PNPOD; OMIM:…”
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On the catalytic mechanism and stereospecificity of Escherichia coli l‐threonine aldolase by Salvo, Martino L., Remesh, Soumya G., Vivoli, Mirella, Ghatge, Mohini S., Paiardini, Alessandro, D'Aguanno, Simona, Safo, Martin K., Contestabile, Roberto

“…l‐Threonine aldolases (l‐TAs) represent a family of homologous pyridoxal 5′‐phosphate‐dependent enzymes found in bacteria and fungi, and catalyse the…”
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Glycine consumption and mitochondrial serine hydroxymethyltransferase in cancer cells: The heme connection by di Salvo, Martino L, Contestabile, Roberto, Paiardini, Alessandro, Maras, Bruno

“…Abstract It was recently discovered that glycine consumption is strongly related to the rate of proliferation across cancer cells. This is very intriguing and…”
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Molecular mechanism of PdxR – a transcriptional activator involved in the regulation of vitamin B6 biosynthesis in the probiotic bacterium Bacillus clausii by Tramonti, Angela, Fiascarelli, Alessio, Milano, Teresa, Salvo, Martino L, Nogués, Isabel, Pascarella, Stefano, Contestabile, Roberto

“…Pyridoxal 5′‐phosphate (PLP), the well‐known active form of vitamin B₆, is an essential enzyme cofactor involved in a large number of metabolic processes. PLP…”
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Physiological and Biochemical Markers of the Sex-Specific Sensitivity to Epileptogenic Factors, Delayed Consequences of Seizures and Their Response to Vitamins B1 and B6 in a Rat Model by Aleshin, Vasily A., Graf, Anastasia V., Artiukhov, Artem V., Boyko, Alexandra I., Ksenofontov, Alexander L., Maslova, Maria V., Nogués, Isabel, di Salvo, Martino L., Bunik, Victoria I.

“…The disturbed metabolism of vitamins B1 or B6, which are essential for neurotransmitters homeostasis, may cause seizures. Our study aims at revealing…”
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A Novel, Easy Assay Method for Human Cysteine Sulfinic Acid Decarboxylase by Tramonti, Angela, Contestabile, Roberto, Florio, Rita, Nardella, Caterina, Barile, Anna, Di Salvo, Martino L

“…Cysteine sulfinic acid decarboxylase catalyzes the last step of taurine biosynthesis in mammals, and belongs to the fold type I superfamily of…”
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Editorial: PLP-Dependent Enzymes: Extraordinary Versatile Catalysts and Ideal Biotechnological Tools for the Production of Unnatural Amino Acids and Related Compounds by Di Salvo, Martino L, Fesko, Kateryna, Phillips, Robert S, Contestabile, Roberto

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Isolation of a Complex Formed Between Acinetobacter baumannii HemA and HemL, Key Enzymes of Tetrapyrroles Biosynthesis by Nardella, Caterina, Boi, Dalila, di Salvo, Martino L, Barile, Anna, Stetefeld, Jörg, Tramonti, Angela, Contestabile, Roberto

“…Plants, algae and most bacteria synthesize 5-aminolevulinic acid (ALA), the universal precursor of tetrapyrroles such as heme, chlorophyll and coenzyme B , by…”
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Crystal structures of human pyridoxal kinase in complex with the neurotoxins, ginkgotoxin and theophylline: insights into pyridoxal kinase inhibition by Gandhi, Amit K, Desai, Jigar V, Ghatge, Mohini S, di Salvo, Martino L, Di Biase, Stefano, Danso-Danquah, Richmond, Musayev, Faik N, Contestabile, Roberto, Schirch, Verne, Safo, Martin K

“…Several drugs and natural compounds are known to be highly neurotoxic, triggering epileptic convulsions or seizures, and causing headaches, agitations, as well…”
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Inhibition of human pyridoxal kinase by 2-acetyl-4-((1R,2S,3R)-1,2,3,4-tetrahydroxybutyl)imidazole (THI) by Elsinghorst, Paul W, di Salvo, Martino L, Parroni, Alessia, Contestabile, Roberto

“…2-Acetyl-4-((1R,2S,3R)-1,2,3,4-tetrahydroxybutyl)imidazole (THI) is observed as a minor contaminant in caramel food colourings (E 150c). Feeding experiments…”
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Molecular Basis of Reduced Pyridoxine 5′-Phosphate Oxidase Catalytic Activity in Neonatal Epileptic Encephalopathy Disorder by Musayev, Faik N., Di Salvo, Martino L., Saavedra, Mario A., Contestabile, Roberto, Ghatge, Mohini S., Haynes, Alexina, Schirch, Verne, Safo, Martin K.

“…Mutations in pyridoxine 5′-phosphate oxidase are known to cause neonatal epileptic encephalopathy. This disorder has no cure or effective treatment and is…”
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Using selected Habitat European Directive species as garden plants: challenges and opportunities by Mariotti, M., Bonomi, C., Magrini, S., Bacchetta, G., Bavcon, J., Casolo, V., Ceriani, R.M., Di Martino, L., Dixon, L., Fabrini, G., Raimondi, S., Salmeri, C., Villani, M., Buhagiar, J., Cristaudo, A.

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Biochemical data from the characterization of a new pathogenic mutation of human pyridoxine-5'-phosphate oxidase (PNPO) by di Salvo, Martino L., Mastrangelo, Mario, Nogués, Isabel, Tolve, Manuela, Paiardini, Alessandro, Carducci, Carla, Mei, Davide, Montomoli, Martino, Tramonti, Angela, Guerrini, Renzo, Contestabile, Roberto, Leuzzi, Vincenzo

“…PNPO deficiency is responsible of severe neonatal encephalopathy, responsive to pyridoxal-5′-phosphate (PLP) or pyridoxine. Recent studies widened the…”
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Kinetic and structural studies of the role of the active site residue Asp235 of human pyridoxal kinase by Gandhi, Amit K., Ghatge, Mohini S., Musayev, Faik N., Sease, Aaron, Aboagye, Samuel O., di Salvo, Martino L., Schirch, Verne, Safo, Martin K.

“…Pyridoxal kinase catalyzes the phosphorylation of pyridoxal (PL) to pyridoxal 5′-phosphate (PLP). A D235A variant shows 7-fold and 15-fold decreases in…”
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